Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.2 uM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay | ChEMBL. | 23755850 |
IC50 (functional) | = 5.4 uM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 1 day by Griess assay | ChEMBL. | 25821895 |
Inhibition (functional) | = 50.4 % | In vitro inhibitory activity on the production of nitric oxide (NO) induced by LPS in mouse peritoneal macrophages at a concentration of 10e-4 M | ChEMBL. | 9871681 |
Inhibition (functional) | = 50.7 % | In vivo inhibitory activity on the increase of serum GPT induced by D-GalN / LPS (liver injury) in mice at 50 mg/kg peroral administation | ChEMBL. | 9871681 |
Inhibition (functional) | = 53.3 % | In vivo inhibitory activity on the increase of serum GOT induced by D-GalN / LPS (liver injury) in mice at 50 mg/kg peroral administation | ChEMBL. | 9871681 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 23755850 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.