Detailed information for compound 1743996

Basic information

Technical information
  • TDR Targets ID: 1743996
  • Name: (2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S) -2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino )-2-[(2-methylaminoacetyl)amino]pentanoyl]ami no]-3-methylbutanoyl]amino]-3-(4-methoxypheny l)propanoyl]amino]-3-methylpentanoyl]amino]-3 -(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-ca rbonyl]amino]-3-methylpentanoic acid
  • MW: 982.179 | Formula: C47H75N13O10
  • H donors: 11 H acceptors: 10 LogP: -0.62 Rotable bonds: 36
    Rule of 5 violations (Lipinski): 3
  • SMILES: CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@H](CC)C)C(=O)O)Cc1c[nH]cn1)[C@H](CC)C)Cc1ccc(cc1)OC)C(C)C)CCCN=C(N)N
  • InChi: 1S/C47H75N13O10/c1-9-27(5)38(44(66)56-34(22-30-23-51-25-53-30)45(67)60-20-12-14-35(60)42(64)59-39(46(68)69)28(6)10-2)58-41(63)33(21-29-15-17-31(70-8)18-16-29)55-43(65)37(26(3)4)57-40(62)32(54-36(61)24-50-7)13-11-19-52-47(48)49/h15-18,23,25-28,32-35,37-39,50H,9-14,19-22,24H2,1-8H3,(H,51,53)(H,54,61)(H,55,65)(H,56,66)(H,57,62)(H,58,63)(H,59,64)(H,68,69)(H4,48,49,52)/t27-,28-,32-,33-,34-,35-,37-,38-,39-/m0/s1
  • InChiKey: CJJRANANVDTGEN-CGBZEDCRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-guanidino-2-[(2-methylaminoacetyl)amino]pentanoyl]amino]-3-methyl-butanoyl]amino]-3-(4-methoxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-methyl-pentanoic acid
  • (2S,3S)-2-[[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-guanidino-2-[(2-methylamino-1-oxoethyl)amino]-1-oxopentyl]amino]-3-methyl-1-oxobutyl]amino]-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3-methyl-1-oxopentyl]amino]-3-(3H-imidazol-4-yl)-1-oxopropyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-methylpentanoic acid
  • (2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-guanidino-2-(sarcosylamino)pentanoyl]amino]-3-methyl-butanoyl]amino]-3-(4-methoxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-methyl-valeric acid
  • (2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-(2-methylaminoethanoylamino)pentanoyl]amino]-3-methyl-butanoyl]amino]-3-(4-methoxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]carbonylamino]-3-methyl-pentanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 Starlite/ChEMBL References
Rattus norvegicus Angiotensin II receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis allatostatin A receptor Angiotensin II receptor   359 aa 348 aa 25.9 %
Schistosoma mansoni adenoreceptor Angiotensin II receptor   359 aa 329 aa 24.0 %
Onchocerca volvulus Angiotensin II receptor   359 aa 303 aa 25.1 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Angiotensin II receptor   359 aa 346 aa 18.2 %
Onchocerca volvulus Angiotensin II receptor   359 aa 314 aa 25.8 %
Schistosoma mansoni opsin-like receptor Angiotensin II receptor   359 aa 299 aa 25.1 %
Onchocerca volvulus Angiotensin II receptor   359 aa 312 aa 19.2 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Angiotensin II receptor   359 aa 311 aa 23.5 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Angiotensin II receptor   359 aa 351 aa 21.9 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 355 aa 23.9 %
Echinococcus granulosus neuropeptide receptor Angiotensin II receptor   359 aa 316 aa 25.0 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Angiotensin II receptor   359 aa 303 aa 22.4 %
Onchocerca volvulus Angiotensin II receptor   359 aa 395 aa 23.0 %
Loa Loa (eye worm) neuropeptide F receptor Angiotensin II receptor   359 aa 356 aa 24.2 %
Brugia malayi GnHR receptor homolog Angiotensin II receptor   359 aa 364 aa 20.9 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Angiotensin II receptor   359 aa 407 aa 19.4 %
Brugia malayi ORL1-like opioid receptor Angiotensin II receptor   359 aa 314 aa 20.1 %
Onchocerca volvulus Angiotensin II receptor   359 aa 294 aa 23.8 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Angiotensin II receptor   359 aa 351 aa 21.9 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Angiotensin II receptor   359 aa 336 aa 22.3 %
Echinococcus granulosus allatostatin A receptor Angiotensin II receptor   359 aa 348 aa 25.9 %
Loa Loa (eye worm) hypothetical protein Angiotensin II receptor   359 aa 335 aa 23.3 %
Onchocerca volvulus Angiotensin II receptor   359 aa 386 aa 24.9 %
Echinococcus multilocularis G-protein coupled receptor, putative Angiotensin II receptor   359 aa 308 aa 22.4 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Angiotensin II receptor   359 aa 406 aa 20.0 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Angiotensin II receptor   359 aa 334 aa 23.7 %
Brugia malayi putative neuropeptide receptor NPR1 Angiotensin II receptor   359 aa 295 aa 27.5 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Angiotensin II receptor   359 aa 352 aa 20.5 %
Echinococcus granulosus thyrotropin releasing hormone receptor Angiotensin II receptor   359 aa 337 aa 24.0 %
Echinococcus granulosus tm gpcr rhodopsin Angiotensin II receptor   359 aa 303 aa 22.4 %
Loa Loa (eye worm) hypothetical protein Angiotensin II receptor   359 aa 330 aa 26.7 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Angiotensin II receptor (AT-1) type-1   359 aa 350 aa 23.1 %
Echinococcus multilocularis neuropeptide receptor Angiotensin II receptor   359 aa 316 aa 25.3 %
Schistosoma mansoni peptide (allatostatin)-like receptor Angiotensin II receptor   359 aa 314 aa 26.1 %
Schistosoma japonicum Rhodopsin, putative Angiotensin II receptor   359 aa 327 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0088 0.0064
Echinococcus granulosus tyrosine kinase 0.0129 0.0269 0.0255
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0028 0.0000010674 0.0000010674
Schistosoma mansoni hypothetical protein 0.3784 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0129 0.0269 0.0255
Echinococcus granulosus tyrosine protein kinase Src42A 0.0055 0.0072 0.0057
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0055 0.0072 0.0057
Echinococcus multilocularis tyrosine protein kinase HCK 0.0074 0.0123 0.0108
Brugia malayi SRC-1 0.0129 0.0269 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.0088 0.0064
Echinococcus granulosus c src tyrosine kinase 0.0129 0.0269 0.0255
Loa Loa (eye worm) TK protein kinase 0.0129 0.0269 1
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Brugia malayi SH2 domain containing protein 0.0055 0.0072 0.2238
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Echinococcus granulosus aurora kinase A 0.0123 0.0253 0.0238
Schistosoma mansoni suppressor of cytokine signaling 0.0055 0.0072 0.0057
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0055 0.0072 0.0057
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0055 0.0072 0.2238
Entamoeba histolytica hypothetical protein 0.0074 0.0123 0.0099
Brugia malayi hypothetical protein 0.0074 0.0123 0.4244
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Toxoplasma gondii protein kinase domain-containing protein 0.0074 0.0123 0.432
Toxoplasma gondii STE kinase 0.0074 0.0123 0.432
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Schistosoma mansoni tensin-related 0.0055 0.0072 0.0057
Echinococcus multilocularis tyrosine protein kinase Abl 0.0129 0.0269 0.0255
Brugia malayi Probable ATP-dependent helicase DHX35 0.0038 0.0027 0.0476
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0055 0.0072 0.0057
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0074 0.0123 0.2584
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0055 0.0072 0.0057
Echinococcus granulosus tyrosine protein kinase ABL1 0.0129 0.0269 0.0255
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Brugia malayi hypothetical protein 0.0074 0.0123 0.4244
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Brugia malayi integrin-linked kinase 0.0074 0.0123 0.4244
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Leishmania major protein kinase, putative 0.0074 0.0123 0.0099
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0024 0.0024
Entamoeba histolytica serine/threonine kinase, putative 0.0074 0.0123 0.0099
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Giardia lamblia Kinase, NEK 0.0074 0.0123 0.0035
Echinococcus granulosus signal transduction protein lnk realted 0.0055 0.0072 0.0057
Brugia malayi SH2 domain containing protein 0.0129 0.0269 1
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0037 0.0024 0.0009
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine protein kinase Srms 0.0129 0.0269 0.0255
Loa Loa (eye worm) TK protein kinase 0.0074 0.0123 0.4244
Schistosoma mansoni tyrosine kinase 0.0129 0.0269 0.0255
Schistosoma mansoni hypothetical protein 0.0055 0.0072 0.0057
Brugia malayi protein-tyrosine kinase 0.0129 0.0269 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0055 0.0072 0.2238
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Brugia malayi ephrin receptor 1 precursor 0.0074 0.0123 0.4244
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Schistosoma mansoni growth factor receptor-bound protein 0.0055 0.0072 0.0057
Loa Loa (eye worm) hypothetical protein 0.0129 0.0269 1
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Brugia malayi bone morphogenetic protein type 1 receptor 0.0074 0.0123 0.4244
Entamoeba histolytica protein kinase, putative 0.0123 0.0253 0.0229
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Brugia malayi SH2 domain containing protein 0.0055 0.0072 0.2238
Loa Loa (eye worm) RGC/RGC protein kinase 0.0074 0.0123 0.4244
Schistosoma mansoni ephrin receptor 0.0074 0.0123 0.0108
Brugia malayi MAP kinase sur-1 0.0061 0.0088 0.2886
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus granulosus tyrosine protein kinase csk 0.0074 0.0123 0.0108
Trypanosoma brucei aurora B kinase 0.0123 0.0253 0.0252
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.3784 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0123 0.0108
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0074 0.0123 0.4244
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus multilocularis SH2 domain containing protein 7 0.0055 0.0072 0.0057
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0037 0.0024 0.0009
Plasmodium falciparum protein kinase, putative 0.0074 0.0123 0.432
Echinococcus multilocularis tyrosine kinase 0.0074 0.0123 0.0108
Brugia malayi serine/threonine kinase 12 0.0123 0.0253 0.9335
Echinococcus granulosus twitchin 0.0035 0.0019 0.0004
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.0088 0.2886
Entamoeba histolytica hypothetical protein 0.0074 0.0123 0.0099
Onchocerca volvulus 0.0074 0.0123 0.2584
Echinococcus multilocularis SH2 motif 0.0055 0.0072 0.0057
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0055 0.0072 0.2238
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.3784 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0129 0.0269 0.0255
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0129 0.0269 0.0255
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.3784 1 1
Loa Loa (eye worm) SRC-1 0.0129 0.0269 1
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Trypanosoma cruzi protein kinase, putative 0.0074 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0055 0.0072 0.0057
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0123 0.4244
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Schistosoma mansoni SH2A 0.0055 0.0072 0.0057
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0074 0.0123 0.0108
Echinococcus granulosus epidermal growth factor receptor 0.0074 0.0123 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0123 0.0099
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.0269 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0074 0.0123 0.0123
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Echinococcus granulosus tyrosine protein kinase Lyn 0.0131 0.0274 0.0259
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Schistosoma mansoni protein kinase 0.0076 0.0127 0.0112
Trypanosoma brucei protein kinase, putative 0.0061 0.0088 0.0088
Schistosoma mansoni protein kinase 0.0123 0.0253 0.0238
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0123 0.4244
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.3784 1 1
Plasmodium falciparum tyrosine kinase-like protein 0.0074 0.0123 0.432
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0055 0.0072 0.0057
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Entamoeba histolytica SH2 domain containing protein 0.0055 0.0072 0.0048
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Schistosoma mansoni vav2 0.0055 0.0072 0.0057
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0123 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0088 0.0064
Brugia malayi SH2 domain containing protein 0.0129 0.0269 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0074 0.0123 0.0108
Echinococcus granulosus protein tyrosine kinase 0.0074 0.0123 0.0108
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Echinococcus granulosus tyrosine protein kinase csk 0.0074 0.0123 0.0108
Onchocerca volvulus 0.0074 0.0123 0.2584
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Brugia malayi tRNA modification GTPase TrmE family protein 0.0055 0.0072 0.2238
Brugia malayi Tyrosine-protein kinase abl-1 0.0129 0.0269 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0129 0.0269 0.0255
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0088 0.0064
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0129 0.0269 0.0255
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0074 0.0123 0.4244
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Brugia malayi Guanylyl cyclase protein 23 0.0074 0.0123 0.4244
Echinococcus multilocularis heat shock protein 70 0.0074 0.0123 0.0108
Echinococcus multilocularis tensin 0.0055 0.0072 0.0057
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Echinococcus granulosus NCK adaptor protein 0.0055 0.0072 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0074 0.0123 0.0108
Entamoeba histolytica protein kinase, putative 0.0123 0.0253 0.0229
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0028 0.0000010674 0.0000010674
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.0088 0.0088
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0088 0.0064
Entamoeba histolytica hypothetical protein, conserved 0.3784 1 1
Brugia malayi SH2 domain containing protein 0.0055 0.0072 0.2238
Trypanosoma cruzi trans-sialidase, putative 0.0028 0.0000010674 0.0000010674
Echinococcus granulosus insulin receptor 0.0074 0.0123 0.0108
Loa Loa (eye worm) RGC/RGC protein kinase 0.0074 0.0123 0.4244
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Entamoeba histolytica tyrosin kinase, putative 0.0074 0.0123 0.0099
Brugia malayi Sex muscle abnormal protein 5 0.0055 0.0072 0.2238
Trypanosoma cruzi trans-sialidase, putative 0.0028 0.0000010674 0.0000010674
Entamoeba histolytica DNA repair and recombination protein, putative 0.3784 1 1
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0028 0.0000010674 0.0000010674
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0074 0.0123 0.0108
Echinococcus granulosus retinal guanylyl cyclase 2 0.0074 0.0123 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.0269 1
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.0088 0.0064
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.0088 0.0074
Echinococcus granulosus SH2 domain containing adapter protein F 0.0055 0.0072 0.0057
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0074 0.0123 0.432
Trichomonas vaginalis AGC family protein kinase 0.0123 0.0253 0.0229
Brugia malayi SH2 domain containing protein 0.0055 0.0072 0.2238
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.0269 1
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Plasmodium falciparum protein kinase, putative 0.0074 0.0123 0.432
Echinococcus granulosus tyrosine protein kinase shark 0.0129 0.0269 0.0255
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0055 0.0072 0.0057
Brugia malayi Variant SH3 domain containing protein 0.0055 0.0072 0.2238
Loa Loa (eye worm) TK/ACK protein kinase 0.0074 0.0123 0.4244
Loa Loa (eye worm) RGC/RGC protein kinase 0.0074 0.0123 0.4244
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0123 0.0099
Onchocerca volvulus 0.0129 0.0269 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0129 0.0269 0.0255
Echinococcus granulosus receptor type guanylyl cyclase 0.0074 0.0123 0.0108
Echinococcus multilocularis activated cdc42 kinase 1 0.0074 0.0123 0.0108
Brugia malayi Cytochrome P450 family protein 0.0044 0.0043 0.1129
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Schistosoma mansoni serine/threonine RGC 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0057 0.0076 0.0052
Entamoeba histolytica serine/threonine kinase, putative 0.0074 0.0123 0.0099
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Brugia malayi SH2 domain containing protein 0.0055 0.0072 0.2238
Echinococcus granulosus retinal guanylyl cyclase 2 0.0074 0.0123 0.0108
Entamoeba histolytica serine/threonine kinase, putative 0.0074 0.0123 0.0099
Schistosoma mansoni tensin 0.0055 0.0072 0.0057
Loa Loa (eye worm) DEAH box polypeptide 35 0.0038 0.0027 0.0476
Loa Loa (eye worm) protein kinase domain-containing protein 0.0074 0.0123 0.4244
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.0269 0.0255
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0076 0.0127 0.0112
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.0088 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Brugia malayi STAT protein, DNA binding domain containing protein 0.0055 0.0072 0.2238
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Schistosoma mansoni protein kinase 0.0074 0.0123 0.0108
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0123 0.0099
Echinococcus granulosus SHC transforming protein 3 0.0055 0.0072 0.0057
Echinococcus granulosus retinal guanylyl cyclase 2 0.0074 0.0123 0.0108
Loa Loa (eye worm) TK/DDR protein kinase 0.0074 0.0123 0.4244
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0055 0.0072 0.0057
Trichomonas vaginalis AGC family protein kinase 0.0123 0.0253 0.0229
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.0269 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Loa Loa (eye worm) STAT protein 0.0055 0.0072 0.2238
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Onchocerca volvulus 0.0074 0.0123 0.2584
Entamoeba histolytica hypothetical protein 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0129 0.0269 0.0255
Loa Loa (eye worm) TK protein kinase 0.0074 0.0123 0.4244
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.0088 0.0074
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0074 0.0123 0.4244
Brugia malayi Immunoglobulin I-set domain containing protein 0.0108 0.0212 0.7762
Plasmodium falciparum protein kinase, putative 0.0076 0.0127 0.45
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0055 0.0072 0.0057
Echinococcus multilocularis kinase suppressor of Ras 1 0.0074 0.0123 0.0108
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0055 0.0072 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0123 0.0099
Loa Loa (eye worm) SH2 domain-containing protein 0.0055 0.0072 0.2238
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0123 0.0099
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0074 0.0123 0.0108
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0076 0.0127 0.0127
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0037 0.0024 0.0372
Echinococcus granulosus activated cdc42 kinase 1 0.0074 0.0123 0.0108
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0074 0.0123 0.4244
Echinococcus granulosus raf serine:threonine protein kinase 0.0074 0.0123 0.0108
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0028 0.0000010674 0.0000010674
Loa Loa (eye worm) TK/Met protein kinase 0.0074 0.0123 0.4244
Schistosoma mansoni tyrosine kinase 0.0129 0.0269 0.0255
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0074 0.0123 0.0108
Schistosoma mansoni tyrosine kinase 0.0129 0.0269 0.0255
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0129 0.0269 0.0255
Brugia malayi Protein kinase domain containing protein 0.0129 0.0269 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0129 0.0269 0.0255
Trichomonas vaginalis protein kinase atn1, putative 0.0074 0.0123 0.0099
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0074 0.0123 0.0108
Echinococcus multilocularis c src tyrosine kinase 0.0129 0.0269 0.0255
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Trypanosoma cruzi trans-sialidase, putative 0.0028 0.0000010674 0.0000010674
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0123 0.0253 0.0229
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0024 0.0372
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0055 0.0072 0.2238
Echinococcus granulosus tyrosine protein kinase Srms 0.0129 0.0269 0.0255
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.0269 0.0255
Echinococcus granulosus tyrosine protein kinase 0.0074 0.0123 0.0108
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Brugia malayi Protein kinase domain containing protein 0.0129 0.0269 1
Giardia lamblia Kinase 0.0074 0.0123 0.0035
Echinococcus granulosus tyrosine kinase 0.0129 0.0269 0.0255
Echinococcus multilocularis SHC transforming protein 3 0.0055 0.0072 0.0057
Entamoeba histolytica hypothetical protein 0.0074 0.0123 0.0099
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0074 0.0123 0.0108
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0074 0.0123 0.0108
Onchocerca volvulus 0.0074 0.0123 0.2584
Plasmodium falciparum tyrosine kinase-like protein 0.0074 0.0123 0.432
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Schistosoma mansoni adapter molecule crk 0.0055 0.0072 0.0057
Brugia malayi Raf kinase 0.0074 0.0123 0.4244
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0074 0.0123 0.4244
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0024 0.0024
Loa Loa (eye worm) TK protein kinase 0.0074 0.0123 0.4244
Schistosoma mansoni signal transduction protein lnk-related 0.0055 0.0072 0.0057
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0074 0.0123 0.0099
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0074 0.0123 0.0108
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0476
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0074 0.0123 0.0108
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0129 0.0269 0.0246
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0028 0.0000010674 0.0000010674
Schistosoma mansoni tyrosine kinase 0.0129 0.0269 0.0255
Trypanosoma brucei Pseudokinase, putative 0.0074 0.0123 0.0123
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Brugia malayi SH2 domain containing protein 0.0055 0.0072 0.2238
Entamoeba histolytica hypothetical protein 0.0074 0.0123 0.0099
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0123 0.4244
Leishmania major hypothetical protein, conserved 0.0074 0.0123 0.0099
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Loa Loa (eye worm) TK/INSR protein kinase 0.0074 0.0123 0.4244
Brugia malayi Variant SH3 domain containing protein 0.0055 0.0072 0.2238
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0123 0.4244
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0074 0.0123 0.0099
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0028 0.0000010674 0.0000010674
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Loa Loa (eye worm) TK/ABL protein kinase 0.0129 0.0269 1
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0074 0.0123 0.0108
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0074 0.0123 0.4244
Echinococcus granulosus growth factor receptor bound protein 2 0.0055 0.0072 0.0057
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Entamoeba histolytica receptor protein kinase, putative 0.0074 0.0123 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0123 0.0253 0.0229
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0037 0.0024 0.0009
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Schistosoma mansoni protein kinase 0.0074 0.0123 0.0108
Trypanosoma cruzi protein kinase, putative 0.0074 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Echinococcus granulosus ephrin type A receptor 4 A 0.0074 0.0123 0.0108
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.3784 1 1
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Onchocerca volvulus Tyrosine kinase homolog 0.0074 0.0123 0.2584
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0074 0.0123 0.0108
Schistosoma mansoni tyrosine kinase 0.0129 0.0269 0.0255
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Entamoeba histolytica hypothetical protein 0.0074 0.0123 0.0099
Echinococcus multilocularis natriuretic peptide receptor 1 0.0074 0.0123 0.0108
Entamoeba histolytica protein kinase, putative 0.0057 0.0076 0.0052
Trichomonas vaginalis protein tyrosine kinase, putative 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus multilocularis ephrin type A receptor 4 A 0.0074 0.0123 0.0108
Echinococcus multilocularis tyrosine protein kinase csk 0.0074 0.0123 0.0108
Brugia malayi Tyrosine-protein kinase PR2 0.0074 0.0123 0.4244
Echinococcus granulosus activated cdc42 kinase 1 0.0074 0.0123 0.0108
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.0088 0.0074
Echinococcus granulosus suppressor of cytokine signaling 6 0.0055 0.0072 0.0057
Echinococcus multilocularis SH2 motif 0.0055 0.0072 0.0057
Echinococcus multilocularis NCK adaptor protein 0.0055 0.0072 0.0057
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine protein kinase 0.0074 0.0123 0.0108
Echinococcus granulosus suppressor of cytokine signaling 7 0.0055 0.0072 0.0057
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0088 0.0088
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0123 0.0253 0.0229
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Entamoeba histolytica tyrosin kinase, putative 0.0074 0.0123 0.0099
Brugia malayi Tensin 0.0055 0.0072 0.2238
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0055 0.0072 0.0057
Trypanosoma brucei protein kinase, putative 0.0076 0.0127 0.0127
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.3784 1 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0074 0.0123 0.2584
Loa Loa (eye worm) TK protein kinase 0.0074 0.0123 0.4244
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.0269 0.0255
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Toxoplasma gondii protein kinase 0.0074 0.0123 0.432
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0055 0.0072 0.2238
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Onchocerca volvulus 0.0074 0.0123 0.2584
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0129 0.0269 0.0255
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0074 0.0123 0.4244
Entamoeba histolytica tyrosin kinase, putative 0.0074 0.0123 0.0099
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0076 0.0127 0.0112
Plasmodium vivax tyrosine kinase-like protein, putative 0.0074 0.0123 0.432
Echinococcus multilocularis activin receptor type 0.0076 0.0127 0.0112
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0123 0.0099
Loa Loa (eye worm) TK/RYK protein kinase 0.0074 0.0123 0.4244
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0055 0.0072 0.0057
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0074 0.0123 0.4244
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0037 0.0024 0.0372
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine kinase 0.0129 0.0269 0.0255
Echinococcus multilocularis SH2 motif 0.0055 0.0072 0.0057
Loa Loa (eye worm) RGC/RGC protein kinase 0.0074 0.0123 0.4244
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0129 0.0269 0.0255
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0074 0.0123 0.4244
Schistosoma mansoni shc transforming protein 0.0055 0.0072 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0088 0.0088
Entamoeba histolytica receptor protein kinase, putative 0.0074 0.0123 0.0099
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.0269 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0055 0.0072 0.0057
Plasmodium falciparum serine/threonine protein kinase, putative 0.0123 0.0253 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0074 0.0123 0.0108
Schistosoma mansoni nck2/grb4 0.0055 0.0072 0.0057
Echinococcus multilocularis integrin linked protein kinase 0.0074 0.0123 0.0108
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Trypanosoma cruzi aurora B kinase, putative 0.0123 0.0253 0.0253
Schistosoma mansoni protein kinase 0.0074 0.0123 0.0108
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Echinococcus multilocularis tensin 0.0055 0.0072 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Brugia malayi Protein kinase domain containing protein 0.0129 0.0269 1
Schistosoma mansoni protein kinase 0.0076 0.0127 0.0112
Echinococcus granulosus fibroblast growth factor receptor 4 0.0074 0.0123 0.0108
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0074 0.0123 0.0108
Brugia malayi RhoGAP domain containing protein 0.0055 0.0072 0.2238
Trichomonas vaginalis STE family protein kinase 0.0074 0.0123 0.0099
Loa Loa (eye worm) TK/FAK protein kinase 0.0074 0.0123 0.4244
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0074 0.0123 0.0108
Schistosoma mansoni suppressor of cytokine signaling 0.0055 0.0072 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.0088 0.2804
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0028 0.0000010674 0.0000010674
Brugia malayi Variant SH3 domain containing protein 0.0055 0.0072 0.2238
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0074 0.0123 0.0108
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Entamoeba histolytica ankyrin repeat protein 0.0074 0.0123 0.0099
Entamoeba histolytica protein kinase , putative 0.0123 0.0253 0.0229
Echinococcus multilocularis N chimaerin 0.0055 0.0072 0.0057
Schistosoma mansoni protein kinase 0.0074 0.0123 0.0108
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0055 0.0072 0.0057
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0074 0.0123 0.0099
Giardia lamblia Aurora kinase 0.0123 0.0253 0.0166
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Trichomonas vaginalis TK family protein kinase 0.0074 0.0123 0.0099
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0123 0.0253 0.0229
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0074 0.0123 0.4244
Loa Loa (eye worm) AUR protein kinase 0.0123 0.0253 0.9335
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus multilocularis transfer RNA-Thr 0.0074 0.0123 0.0108
Loa Loa (eye worm) TK protein kinase 0.0074 0.0123 0.4244
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.0269 1
Onchocerca volvulus 0.0129 0.0269 1
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0129 0.0269 0.0255
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Echinococcus multilocularis epidermal growth factor receptor 0.0074 0.0123 0.0108
Schistosoma mansoni tyrosine protein kinase 0.0074 0.0123 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0123 0.4244
Entamoeba histolytica ankyrin repeat protein 0.0074 0.0123 0.0099
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Echinococcus multilocularis tyrosine protein kinase csk 0.0074 0.0123 0.0108
Echinococcus multilocularis 0.0055 0.0072 0.0057
Entamoeba histolytica hypothetical protein 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus multilocularis epidermal growth factor receptor 0.0074 0.0123 0.0108
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0074 0.0123 0.432
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0129 0.0269 0.0255
Loa Loa (eye worm) AUR protein kinase 0.0123 0.0253 0.9335
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Entamoeba histolytica cysteine surface protein, putative 0.0074 0.0123 0.0099
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0037 0.0024 0.0024
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0074 0.0123 0.0108
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0129 0.0269 0.0255
Schistosoma mansoni protein kinase 0.0074 0.0123 0.0108
Echinococcus granulosus SH2 motif 0.0055 0.0072 0.0057
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.3784 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0123 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0088 0.0074
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.0269 0.0255
Echinococcus multilocularis aurora kinase A 0.0123 0.0253 0.0238
Echinococcus multilocularis tyrosine protein kinase shark 0.0129 0.0269 0.0255
Loa Loa (eye worm) TK/EGFR protein kinase 0.0074 0.0123 0.4244
Loa Loa (eye worm) serine/threonine protein kinase 0.0074 0.0123 0.4244
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0043 0.1129
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0123 0.0253 1
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0074 0.0123 0.0099
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Onchocerca volvulus 0.0074 0.0123 0.2584
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0123 0.4244
Loa Loa (eye worm) TK protein kinase 0.0074 0.0123 0.4244
Schistosoma mansoni tensin-related 0.0055 0.0072 0.0057
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Brugia malayi hypothetical protein 0.0129 0.0269 1
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Brugia malayi Receptor family ligand binding region containing protein 0.0074 0.0123 0.4244
Brugia malayi serine/threonine protein kinase 6 0.0123 0.0253 0.9335
Echinococcus granulosus tyrosine protein kinase Src42A 0.0129 0.0269 0.0255
Onchocerca volvulus 0.0129 0.0269 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Echinococcus granulosus tyrosine protein kinase Blk 0.0129 0.0269 0.0255
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0129 0.0269 0.0255
Giardia lamblia Protein 21.1 0.0074 0.0123 0.0035
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.0127 0.0103
Entamoeba histolytica hypothetical protein 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Brugia malayi Protein kinase domain containing protein 0.0129 0.0269 1
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Schistosoma mansoni GTPase activating protein 0.0055 0.0072 0.0057
Echinococcus granulosus expressed conserved protein 0.0055 0.0072 0.0057
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0123 0.4244
Echinococcus granulosus protein kinase 0.0074 0.0123 0.0108
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0074 0.0123 0.0108
Entamoeba histolytica serine/threonine kinase, putative 0.0074 0.0123 0.0099
Plasmodium vivax protein kinase, putative 0.0074 0.0123 0.432
Entamoeba histolytica tyrosin kinase, putative 0.0074 0.0123 0.0099
Giardia lamblia Kinase, NEK 0.0074 0.0123 0.0035
Onchocerca volvulus 0.0074 0.0123 0.2584
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Loa Loa (eye worm) AUR protein kinase 0.0123 0.0253 0.9335
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Loa Loa (eye worm) SH2 domain-containing protein 0.0055 0.0072 0.2238
Echinococcus multilocularis receptor type guanylyl cyclase 0.0074 0.0123 0.0108
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Echinococcus granulosus SH2 motif 0.0055 0.0072 0.0057
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Schistosoma mansoni protein kinase 0.0076 0.0127 0.0112
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0074 0.0123 0.4244
Echinococcus granulosus N chimaerin 0.0055 0.0072 0.0057
Schistosoma mansoni growth factor receptor-bound protein 0.0055 0.0072 0.0057
Trichomonas vaginalis AGC family protein kinase 0.0123 0.0253 0.0229
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.0269 0.0255
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0123 0.4244
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Entamoeba histolytica hypothetical protein 0.0074 0.0123 0.0099
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0074 0.0123 0.4244
Echinococcus multilocularis insulin receptor 0.0074 0.0123 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.0269 1
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Echinococcus multilocularis FL cytokine receptor 0.0074 0.0123 0.0108
Echinococcus granulosus tyrosine protein kinase csk 0.0074 0.0123 0.0108
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0076 0.0127 0.0127
Loa Loa (eye worm) TK protein kinase 0.0074 0.0123 0.4244
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Echinococcus granulosus tyrosine protein kinase pr2 0.0074 0.0123 0.0108
Entamoeba histolytica hypothetical protein 0.0074 0.0123 0.0099
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0074 0.0123 0.0108
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Entamoeba histolytica hypothetical protein 0.0074 0.0123 0.0099
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0074 0.0123 0.0108
Schistosoma mansoni tensin 0.0055 0.0072 0.0057
Schistosoma mansoni protein kinase 0.0074 0.0123 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.0269 1
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Echinococcus granulosus hypothetical protein 0.0055 0.0072 0.0057
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0028 0.0000010674 0.0000010674
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Schistosoma mansoni hypothetical protein 0.0074 0.0123 0.0108
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0055 0.0072 0.2238
Brugia malayi Protein kinase domain containing protein 0.0129 0.0269 1
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.0269 1
Entamoeba histolytica serine/threonine kinase, putative 0.0074 0.0123 0.0099
Onchocerca volvulus 0.0129 0.0269 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0055 0.0072 0.2238
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Entamoeba histolytica hypothetical protein, conserved 0.0074 0.0123 0.0099
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0123 0.0253 0.0238
Schistosoma mansoni protein tyrosine kinase 0.0074 0.0123 0.0108
Brugia malayi serine/threonine-protein kinase 6 0.0123 0.0253 0.9335
Leishmania major protein kinase, putative 0.0076 0.0127 0.0103
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0123 0.0253 0.0238
Onchocerca volvulus 0.0074 0.0123 0.2584
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Entamoeba histolytica serine/threonine kinase, putative 0.0074 0.0123 0.0099
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.0088 0.0074
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0028 0.0000010674 0.0000010674
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus granulosus tyrosine kinase 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Schistosoma mansoni ephrin receptor 0.0074 0.0123 0.0108
Brugia malayi hypothetical protein 0.0055 0.0072 0.2238
Loa Loa (eye worm) TK protein kinase 0.0074 0.0123 0.4244
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Echinococcus granulosus activin receptor type 0.0076 0.0127 0.0112
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0074 0.0123 0.0099
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0055 0.0072 0.2238
Echinococcus multilocularis tyrosine protein kinase pr2 0.0074 0.0123 0.0108
Brugia malayi SH2 domain containing protein 0.0055 0.0072 0.2238
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0074 0.0123 0.0108
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0074 0.0123 0.0108
Echinococcus multilocularis protein kinase 0.0074 0.0123 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0253 0.0238
Echinococcus multilocularis signal transduction protein lnk realted 0.0055 0.0072 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0123 0.0108
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Schistosoma mansoni protein kinase 0.0074 0.0123 0.0108
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0028 0.0000010674 0.0000010674
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0055 0.0072 0.0057
Echinococcus multilocularis protein kinase 0.0074 0.0123 0.0108
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0055 0.0072 0.0057
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0074 0.0123 0.0108
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0055 0.0072 0.0057
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0055 0.0072 0.0057
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0028 0.0000010674 0.0000010674
Echinococcus granulosus tyrosine protein kinase HCK 0.0074 0.0123 0.0108
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0024 0.0372
Loa Loa (eye worm) TK/EPH protein kinase 0.0074 0.0123 0.4244
Schistosoma mansoni tyrosine kinase 0.0129 0.0269 0.0255
Leishmania major protein kinase, putative 0.0123 0.0253 0.0229
Loa Loa (eye worm) TK/ROR protein kinase 0.0074 0.0123 0.4244
Brugia malayi Furin-like cysteine rich region family protein 0.0074 0.0123 0.4244
Loa Loa (eye worm) TK protein kinase 0.0074 0.0123 0.4244
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Loa Loa (eye worm) SH2 domain-containing protein 0.0055 0.0072 0.2238
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Trypanosoma brucei Flagellum attachment zone protein 20 0.0074 0.0123 0.0123
Echinococcus granulosus tensin 0.0055 0.0072 0.0057
Loa Loa (eye worm) hypothetical protein 0.0074 0.0123 0.4244
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0055 0.0072 0.0057
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.3784 1 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.3784 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0129 0.0269 0.0255
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0253 0.0229
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Echinococcus granulosus epidermal growth factor receptor 0.0074 0.0123 0.0108
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.0269 0.0255
Brugia malayi Variant SH3 domain containing protein 0.0055 0.0072 0.2238
Schistosoma mansoni tensin 0.0055 0.0072 0.0057
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.0088 0.0088
Echinococcus granulosus integrin linked protein kinase 0.0074 0.0123 0.0108
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0076 0.0127 0.0127
Echinococcus granulosus kinase suppressor of Ras 1 0.0074 0.0123 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.0269 1
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Loa Loa (eye worm) TK/CSK protein kinase 0.0074 0.0123 0.4244
Loa Loa (eye worm) TK/ALK protein kinase 0.0074 0.0123 0.4244
Entamoeba histolytica tyrosine kinase, putative 0.0074 0.0123 0.0099
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0074 0.0123 0.4244
Onchocerca volvulus 0.0129 0.0269 1
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Brugia malayi C-terminal src kinase protein 1 0.0074 0.0123 0.4244
Echinococcus multilocularis tyrosine protein kinase csk 0.0074 0.0123 0.0108
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0074 0.0123 0.0099
Schistosoma mansoni protein kinase 0.0074 0.0123 0.0108
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.2238
Onchocerca volvulus 0.0129 0.0269 1
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.0269 0.0255
Echinococcus granulosus SH2 domain containing protein 7 0.0055 0.0072 0.0057
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0074 0.0123 0.0108
Echinococcus multilocularis growth factor receptor bound protein 2 0.0055 0.0072 0.0057
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0129 0.0269 0.0255
Echinococcus multilocularis raf serine:threonine protein kinase 0.0074 0.0123 0.0108
Brugia malayi Protein kinase domain containing protein 0.0074 0.0123 0.4244
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0055 0.0072 0.0057
Toxoplasma gondii aurora kinase 0.0123 0.0253 1
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Onchocerca volvulus 0.0074 0.0123 0.2584
Echinococcus multilocularis protein tyrosine kinase 0.0074 0.0123 0.0108
Schistosoma mansoni tyrosine kinase 0.0074 0.0123 0.0108
Plasmodium vivax tyrosine kinase-like protein, putative 0.0074 0.0123 0.432
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0123 0.0099
Entamoeba histolytica protein kinase, putative 0.0074 0.0123 0.0099
Giardia lamblia Rrm3p helicase 0.3784 1 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0074 0.0123 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0108 0.0212 0.7762
Trichomonas vaginalis TKL family protein kinase 0.0074 0.0123 0.0099
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0076 0.0127 0.45

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % Angiotensin II-like agonist activity, measured in the in vitro rabbit aorta strip assay ChEMBL. 2724307
Activity (functional) < 0.1 % Angiotensin II receptor agonist activity was tested in rat isolated uterus assay using [Asp1,Ile5]ANG II (human angiotensin II) as the standard ChEMBL. 3754902
Blood pressure (functional) = 3 mmHg In vivo blood pressure increase produced by a 1 ug bolus i.v. ChEMBL. 2724307
Kd (functional) = 6.6 Antagonistic activity against Angiotensin II receptor type 1 in rat uterus ChEMBL. 10782679
Kd (functional) = 6.6 Angiotensin II receptor antagonist activity was tested in rat isolated uterus assay using [Asp1,Ile5]ANG II (human angiotensin II) as the standard ChEMBL. 3754902

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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