TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 619.627 | Formula: C26H37N9O9
H donors: 10 H acceptors: 9 LogP: -5.86 Rotable bonds: 5
Rule of 5 violations (Lipinski): 3
SMILES: OC[C@@H]1NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CCC/N=C(\NC(=O)CNC(=O)[C@@H](NC1=O)Cc1ccccc1)/N)CC(=O)O
InChi: 1S/C26H37N9O9/c27-15-7-4-8-29-26(28)35-20(38)12-31-23(42)16(9-14-5-2-1-3-6-14)33-25(44)18(13-36)34-24(43)17(10-21(39)40)32-19(37)11-30-22(15)41/h1-3,5-6,15-18,36H,4,7-13,27H2,(H,30,41)(H,31,42)(H,32,37)(H,33,44)(H,34,43)(H,39,40)(H3,28,29,35,38)/t15-,16-,17-,18-/m0/s1
InChiKey: QPJXYZMKAFDSFD-XSLAGTTESA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	integrin beta-2	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma japonicum	Integrin beta-3 precursor, putative	Get druggable targets OG5_127959	All targets in OG5_127959
Echinococcus multilocularis	integrin beta 2	Get druggable targets OG5_127959	All targets in OG5_127959
Echinococcus granulosus	integrin beta 2	Get druggable targets OG5_127959	All targets in OG5_127959
Brugia malayi	Integrin beta pat-3 precursor	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma japonicum	Integrin beta-PS precursor, putative	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma mansoni	integrin beta subunit	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma japonicum	ko:K06464 integrin beta 2, putative	Get druggable targets OG5_127959	All targets in OG5_127959

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0513	0.2031	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1653	1	1
Brugia malayi	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.0575	0.0575
Echinococcus multilocularis	neuropeptide Y receptor	0.0513	0.2031	0.1697
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0513	0.2031	0.1697
Brugia malayi	Serotonin receptor	0.0513	0.2031	0.1545
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0546	0.2263	0.1791
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0513	0.2031	0.2031
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	neuropeptide F-like receptor	0.0513	0.2031	0.2031
Echinococcus granulosus	sex peptide receptor	0.0513	0.2031	0.1697
Onchocerca volvulus	Cathepsin L homolog	0.1653	1	1
Onchocerca volvulus		0.0513	0.2031	0.1545
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1653	1	1
Plasmodium vivax	vivapain-2	0.1653	1	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0513	0.2031	0.1697
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0305	0.0575	0.0575
Onchocerca volvulus		0.0513	0.2031	0.1545
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1106	0.6179	0.5946
Brugia malayi	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	opsin-like receptor	0.0513	0.2031	0.2031
Brugia malayi	Cathepsin L-like precursor	0.1106	0.6179	0.5946
Giardia lamblia	Cathepsin B precursor	0.0305	0.0575	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Brugia malayi	Dopamine receptor	0.0513	0.2031	0.1545
Brugia malayi	Cathepsin L-like precursor	0.0546	0.2263	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0513	0.2031	0.2031
Leishmania major	cysteine peptidase A (CPA)	0.1653	1	1
Echinococcus granulosus	g protein coupled receptor	0.0513	0.2031	0.1697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0513	0.2031	0.1697
Onchocerca volvulus		0.1653	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0513	0.2031	0.1697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1653	1	1
Giardia lamblia	Cathepsin L precursor	0.0305	0.0575	0.5
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Echinococcus multilocularis	cathepsin L	0.0851	0.4396	0.4161
Echinococcus multilocularis	cathepsin L cysteine protease	0.1653	1	1
Onchocerca volvulus		0.1653	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus multilocularis	g-protein coupled receptor	0.0513	0.2031	0.1697
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1653	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Schistosoma mansoni	neuropeptide receptor	0.0513	0.2031	0.2031
Brugia malayi	neuropeptide F receptor	0.0513	0.2031	0.1545
Echinococcus granulosus	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Onchocerca volvulus		0.0513	0.2031	0.1545
Giardia lamblia	Cathepsin L-like protease	0.0305	0.0575	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0851	0.4396	0.4054
Giardia lamblia	Cysteine protease	0.0305	0.0575	0.5
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0851	0.4396	0.4396
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0513	0.2031	0.1697
Giardia lamblia	Hypothetical protein	0.0305	0.0575	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1653	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0513	0.2031	0.2031
Brugia malayi	Melatonin receptor type 1A	0.0513	0.2031	0.1545
Echinococcus granulosus	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Onchocerca volvulus		0.0513	0.2031	0.1545
Echinococcus multilocularis	neuropeptides capa receptor	0.0513	0.2031	0.1697
Echinococcus granulosus	cathepsin L cysteine protease	0.0851	0.4396	0.4161
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Schistosoma mansoni	amine GPCR	0.0513	0.2031	0.2031
Brugia malayi	G-protein coupled receptor	0.0513	0.2031	0.1545
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.0575	0.0575
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0513	0.2031	0.2031
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0513	0.2031	0.1545
Leishmania major	cathepsin L-like protease	0.1653	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0513	0.2031	0.2031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.1106	0.6179	0.5946
Onchocerca volvulus		0.0513	0.2031	0.1545
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0513	0.2031	0.2031
Trypanosoma cruzi	cysteine proteinase, putative	0.0851	0.4396	0.4054
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0513	0.2031	0.2031
Onchocerca volvulus		0.0513	0.2031	0.1545
Brugia malayi	putative neuropeptide receptor NPR1	0.0513	0.2031	0.1545
Brugia malayi	GnHR receptor homolog	0.0513	0.2031	0.1545
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1653	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0513	0.2031	0.1697
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0851	0.4396	0.4396
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0513	0.2031	0.1545
Schistosoma mansoni	histamine h1 receptor	0.0513	0.2031	0.2031
Brugia malayi	follicle stimulating hormone receptor	0.0513	0.2031	0.1545
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Echinococcus multilocularis	neuropeptide receptor	0.0513	0.2031	0.1697
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0513	0.2031	0.2031
Echinococcus multilocularis	neuropeptide Y receptor	0.0513	0.2031	0.1697
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0513	0.2031	0.2031
Trypanosoma cruzi	cysteine peptidase, putative	0.0546	0.2263	0.1791
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Brugia malayi	Cathepsin L-like precursor	0.1653	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0513	0.2031	0.2031
Schistosoma mansoni	biogenic amine receptor	0.0513	0.2031	0.2031
Brugia malayi	Serotonin receptor	0.0513	0.2031	0.1545
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1653	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Entamoeba histolytica	cysteine proteinase, putative	0.1653	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.1653	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0513	0.2031	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Entamoeba histolytica	cysteine proteinase, putative	0.0851	0.4396	0.4054
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0513	0.2031	0.1697
Onchocerca volvulus		0.0513	0.2031	0.1545
Echinococcus multilocularis	cysteine protease	0.1653	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1653	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0513	0.2031	0.1697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1653	1	1
Brugia malayi	AKH receptor	0.0513	0.2031	0.1545
Echinococcus multilocularis	cathepsin b	0.0305	0.0575	0.018
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0305	0.0575	0.0575
Brugia malayi	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus granulosus	tm gpcr rhodopsin	0.0513	0.2031	0.1697
Giardia lamblia	Cathepsin L precursor	0.0305	0.0575	0.5
Giardia lamblia	Cathepsin B precursor	0.0305	0.0575	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0305	0.0575	0.0575
Trypanosoma cruzi	cysteine peptidase, putative	0.1653	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0513	0.2031	0.2031
Schistosoma mansoni	hypothetical protein	0.0513	0.2031	0.2031
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0513	0.2031	0.2031
Schistosoma mansoni	hypothetical protein	0.0513	0.2031	0.2031
Onchocerca volvulus		0.1653	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.0575	0.0575
Echinococcus granulosus	cysteine protease	0.0851	0.4396	0.4161
Schistosoma mansoni	myosin xvIII	0.0513	0.2031	0.2031
Onchocerca volvulus		0.1106	0.6179	0.5946
Loa Loa (eye worm)	cysteine protease	0.1653	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Brugia malayi	Integrin beta pat-3 precursor	0.0378	0.1088	0.0544
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0851	0.4396	0.4054
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0513	0.2031	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus granulosus	neuropeptides capa receptor	0.0513	0.2031	0.1697
Trypanosoma cruzi	cruzipain precursor, putative	0.0546	0.2263	0.1791
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0513	0.2031	0.1697
Brugia malayi	sulfakinin receptor protein	0.0513	0.2031	0.1545
Echinococcus granulosus	7tm_1 domain containing protein	0.0513	0.2031	0.1697
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0513	0.2031	0.1697
Schistosoma mansoni	amine GPCR	0.0513	0.2031	0.2031
Brugia malayi	ORL1-like opioid receptor	0.0513	0.2031	0.1545
Echinococcus granulosus	allatostatin A receptor	0.0513	0.2031	0.1697
Schistosoma mansoni	amine GPCR	0.0513	0.2031	0.2031
Onchocerca volvulus		0.0513	0.2031	0.1545
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0513	0.2031	0.1697
Toxoplasma gondii	cathepsin CPL	0.1653	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0513	0.2031	0.2031
Loa Loa (eye worm)	melatonin receptor type 1A	0.0513	0.2031	0.1545
Giardia lamblia	Cathepsin B precursor	0.0305	0.0575	0.5
Giardia lamblia	Cysteine protease	0.0305	0.0575	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0513	0.2031	0.2031
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus multilocularis	g protein coupled receptor	0.0513	0.2031	0.1697
Schistosoma mansoni	cathepsin F (C01 family)	0.1106	0.6179	0.6179
Loa Loa (eye worm)	fibroinase	0.1653	1	1
Brugia malayi	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0546	0.2263	0.1791
Brugia malayi	cathepsin F-like cysteine proteinase	0.0546	0.2263	0.1791
Brugia malayi	G protein-coupled receptor F59B2.13	0.0513	0.2031	0.1545
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0513	0.2031	0.1697
Schistosoma mansoni	neuropeptide receptor	0.0513	0.2031	0.2031
Echinococcus multilocularis	cathepsin L	0.0305	0.0575	0.018
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.0575	0.0575
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0513	0.2031	0.2031
Echinococcus multilocularis	dro:myosuppressin receptor	0.0513	0.2031	0.1697
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0513	0.2031	0.1545
Schistosoma mansoni	cathepsin F (C01 family)	0.1653	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1653	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1106	0.6179	0.5946
Onchocerca volvulus		0.1653	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Leishmania major	cathepsin L-like protease	0.1653	1	1
Onchocerca volvulus		0.0513	0.2031	0.1545
Brugia malayi	hypothetical protein	0.0513	0.2031	0.1545
Brugia malayi	Dopamine receptor protein 1	0.0513	0.2031	0.1545
Loa Loa (eye worm)	G-protein coupled receptor	0.0513	0.2031	0.1545
Echinococcus multilocularis	neuropeptide receptor A26	0.0513	0.2031	0.1697
Echinococcus granulosus	neuropeptide receptor	0.0513	0.2031	0.1697
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1653	1	1
Onchocerca volvulus	Cathepsin L homolog	0.1653	1	1
Giardia lamblia	Cathepsin B precursor	0.0305	0.0575	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0513	0.2031	0.1697
Giardia lamblia	Cathepsin B precursor	0.0305	0.0575	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0851	0.4396	0.4054
Schistosoma mansoni	neuropeptide F-like receptor	0.0513	0.2031	0.2031
Leishmania major	cathepsin L-like protease	0.1653	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0305	0.0575	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0851	0.4396	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Giardia lamblia	Cathepsin L precursor	0.0305	0.0575	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0513	0.2031	0.1697
Giardia lamblia	Hypothetical protein	0.0305	0.0575	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1653	1	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0513	0.2031	0.1545
Trypanosoma cruzi	cysteine proteinase, putative	0.0851	0.4396	0.4054
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0513	0.2031	0.1697
Brugia malayi	Cathepsin L-like precursor	0.1106	0.6179	0.5946
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0513	0.2031	0.1697
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Schistosoma mansoni	hypothetical protein	0.0513	0.2031	0.2031
Brugia malayi	cathepsin L-like precursor	0.1106	0.6179	0.5946
Onchocerca volvulus		0.0513	0.2031	0.1545
Echinococcus multilocularis	cathepsin b	0.0305	0.0575	0.018
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0513	0.2031	0.1545
Schistosoma mansoni	cathepsin s	0.0546	0.2263	0.2263
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0513	0.2031	0.1697
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1106	0.6179	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1653	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0851	0.4396	0.4054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0513	0.2031	0.2031
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0305	0.0575	0.0575
Giardia lamblia	Cathepsin L precursor	0.0305	0.0575	0.5
Giardia lamblia	Cathepsin L precursor	0.0305	0.0575	0.5
Schistosoma mansoni	biogenic amine receptor	0.0513	0.2031	0.2031
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0513	0.2031	0.2031
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	opsin-like receptor	0.0513	0.2031	0.2031
Echinococcus granulosus	g protein coupled receptor	0.0513	0.2031	0.1697
Entamoeba histolytica	cysteine proteinase, putative	0.1653	1	1
Onchocerca volvulus		0.0513	0.2031	0.1545
Trypanosoma cruzi	cysteine peptidase, putative	0.1653	1	1
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0513	0.2031	0.1697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Echinococcus multilocularis	sex peptide receptor	0.0513	0.2031	0.1697
Onchocerca volvulus		0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0546	0.2263	0.1791
Brugia malayi	Cathepsin L-like precursor	0.1653	1	1
Giardia lamblia	Cathepsin B precursor	0.0305	0.0575	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0513	0.2031	0.1697
Loa Loa (eye worm)	G-protein coupled receptor	0.0513	0.2031	0.1545
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Leishmania major	cathepsin L-like protease	0.1653	1	1
Echinococcus granulosus	cathepsin l1	0.1653	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.0575	0.0575
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0305	0.0575	0.0575
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0513	0.2031	0.1697
Giardia lamblia	Cathepsin B precursor	0.0305	0.0575	0.5
Echinococcus granulosus	cathepsin l1	0.1106	0.6179	0.6019
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Leishmania major	cathepsin L-like protease	0.1653	1	1
Echinococcus granulosus	somatostatin receptor	0.0513	0.2031	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Brugia malayi	hypothetical protein	0.0513	0.2031	0.1545
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0513	0.2031	0.1545
Echinococcus multilocularis	cysteine protease	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	biogenic amine receptor	0.0513	0.2031	0.2031
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0513	0.2031	0.1545
Echinococcus granulosus	tm gpcr rhodopsin	0.0513	0.2031	0.1697
Echinococcus multilocularis	fmrfamide receptor	0.0513	0.2031	0.1697
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0851	0.4396	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1653	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0513	0.2031	0.1697
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1653	1	1
Brugia malayi	Cathepsin L-like precursor	0.1653	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0513	0.2031	0.1545
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0513	0.2031	0.2031
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1653	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0851	0.4396	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0851	0.4396	0.4396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1653	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0851	0.4396	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0851	0.4396	0.4054
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0513	0.2031	0.1545
Echinococcus granulosus	fmrfamide receptor	0.0513	0.2031	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1653	1	1
Brugia malayi	neuropeptide F receptor	0.0513	0.2031	0.1545
Loa Loa (eye worm)	neuropeptide F receptor	0.0513	0.2031	0.1545
Brugia malayi	larval opioid receptor	0.0513	0.2031	0.1545
Entamoeba histolytica	cysteine proteinase, putative	0.0851	0.4396	0.4054
Schistosoma mansoni	neuropeptide receptor	0.0513	0.2031	0.2031
Echinococcus granulosus	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Leishmania major	cathepsin L-like protease	0.1653	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0513	0.2031	0.1697
Onchocerca volvulus	Cathepsin F homolog	0.1653	1	1
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus granulosus	cathepsin b	0.0305	0.0575	0.018
Echinococcus granulosus	cathepsin L	0.0305	0.0575	0.018
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0305	0.0575	0.5
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	neuropeptide receptor	0.0513	0.2031	0.2031
Entamoeba histolytica	cysteine proteinase 2	0.0851	0.4396	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.0575	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0513	0.2031	0.2031
Onchocerca volvulus		0.0513	0.2031	0.1545
Echinococcus multilocularis	somatostatin receptor	0.0513	0.2031	0.1697
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0305	0.0575	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus multilocularis	cathepsin L cysteine protease	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus granulosus	G protein coupled receptor 139	0.0513	0.2031	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Brugia malayi	RE15519p	0.0513	0.2031	0.1545
Entamoeba histolytica	cysteine protease, putative	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus multilocularis	g protein coupled receptor	0.0513	0.2031	0.1697
Plasmodium vivax	unspecified product	0.0851	0.4396	0.4054
Echinococcus granulosus	g-protein coupled receptor	0.0513	0.2031	0.1697
Echinococcus granulosus	neuropeptide Y receptor	0.0513	0.2031	0.1697
Onchocerca volvulus		0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	amine GPCR	0.0513	0.2031	0.2031
Schistosoma mansoni	opsin-like receptor	0.0513	0.2031	0.2031
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.0575	0.0575
Schistosoma mansoni	hypothetical protein	0.0513	0.2031	0.2031
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Schistosoma mansoni	neuropeptide f receptor 76f	0.0513	0.2031	0.2031
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.0575	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	TYRA-2 protein	0.0513	0.2031	0.1545
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0513	0.2031	0.1697
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0513	0.2031	0.2031
Brugia malayi	G-protein coupled receptor	0.0513	0.2031	0.1545
Trypanosoma cruzi	cysteine protease, putative	0.0851	0.4396	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0851	0.4396	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Plasmodium vivax	vivapain-3	0.0851	0.4396	0.4054
Giardia lamblia	Cathepsin B precursor	0.0305	0.0575	0.5
Giardia lamblia	Cathepsin L-like protease	0.0305	0.0575	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Echinococcus granulosus	7TM GPCR rhodopsin	0.0513	0.2031	0.1697
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0513	0.2031	0.2031
Brugia malayi	Cathepsin L-like precursor	0.1653	1	1
Onchocerca volvulus		0.0513	0.2031	0.1545
Echinococcus granulosus	hypothetical protein	0.0513	0.2031	0.1697
Echinococcus multilocularis	neuropeptide s receptor	0.0513	0.2031	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus granulosus	neuropeptide s receptor	0.0513	0.2031	0.1697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Giardia lamblia	Cysteine protease	0.0305	0.0575	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0513	0.2031	0.1697
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Echinococcus granulosus	biogenic amine 5HT receptor	0.0513	0.2031	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0305	0.0575	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.1106	0.6179	0.5946
Plasmodium vivax	vivapain-1	0.0851	0.4396	0.4054
Brugia malayi	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0546	0.2263	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0513	0.2031	0.2031
Echinococcus multilocularis	neuropeptides capa receptor	0.0513	0.2031	0.1697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1653	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.1653	1	1
Loa Loa (eye worm)	ctsf protein	0.1653	1	1
Giardia lamblia	Cathepsin L precursor	0.0305	0.0575	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0513	0.2031	0.1697
Trypanosoma cruzi	cysteine peptidase, putative	0.1653	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Loa Loa (eye worm)	integrin beta-2	0.0378	0.1088	0.0544
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0513	0.2031	0.1697
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Onchocerca volvulus		0.1653	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1653	1	1
Onchocerca volvulus		0.1653	1	1
Brugia malayi	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0513	0.2031	0.1697
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0546	0.2263	0.1791
Onchocerca volvulus		0.0513	0.2031	0.1545
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1653	1	1
Brugia malayi	Dopamine receptor protein 2	0.0513	0.2031	0.1545
Brugia malayi	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Echinococcus granulosus	cathepsin L	0.0851	0.4396	0.4161
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1653	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0513	0.2031	0.1697
Schistosoma mansoni	cathepsin C	0.0305	0.0575	0.0575
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Plasmodium vivax	vivapain-2	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0513	0.2031	0.2031
Giardia lamblia	Encystation-specific protease	0.0305	0.0575	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0513	0.2031	0.1545
Brugia malayi	G protein-coupled receptor	0.0513	0.2031	0.1545
Brugia malayi	putative neuropeptide receptor	0.0513	0.2031	0.1545
Echinococcus granulosus	neuropeptide receptor A26	0.0513	0.2031	0.1697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0851	0.4396	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1653	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0513	0.2031	0.2031
Echinococcus granulosus	neuropeptide receptor	0.0513	0.2031	0.1697
Schistosoma mansoni	cathepsin B (C01 family)	0.0305	0.0575	0.0575
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0513	0.2031	0.2031
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0305	0.0575	0.5
Echinococcus granulosus	g protein coupled receptor	0.0513	0.2031	0.1697
Echinococcus multilocularis	orexin receptor type 2	0.0513	0.2031	0.1697
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1653	1	1
Onchocerca volvulus		0.0513	0.2031	0.1545
Schistosoma mansoni	adenoreceptor	0.0513	0.2031	0.2031
Leishmania major	cathepsin L-like protease	0.1653	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0513	0.2031	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Leishmania major	cathepsin L-like protease	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.1106	0.6179	0.5946
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0513	0.2031	0.1545
Echinococcus granulosus	orexin receptor type 2	0.0513	0.2031	0.1697
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1653	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1653	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0513	0.2031	0.1697
Plasmodium vivax	unspecified product	0.0546	0.2263	0.1791
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0513	0.2031	0.1545
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1106	0.6179	0.5946
Brugia malayi	Cathepsin L-like precursor	0.1653	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Giardia lamblia	Cysteine protease	0.0305	0.0575	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0513	0.2031	0.1545
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1653	1	1
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Entamoeba histolytica	cysteine proteinase, putative	0.0851	0.4396	0.4054
Echinococcus granulosus	biogenic amine 5HT receptor	0.0513	0.2031	0.1697
Loa Loa (eye worm)	hypothetical protein	0.1106	0.6179	0.5946
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0513	0.2031	0.2031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1653	1	1
Onchocerca volvulus		0.0513	0.2031	0.1545
Echinococcus granulosus	rhodopsin orphan GPCR	0.0513	0.2031	0.1697
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0513	0.2031	0.1697
Echinococcus granulosus	neuropeptide FF receptor 2	0.0513	0.2031	0.1697
Echinococcus multilocularis	serotonin receptor	0.0513	0.2031	0.1697
Echinococcus multilocularis	serotonin receptor	0.0513	0.2031	0.1697
Schistosoma mansoni	amine GPCR	0.0513	0.2031	0.2031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1653	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.0575	0.0575
Echinococcus granulosus	cathepsin b	0.0305	0.0575	0.018
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0513	0.2031	0.1545
Entamoeba histolytica	cysteine protease, putative	0.0851	0.4396	0.4054
Echinococcus granulosus	serotonin receptor	0.0513	0.2031	0.1697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1653	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.01 uM	Affinity for vitronectin receptor, integrin alphaV-beta3	ChEMBL.	9240343
Ki (binding)	= 75 uM	Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3	ChEMBL.	9240343

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2369776

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1743588