Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0439 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0439 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0439 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0439 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0439 | 0.5 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0439 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0439 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0439 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0439 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0439 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0439 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0439 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0439 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0439 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0439 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0439 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0439 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0439 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0439 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0439 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0439 | 0.5 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0439 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0439 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0439 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0439 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0439 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0439 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0439 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0439 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimicrobial activity against Cryptococcus neoformans ATCC 90113 | ChEMBL. | 24758242 | |
Activity (functional) | Antimicrobial activity against Candida albicans ATCC 90028 | ChEMBL. | 24758242 | |
Activity (functional) | Antimicrobial activity against Escherichia coli ATCC 35218 | ChEMBL. | 24758242 | |
Ip (functional) | = 1 | Sensory evaluation was done for sweetness at a concentration of 650 p.p.m. against sample intensity relative to 10% sucrose. | ChEMBL. | 3965718 |
Pm (functional) | = 370 | Sensory evaluation was done for sweetness at a concentration of 650 p.p.m. against compound potency calculated on a molar basis . | ChEMBL. | 3965718 |
Pw (functional) | = 150 | Sensory evaluation was done for sweetness at a concentration of 650 p.p.m. against compound potency calculated on weight basis. | ChEMBL. | 3965718 |
Sensory evaluation (functional) | = 4 | Sensory evaluation was done at a concentration of 650 p.p.m. against property of bitterness. | ChEMBL. | 3965718 |
Sensory evaluation (functional) | = 8 | Sensory evaluation was done at a concentration of 650 p.p.m. against other properties. | ChEMBL. | 3965718 |
Sensory evaluation (functional) | = 88 | Sensory evaluation was done at a concentration of 650 p.p.m. against property of sweetness. | ChEMBL. | 3965718 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.