TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 486.456 | Formula: C17H22N6O9S
H donors: 7 H acceptors: 9 LogP: -3.72 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: O=C(CNC(=O)c1ccc(cc1)S(=O)(=O)N)NCC(=O)NCC(=O)N[C@H](C(=O)O)CC(=O)N
InChi: 1S/C17H22N6O9S/c18-12(24)5-11(17(29)30)23-15(27)8-21-13(25)6-20-14(26)7-22-16(28)9-1-3-10(4-2-9)33(19,31)32/h1-4,11H,5-8H2,(H2,18,24)(H,20,26)(H,21,25)(H,22,28)(H,23,27)(H,29,30)(H2,19,31,32)/t11-/m0/s1
InChiKey: OICJOVTUOUIYLX-NSHDSACASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	carbonic anhydrase II	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus multilocularis	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei gambiense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania braziliensis	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Putative carbonic anhydrase 5 precursor	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania donovani	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania mexicana	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	carbonic anhydrase 3	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus granulosus	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania infantum	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania major	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase II	260 aa	259 aa	32.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	protein kinase	0.0901	0.3765	0.3765
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.3765	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2246	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2246	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2246	1	1
Echinococcus granulosus	tyrosine kinase	0.2246	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0901	0.3765	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2246	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Trypanosoma cruzi	protein kinase, putative	0.0901	0.3765	1
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Plasmodium falciparum	protein kinase, putative	0.0901	0.3765	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0901	0.3765	0.3765
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Schistosoma mansoni	hypothetical protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Schistosoma mansoni	hypothetical protein	0.1344	0.5821	0.5821
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0901	0.3765	0.3765
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.3765	1
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Schistosoma mansoni	growth factor receptor-bound protein	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0901	0.3765	1
Plasmodium falciparum	protein kinase, putative	0.0901	0.3765	0.5
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Schistosoma mansoni	protein kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0901	0.3765	0.3765
Plasmodium falciparum	tyrosine kinase-like protein	0.0901	0.3765	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0901	0.3765	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1344	0.5821	0.5821
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	c src tyrosine kinase	0.2246	1	1
Echinococcus granulosus	c src tyrosine kinase	0.2246	1	1
Schistosoma mansoni	protein kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	tensin-related	0.1344	0.5821	0.5821
Trichomonas vaginalis	CAMK family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/FAK protein kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	SRC-1	0.2246	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	epidermal growth factor receptor	0.0901	0.3765	0.3765
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0901	0.3765	0.3765
Brugia malayi	SH2 domain containing protein	0.1344	0.5821	0.5821
Entamoeba histolytica	tyrosin kinase, putative	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/FER protein kinase	0.2246	1	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1344	0.5821	0.5821
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0901	0.3765	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.2246	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1344	0.5821	0.3297
Onchocerca volvulus		0.2246	1	1
Onchocerca volvulus		0.2246	1	1
Schistosoma mansoni	tensin	0.1344	0.5821	0.5821
Loa Loa (eye worm)	TK protein kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0901	0.3765	0.3765
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1344	0.5821	0.5821
Echinococcus granulosus	NCK adaptor protein	0.1344	0.5821	0.5821
Echinococcus granulosus	SH2 motif	0.1344	0.5821	0.5821
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Echinococcus multilocularis	epidermal growth factor receptor	0.0901	0.3765	0.3765
Toxoplasma gondii	STE kinase	0.0901	0.3765	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0901	0.3765	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2246	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Trichomonas vaginalis	AGC family protein kinase	0.0901	0.3765	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/FER protein kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1344	0.5821	0.5821
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	tensin	0.1344	0.5821	0.5821
Loa Loa (eye worm)	TK/FER protein kinase	0.2246	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0901	0.3765	0.3765
Leishmania major	protein kinase, putative	0.0901	0.3765	1
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Echinococcus multilocularis	tensin	0.1344	0.5821	0.5821
Entamoeba histolytica	hypothetical protein	0.0901	0.3765	0.3765
Trypanosoma brucei	Pseudokinase, putative	0.0901	0.3765	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0901	0.3765	0.3765
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0901	0.3765	0.3765
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.3765	1
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Schistosoma mansoni	serine/threonine protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1344	0.5821	0.5821
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1344	0.5821	0.5821
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0901	0.3765	0.3765
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0901	0.3765	0.3765
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/ALK protein kinase	0.0901	0.3765	0.3765
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2246	1	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0901	0.3765	0.3765
Schistosoma mansoni	serine/threonine protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	hypothetical protein	0.0901	0.3765	0.3765
Schistosoma mansoni	nck2/grb4	0.1344	0.5821	0.5821
Brugia malayi	RhoGAP domain containing protein	0.1344	0.5821	0.5821
Brugia malayi	Receptor family ligand binding region containing protein	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	protein kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0147	0.0268	0.0268
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0147	0.0268	0.0268
Schistosoma mansoni	serine/threonine protein kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Brugia malayi	hypothetical protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	N chimaerin	0.1344	0.5821	0.5821
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0147	0.0268	0.0268
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	SH2 domain containing protein 7	0.1344	0.5821	0.5821
Giardia lamblia	Protein 21.1	0.0901	0.3765	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2246	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Echinococcus granulosus	signal transduction protein lnk realted	0.1344	0.5821	0.5821
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1344	0.5821	0.5821
Plasmodium vivax	protein kinase, putative	0.0901	0.3765	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1344	0.5821	0.5821
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	serine/threonine kinase, putative	0.0901	0.3765	0.3765
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	carbonic anhydrase II	0.0147	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/FER protein kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine protein kinase Srms	0.2246	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Plasmodium falciparum	protein kinase, putative	0.0901	0.3765	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1344	0.5821	0.5821
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0901	0.3765	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0901	0.3765	0.3765
Brugia malayi	Furin-like cysteine rich region family protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0901	0.3765	0.3765
Echinococcus multilocularis	SH2 motif	0.1344	0.5821	0.5821
Entamoeba histolytica	hypothetical protein	0.0901	0.3765	0.3765
Echinococcus granulosus	tensin	0.1344	0.5821	0.5821
Loa Loa (eye worm)	TK protein kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	ephrin type A receptor 4 A	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0901	0.3765	0.3765
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0901	0.3765	0.3765
Echinococcus multilocularis	carbonic anhydrase II	0.0147	0.0268	0.0268
Echinococcus granulosus	activin receptor type	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2246	1	1
Brugia malayi	Variant SH3 domain containing protein	0.1344	0.5821	0.5821
Entamoeba histolytica	SH2 domain containing protein	0.1344	0.5821	0.5821
Leishmania major	hypothetical protein, conserved	0.0901	0.3765	1
Schistosoma mansoni	suppressor of cytokine signaling	0.1344	0.5821	0.5821
Brugia malayi	Tensin	0.1344	0.5821	0.5821
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/Met protein kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	protein kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	SH2 domain-containing protein	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/FER protein kinase	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Schistosoma mansoni	tensin	0.1344	0.5821	0.5821
Echinococcus granulosus	protein tyrosine kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/ACK protein kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Onchocerca volvulus		0.1344	0.5821	0.3297
Entamoeba histolytica	serine/threonine kinase, putative	0.0901	0.3765	0.3765
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Echinococcus multilocularis	signal transduction protein lnk realted	0.1344	0.5821	0.5821
Schistosoma mansoni	tyrosine protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	transfer RNA-Thr	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.2246	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Schistosoma mansoni	ephrin receptor	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK protein kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	serine/threonine protein kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Schistosoma mansoni	protein tyrosine kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase csk	0.0901	0.3765	0.3765
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1344	0.5821	0.5821
Brugia malayi	C-terminal src kinase protein 1	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase csk	0.0901	0.3765	0.3765
Entamoeba histolytica	receptor protein kinase, putative	0.0901	0.3765	0.3765
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.3765	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2246	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0901	0.3765	0.3765
Trypanosoma cruzi	protein kinase, putative	0.0901	0.3765	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1344	0.5821	0.5821
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0901	0.3765	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1344	0.5821	0.5821
Echinococcus multilocularis	tyrosine protein kinase shark	0.2246	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2246	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0901	0.3765	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0901	0.3765	0.3765
Echinococcus granulosus	SHC transforming protein 3	0.1344	0.5821	0.5821
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1344	0.5821	0.5821
Echinococcus granulosus	tyrosine protein kinase shark	0.2246	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Brugia malayi	Raf kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	N chimaerin	0.1344	0.5821	0.5821
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0901	0.3765	0.3765
Leishmania major	protein kinase, putative	0.0901	0.3765	1
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	protein kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	hypothetical protein, conserved	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2246	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2246	1	1
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Toxoplasma gondii	protein kinase domain-containing protein	0.0901	0.3765	0.5
Schistosoma mansoni	GTPase activating protein	0.1344	0.5821	0.5821
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Schistosoma mansoni	tensin	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1344	0.5821	0.5821
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK protein kinase	0.0901	0.3765	0.3765
Leishmania major	carbonic anhydrase-like protein	0.0147	0.0268	0.0713
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2246	1	1
Giardia lamblia	Kinase	0.0901	0.3765	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0901	0.3765	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1344	0.5821	0.5821
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Brugia malayi	SH2 domain containing protein	0.1344	0.5821	0.5821
Entamoeba histolytica	cysteine surface protein, putative	0.0901	0.3765	0.3765
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0901	0.3765	0.3765
Echinococcus multilocularis	insulin receptor	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2246	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2246	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0147	0.0268	0.0713
Entamoeba histolytica	hypothetical protein	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1344	0.5821	0.5821
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2246	1	1
Echinococcus granulosus	integrin linked protein kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	protein kinase	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	serine/threonine kinase, putative	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/CSK protein kinase	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1344	0.5821	0.3297
Brugia malayi	Variant SH3 domain containing protein	0.1344	0.5821	0.5821
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	ankyrin repeat protein	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine kinase	0.2246	1	1
Loa Loa (eye worm)	TK protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine protein kinase pr2	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.2246	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	tyrosine protein kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1344	0.5821	0.5821
Entamoeba histolytica	tyrosin kinase, putative	0.0901	0.3765	0.3765
Entamoeba histolytica	serine/threonine kinase, putative	0.0901	0.3765	0.3765
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Schistosoma mansoni	protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Giardia lamblia	Kinase, NEK	0.0901	0.3765	1
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0901	0.3765	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/RYK protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	serine/threonine kinase, putative	0.0901	0.3765	0.3765
Giardia lamblia	Kinase, NEK	0.0901	0.3765	1
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	hypothetical protein	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2246	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Echinococcus granulosus	receptor type guanylyl cyclase	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Echinococcus granulosus	SH2 motif	0.1344	0.5821	0.5821
Loa Loa (eye worm)	SH2 domain-containing protein	0.1344	0.5821	0.5821
Loa Loa (eye worm)	STAT protein	0.1344	0.5821	0.5821
Schistosoma mansoni	suppressor of cytokine signaling	0.1344	0.5821	0.5821
Entamoeba histolytica	hypothetical protein	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.2246	1	1
Echinococcus multilocularis	protein kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	insulin receptor	0.0901	0.3765	0.3765
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2246	1	1
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	ankyrin repeat protein	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Schistosoma mansoni	ephrin receptor	0.0901	0.3765	0.3765
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.3765	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2246	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Brugia malayi	SH2 domain containing protein	0.1344	0.5821	0.5821
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0901	0.3765	0.3765
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.3765	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Brugia malayi	SH2 domain containing protein	0.2246	1	1
Loa Loa (eye worm)	TK protein kinase	0.0901	0.3765	0.3765
Onchocerca volvulus		0.2246	1	1
Loa Loa (eye worm)	carbonic anhydrase 3	0.0147	0.0268	0.0268
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK protein kinase	0.2246	1	1
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Entamoeba histolytica	serine/threonine kinase, putative	0.0901	0.3765	0.3765
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1344	0.5821	0.5821
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0901	0.3765	0.3765
Echinococcus granulosus	raf serine:threonine protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0901	0.3765	0.3765
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2246	1	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1344	0.5821	0.5821
Trichomonas vaginalis	STE family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2246	1	1
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/ABL protein kinase	0.2246	1	1
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2246	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2246	1	1
Brugia malayi	SH2 domain containing protein	0.1344	0.5821	0.5821
Echinococcus multilocularis	activated cdc42 kinase 1	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	tyrosine kinase	0.2246	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Onchocerca volvulus		0.1344	0.5821	0.3297
Plasmodium falciparum	tyrosine kinase-like protein	0.0901	0.3765	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Brugia malayi	Variant SH3 domain containing protein	0.1344	0.5821	0.5821
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0901	0.3765	0.3765
Echinococcus granulosus	expressed conserved protein	0.1344	0.5821	0.5821
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0901	0.3765	0.3765
Schistosoma mansoni	growth factor receptor-bound protein	0.1344	0.5821	0.5821
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2246	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1344	0.5821	0.5821
Loa Loa (eye worm)	TK/FER protein kinase	0.2246	1	1
Entamoeba histolytica	protein kinase, putative	0.1344	0.5821	0.5821
Loa Loa (eye worm)	TK/INSR protein kinase	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	SH2 domain-containing protein	0.1344	0.5821	0.5821
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2246	1	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.2246	1	1
Schistosoma mansoni	hypothetical protein	0.1344	0.5821	0.5821
Trypanosoma brucei	carbonic anhydrase-like protein	0.0147	0.0268	0.0713
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Schistosoma mansoni	vav2	0.1344	0.5821	0.5821
Onchocerca volvulus		0.1344	0.5821	0.3297
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.3765	1
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2246	1	1
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Echinococcus granulosus	activated cdc42 kinase 1	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0901	0.3765	0.3765
Brugia malayi	SH2 domain containing protein	0.1344	0.5821	0.5821
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0901	0.3765	0.5
Echinococcus multilocularis	tyrosine kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2246	1	1
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Schistosoma mansoni	serine/threonine RGC	0.0901	0.3765	0.3765
Schistosoma mansoni	protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1344	0.5821	0.5821
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1344	0.5821	0.5821
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2246	1	1
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Trichomonas vaginalis	TK family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2246	1	1
Entamoeba histolytica	receptor protein kinase, putative	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	activin receptor type	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.2246	1	1
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Entamoeba histolytica	hypothetical protein	0.0901	0.3765	0.3765
Brugia malayi	integrin-linked kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	SH2 domain containing protein 7	0.1344	0.5821	0.5821
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0901	0.3765	1
Echinococcus multilocularis	SH2 motif	0.1344	0.5821	0.5821
Toxoplasma gondii	protein kinase	0.0901	0.3765	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Brugia malayi	hypothetical protein	0.2246	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1344	0.5821	0.5821
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0147	0.0268	0.0268
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK protein kinase	0.0901	0.3765	0.3765
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0147	0.0268	0.0268
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0901	0.3765	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0901	0.3765	1
Schistosoma mansoni	tyrosine kinase	0.2246	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1344	0.5821	0.5821
Schistosoma mansoni	protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0901	0.3765	0.3765
Brugia malayi	SH2 domain containing protein	0.1344	0.5821	0.5821
Onchocerca volvulus		0.1344	0.5821	0.3297
Schistosoma mansoni	protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Onchocerca volvulus		0.1344	0.5821	0.3297
Brugia malayi	hypothetical protein	0.0901	0.3765	0.3765
Onchocerca volvulus		0.2246	1	1
Echinococcus multilocularis	NCK adaptor protein	0.1344	0.5821	0.5821
Loa Loa (eye worm)	TK/FER protein kinase	0.2246	1	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0901	0.3765	0.3765
Echinococcus granulosus	growth factor receptor bound protein 2	0.1344	0.5821	0.5821
Schistosoma mansoni	adapter molecule crk	0.1344	0.5821	0.5821
Onchocerca volvulus		0.2246	1	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0901	0.3765	0.3765
Onchocerca volvulus		0.1344	0.5821	0.3297
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1344	0.5821	0.5821
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Echinococcus multilocularis	protein tyrosine kinase	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	hypothetical protein	0.1344	0.5821	0.5821
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2246	1	1
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Loa Loa (eye worm)	TK protein kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.2246	1	1
Brugia malayi	SRC-1	0.2246	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.1344	0.5821	0.5821
Echinococcus multilocularis	tyrosine protein kinase csk	0.0901	0.3765	0.3765
Brugia malayi	protein-tyrosine kinase	0.2246	1	1
Echinococcus multilocularis	FL cytokine receptor	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Schistosoma mansoni	shc transforming protein	0.1344	0.5821	0.5821
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1344	0.5821	0.5821
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0901	0.3765	0.3765
Entamoeba histolytica	hypothetical protein	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0901	0.3765	0.3765
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1344	0.5821	0.5821
Schistosoma mansoni	tensin-related	0.1344	0.5821	0.5821
Echinococcus multilocularis		0.1344	0.5821	0.5821
Echinococcus multilocularis	SHC transforming protein 3	0.1344	0.5821	0.5821
Loa Loa (eye worm)	TK/FER protein kinase	0.0901	0.3765	0.3765
Brugia malayi	hypothetical protein	0.1344	0.5821	0.5821
Schistosoma mansoni	SH2A	0.1344	0.5821	0.5821
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Brugia malayi	SH2 domain containing protein	0.2246	1	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2246	1	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0901	0.3765	1
Echinococcus multilocularis	heat shock protein 70	0.0901	0.3765	0.3765
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0901	0.3765	0.3765
Brugia malayi	SH2 domain containing protein	0.1344	0.5821	0.5821
Entamoeba histolytica	tyrosin kinase, putative	0.0901	0.3765	0.3765
Entamoeba histolytica	hypothetical protein	0.0901	0.3765	0.3765
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0147	0.0268	0.0713
Entamoeba histolytica	hypothetical protein	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.2246	1	1
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Brugia malayi	ephrin receptor 1 precursor	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1344	0.5821	0.5821
Echinococcus granulosus	tyrosine protein kinase csk	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0901	0.3765	1
Schistosoma mansoni	protein kinase	0.0901	0.3765	0.3765
Brugia malayi	Sex muscle abnormal protein 5	0.1344	0.5821	0.5821
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2246	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0901	0.3765	0.3765
Onchocerca volvulus		0.2246	1	1
Entamoeba histolytica	hypothetical protein	0.0901	0.3765	0.3765
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase, putative	0.0901	0.3765	0.3765
Trypanosoma brucei	protein kinase, putative	0.0901	0.3765	1
Brugia malayi	Guanylyl cyclase protein 23	0.0901	0.3765	0.3765
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2246	1	1
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/ROR protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	integrin linked protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	SH2 motif	0.1344	0.5821	0.5821
Schistosoma mansoni	tyrosine kinase	0.2246	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Echinococcus granulosus	kinase suppressor of Ras 1	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine protein kinase HCK	0.0901	0.3765	0.3765
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1344	0.5821	0.5821
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2246	1	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Brugia malayi	Tyrosine-protein kinase abl-1	0.2246	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0901	0.3765	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/DDR protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase csk	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.0901	0.3765	0.3765
Entamoeba histolytica	tyrosine kinase, putative	0.0901	0.3765	0.3765
Entamoeba histolytica	protein kinase domain containing protein	0.0901	0.3765	0.3765
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.2246	1	1
Schistosoma mansoni	protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0901	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.1344	0.5821	0.5821
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1344	0.5821	0.5821
Loa Loa (eye worm)	TK/FER protein kinase	0.2246	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0901	0.3765	0.3765
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2246	1	1
Brugia malayi	Protein kinase domain containing protein	0.0901	0.3765	0.3765
Schistosoma mansoni	tyrosine kinase	0.2246	1	1
Brugia malayi	Variant SH3 domain containing protein	0.1344	0.5821	0.5821
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0901	0.3765	0.3765

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 290 nM	Dissociation constant against human carbonic anhydrase II at 37 degree centigrade	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2371118

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1743682