Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0301 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.3176 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.2127 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.3176 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.3176 | 0.5 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0293 | 0.9601 | 0.5 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0301 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.3176 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.3176 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.2127 | 0.5 |
Onchocerca volvulus | 0.0091 | 0 | 0.5 | |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0301 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T1/2 (ADMET) | = 25 min | Half-life of the compound was determined using mouse brain homogenate | ChEMBL. | 12643900 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.