Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0201 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0038 | 0.0669 | 0.0248 |
Loa Loa (eye worm) | aminopeptidase N | 0.0052 | 0.1489 | 0.1489 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0052 | 0.1489 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0201 | 1 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0041 | 0.082 | 0.0406 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0041 | 0.082 | 0.082 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0052 | 0.1489 | 0.1105 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0052 | 0.1489 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0052 | 0.1489 | 0.1105 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0052 | 0.1489 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0432 | 0.0432 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0034 | 0.0432 | 0.0432 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0052 | 0.1489 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0432 | 0.0432 |
Echinococcus multilocularis | aminopeptidase N | 0.0041 | 0.082 | 0.0406 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0052 | 0.1489 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0432 | 0.0432 |
Echinococcus granulosus | aminopeptidase N | 0.0041 | 0.082 | 0.0406 |
Entamoeba histolytica | aminopeptidase, putative | 0.0052 | 0.1489 | 0.5 |
Onchocerca volvulus | 0.0041 | 0.082 | 1 | |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0052 | 0.1489 | 0.1105 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0432 | 0.0432 |
Brugia malayi | hypothetical protein | 0.0041 | 0.082 | 0.0406 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0432 | 0.0432 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0052 | 0.1489 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0034 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0432 | 0.0432 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0041 | 0.082 | 0.5508 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0052 | 0.1489 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0.0432 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0052 | 0.1489 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0034 | 0.0432 | 0.0432 |
Brugia malayi | Carboxylesterase family protein | 0.0201 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0052 | 0.1489 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0201 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0052 | 0.1489 | 0.1105 |
Brugia malayi | Peptidase family M1 containing protein | 0.0052 | 0.1489 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0432 | 0.0432 |
Echinococcus granulosus | acetylcholinesterase | 0.0201 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0034 | 0.0432 | 0.0432 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0052 | 0.1489 | 0.1105 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0034 | 0.0432 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0201 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0201 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0034 | 0.0432 | 0.0432 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0432 | 0.0432 |
Schistosoma mansoni | gliotactin | 0.0034 | 0.0432 | 0.0432 |
Onchocerca volvulus | 0.0041 | 0.082 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0432 | 0.0432 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0052 | 0.1489 | 0.1105 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0052 | 0.1489 | 0.1105 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0.0432 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0052 | 0.1489 | 0.1105 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0052 | 0.1489 | 0.1489 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0432 | 0.0432 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 57 uM | Cytotoxic concentration for inhibition of human lymphoblastoid P3HR-1 cell growth | ChEMBL. | 12408726 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.