Detailed information for compound 1744906

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 292.329 | Formula: C19H16O3
  • H donors: 1 H acceptors: 2 LogP: 2.69 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1CC(=O)O[C@@H](C1)C=C1c2ccccc2c2c1cccc2
  • InChi: 1S/C19H16O3/c20-12-9-13(22-19(21)10-12)11-18-16-7-3-1-5-14(16)15-6-2-4-8-17(15)18/h1-8,11-13,20H,9-10H2/t12-,13+/m1/s1
  • InChiKey: CQRTWQUVDHQCCK-OLZOCXBDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus HMG-CoA reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania donovani 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania mexicana 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania braziliensis 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania infantum 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Schistosoma japonicum ko:K00021 3-hydroxy-3-methylglutaryl-CoA reductase [EC1.1.1.34], putative Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma brucei gambiense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma congolense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0168 0.0337 0.0337
Schistosoma mansoni hypothetical protein 0.0074 0.0136 0.0173
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0074 0.0136 0.0143
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0012 0.0003 0.0003
Echinococcus multilocularis Niemann Pick C1 protein 0.0068 0.0123 0.016
Schistosoma mansoni cpg binding protein 0.0034 0.005 0.0061
Schistosoma mansoni hypothetical protein 0.0478 0.1 0.1292
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Echinococcus multilocularis roundabout 2 0.0458 0.0956 0.1238
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0094 0.0179 0.0229
Echinococcus multilocularis titin 0.0074 0.0136 0.0176
Echinococcus granulosus tyrosine protein kinase pr2 0.0012 0.0003 0.0003
Echinococcus granulosus tyrosine protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.0179 0.0177
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0094 0.0179 0.0179
Brugia malayi Peroxidasin 0.0168 0.0337 0.0335
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Echinococcus multilocularis transfer RNA-Thr 0.0012 0.0003 0.0003
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0074 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0289 0.0596 0.0596
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.013 0.0164
Echinococcus granulosus contactin 0.0168 0.0337 0.0437
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Echinococcus granulosus neuroglian 0.0168 0.0337 0.0437
Loa Loa (eye worm) TK/EGFR protein kinase 0.0012 0.0003 0.0003
Echinococcus granulosus titin 0.0074 0.0136 0.0176
Echinococcus granulosus sterol regulatory element binding protein 0.0068 0.0123 0.016
Echinococcus multilocularis FL cytokine receptor 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0458 0.0956 0.0956
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0012 0.0003 0.0003
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0094 0.0179 0.0229
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.2335 0.4968 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Echinococcus multilocularis natriuretic peptide receptor 1 0.0012 0.0003 0.0003
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0168 0.0337 0.0337
Loa Loa (eye worm) animal heme peroxidase 0.0074 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Echinococcus granulosus Immunoglobulin 0.0094 0.0179 0.0232
Loa Loa (eye worm) hypothetical protein 0.0289 0.0596 0.0596
Loa Loa (eye worm) dihydrofolate reductase 0.3623 0.7721 0.7721
Leishmania major dihydrofolate reductase-thymidylate synthase 0.2335 0.4968 1
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0143 0.1888
Loa Loa (eye worm) hypothetical protein 0.0068 0.0123 0.0123
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0012 0.0003 0.0003
Echinococcus multilocularis insulin receptor 0.0012 0.0003 0.0003
Echinococcus granulosus Immunoglobulin subtype 0.0094 0.0179 0.0232
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0114 0.0224
Loa Loa (eye worm) RGC/RGC protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Echinococcus multilocularis 0.0074 0.0136 0.0176
Onchocerca volvulus 0.0074 0.0136 0.0143
Echinococcus multilocularis protein dispatched 1 0.0068 0.0123 0.016
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0074 0.0136 0.0176
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0168 0.0337 0.0437
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0012 0.0003 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0168 0.0337 0.0434
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0012 0.0003 0.0003
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0074 0.0136 0.0173
Echinococcus multilocularis roundabout 2 0.0168 0.0337 0.0437
Loa Loa (eye worm) TK protein kinase 0.0012 0.0003 0.0003
Echinococcus granulosus defective proboscis extension response 0.0289 0.0596 0.0773
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Schistosoma mansoni basigin related 0.0094 0.0179 0.0229
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0168 0.0337 0.0337
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0337 0.0335
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Loa Loa (eye worm) CAMK protein kinase 0.0074 0.0136 0.0136
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0337 0.0335
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0012 0.0003 0.0003
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0074 0.0136 0.0176
Echinococcus multilocularis peroxidasin 0.0168 0.0337 0.0437
Loa Loa (eye worm) TK/ALK protein kinase 0.0012 0.0003 0.0003
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0086 0.0161 0.0208
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0012 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase HCK 0.0012 0.0003 0.0003
Schistosoma mansoni cell adhesion molecule 0.0074 0.0136 0.0173
Brugia malayi hypothetical protein 0.0094 0.0179 0.0177
Onchocerca volvulus 0.0074 0.0136 0.0143
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Onchocerca volvulus 0.0034 0.005 0.005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0289 0.0596 0.0594
Echinococcus granulosus receptor type guanylyl cyclase 0.0012 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.5
Echinococcus granulosus dihydrofolate reductase 0.3623 0.7721 1
Entamoeba histolytica serine/threonine kinase, putative 0.0012 0.0003 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0337 0.0335
Schistosoma mansoni microtubule-associated protein tau 0.0807 0.1702 0.2202
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0161 0.0158
Schistosoma mansoni tyrosine kinase 0.018 0.0362 0.0466
Echinococcus multilocularis titin 0.0074 0.0136 0.0176
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Brugia malayi CHE-14 protein 0.0068 0.0123 0.0121
Loa Loa (eye worm) TK/CSK protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0074 0.0136 0.0136
Loa Loa (eye worm) protein kinase domain-containing protein 0.0012 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase csk 0.0012 0.0003 0.0003
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.5
Onchocerca volvulus 0.0074 0.0136 0.0143
Entamoeba histolytica serine/threonine kinase, putative 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0289 0.0596 0.0596
Echinococcus granulosus neuroglian 0.0363 0.0754 0.0977
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0012 0.0003 0.0003
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.2335 0.4968 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0168 0.0337 0.0434
Echinococcus granulosus Niemann Pick C1 protein 0.0068 0.0123 0.016
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.5
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0012 0.0003 0.0003
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0012 0.0003 0.0003
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0012 0.0003 0.5
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Echinococcus multilocularis protein kinase 0.0012 0.0003 0.0003
Onchocerca volvulus Tyrosine kinase homolog 0.438 0.9338 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0012 0.0003 0.0003
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0168 0.0337 0.0437
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0143 0.1888
Schistosoma mansoni nephrin related 0.0094 0.0179 0.0229
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0074 0.0136 0.0136
Echinococcus granulosus nephrin 0.0074 0.0136 0.0176
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0094 0.0179 0.0232
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0074 0.0136 0.0133
Onchocerca volvulus 0.0074 0.0136 0.0143
Loa Loa (eye worm) hypothetical protein 0.0168 0.0337 0.0337
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0086 0.0161 0.0208
Loa Loa (eye worm) TK/KIN16 protein kinase 0.469 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0012 0.0003 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Schistosoma mansoni hypothetical protein 0.0074 0.0136 0.0173
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0012 0.0003 0.5
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.5
Schistosoma mansoni hypothetical protein 0.0074 0.0136 0.0173
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0074 0.0136 0.0136
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0337 0.0335
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.5
Brugia malayi Prion-like- 0.0168 0.0337 0.0335
Echinococcus multilocularis kinase suppressor of Ras 1 0.0012 0.0003 0.0003
Echinococcus multilocularis protein KINase family member (kin 25) 0.0012 0.0003 0.0003
Echinococcus granulosus neuropeptide s receptor 0.0541 0.1133 0.1468
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0074 0.0136 0.0176
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.013 0.0168
Loa Loa (eye worm) hypothetical protein 0.0168 0.0337 0.0337
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0165 0.0331 0.0429
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0012 0.0003 0.0003
Schistosoma mansoni titin 0.0168 0.0337 0.0434
Echinococcus multilocularis receptor type guanylyl cyclase 0.0012 0.0003 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Loa Loa (eye worm) disorganized muscle protein 1 0.0074 0.0136 0.0136
Schistosoma mansoni septate junction protein 0.0094 0.0179 0.0229
Echinococcus multilocularis thymidylate synthase 0.0759 0.1599 0.2071
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0012 0.0003 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0012 0.0003 0.0003
Echinococcus multilocularis epidermal growth factor receptor 0.0012 0.0003 0.0003
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0168 0.0337 0.0337
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.0179 0.0179
Echinococcus granulosus retinal guanylyl cyclase 2 0.0012 0.0003 0.0003
Echinococcus multilocularis neuropeptide receptor A26 0.0541 0.1133 0.1468
Loa Loa (eye worm) TK protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis netrin receptor unc 5 0.0094 0.0179 0.0232
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0136 0.0173
Echinococcus granulosus integrin linked protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Schistosoma mansoni nephrin 0.0168 0.0337 0.0434
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0094 0.0179 0.0232
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0012 0.0003 0.0003
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0012 0.0003 0.0003
Schistosoma mansoni netrin receptor unc5 0.0094 0.0179 0.0229
Onchocerca volvulus 0.4294 0.9155 0.9804
Echinococcus multilocularis titin 0.0074 0.0136 0.0176
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0012 0.0003 0.0003
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0012 0.0003 0.0003
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0074 0.0136 0.0136
Entamoeba histolytica ankyrin repeat protein 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0168 0.0337 0.0337
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0168 0.0337 0.0437
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Loa Loa (eye worm) hypothetical protein 0.0289 0.0596 0.0596
Schistosoma mansoni septate junction protein 0.0168 0.0337 0.0434
Echinococcus granulosus lachesin 0.0168 0.0337 0.0437
Loa Loa (eye worm) TK protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0094 0.0179 0.0179
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Echinococcus granulosus basement membrane specific heparan sulfate 0.0094 0.0179 0.0232
Echinococcus granulosus tyrosine protein kinase csk 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0759 0.1599 0.171
Echinococcus multilocularis ephrin type A receptor 4 A 0.0012 0.0003 0.0003
Schistosoma mansoni cell adhesion molecule 0.0168 0.0337 0.0434
Brugia malayi Immunoglobulin domain containing protein 0.0094 0.0179 0.0177
Brugia malayi dihydrofolate reductase family protein 0.3623 0.7721 0.7721
Echinococcus multilocularis tyrosine protein kinase shark 0.0012 0.0003 0.0003
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.2335 0.4968 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0179 0.0179
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0094 0.0179 0.0232
Chlamydia trachomatis dihydrofolate reductase 0.3623 0.7721 0.5
Schistosoma mansoni cell adhesion molecule 0.0168 0.0337 0.0434
Trichomonas vaginalis conserved hypothetical protein 0.0361 0.0749 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0012 0.0003 0.0003
Echinococcus granulosus down syndrome cell adhesion 0.0074 0.0136 0.0176
Echinococcus granulosus hemicentin 1 0.0168 0.0337 0.0437
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0012 0.0003 0.0003
Brugia malayi Myb-like DNA-binding domain containing protein 0.0074 0.0136 0.0133
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Loa Loa (eye worm) TK protein kinase 0.0012 0.0003 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.0179 0.0177
Echinococcus multilocularis hemicentin 1 0.0168 0.0337 0.0437
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0094 0.0179 0.0229
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Echinococcus granulosus tyrosine protein kinase Blk 0.0012 0.0003 0.0003
Echinococcus granulosus roundabout 2 0.0168 0.0337 0.0437
Echinococcus granulosus titin 0.0074 0.0136 0.0176
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0289 0.0596 0.0773
Schistosoma mansoni cell adhesion molecule 0.0074 0.0136 0.0173
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Schistosoma mansoni titin 0.0074 0.0136 0.0173
Brugia malayi CXXC zinc finger family protein 0.0034 0.005 0.0047
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0337 0.0335
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Schistosoma mansoni titin 0.0074 0.0136 0.0173
Loa Loa (eye worm) TK/DDR protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0012 0.0003 0.0003
Echinococcus multilocularis hemicentin 1 0.0168 0.0337 0.0437
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0074 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Schistosoma mansoni neuroglian 0.0168 0.0337 0.0434
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0289 0.0596 0.0769
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0384 0.0798 0.0798
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0012 0.0003 0.0003
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Brugia malayi Leucine Rich Repeat family protein 0.0074 0.0136 0.0133
Echinococcus multilocularis titin 0.0074 0.0136 0.0176
Echinococcus multilocularis tyrosine protein kinase otk 0.0168 0.0337 0.0437
Schistosoma mansoni hemicentin 0.0074 0.0136 0.0173
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.5
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0168 0.0337 0.0359
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.013 0.0164
Loa Loa (eye worm) hypothetical protein 0.0094 0.0179 0.0179
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0012 0.0003 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0012 0.0003 0.0003
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Schistosoma mansoni hypothetical protein 0.0094 0.0179 0.0229
Echinococcus granulosus roundabout 2 0.0168 0.0337 0.0437
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.013 0.0256
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0759 0.1599 0.1936
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Brugia malayi Disorganized muscle protein 1 0.0074 0.0136 0.0133
Echinococcus granulosus twitchin 0.0363 0.0754 0.0977
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0168 0.0337 0.0337
Brugia malayi Animal haem peroxidase family protein 0.0074 0.0136 0.0133
Echinococcus granulosus tyrosine protein kinase Fyn 0.0012 0.0003 0.0003
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0078 0.0143 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0012 0.0003 0.0003
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0012 0.0003 0.0003
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.2335 0.4968 1
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0168 0.0337 0.0437
Echinococcus granulosus protein tyrosine kinase 0.0012 0.0003 0.0003
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0165 0.0331 0.0425
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) TK/Met protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Echinococcus multilocularis tyrosine protein kinase Blk 0.0012 0.0003 0.0003
Echinococcus multilocularis lachesin 0.0168 0.0337 0.0437
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis dihydrofolate reductase 0.3623 0.7721 1
Echinococcus granulosus protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) TK protein kinase 0.0012 0.0003 0.0003
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0143 0.1888
Echinococcus multilocularis Immunoglobulin 0.0094 0.0179 0.0232
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0361 0.0749 0.1503
Schistosoma mansoni myosin-binding protein-related 0.0074 0.0136 0.0173
Schistosoma mansoni hypothetical protein 0.0094 0.0179 0.0229
Loa Loa (eye worm) one IG domain family member 0.0074 0.0136 0.0136
Schistosoma mansoni nephrin 0.0363 0.0754 0.0974
Loa Loa (eye worm) TK protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis protein tyrosine kinase 0.0012 0.0003 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0337 0.0335
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0168 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Schistosoma mansoni titin 0.0074 0.0136 0.0173
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.0179 0.0177
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Schistosoma mansoni hypothetical protein 0.0074 0.0136 0.0173
Entamoeba histolytica serine/threonine kinase, putative 0.0012 0.0003 0.5
Onchocerca volvulus Peroxidasin homolog 0.0074 0.0136 0.0143
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0012 0.0003 0.0003
Echinococcus multilocularis cpg binding protein 0.0035 0.0054 0.0069
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.0331 0.0661
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0012 0.0003 0.0003
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.0331 0.0661
Loa Loa (eye worm) SRC-1 0.0012 0.0003 0.0003
Schistosoma mansoni titin 0.0074 0.0136 0.0173
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Echinococcus granulosus tyrosine protein kinase otk 0.0168 0.0337 0.0437
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.5
Schistosoma mansoni nephrin related 0.0074 0.0136 0.0173
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.013 0.0256
Entamoeba histolytica tyrosin kinase, putative 0.0012 0.0003 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0074 0.0136 0.0143
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Onchocerca volvulus Peroxidasin homolog 0.0074 0.0136 0.0143
Loa Loa (eye worm) TK/ABL protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica tyrosin kinase, putative 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0289 0.0596 0.0596
Echinococcus granulosus cpg binding protein 0.0035 0.0054 0.0069
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0074 0.0136 0.0176
Entamoeba histolytica cysteine surface protein, putative 0.0012 0.0003 0.5
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0384 0.0798 0.1034
Brugia malayi basement membrane proteoglycan precursor 0.0094 0.0179 0.0177
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0094 0.0179 0.0232
Schistosoma mansoni dihydrofolate reductase 0.3623 0.7721 1
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Echinococcus granulosus insulin growth factor binding 0.0074 0.0136 0.0176
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Echinococcus granulosus retinal guanylyl cyclase 2 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0289 0.0596 0.0596
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0074 0.0136 0.0136
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0012 0.0003 0.0003
Entamoeba histolytica tyrosin kinase, putative 0.0012 0.0003 0.5
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0165 0.0331 0.0429
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.013 0.0168
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0094 0.0179 0.0232
Echinococcus granulosus tyrosine protein kinase shark 0.0012 0.0003 0.0003
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0074 0.0136 0.0136
Schistosoma mansoni cell adhesion molecule 0.0094 0.0179 0.0229
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Echinococcus granulosus netrin receptor unc 5 0.0094 0.0179 0.0232
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0541 0.1133 0.1468
Echinococcus multilocularis tyrosine kinase 0.0012 0.0003 0.0003
Mycobacterium ulcerans thymidylate synthase 0.0759 0.1599 0.1936
Schistosoma mansoni hypothetical protein 0.0094 0.0179 0.0229
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0168 0.0337 0.0337
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0012 0.0003 0.5
Echinococcus granulosus Protein patched homolog 1 0.0068 0.0123 0.016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.0179 0.0177
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.5
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0068 0.0123 0.0156
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0289 0.0596 0.0769
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Echinococcus granulosus tyrosine kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase csk 0.0012 0.0003 0.0003
Echinococcus multilocularis Immunoglobulin 0.0289 0.0596 0.0773
Echinococcus granulosus tyrosine protein kinase Fyn 0.0012 0.0003 0.0003
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0094 0.0179 0.0232
Loa Loa (eye worm) TK protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0168 0.0337 0.0437
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Brugia malayi protein unc-22 0.0074 0.0136 0.0133
Schistosoma mansoni cpg binding protein 0.0035 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Brugia malayi Dihydrofolate reductase 0.3623 0.7721 0.7721
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0123 0.1616
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Schistosoma mansoni septate junction protein 0.0168 0.0337 0.0434
Loa Loa (eye worm) RGC/RGC protein kinase 0.0012 0.0003 0.0003
Echinococcus granulosus leucine rich repeat containing protein 4 0.0074 0.0136 0.0176
Echinococcus granulosus low density lipoprotein receptor ldl 0.0094 0.0179 0.0232
Echinococcus multilocularis Immunoglobulin subtype 0.0094 0.0179 0.0232
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Echinococcus granulosus raf serine:threonine protein kinase 0.0012 0.0003 0.0003
Schistosoma mansoni titin 0.0074 0.0136 0.0173
Echinococcus multilocularis tyrosine protein kinase csk 0.0012 0.0003 0.0003
Schistosoma mansoni netrin receptor unc5 0.0094 0.0179 0.0229
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0074 0.0136 0.0176
Brugia malayi basement membrane proteoglycan 0.0094 0.0179 0.0177
Echinococcus granulosus peroxidasin 0.0168 0.0337 0.0437
Echinococcus multilocularis neuroglian 0.0168 0.0337 0.0437
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.005 0.005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Schistosoma mansoni cell adhesion molecule 0.0384 0.0798 0.1031
Brugia malayi kettin 0.0074 0.0136 0.0133
Schistosoma mansoni cell adhesion molecule 0.0074 0.0136 0.0173
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Echinococcus multilocularis neuroglian 0.0363 0.0754 0.0977
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.5
Onchocerca volvulus Netrin receptor homolog 0.0074 0.0136 0.0143
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase pr2 0.0012 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0168 0.0337 0.0337
Echinococcus multilocularis heat shock protein 70 0.0012 0.0003 0.0003
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.0331 0.0661
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.3623 0.7721 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0458 0.0956 0.0956
Schistosoma mansoni titin 0.0074 0.0136 0.0173
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0074 0.0136 0.0176
Loa Loa (eye worm) TK protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0012 0.0003 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.013 0.0165
Schistosoma mansoni slit 0.0074 0.0136 0.0173
Echinococcus granulosus natriuretic peptide receptor 1 0.0012 0.0003 0.0003
Loa Loa (eye worm) thymidylate synthase 0.0759 0.1599 0.1599
Echinococcus multilocularis down syndrome cell adhesion 0.0074 0.0136 0.0176
Brugia malayi Prion-like- 0.0074 0.0136 0.0133
Loa Loa (eye worm) projectin 0.0074 0.0136 0.0136
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.0179 0.0177
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.0086 0.0161 0.0161
Echinococcus multilocularis epidermal growth factor receptor 0.0012 0.0003 0.0003
Echinococcus granulosus Immunoglobulin 0.0094 0.0179 0.0232
Schistosoma mansoni hypothetical protein 0.0094 0.0179 0.0229
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Onchocerca volvulus 0.0074 0.0136 0.0143
Echinococcus granulosus tyrosine protein kinase HCK 0.0012 0.0003 0.0003
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Brugia malayi Fibronectin type III domain containing protein 0.0289 0.0596 0.0594
Entamoeba histolytica receptor protein kinase, putative 0.0012 0.0003 0.5
Schistosoma mansoni cell adhesion molecule 0.0168 0.0337 0.0434
Echinococcus granulosus fibroblast growth factor receptor 4 0.0012 0.0003 0.0003
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.0331 0.0661
Echinococcus granulosus retinal guanylyl cyclase 2 0.0012 0.0003 0.0003
Echinococcus granulosus tyrosine protein kinase Srms 0.0012 0.0003 0.0003
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0074 0.0136 0.0136
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase Srms 0.0012 0.0003 0.0003
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.2335 0.4968 1
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0165 0.0331 0.0265
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Echinococcus granulosus activated cdc42 kinase 1 0.0012 0.0003 0.0003
Entamoeba histolytica serine/threonine kinase, putative 0.0012 0.0003 0.5
Echinococcus multilocularis tyrosine protein kinase Abl 0.0012 0.0003 0.0003
Echinococcus multilocularis integrin linked protein kinase 0.0012 0.0003 0.0003
Schistosoma mansoni cell adhesion molecule 0.0094 0.0179 0.0229
Echinococcus multilocularis microtubule associated protein 2 0.0807 0.1702 0.2204
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Echinococcus multilocularis twitchin 0.0074 0.0136 0.0176
Onchocerca volvulus 0.0074 0.0136 0.0143
Echinococcus multilocularis activin receptor type 0.0012 0.0003 0.0003
Echinococcus multilocularis tyrosine kinase 0.0012 0.0003 0.0003
Echinococcus granulosus titin 0.0074 0.0136 0.0176
Schistosoma mansoni basigin related 0.0094 0.0179 0.0229
Entamoeba histolytica receptor protein kinase, putative 0.0012 0.0003 0.5
Entamoeba histolytica protein kinase, putative 0.0012 0.0003 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Echinococcus granulosus Immunoglobulin 0.0289 0.0596 0.0773
Echinococcus granulosus titin 0.0074 0.0136 0.0176
Echinococcus multilocularis transfer RNA-Phe 0.0074 0.0136 0.0176
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Echinococcus granulosus ephrin type A receptor 4 A 0.0012 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0094 0.0179 0.0229
Schistosoma mansoni peroxidasin 0.0094 0.0179 0.0229
Schistosoma mansoni basigin related 0.0094 0.0179 0.0229
Echinococcus multilocularis Immunoglobulin 0.0094 0.0179 0.0232
Echinococcus granulosus activin receptor type 0.0012 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0012 0.0003 0.0003
Echinococcus granulosus c src tyrosine kinase 0.0012 0.0003 0.0003
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0094 0.0179 0.0229
Brugia malayi hypothetical protein 0.0289 0.0596 0.0594
Loa Loa (eye worm) hypothetical protein 0.0165 0.0331 0.0331
Echinococcus multilocularis neuropeptide s receptor 0.0541 0.1133 0.1468
Loa Loa (eye worm) hypothetical protein 0.0168 0.0337 0.0337
Echinococcus granulosus dnaJ subfamily B 0.0478 0.1 0.1295
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0337 0.0335
Schistosoma mansoni roundabout 0.0168 0.0337 0.0434
Onchocerca volvulus 0.0074 0.0136 0.0143
Echinococcus multilocularis sterol regulatory element binding protein 0.0068 0.0123 0.016
Echinococcus granulosus titin 0.0074 0.0136 0.0176
Schistosoma mansoni titin 0.0074 0.0136 0.0173
Onchocerca volvulus 0.0074 0.0136 0.0143
Echinococcus granulosus thymidylate synthase 0.0759 0.1599 0.2071
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0068 0.0123 0.0123
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0337 0.0335
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.0003 0.5
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0165 0.0331 0.0328
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0168 0.0337 0.0437
Brugia malayi Immunoglobulin I-set domain containing protein 0.0168 0.0337 0.0335
Schistosoma mansoni hypothetical protein 0.0074 0.0136 0.0173
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis insulin growth factor binding 0.0074 0.0136 0.0176
Echinococcus granulosus epidermal growth factor receptor 0.0012 0.0003 0.0003
Brugia malayi Prion-like- 0.0074 0.0136 0.0133
Loa Loa (eye worm) LAD-2 short isoform 0.0094 0.0179 0.0179
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0074 0.0136 0.0143
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0012 0.0003 0.0003
Schistosoma mansoni septate junction protein 0.0094 0.0179 0.0229
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0759 0.1599 0.2068
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0074 0.0136 0.0173
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0074 0.0136 0.0176
Echinococcus multilocularis activated cdc42 kinase 1 0.0012 0.0003 0.0003
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0094 0.0179 0.0232
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Loa Loa (eye worm) TK protein kinase 0.0086 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Echinococcus granulosus roundabout 2 0.0458 0.0956 0.1238
Brugia malayi Immunoglobulin domain containing protein 0.0094 0.0179 0.0177
Echinococcus granulosus tyrosine protein kinase Fyn 0.0012 0.0003 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0478 0.1 0.1295
Echinococcus granulosus tyrosine protein kinase csk 0.0012 0.0003 0.0003
Echinococcus multilocularis roundabout 2 0.0168 0.0337 0.0437
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0074 0.0136 0.0173
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Echinococcus multilocularis c src tyrosine kinase 0.0012 0.0003 0.0003
Echinococcus granulosus tyrosine protein kinase Src64B 0.0012 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0094 0.0179 0.0229
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0094 0.0179 0.0179
Echinococcus multilocularis raf serine:threonine protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) RGC/RGC protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0012 0.0003 0.0003
Brugia malayi Heparan sulfate 0.0094 0.0179 0.0177
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0012 0.0003 0.0003
Brugia malayi Prion-like- 0.0074 0.0136 0.0133
Loa Loa (eye worm) hypothetical protein 0.0094 0.0179 0.0179
Echinococcus granulosus insulin receptor 0.0012 0.0003 0.0003
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0012 0.0003 0.0003
Brugia malayi thymidylate synthase 0.0759 0.1599 0.1597
Echinococcus granulosus tyrosine kinase 0.0012 0.0003 0.0003
Onchocerca volvulus Putative titin 0.0074 0.0136 0.0143
Mycobacterium tuberculosis Hypothetical protein 0.0361 0.0749 0.0816
Echinococcus granulosus kinase suppressor of Ras 1 0.0012 0.0003 0.0003
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0012 0.0003 0.5
Loa Loa (eye worm) TK/ACK protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) TK/FAK protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica ankyrin repeat protein 0.0012 0.0003 0.5
Loa Loa (eye worm) TK/EPH protein kinase 0.0012 0.0003 0.0003
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.3623 0.7721 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0012 0.0003 0.0003
Schistosoma mansoni vesicular amine transporter 0.0289 0.0596 0.0769
Entamoeba histolytica serine/threonine kinase, putative 0.0012 0.0003 0.5
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.3623 0.7721 1
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0094 0.0179 0.0232
Loa Loa (eye worm) TK/INSR protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Schistosoma mansoni patched 1 0.0068 0.0123 0.0156
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0136 0.0133
Brugia malayi hypothetical protein 0.0361 0.0749 0.0747
Schistosoma mansoni cpg binding protein 0.0035 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Echinococcus multilocularis protein patched 0.0068 0.0123 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0094 0.0179 0.0232
Loa Loa (eye worm) hypothetical protein 0.0074 0.0136 0.0136
Echinococcus granulosus tyrosine kinase 0.0012 0.0003 0.0003
Brugia malayi Immunoglobulin domain containing protein 0.0094 0.0179 0.0177
Loa Loa (eye worm) serine/threonine protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0012 0.0003 0.5
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0094 0.0179 0.0229
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) TK protein kinase 0.0012 0.0003 0.0003
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0003 0.0003
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Echinococcus multilocularis protein kinase 0.0012 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0012 0.0003 0.0003
Echinococcus multilocularis Immunoglobulin 0.0289 0.0596 0.0773
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0012 0.0003 0.0003
Echinococcus granulosus microtubule associated protein 2 0.0807 0.1702 0.2204
Entamoeba histolytica protein kinase domain containing protein 0.0012 0.0003 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0012 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0136 0.0173

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.89 uM In vitro inhibitory activity against HMG CoA reductase ChEMBL. 3973903
IC50 (binding) = 0.89 uM Compound was tested in vitro for its ability to inhibit rat liver HMG-CoA reductase ChEMBL. 3701793
Inhibition (binding) = 25 % Inhibitory activity of the compound against partially purified rat liver HMG CoA reductase at 0.1 ug/ml concentration ChEMBL. 3973903
Inhibition (binding) = 48 % Inhibitory activity of the compound against partially purified rat liver HMG CoA reductase at 0.2 ug/ml concentration ChEMBL. 3973903
Inhibition (binding) = 61 % Inhibitory activity of the compound against partially purified rat liver HMG CoA reductase at 1.4 ug/ml concentration ChEMBL. 3973903
Inhibition (binding) = 81 % Inhibitory activity of the compound against partially purified rat liver HMG CoA reductase at 0.8 ug/ml concentration ChEMBL. 3973903
Relative potency (binding) = 1.5 Compound was tested for its ability to inhibit solubilized, purified rat liver HMG-CoA reductase, relative to compactin(100) ChEMBL. 3701793

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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