Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.3388 | 0.3871 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0305 | 0.0415 |
Echinococcus granulosus | tar DNA binding protein | 0.0253 | 0.7365 | 0.7365 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0062 | 0.0715 | 0.0715 |
Schistosoma mansoni | jumonji domain containing protein | 0.0059 | 0.0639 | 0.0639 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0639 | 0.0868 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0217 | 0.5 |
Brugia malayi | RNA binding protein | 0.0253 | 0.7365 | 1 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.2762 | 0.375 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0293 | 0.8742 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0293 | 0.8742 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.7365 | 0.7365 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.8742 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0253 | 0.7365 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0639 | 0.0639 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0305 | 0.0305 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.3932 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.5851 | 0.7944 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0305 | 0.0305 |
Trichomonas vaginalis | set domain proteins, putative | 0.0238 | 0.6856 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0253 | 0.7365 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0305 | 0.0305 |
Loa Loa (eye worm) | RNA binding protein | 0.0253 | 0.7365 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.032 | 0.0358 |
Schistosoma mansoni | hypothetical protein | 0.0329 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0062 | 0.0715 | 0.0715 |
Onchocerca volvulus | 0.0238 | 0.6856 | 1 | |
Echinococcus multilocularis | GPCR, family 2 | 0.0062 | 0.0715 | 0.0715 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.2762 | 0.375 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0305 | 0.0305 |
Brugia malayi | TAR-binding protein | 0.0253 | 0.7365 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.7365 | 0.7365 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0194 | 0.5331 | 0.7237 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.7365 | 0.7365 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.7365 | 0.7365 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0194 | 0.5331 | 0.7237 |
Echinococcus multilocularis | geminin | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0715 | 0.097 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0062 | 0.0715 | 0.097 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.0639 | 0.0868 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.3194 | 0.4337 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0305 | 0.0305 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.8742 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0715 | 0.0715 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0062 | 0.0715 | 0.097 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.2762 | 0.375 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0059 | 0.0639 | 0.0639 |
Schistosoma mansoni | hypothetical protein | 0.0329 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0059 | 0.0639 | 0.0639 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0062 | 0.0715 | 0.0715 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0059 | 0.0639 | 0.0639 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0715 | 0.0715 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0062 | 0.0715 | 0.097 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0139 | 0.3388 | 0.3871 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.7365 | 0.7365 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.3194 | 0.3194 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0062 | 0.0715 | 0.0715 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0226 | 0.6425 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.0639 | 0.0868 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.5331 | 0.7237 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0062 | 0.0715 | 0.0715 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0639 | 0.0639 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0133 | 0.3194 | 0.4337 |
Echinococcus multilocularis | tar DNA binding protein | 0.0253 | 0.7365 | 0.7365 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0715 | 0.0715 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0305 | 0.0415 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0305 | 0.0305 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.5851 | 0.7944 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0253 | 0.7365 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0305 | 0.0305 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0059 | 0.0639 | 0.0639 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0194 | 0.5331 | 0.7237 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0715 | 0.0715 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.2 | In vitro antagonistic potency relative to Ac-delta3Pro1-(D)Fpa2-(D)Trp3,6]GnRH | ChEMBL. | 1280300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.