Detailed information for compound 1743298

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1221.24 | Formula: C56H64F4N12O13S
  • H donors: 9 H acceptors: 15 LogP: -0.5 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 4
  • SMILES: OS(=O)(=O)O.O=C(N1CCC(CC1)n1c(=O)[nH]c2c1cccn2)O[C@@H]1CC[C@H]([C@@H](c2c1nccc2)N)c1cccc(c1F)F.O=C(N1CCC(CC1)n1c(=O)[nH]c2c1cccn2)O[C@@H]1CC[C@H]([C@@H](c2c1nccc2)N)c1cccc(c1F)F.O.O.O
  • InChi: 1S/2C28H28F2N6O3.H2O4S.3H2O/c2*29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37;1-5(2,3)4;;;/h2*1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37);(H2,1,2,3,4);3*1H2/t2*18-,22+,24-;;;;/m00..../s1
  • InChiKey: SOGUOEZRYKUOHR-CQZKMDJHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni bromodomain containing protein 0.0063 0.0609 0.1437
Echinococcus granulosus carbonic anhydrase II 0.0172 0.2009 0.4739
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0553 0.1304
Brugia malayi Carboxylesterase family protein 0.0058 0.0553 0.1033
Brugia malayi Cytochrome P450 family protein 0.0024 0.0106 0.0198
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.05 0.4744
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0433 0.5348 1
Echinococcus multilocularis neuroligin 0.0058 0.0553 0.0553
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.0867 0.0867
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0058 0.0553 0.8892
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0867 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0402 0.0948
Loa Loa (eye worm) hypothetical protein 0.0106 0.1158 0.2165
Onchocerca volvulus 0.0058 0.0553 0.0237
Schistosoma mansoni eyes absent homolog 0.0085 0.0898 0.212
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0598 0.6904
Loa Loa (eye worm) carboxylesterase 0.0058 0.0553 0.1033
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0418 0.0986
Echinococcus multilocularis carboxylesterase 5A 0.0346 0.4239 0.4239
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0172 0.2009 1
Echinococcus multilocularis protein dispatched 1 0.0098 0.1065 0.1065
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0201 0.238 1
Schistosoma mansoni carbonic anhydrase-related 0.0081 0.0839 0.198
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0615 0.0615
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0615 0.1452
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1324 0.2476
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.0867 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0172 0.2009 0.4739
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0048 0.0241
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0402 0.0751
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0566 0.1058
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0081 0.0839 0.157
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0261 0.0615
Loa Loa (eye worm) hypothetical protein 0.0038 0.0292 0.0546
Echinococcus granulosus carbonic anhydrase 0.0081 0.0839 0.198
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.039 0.0729
Loa Loa (eye worm) hypothetical protein 0.0042 0.0346 0.0648
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.1033
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.1695 0.317
Echinococcus multilocularis BC026374 protein (S09 family) 0.0058 0.0553 0.0553
Schistosoma mansoni zinc finger protein 0.0019 0.0053 0.0124
Brugia malayi Pre-SET motif family protein 0.0062 0.0598 0.1119
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0079 0.0816 0.0816
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0079 0.0816 0.1924
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0615 0.693
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.002 0.0048
Onchocerca volvulus 0.0058 0.0553 0.0237
Onchocerca volvulus 0.0058 0.0553 0.0237
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.05 0.7969
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0566 0.1334
Loa Loa (eye worm) hypothetical protein 0.0083 0.0867 0.1621
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0081 0.0839 0.157
Echinococcus granulosus tumor protein p63 0.0328 0.4003 0.9444
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0028 0.0053
Echinococcus multilocularis Niemann Pick C1 protein 0.0201 0.238 0.238
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0048 0.0114
Plasmodium vivax SET domain protein, putative 0.0062 0.0598 0.6904
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0172 0.2009 0.3757
Loa Loa (eye worm) hypothetical protein 0.0101 0.1096 0.205
Echinococcus granulosus Niemann Pick C1 protein 0.0201 0.238 0.5615
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.0867 0.2045
Echinococcus granulosus neuroligin 0.0058 0.0553 0.1304
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0615 0.1452
Loa Loa (eye worm) hypothetical protein 0.007 0.0704 0.1317
Echinococcus granulosus histone lysine methyltransferase setb 0.0079 0.0816 0.1924
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0048 0.009
Brugia malayi Carboxylesterase family protein 0.0058 0.0553 0.1033
Brugia malayi CHE-14 protein 0.0086 0.0909 0.17
Brugia malayi Carboxylesterase family protein 0.0058 0.0553 0.1033
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.05 0.118
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.0867 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.039 0.039
Loa Loa (eye worm) acetylcholinesterase 1 0.0346 0.4239 0.7927
Echinococcus multilocularis acetylcholinesterase 0.0346 0.4239 0.4239
Brugia malayi Bromodomain containing protein 0.0038 0.0291 0.0544
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.039 0.0919
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.002 0.002
Mycobacterium ulcerans carboxylesterase, LipT 0.0058 0.0553 0.6162
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.05 0.05
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0615 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0816 0.1525
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1324 0.2476
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.009 0.0213
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.009 0.0213
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.0867 0.2045
Echinococcus granulosus para nitrobenzyl esterase 0.0058 0.0553 0.1304
Brugia malayi Bromodomain containing protein 0.0075 0.0759 0.1418
Schistosoma mansoni hypothetical protein 0.0047 0.0402 0.0948
Schistosoma mansoni gliotactin 0.0058 0.0553 0.1304
Loa Loa (eye worm) hypothetical protein 0.0346 0.4239 0.7927
Schistosoma mansoni hypothetical protein 0.0047 0.0402 0.0948
Echinococcus granulosus zinc finger protein 0.0019 0.0053 0.0124
Echinococcus multilocularis carbonic anhydrase 0.0081 0.0839 0.0839
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0541 0.0541
Loa Loa (eye worm) carbonic anhydrase 3 0.0172 0.2009 0.3757
Toxoplasma gondii exonuclease III APE 0.0019 0.0048 0.0558
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0058 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.1033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0402 0.0948
Loa Loa (eye worm) hypothetical protein 0.0081 0.0839 0.157
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0615 0.693
Brugia malayi Pre-SET motif family protein 0.0433 0.5348 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0598 0.1412
Schistosoma mansoni neuroligin 3 (S09 family) 0.0058 0.0553 0.1304
Plasmodium falciparum carbonic anhydrase 0.0081 0.0839 0.9684
Toxoplasma gondii hypothetical protein 0.0081 0.0839 0.9684
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.0086 0.0909 0.17
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0598 0.1412
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0346 0.4239 1
Brugia malayi Carboxylesterase family protein 0.0346 0.4239 0.7927
Loa Loa (eye worm) hypothetical protein 0.0081 0.0839 0.157
Loa Loa (eye worm) hypothetical protein 0.0201 0.238 0.4451
Brugia malayi Carboxylesterase family protein 0.0346 0.4239 0.7927
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0402 0.0402
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0402 0.0751
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0402 0.0751
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.039 0.039
Onchocerca volvulus 0.0058 0.0553 0.0237
Echinococcus multilocularis carbonic anhydrase 0.0081 0.0839 0.0839
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.1033
Toxoplasma gondii hypothetical protein 0.0029 0.017 0.1956
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.039 0.0919
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0564 0.133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.039 0.0919
Schistosoma mansoni BC026374 protein (S09 family) 0.0058 0.0553 0.1304
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0204 0.242 0.5709
Echinococcus granulosus carbonic anhydrase 0.0081 0.0839 0.198
Schistosoma mansoni hypothetical protein 0.0081 0.0839 0.198
Onchocerca volvulus 0.0492 0.6113 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0058 0.0553 0.1304
Trypanosoma brucei carbonic anhydrase-like protein 0.0172 0.2009 1
Schistosoma mansoni hypothetical protein 0.0083 0.0869 0.205
Brugia malayi Niemann-Pick C1 protein precursor 0.0201 0.238 0.4451
Brugia malayi hypothetical protein 0.0058 0.0553 0.1033
Schistosoma mansoni hypothetical protein 0.0083 0.0869 0.205
Echinococcus granulosus carboxylesterase 5A 0.0346 0.4239 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.05 0.7969
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0541 0.0541
Schistosoma mansoni hypothetical protein 0.0083 0.0869 0.205
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0048 0.009
Loa Loa (eye worm) hypothetical protein 0.0148 0.1695 0.317
Schistosoma mansoni patched 1 0.0086 0.0909 0.2144
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.017 0.1956
Brugia malayi Carboxylesterase family protein 0.0058 0.0553 0.1033
Schistosoma mansoni carbonic anhydrase-related 0.0081 0.0839 0.198
Echinococcus multilocularis carbonic anhydrase 0.0081 0.0839 0.0839
Echinococcus granulosus BC026374 protein S09 family 0.0058 0.0553 0.1304
Loa Loa (eye worm) hypothetical protein 0.0085 0.0898 0.168
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0081 0.0839 0.157
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0553 0.1304
Schistosoma mansoni carbonic anhydrase 0.0081 0.0839 0.198
Brugia malayi hypothetical protein 0.0085 0.0898 0.168
Echinococcus multilocularis para nitrobenzyl esterase 0.0058 0.0553 0.0553
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0867 1
Echinococcus granulosus expressed conserved protein 0.0189 0.2224 0.5246
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0261 0.0261
Onchocerca volvulus 0.0062 0.0598 0.0317
Echinococcus granulosus acetylcholinesterase 0.0346 0.4239 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0602
Schistosoma mansoni hypothetical protein 0.0101 0.1096 0.2586
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0079 0.0816 0.1924
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.1033
Mycobacterium tuberculosis Carboxylesterase LipT 0.0058 0.0553 0.8892
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0114
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0048 0.0048
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0024 0.0057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.039 0.0729
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0564 0.0564
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0024 0.0024
Echinococcus multilocularis acetylcholinesterase 0.0346 0.4239 0.4239
Echinococcus granulosus GPCR family 2 0.0047 0.0402 0.0948
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0172 0.2009 0.4739
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0615 0.7101
Brugia malayi jmjC domain containing protein 0.0059 0.0566 0.1058
Echinococcus granulosus carbonic anhydrase 0.0081 0.0839 0.198
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.1695 0.317
Loa Loa (eye worm) hypothetical protein 0.0346 0.4239 0.7927
Echinococcus multilocularis carbonic anhydrase II 0.0172 0.2009 0.2009
Brugia malayi Probable ClpP-like protease 0.0083 0.0867 0.1621
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0058 0.0553 0.0831
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0048 0.0241
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0541 0.1277
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0909 0.2144
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 0.0558
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0081 0.0839 0.157
Loa Loa (eye worm) hypothetical protein 0.0085 0.0898 0.168
Schistosoma mansoni carbonic anhydrase-related 0.0081 0.0839 0.198
Echinococcus granulosus acetylcholinesterase 0.0346 0.4239 1
Echinococcus multilocularis zinc finger protein 0.0019 0.0053 0.0053
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0172 0.2009 0.3757
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.039 0.0919
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0867 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0867 1
Schistosoma mansoni hypothetical protein 0.0047 0.0402 0.0948
Echinococcus multilocularis tumor protein p63 0.0328 0.4003 0.4003
Schistosoma mansoni acetylcholinesterase 0.0058 0.0553 0.1304
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0867 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0569 0.1343
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0048 0.5
Brugia malayi MH2 domain containing protein 0.0119 0.1324 0.2476
Schistosoma mansoni hypothetical protein 0.0083 0.0869 0.205
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0172 0.2009 0.3757
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0867 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0839 0.157
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0615 0.3063
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.017 0.1481
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0615 0.1452
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.1096 0.205
Loa Loa (eye worm) carboxylesterase 0.0346 0.4239 0.7927
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0066 0.0123
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.002 0.0048
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0048 0.0241
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.1033
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0909 0.17
Leishmania major carbonic anhydrase-like protein 0.0172 0.2009 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0867 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0553 0.1304
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0566 0.1334
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0909 0.1419
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0566 0.1334
Brugia malayi PHD-finger family protein 0.0025 0.012 0.0225
Trichomonas vaginalis set domain proteins, putative 0.0492 0.6113 1
Schistosoma mansoni hypothetical protein 0.0021 0.0066 0.0156
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0615 0.693
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.002 0.0048
Echinococcus multilocularis Niemann Pick C1 protein 0.0287 0.3486 0.3486
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 0.0558
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.1033
Echinococcus multilocularis GPCR, family 2 0.0047 0.0402 0.0402
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0598 0.0598
Loa Loa (eye worm) hypothetical protein 0.0047 0.0402 0.0751
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0867 0.5
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0058 0.0553 0.8892
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.017 0.1956
Loa Loa (eye worm) hypothetical protein 0.0048 0.0418 0.0781
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0172 0.2009 1
Echinococcus multilocularis expressed conserved protein 0.0189 0.2224 0.2224
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0081 0.0839 0.157
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0402 0.0402
Loa Loa (eye worm) carboxylesterase 0.0058 0.0553 0.1033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.1695 0.317
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.1033
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0909 0.2144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.039 0.0919
Trichomonas vaginalis spcc417.12 protein, putative 0.0058 0.0553 0.0831
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0106 0.0198
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0114
Brugia malayi jmjC domain containing protein 0.0058 0.0541 0.1012
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0541 0.1277
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0081 0.0839 0.157
Echinococcus granulosus Niemann Pick C1 protein 0.0287 0.3486 0.8224
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0867 0.5
Onchocerca volvulus 0.0058 0.0553 0.0237
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0048 0.0241
Schistosoma mansoni hypothetical protein 0.0047 0.0402 0.0948
Echinococcus multilocularis protein patched 0.0086 0.0909 0.0909

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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