Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Cathepsin B precursor | 0.0073 | 0.0593 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0098 | 0.165 | 0.165 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.165 | 0.1523 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0183 | 0.5269 | 0.5269 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0098 | 0.165 | 0.1523 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0098 | 0.165 | 0.165 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0293 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0293 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0183 | 0.5269 | 0.5269 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0098 | 0.165 | 0.165 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0063 | 0.015 | 0.015 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0098 | 0.165 | 0.165 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Toxoplasma gondii | cathepsin CPL | 0.0098 | 0.165 | 0.1123 |
Plasmodium vivax | vivapain-2 | 0.0098 | 0.165 | 0.165 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0098 | 0.165 | 0.165 |
Onchocerca volvulus | Cathepsin L homolog | 0.0098 | 0.165 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0098 | 0.165 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0098 | 0.165 | 0.165 |
Giardia lamblia | Cathepsin B precursor | 0.0073 | 0.0593 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0073 | 0.0593 | 0.0593 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.5269 | 0.5197 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0183 | 0.5269 | 0.5269 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0293 | 1 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0098 | 0.165 | 0.165 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0293 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0183 | 0.5269 | 0.5269 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0063 | 0.015 | 0.015 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0063 | 0.015 | 0.015 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0183 | 0.5269 | 0.5269 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0063 | 0.015 | 0.0909 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0063 | 0.015 | 0.0909 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0183 | 0.5269 | 0.5269 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0293 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0098 | 0.165 | 0.165 |
Brugia malayi | Isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0098 | 0.165 | 0.165 |
Onchocerca volvulus | Cathepsin L homolog | 0.0098 | 0.165 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0063 | 0.015 | 0.0909 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0098 | 0.165 | 0.165 |
Loa Loa (eye worm) | fibroinase | 0.0098 | 0.165 | 0.1523 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0293 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0098 | 0.165 | 0.165 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0098 | 0.165 | 0.165 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Plasmodium vivax | vivapain-2 | 0.0098 | 0.165 | 0.165 |
Brugia malayi | Cathepsin L-like precursor | 0.0063 | 0.015 | 0.015 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Echinococcus granulosus | cathepsin b | 0.0183 | 0.5269 | 0.5269 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0293 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0098 | 0.165 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0073 | 0.0593 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0098 | 0.165 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0073 | 0.0593 | 0.0593 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Brugia malayi | Cathepsin L-like precursor | 0.0063 | 0.015 | 0.015 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0293 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0183 | 0.5269 | 0.5269 |
Loa Loa (eye worm) | ctsf protein | 0.0098 | 0.165 | 0.1523 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0073 | 0.0593 | 0.0593 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0293 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0098 | 0.165 | 0.165 |
Loa Loa (eye worm) | cysteine protease | 0.0098 | 0.165 | 0.1523 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0098 | 0.165 | 0.1123 |
Brugia malayi | cathepsin L-like precursor | 0.0063 | 0.015 | 0.015 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Echinococcus granulosus | cathepsin b | 0.0183 | 0.5269 | 0.5269 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0098 | 0.165 | 0.1523 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0098 | 0.165 | 0.165 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0098 | 0.165 | 0.165 |
Echinococcus multilocularis | cysteine protease | 0.0098 | 0.165 | 0.165 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0098 | 0.165 | 0.165 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0098 | 0.165 | 0.165 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0098 | 0.165 | 0.165 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0073 | 0.0593 | 0.3596 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Loa Loa (eye worm) | cathepsin B | 0.0073 | 0.0593 | 0.045 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0063 | 0.015 | 0.015 |
Echinococcus multilocularis | cathepsin b | 0.0183 | 0.5269 | 0.5269 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.