Detailed information for compound 1744086

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2300.44 | Formula: C108H142N26O31
  • H donors: 34 H acceptors: 30 LogP: -1.42 Rotable bonds: 85
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCC[C@H]1NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)/C=C\C=C\CCCCC(CC)C)CC(=O)O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@H](CC2CNC(=N)N2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC1=O)[C@H](O)C)c1ccc(cc1)O)c1ccc(cc1)O)[C@@H](O)C)CCCNC(=O)N)CC1CNC(=N)N1)c1ccc(cc1)O)CO)c1ccc(cc1)O)c1ccc(cc1)O)c1ccc(cc1)O
  • InChi: 1S/C108H142N26O31/c1-7-53(2)16-12-10-8-9-11-13-19-78(144)120-76(48-80(146)147)95(153)128-83-57(6)165-105(163)89(63-30-42-71(143)43-31-63)134-90(148)54(3)117-93(151)74(46-64-49-115-106(110)118-64)121-79(145)51-114-97(155)84(58-20-32-66(138)33-21-58)129-96(154)77(52-135)125-102(160)85(59-22-34-67(139)35-23-59)130-94(152)75(47-65-50-116-107(111)119-65)124-91(149)73(18-15-45-113-108(112)164)122-98(156)81(55(4)136)127-103(161)87(61-26-38-69(141)39-27-61)133-104(162)88(62-28-40-70(142)41-29-62)131-99(157)82(56(5)137)126-92(150)72(17-14-44-109)123-101(159)86(132-100(83)158)60-24-36-68(140)37-25-60/h9,11,13,19-43,53-57,64-65,72-77,81-89,135-143H,7-8,10,12,14-18,44-52,109H2,1-6H3,(H,114,155)(H,117,151)(H,120,144)(H,121,145)(H,122,156)(H,123,159)(H,124,149)(H,125,160)(H,126,150)(H,127,161)(H,128,153)(H,129,154)(H,130,152)(H,131,157)(H,132,158)(H,133,162)(H,134,148)(H,146,147)(H3,110,115,118)(H3,111,116,119)(H3,112,113,164)/b11-9+,19-13-/t53?,54-,55+,56-,57-,64?,65?,72-,73+,74+,75?,76+,77-,81+,82-,83+,84+,85+,86-,87-,88+,89+/m1/s1
  • InChiKey: LJTMKQJHTUUVAT-BCRSBKQYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0048 0.004
Onchocerca volvulus 0.0036 0.0316 0.1415
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0048 0.004
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0551 1
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0847 0.0847
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0509 0.0509
Onchocerca volvulus 0.0151 0.2159 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0316 0.0316
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0705 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0012
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0754 0.1497
Loa Loa (eye worm) cysteine protease 0.0017 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Brugia malayi jmjC domain containing protein 0.0058 0.0675 0.0675
Mycobacterium ulcerans hypothetical protein 0.0036 0.0316 0.4072
Mycobacterium ulcerans beta-lactamase 0.0036 0.0316 0.4072
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0012 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0705 0.0694
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0316 0.0316
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0048 0.0048
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0316 0.0316
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0551 0.1095
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0675 0.0664
Echinococcus granulosus single minded 2 0.0045 0.0466 0.0458
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0667 0.1324
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0411 0.1857
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0007 0.0014
Schistosoma mansoni chromobox protein 0.0069 0.0847 0.0836
Echinococcus multilocularis chromobox protein 1 0.0069 0.0847 0.0839
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0012 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0705 0.0694
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0115 0.1583 0.1583
Trichomonas vaginalis Inorganic phosphate transporter, putative 0.0643 1 1
Brugia malayi hypothetical protein 0.0151 0.2159 0.2159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0012
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0007 0.0014
Mycobacterium ulcerans putative regulatory protein 0.0045 0.0466 0.6357
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0082 0.105 0.105
Brugia malayi beta-lactamase family protein 0.0036 0.0316 0.0316
Brugia malayi chromobox protein homolog 3 0.0039 0.0364 0.0364
Leishmania major cathepsin L-like protease 0.0017 0.0012 0.0012
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0551 0.1095
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0754 0.1497
Echinococcus granulosus cathepsin l1 0.0017 0.0012 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0316
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0012 0.0004
Leishmania major cathepsin L-like protease 0.0063 0.0754 0.0754
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.3477 0.3472
Toxoplasma gondii exonuclease III APE 0.0019 0.0048 0.0519
Schistosoma mansoni survival motor neuron protein 0.0048 0.0509 0.0497
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0411 0.0411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0754 1
Trichomonas vaginalis conserved hypothetical protein 0.0643 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0364 0.0364
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0316 0.0805
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0316 0.0805
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0012 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0551 0.0551
Onchocerca volvulus 0.003 0.0231 0.1019
Loa Loa (eye worm) hypothetical protein 0.0115 0.1583 0.1583
Leishmania major protein kinase, putative 0.0016 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0012
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0036
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0705 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0316 0.0316
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0316 0.0805
Brugia malayi beta-lactamase family protein 0.0036 0.0316 0.0316
Leishmania major cathepsin L-like protease 0.0017 0.0012 0.0012
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0184 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0643 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0551 0.1095
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0316
Onchocerca volvulus 0.0048 0.0509 0.2313
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0364 0.0364
Echinococcus multilocularis transfer RNA-Lys 0.0045 0.0466 0.0458
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0316
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0705 0.0698
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0007 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0705 1
Trichomonas vaginalis conserved hypothetical protein 0.0643 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0754 1
Loa Loa (eye worm) fibroinase 0.0017 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0151 0.2159 0.2159
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0316 0.0805
Brugia malayi Heterochromatin protein 1 0.0069 0.0847 0.0847
Echinococcus multilocularis cysteine protease 0.0017 0.0012 0.0004
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0012 0.0012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0316 0.0308
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0551 0.0551
Mycobacterium tuberculosis Conserved protein 0.0036 0.0316 0.0805
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0754 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0012 0.0012
Echinococcus multilocularis solute carrier family 13 0.0643 1 1
Loa Loa (eye worm) hypothetical protein 0.0643 1 1
Brugia malayi beta-lactamase 0.0036 0.0316 0.0316
Schistosoma mansoni chromobox protein 0.0069 0.0847 0.0836
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0012
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0551 0.7132
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0754 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0364 0.0364
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0316 0.0316
Echinococcus granulosus aryl hydrocarbon receptor 0.0131 0.1843 0.1837
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.105 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0316 0.0627
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0316
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0316 0.3792
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0551 0.0551
Onchocerca volvulus 0.0036 0.0316 0.1415
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0316 0.0304
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0316 0.0316
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0012
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0048 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0316 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.105 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0551 0.0544
Leishmania major protein kinase, putative 0.0016 0.0007 0.0007
Onchocerca volvulus 0.0131 0.1835 0.8492
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0016 0.0008 0.0008
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0012
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0551 0.7779
Leishmania major cathepsin L-like protease 0.0017 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0231
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0675 0.0668
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 0.1185
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0539 0.1069
Trichomonas vaginalis sodium-dependent high-affinity dicarboxylate transporter, putative 0.0643 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0184 0.0184
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0316 0.0304
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0012 0.0012
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0551 0.0544
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0316 0.4072
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0551 0.0551
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0675 0.0668
Schistosoma mansoni hypothetical protein 0.0048 0.0509 0.0497
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0551 0.0551
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0643 1 1
Leishmania major cathepsin L-like protease 0.0017 0.0012 0.0012
Echinococcus multilocularis geminin 0.0168 0.242 0.2414
Brugia malayi hypothetical protein 0.0234 0.3477 0.3477
Brugia malayi jmjC domain containing protein 0.0058 0.0675 0.0675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0754 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0316
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0332 0.5036 0.503
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0364 0.1639
Echinococcus multilocularis cysteine protease 0.0017 0.0012 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0754 0.1497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0048 0.0347
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.3477 0.3472
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0705 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0754 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0316 0.0316
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0316 0.0308
Mycobacterium tuberculosis Conserved protein 0.0036 0.0316 0.0805
Mycobacterium tuberculosis Conserved protein 0.0036 0.0316 0.0805
Leishmania major cathepsin L-like protease 0.0063 0.0754 0.0754
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0048 0.5
Echinococcus multilocularis aryl hydrocarbon receptor 0.0131 0.1843 0.1837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Echinococcus multilocularis solute carrier family 13 0.0643 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0012 0.0004
Trichomonas vaginalis Inorganic phosphate transporter, putative 0.0643 1 1
Echinococcus granulosus chromobox protein 1 0.0069 0.0847 0.0839
Leishmania major sodium/sulphate symporter, putative 0.0643 1 1
Schistosoma mansoni single-minded 0.0061 0.0718 0.0707
Trichomonas vaginalis esterase, putative 0.0036 0.0316 0.0316
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0675 0.0668
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0012 0.0012
Brugia malayi bHLH-PAS transcription factor 0.0045 0.0466 0.0466
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0316 0.0805
Trypanosoma cruzi Low-affinity phosphate transporter PHO91 0.0332 0.5036 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.1591 0.1591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0754 1
Onchocerca volvulus 0.0046 0.0474 0.2154
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0551 0.0551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Schistosoma mansoni aryl hydrocarbon receptor 0.0177 0.2562 0.2553
Schistosoma mansoni sodium/dicarboxylate cotransporter-related 0.0643 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0332 0.5036 0.5036
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0048 0.0048
Trypanosoma brucei protein kinase, putative 0.005 0.0551 0.7132
Mycobacterium leprae Probable lipase LipE 0.0036 0.0316 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0754 1
Echinococcus multilocularis chromobox protein 1 0.0069 0.0847 0.0839
Mycobacterium ulcerans lipase LipD 0.0036 0.0316 0.4072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0012
Leishmania major hypothetical protein, conserved 0.0036 0.0316 0.0316
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0705 0.0705
Brugia malayi MAP kinase sur-1 0.005 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0234 0.3477 0.3477
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0847 0.0847
Schistosoma mansoni hypothetical protein 0.0168 0.242 0.2411
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 1
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0675 0.0664
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.3376 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0551 0.054
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0847 0.0847
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0551 0.0544
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0048 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0754 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0754 1
Echinococcus granulosus chromobox protein 1 0.0069 0.0847 0.0839
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0048 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0316 0.4072
Echinococcus granulosus solute carrier family 13 0.0643 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0007 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0012 0.0012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0048 0.0095
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0316 0.0316
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0048 0.0095
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0675 0.0668
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0551 0.1095
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0411 0.0411
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0643 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0551 0.0544
Toxoplasma gondii ABC1 family protein 0.0036 0.0316 0.438
Loa Loa (eye worm) ctsf protein 0.0017 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Echinococcus granulosus solute carrier family 13 0.0643 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0754 0.1497
Onchocerca volvulus 0.0036 0.0316 0.1415
Trichomonas vaginalis conserved hypothetical protein 0.0643 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0675 0.0664
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0675 0.0675
Leishmania major cathepsin L-like protease 0.0063 0.0754 0.0754
Brugia malayi PAS domain containing protein 0.0061 0.0718 0.0718
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0551 0.0551
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0316 0.0805
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0316 0.0627
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0012 0.0004
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0012 0.0004
Echinococcus granulosus solute carrier family 13 0.0643 1 1
Schistosoma mansoni hypothetical protein 0.0168 0.242 0.2411
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0316 0.0805
Leishmania major cathepsin L-like protease 0.0017 0.0012 0.0012
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0316 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0705 0.1976
Echinococcus multilocularis solute carrier family 13 0.0643 1 1
Echinococcus granulosus geminin 0.0168 0.242 0.2414
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0705 0.0698
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0754 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0012
Chlamydia trachomatis dicarboxylate translocator 0.0311 0.4711 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0131 0.1835 0.1835

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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