Detailed information for compound 1743369

Basic information

Technical information
  • TDR Targets ID: 1743369
  • Name: tert-butyl N-[(1S)-2-[(2S)-2-[[(2S)-5-(diamin omethylideneamino)-1-oxopentan-2-yl]carbamoyl ]pyrrolidin-1-yl]-1-(4-fluorophenyl)-2-oxoeth yl]carbamate
  • MW: 506.57 | Formula: C24H35FN6O5
  • H donors: 4 H acceptors: 4 LogP: 0.85 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](c1ccc(cc1)F)NC(=O)OC(C)(C)C)CCCN=C(N)N
  • InChi: 1S/C24H35FN6O5/c1-24(2,3)36-23(35)30-19(15-8-10-16(25)11-9-15)21(34)31-13-5-7-18(31)20(33)29-17(14-32)6-4-12-28-22(26)27/h8-11,14,17-19H,4-7,12-13H2,1-3H3,(H,29,33)(H,30,35)(H4,26,27,28)/t17-,18-,19-/m0/s1
  • InChiKey: UNTYULOIKNKYHN-FHWLQOOXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • tert-butyl N-[(1S)-1-(4-fluorophenyl)-2-[(2S)-2-[[(1S)-1-formyl-4-guanidino-butyl]carbamoyl]pyrrolidin-1-yl]-2-oxo-ethyl]carbamate
  • N-[(1S)-1-(4-fluorophenyl)-2-[(2S)-2-[[[(1S)-1-formyl-4-guanidinobutyl]amino]-oxomethyl]-1-pyrrolidinyl]-2-oxoethyl]carbamic acid tert-butyl ester
  • N-[(1S)-1-(4-fluorophenyl)-2-[(2S)-2-[[(1S)-1-formyl-4-guanidino-butyl]carbamoyl]pyrrolidin-1-yl]-2-keto-ethyl]carbamic acid tert-butyl ester
  • tert-butyl N-[(1S)-2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-oxo-pentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-(4-fluorophenyl)-2-oxo-ethyl]carbamate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Homo sapiens protease, serine, 1 (trypsin 1) Starlite/ChEMBL References
Homo sapiens plasminogen Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Trypsin family protein protease, serine, 1 (trypsin 1) 247 aa 287 aa 21.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.0001 0.0001
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0217 0.1089 0.1089
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0217 0.1089 0.1792
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.0001 0.0001
Onchocerca volvulus 0.0048 0.0001 0.0004
Echinococcus granulosus para nitrobenzyl esterase 0.0163 0.0742 0.0742
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0001 0.0001
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0001 0.0001
Onchocerca volvulus 0.0048 0.0001 0.0004
Schistosoma mansoni hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.0001 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0001 0.0001
Brugia malayi Carboxylesterase family protein 0.0163 0.0742 0.077
Schistosoma mansoni hypothetical protein 0.0132 0.054 0.054
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0056 0.0053 0.0053
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.0001 0.0001
Toxoplasma gondii carbamoylphosphate synthetase 0.0138 0.0579 0.0579
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0138 0.0579 0.0579
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0002 0.0003
Echinococcus multilocularis tumor protein p63 0.0327 0.1798 0.1798
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0056 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0123 0.0487 0.0505
Leishmania major carboxylase, putative 0.061 0.3618 0.3618
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0056 0.0053 0.0053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Brugia malayi AKH receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0002 0.0003
Echinococcus multilocularis BC026374 protein (S09 family) 0.0163 0.0742 0.0742
Loa Loa (eye worm) hypothetical protein 0.0404 0.2291 0.2377
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0001 0.0001
Mycobacterium tuberculosis Carboxylesterase LipT 0.0163 0.0742 0.1934
Schistosoma mansoni opsin-like receptor 0.0048 0.0001 0.0001
Brugia malayi hypothetical protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi ORL1-like opioid receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0163 0.0742 0.077
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.061 0.3618 0.5957
Echinococcus multilocularis somatostatin receptor 0.0048 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0048 0.0001 0.0001
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.061 0.3618 1
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0056 0.0053 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.0001 0.0001
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0163 0.0742 0.077
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0132 0.054 0.056
Loa Loa (eye worm) hypothetical protein 0.005 0.0012 0.0012
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0404 0.2291 0.2291
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0217 0.1089 0.1089
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0000034744 0.0000036045
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.0001 0.0001
Brugia malayi Dopamine receptor protein 1 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0087 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0001 0.0001
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0056 0.0053 0.0053
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0056 0.0053 0.0053
Echinococcus granulosus fmrfamide receptor 0.0048 0.0001 0.0001
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.061 0.3618 1
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0056 0.0053 0.0055
Echinococcus granulosus acetylcholinesterase 0.0966 0.591 0.591
Trypanosoma brucei acetyl-CoA carboxylase 0.1601 1 1
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0056 0.0053 0.0074
Echinococcus granulosus acetylcholinesterase 0.0966 0.591 0.591
Brugia malayi Trypsin family protein 0.0123 0.0487 0.0505
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.061 0.3618 0.3618
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0001 0.0001
Brugia malayi larval opioid receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Onchocerca volvulus 0.0048 0.0001 0.0004
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.0001 0.0001
Trypanosoma brucei unspecified product 0.0401 0.2273 0.2232
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Onchocerca volvulus Cell death protein 3 homolog 0.0132 0.054 0.2356
Loa Loa (eye worm) hypothetical protein 0.0163 0.0742 0.077
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.0001 0.0001
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.061 0.3618 0.3584
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0001 0.0001
Brugia malayi Carboxylesterase family protein 0.0966 0.591 0.6131
Brugia malayi hypothetical protein 0.0048 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0087 0.0087
Brugia malayi G-protein coupled receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0163 0.0742 0.077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0001 0.0001
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0404 0.2291 0.2377
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0001 0.0001
Schistosoma mansoni glutaminase 0.027 0.1427 0.1427
Onchocerca volvulus 0.0123 0.0487 0.2124
Onchocerca volvulus 0.0048 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.061 0.3618 1
Trichomonas vaginalis glutaminase, putative 0.027 0.1427 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0002 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0001 0.0001
Echinococcus granulosus g protein coupled receptor 0.0048 0.0001 0.0001
Echinococcus granulosus neuroligin 0.0163 0.0742 0.0742
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0217 0.1089 0.2905
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.0001 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0001 0.0001
Brugia malayi hypothetical protein 0.0048 0.0001 0.0001
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1158 0.7151 1
Chlamydia trachomatis biotin carboxylase 0.0554 0.3257 1
Echinococcus multilocularis caspase 2 0.0132 0.054 0.054
Brugia malayi hypothetical protein 0.0132 0.054 0.056
Echinococcus multilocularis serotonin receptor 0.0048 0.0001 0.0001
Echinococcus granulosus BC026374 protein S09 family 0.0163 0.0742 0.0742
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0001 0.0001
Brugia malayi Carboxyl transferase domain containing protein 0.1545 0.9639 1
Brugia malayi hypothetical protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0048 0.0001 0.0001
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0056 0.0053 0.0053
Onchocerca volvulus 0.0048 0.0001 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0056 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Echinococcus multilocularis apoptotic protease activating factor 1 0.0132 0.054 0.054
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0056 0.0053 0.0053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0056 0.0053 0.0087
Brugia malayi hypothetical protein 0.0163 0.0742 0.077
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0000034744 0.0000034744
Onchocerca volvulus 0.0163 0.0742 0.324
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.0001 0.0001
Schistosoma mansoni acetylcholinesterase 0.0163 0.0742 0.0742
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0001 0.0001
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0138 0.0579 0.1476
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Onchocerca volvulus 0.0163 0.0742 0.324
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0217 0.1089 0.2905
Echinococcus granulosus hypothetical protein 0.0048 0.0001 0.0001
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0217 0.1089 0.2905
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.0001 0.0001
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0163 0.0742 0.077
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0404 0.2291 0.2377
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0087 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0001 0.0001
Onchocerca volvulus Deterin homolog 0.0404 0.2291 1
Echinococcus granulosus neuropeptide receptor 0.0048 0.0001 0.0001
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.0001 0.0001
Schistosoma mansoni biogenic amine receptor 0.0048 0.0001 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0001 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.1601 1 1
Brugia malayi neuropeptide F receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis inhibitor of apoptosis protein 0.0404 0.2291 0.2291
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0217 0.1089 0.2905
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0056 0.0053 0.0074
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.0001 0.0001
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0056 0.0053 0.0074
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0056 0.0053 0.0087
Schistosoma mansoni aspartate carbamoyltransferase 0.0138 0.0579 0.0579
Echinococcus granulosus g-protein coupled receptor 0.0048 0.0001 0.0001
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0404 0.2291 0.2377
Brugia malayi glutaminase DH11.1 0.027 0.1427 0.1481
Schistosoma mansoni biogenic amine receptor 0.0048 0.0001 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) acetylcholinesterase 1 0.0966 0.591 0.6131
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0217 0.1089 0.1041
Onchocerca volvulus 0.0048 0.0001 0.0004
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0001 0.0001
Schistosoma mansoni histamine h1 receptor 0.0048 0.0001 0.0001
Brugia malayi Carboxylesterase family protein 0.0966 0.591 0.6131
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0001 0.0001
Echinococcus granulosus serotonin receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.0001 0.0001
Echinococcus granulosus g protein coupled receptor 0.0048 0.0001 0.0001
Schistosoma mansoni caspase-7 (C14 family) 0.0132 0.054 0.054
Brugia malayi Melatonin receptor type 1A 0.0048 0.0001 0.0001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0001 0.0001
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.0001 0.0001
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.0001 0.0001
Echinococcus multilocularis allatostatin A receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0056 0.0053 0.0053
Schistosoma mansoni BC026374 protein (S09 family) 0.0163 0.0742 0.0742
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis acetylcholinesterase 0.0966 0.591 0.591
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Echinococcus multilocularis neuroligin 0.0163 0.0742 0.0742
Onchocerca volvulus 0.0048 0.0001 0.0004
Echinococcus multilocularis acetylcholinesterase 0.0966 0.591 0.591
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0056 0.0053 0.0087
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0138 0.0579 0.0529
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0217 0.1089 0.1089
Brugia malayi G-protein coupled receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Schistosoma mansoni pyruvate carboxylase 0.061 0.3618 0.3618
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.0001 0.0004
Onchocerca volvulus 0.0048 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi Dopamine receptor protein 2 0.0048 0.0001 0.0001
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.0001 0.0001
Brugia malayi hypothetical protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0002 0.0003
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.061 0.3618 1
Treponema pallidum pyruvate carboxylase subunit B 0.0056 0.0053 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.0001 0.0001
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.0001 0.0001
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0056 0.0053 0.0055
Mycobacterium ulcerans carboxylesterase, LipT 0.0163 0.0742 0.1934
Mycobacterium ulcerans pyruvate carboxylase 0.061 0.3618 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0087 0.009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi neuropeptide F receptor 0.0048 0.0001 0.0001
Onchocerca volvulus 0.0163 0.0742 0.324
Brugia malayi RNA binding protein 0.0061 0.0087 0.009
Onchocerca volvulus 0.0048 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0138 0.0579 0.081
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0001 0.0001
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0217 0.1089 0.2905
Onchocerca volvulus 0.0048 0.0001 0.0004
Echinococcus granulosus somatostatin receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) glutaminase 0.027 0.1427 0.1481
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.061 0.3618 1
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0138 0.0579 0.1476
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.0001 0.0001
Brugia malayi Carboxylesterase family protein 0.0163 0.0742 0.077
Schistosoma mansoni neuroligin 3 (S09 family) 0.0163 0.0742 0.0742
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0056 0.0053 0.0087
Echinococcus granulosus carboxylesterase 5A 0.0966 0.591 0.591
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0001 0.0001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0001 0.0001
Onchocerca volvulus 0.0048 0.0001 0.0004
Echinococcus multilocularis serotonin receptor 0.0048 0.0001 0.0001
Echinococcus granulosus metabotropic glutamate receptor 5 0.005 0.0012 0.0012
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0001 0.0001
Brugia malayi Serotonin receptor 0.0048 0.0001 0.0001
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0138 0.0579 0.0579
Onchocerca volvulus 0.0048 0.0001 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0001 0.0001
Loa Loa (eye worm) carboxylesterase 0.0163 0.0742 0.077
Brugia malayi putative neuropeptide receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis Biotin lipoyl attachment 0.0056 0.0053 0.0053
Onchocerca volvulus 0.0048 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0048 0.0001 0.0001
Plasmodium falciparum carbamoyl phosphate synthetase 0.0138 0.0579 0.081
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0163 0.0742 0.0742
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.1601 1 1
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0056 0.0053 0.0055
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.0001 0.0001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.0001 0.0001
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0001 0.0001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0966 0.591 0.591
Echinococcus granulosus neuropeptide receptor 0.0048 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) carboxylesterase 0.0966 0.591 0.6131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123 0.0487 0.0487
Brugia malayi hypothetical protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.061 0.3618 0.3618
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.0001 0.0001
Trypanosoma cruzi acetyl-CoA carboxylase 0.0991 0.6074 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0487 0.0505
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0217 0.1089 0.2905
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0056 0.0053 0.0053
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0056 0.0053 0.0087
Schistosoma mansoni amine GPCR 0.0048 0.0001 0.0001
Brugia malayi RE15519p 0.0048 0.0001 0.0001
Brugia malayi follicle stimulating hormone receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0966 0.591 0.6131
Schistosoma mansoni hypothetical protein 0.0404 0.2291 0.2291
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0056 0.0053 0.0074
Schistosoma mansoni acetyl-CoA carboxylase 0.1601 1 1
Brugia malayi hypothetical protein 0.0048 0.0001 0.0001
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0217 0.1089 0.2905
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0138 0.0579 0.0954
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0056 0.0053 0.0053
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.0001 0.0001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0163 0.0742 0.0742
Onchocerca volvulus 0.0163 0.0742 0.324
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0217 0.1089 0.2905
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi Serotonin receptor 0.0048 0.0001 0.0001
Schistosoma mansoni myosin xvIII 0.0048 0.0001 0.0001
Schistosoma mansoni opsin-like receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0132 0.054 0.056
Onchocerca volvulus 0.0106 0.0377 0.1644
Brugia malayi GnHR receptor homolog 0.0048 0.0001 0.0001
Loa Loa (eye worm) carboxylesterase 0.0163 0.0742 0.077
Brugia malayi hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi sulfakinin receptor protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.061 0.3618 0.5957
Onchocerca volvulus 0.0163 0.0742 0.324
Toxoplasma gondii pyruvate carboxylase 0.061 0.3618 0.3618
Onchocerca volvulus 0.0048 0.0001 0.0004
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.0001 0.0001
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0217 0.1089 0.2905
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0001 0.0001
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0273 0.145 0.5
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0217 0.1089 0.2905
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0217 0.1089 0.1089
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0001 0.0001
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0163 0.0742 0.1934
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0163 0.0742 0.1934
Schistosoma mansoni gliotactin 0.0163 0.0742 0.0742
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.0001 0.0001
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.061 0.3618 0.3584
Onchocerca volvulus 0.0048 0.0001 0.0004
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0056 0.0053 0.0087
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0056 0.0053 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0056 0.0053 0.0055
Echinococcus multilocularis sex peptide receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0087 0.009
Loa Loa (eye worm) hypothetical protein 0.0163 0.0742 0.077
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Echinococcus granulosus neuropeptide s receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Echinococcus multilocularis para nitrobenzyl esterase 0.0163 0.0742 0.0742
Leishmania major acetyl-CoA carboxylase, putative 0.1601 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0087 0.0087
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0056 0.0053 0.0053
Mycobacterium ulcerans glutaminase 0.027 0.1427 0.3855
Loa Loa (eye worm) RNA binding protein 0.0061 0.0087 0.009
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.0001 0.0001
Brugia malayi Dopamine receptor 0.0048 0.0001 0.0001
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0217 0.1089 0.1792
Echinococcus granulosus g protein coupled receptor 0.0048 0.0001 0.0001
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.061 0.3618 0.3618
Loa Loa (eye worm) glutaminase 2 0.027 0.1427 0.1481
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0163 0.0742 0.0742
Brugia malayi G protein-coupled receptor 0.0048 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0001 0.0001
Brugia malayi hypothetical protein 0.0048 0.0001 0.0001
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0217 0.1089 0.3233
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Echinococcus multilocularis metabotropic glutamate receptor 5 0.005 0.0012 0.0012
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.1601 1 1
Brugia malayi Carboxylesterase family protein 0.0163 0.0742 0.077
Schistosoma mansoni amine GPCR 0.0048 0.0001 0.0001
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.061 0.3618 0.3618
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.0001 0.0001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.0001 0.0001
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0404 0.2291 0.2291
Echinococcus multilocularis orexin receptor type 2 0.0048 0.0001 0.0001
Echinococcus granulosus sex peptide receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0056 0.0053 0.0055
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0217 0.1089 0.1089
Echinococcus granulosus apoptotic protease activating factor 1 0.0132 0.054 0.054
Schistosoma mansoni hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi hypothetical protein 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0087 0.0087
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0048 0.0001 0.0001
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.0001 0.0001
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0087 0.0087
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.0001 0.0001
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0273 0.145 0.5
Schistosoma mansoni biogenic amine receptor 0.0048 0.0001 0.0001
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0138 0.0579 0.0954
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.061 0.3618 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.061 0.3618 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.0001 0.0001
Onchocerca volvulus 0.0048 0.0001 0.0004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0163 0.0742 0.0742
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0163 0.0742 0.077
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0217 0.1089 0.1089
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Echinococcus granulosus caspase 2 0.0132 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0056 0.0053 0.0087
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Onchocerca volvulus 0.0404 0.2291 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Schistosoma mansoni adenoreceptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0966 0.591 0.6131
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.1545 0.9639 1
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.0001 0.0001
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0001 0.0001
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0056 0.0053 0.0053
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.0001 0.0001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0087 0.009
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0404 0.2291 0.2291
Brugia malayi Cell death protein 3 precursor 0.0132 0.054 0.056
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.0001 0.0001
Echinococcus granulosus allatostatin A receptor 0.0048 0.0001 0.0001
Onchocerca volvulus 0.0132 0.054 0.2356
Leishmania major carbamoyl-phosphate synthase, putative 0.0138 0.0579 0.0579
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0163 0.0742 0.0742
Echinococcus multilocularis carboxylesterase 5A 0.0966 0.591 0.591
Echinococcus granulosus Biotin lipoyl attachment 0.0056 0.0053 0.0053
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.0001 0.0001
Schistosoma mansoni opsin-like receptor 0.0048 0.0001 0.0001
Echinococcus granulosus tar DNA binding protein 0.0061 0.0087 0.0087
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0056 0.0053 0.0074
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0001 0.0001
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0217 0.1089 0.2905
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.0001 0.0001
Onchocerca volvulus 0.0048 0.0001 0.0004
Brugia malayi TAR-binding protein 0.0061 0.0087 0.009
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.0001 0.0001
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.061 0.3618 0.3618
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0048 0.0001 0.0001
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0001 0.0001
Schistosoma mansoni inhibitor of apoptosis protein 0.0404 0.2291 0.2291
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0056 0.0053 0.0053
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0001 0.0001
Echinococcus granulosus orexin receptor type 2 0.0048 0.0001 0.0001
Echinococcus granulosus inhibitor of apoptosis protein 0.0404 0.2291 0.2291
Brugia malayi Carboxylesterase family protein 0.0163 0.0742 0.077
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0217 0.1089 0.1792
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123 0.0487 0.0487
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.0001 0.0001
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0056 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Echinococcus granulosus tumor protein p63 0.0327 0.1798 0.1798
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0001 0.0001
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0217 0.1089 0.2905
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1158 0.7151 1
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0056 0.0053 0.0053

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.024 uM Inhibitory activity against trypsin ChEMBL. 8426361
IC50 (binding) = 0.085 uM Inhibitory activity against thrombin ChEMBL. 8426361
IC50 (binding) = 0.77 uM Inhibitory activity against plasmin ChEMBL. 8426361
IC50 (binding) = 6.7 uM Inhibitory activity against factor Xa ChEMBL. 8426361
IC50 (binding) = 91 uM Compound was tested in vitro for inhibitory activity against t-PA (tissue plasminogen activator) ChEMBL. 8426361

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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