Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1207 | 0.1201 | 0.1254 |
Loa Loa (eye worm) | thymidylate synthase | 0.9384 | 0.953 | 1 |
Onchocerca volvulus | 0.9384 | 0.953 | 1 | |
Brugia malayi | hypothetical protein | 0.4464 | 0.4519 | 0.3984 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0158 | 0.0133 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1207 | 0.1201 | 0.1254 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4464 | 0.4519 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.9845 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.9384 | 0.953 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.9845 | 1 | 0.5 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0158 | 0.0133 | 0.0132 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.9845 | 1 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.0007 | 0.0008 | |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0158 | 0.0133 | 0.0132 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.9845 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.9384 | 0.953 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.9845 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.9384 | 0.953 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1207 | 0.1201 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.9384 | 0.953 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.9384 | 0.953 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.4464 | 0.4519 | 0.4738 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.9384 | 0.953 | 1 |
Brugia malayi | thymidylate synthase | 0.9384 | 0.953 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1207 | 0.1201 | 0.1254 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.04 mg kg-1 | Antinociceptive activity of subcutaneously administered compound in acetic acid (AA) induced writhing mice | ChEMBL. | 2709377 |
ED50 (functional) | = 0.08 mg kg-1 | Antinociceptive activity of subcutaneously administered compound in phenyl-p-benzoquinone induced writhing mice | ChEMBL. | 2709377 |
ED50 (functional) | = 1.7 mg kg-1 | Antinociceptive activity in the hot plate test (central activity) in rodents, when compound administered subcutaneously | ChEMBL. | 2709377 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.