Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0178597 | 0.996195 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.00679843 | 0.336798 | 0.338085 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.00679843 | 0.336798 | 0.338085 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0178597 | 0.996195 | 1 |
Onchocerca volvulus | 0.0011487 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0178597 | 0.996195 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0179235 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0179235 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.00679843 | 0.336798 | 1 |
Onchocerca volvulus | 0.0011487 | 0 | 0.5 | |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0179235 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.00679843 | 0.336798 | 0.338085 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0179235 | 1 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0179235 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0179235 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.00679843 | 0.336798 | 0.338085 |
Echinococcus granulosus | carboxylesterase 5A | 0.00679843 | 0.336798 | 0.338085 |
Echinococcus multilocularis | serotonin receptor | 0.0178597 | 0.996195 | 1 |
Onchocerca volvulus | 0.0011487 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.00679843 | 0.336798 | 0.338085 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0179235 | 1 | 1 |
Onchocerca volvulus | 0.0011487 | 0 | 0.5 | |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0179235 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.00679843 | 0.336798 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0178597 | 0.996195 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00679843 | 0.336798 | 0.338085 |
Echinococcus multilocularis | serotonin receptor | 0.0178597 | 0.996195 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.00679843 | 0.336798 | 0.338085 |
Onchocerca volvulus | 0.0011487 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.00679843 | 0.336798 | 0.338085 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0179235 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00679843 | 0.336798 | 0.338085 |
Loa Loa (eye worm) | hypothetical protein | 0.00679843 | 0.336798 | 0.338085 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | nM | Compound was tested in vitro for antimalarial activity using [3H]-hypoxanthine as a radioligand against HB3 strain of Plasmodium falciparum; ND = Not determined | ChEMBL. | 14971909 |
IC50 (functional) | = 3.1 nM | Compound was tested in vitro for antimalarial activity using [3H]-hypoxanthine as a radioligand against K1 strain of Plasmodium falciparum | ChEMBL. | 14971909 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 14971909 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.