Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1848 | 0.8496 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2131 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1848 | 0.8496 | 0.7933 |
Schistosoma mansoni | sphingoid long chain base kinase | 0.2131 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.2725 | 0.2725 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0867 | 0.3289 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1848 | 0.8496 | 0.7933 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0867 | 0.3289 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1848 | 0.8496 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1848 | 0.8496 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0867 | 0.3289 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.1848 | 0.8496 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1848 | 0.8496 | 0.7933 |
Brugia malayi | CHE-14 protein | 0.0761 | 0.2725 | 0.3208 |
Entamoeba histolytica | hypothetical protein, conserved | 0.2131 | 1 | 0.5 |
Echinococcus multilocularis | sphingosine kinase 1 | 0.2131 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1848 | 0.8496 | 0.8496 |
Schistosoma mansoni | sphingosine kinase A B | 0.2131 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0867 | 0.3289 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1848 | 0.8496 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.2131 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.2131 | 1 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0761 | 0.2725 | 0.2725 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 120 uM | Compound was evaluated for the inhibition of dTMP synthetase with respect to dUMP. | ChEMBL. | 7328576 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.