TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 814.883 | Formula: C41H50N8O10
H donors: 10 H acceptors: 10 LogP: 0.1 Rotable bonds: 23
Rule of 5 violations (Lipinski): 3
SMILES: OC[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)O)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@H]1NCc2c(C1)cc(cc2)O)C
InChi: 1S/C41H50N8O10/c1-23(45-39(57)30-19-27-18-29(52)14-11-26(27)20-43-30)37(55)47-31(16-24-6-3-2-4-7-24)38(56)44-21-35(53)46-32(17-25-9-12-28(51)13-10-25)41(59)49-15-5-8-34(49)40(58)48-33(22-50)36(42)54/h2-4,6-7,9-14,18,23,30-34,43,50-52H,5,8,15-17,19-22H2,1H3,(H2,42,54)(H,44,56)(H,45,57)(H,46,53)(H,47,55)(H,48,58)/t23-,30+,31+,32+,33+,34+/m1/s1
InChiKey: GURQUERRGAPVSN-RILLOWKESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Delta opioid receptor	Starlite/ChEMBL	References
Rattus norvegicus	Mu opioid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_139759	All targets in OG5_139759
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_139759	All targets in OG5_139759

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Delta opioid receptor	372 aa	330 aa	24.2 %
Schistosoma mansoni	neuropeptide F-like receptor	Mu opioid receptor	398 aa	335 aa	20.6 %
Schistosoma japonicum	Rhodopsin, putative	Mu opioid receptor	398 aa	328 aa	23.2 %
Onchocerca volvulus		Delta opioid receptor	372 aa	349 aa	22.1 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Delta opioid receptor	372 aa	353 aa	29.2 %
Onchocerca volvulus		Delta opioid receptor	372 aa	344 aa	22.1 %
Onchocerca volvulus	Programmed cell death protein 5 homolog	Mu opioid receptor	398 aa	323 aa	24.1 %
Echinococcus granulosus	allatostatin A receptor	Delta opioid receptor	372 aa	302 aa	27.8 %
Loa Loa (eye worm)	neuropeptide F receptor	Delta opioid receptor	372 aa	317 aa	23.3 %
Onchocerca volvulus		Delta opioid receptor	372 aa	386 aa	22.8 %
Onchocerca volvulus		Delta opioid receptor	372 aa	353 aa	21.0 %
Onchocerca volvulus		Delta opioid receptor	372 aa	316 aa	26.9 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Delta opioid receptor	372 aa	330 aa	24.5 %
Brugia malayi	GnHR receptor homolog	Delta opioid receptor	372 aa	313 aa	18.5 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Mu opioid receptor	398 aa	397 aa	22.7 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Delta opioid receptor	372 aa	366 aa	22.7 %
Echinococcus multilocularis	allatostatin A receptor	Delta opioid receptor	372 aa	302 aa	28.5 %
Brugia malayi	ORL1-like opioid receptor	Delta opioid receptor	372 aa	300 aa	24.7 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Delta opioid receptor	372 aa	315 aa	28.6 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Mu opioid receptor	398 aa	334 aa	23.1 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Delta opioid receptor	372 aa	320 aa	25.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	protein kinase, putative	0.0592	0.0245	1
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.584	0.3271	0.3271
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0168	0	0.5
Echinococcus granulosus	protein kinase c iota type	0.584	0.3271	0.4879
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0466	0.0172	0.0257
Entamoeba histolytica	PH domain containing protein kinase, putative	1.1794	0.6705	0.6705
Toxoplasma gondii	Oxysterol-binding protein	0.0466	0.0172	0.0177
Trichomonas vaginalis	AGC family protein kinase	0.584	0.3271	0.3271
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0466	0.0172	0.0257
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0466	0.0172	0.0172
Echinococcus granulosus	GRB2 associated binding protein 3	0.0466	0.0172	0.0257
Echinococcus granulosus	Pleckstrin y	0.0466	0.0172	0.0257
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.584	0.3271	0.3271
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0466	0.0172	0.0257
Trichomonas vaginalis	AGC family protein kinase	1.7508	1	1
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Trypanosoma brucei	protein kinase, putative	0.0592	0.0245	0.0245
Brugia malayi	Oxysterol binding protein	0.0466	0.0172	0.0172
Echinococcus granulosus	serine/threonine protein kinase	1.1794	0.6705	1
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0592	0.0245	1
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Toxoplasma gondii	AGC kinase	1.7041	0.9731	1
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0466	0.0172	0.0172
Brugia malayi	Hr1 repeat family protein	0.584	0.3271	0.3271
Echinococcus granulosus	nervana 2	1.1201	0.6363	0.949
Brugia malayi	Uncoordinated protein 104	0.0466	0.0172	0.0172
Brugia malayi	Dynamin	0.0466	0.0172	0.0172
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0466	0.0172	0.0172
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	1.1327	0.6436	1
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0466	0.0172	0.0257
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Loa Loa (eye worm)	syntrophin-1	0.0466	0.0172	0.0172
Brugia malayi	PH domain containing protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Schistosoma mansoni	vav2	0.0466	0.0172	0.0257
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0466	0.0172	0.0257
Trichomonas vaginalis	centaurin/arf, putative	0.0466	0.0172	0.0172
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0466	0.0172	0.0172
Echinococcus multilocularis	pdz domain containing protein	0.0466	0.0172	0.0257
Trichomonas vaginalis	AGC family protein kinase	1.7508	1	1
Echinococcus granulosus	dynamin 1	0.0466	0.0172	0.0257
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0466	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Brugia malayi	Plekhf2 protein	0.0466	0.0172	0.0172
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0466	0.0172	0.0172
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0466	0.0172	0.0172
Loa Loa (eye worm)	rho-GTPase-activating	0.0466	0.0172	0.0172
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0466	0.0172	0.0257
Leishmania major	serine/threonine-protein kinase a, putative	0.0592	0.0245	1
Entamoeba histolytica	PH domain containing protein	0.0466	0.0172	0.0172
Echinococcus granulosus	Pleckstrin y	0.0466	0.0172	0.0257
Echinococcus multilocularis	serine threonine protein kinase	0.584	0.3271	0.4879
Loa Loa (eye worm)	hypothetical protein	0.584	0.3271	0.3271
Echinococcus multilocularis	cytohesin 1	0.0466	0.0172	0.0257
Schistosoma mansoni	serine/threonine protein kinase	0.584	0.3271	0.4879
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Brugia malayi	Pleckstrin Homology Domain	0.0466	0.0172	0.0172
Trypanosoma cruzi	PH domain containing protein, putative	0.0466	0.0172	0.0257
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0466	0.0172	0.0257
Echinococcus multilocularis	serine:threonine protein kinase N2	0.584	0.3271	0.4879
Trichomonas vaginalis	AGC family protein kinase	1.7508	1	1
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.584	0.3271	0.4879
Leishmania major	hypothetical protein, conserved	0.0466	0.0172	0.7035
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0592	0.0245	0.0365
Onchocerca volvulus	outspread protein homolog	0.0466	0.0172	1
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.584	0.3271	0.4879
Loa Loa (eye worm)	AGC/PKN protein kinase	0.584	0.3271	0.3271
Entamoeba histolytica	protein kinase, putative	0.0592	0.0245	0.0245
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0592	0.0245	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0592	0.0245	0.0245
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0466	0.0172	0.0257
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0466	0.0172	0.0172
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0592	0.0245	0.0245
Brugia malayi	MAX-1A	0.0466	0.0172	0.0172
Entamoeba histolytica	protein kinase, putative	0.0592	0.0245	0.0245
Echinococcus granulosus	oxysterol binding protein 1	0.0466	0.0172	0.0257
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Trypanosoma cruzi	hypothetical protein	0.0466	0.0172	0.0257
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0466	0.0172	0.0172
Schistosoma mansoni	rho gtpase activating protein	0.0466	0.0172	0.0257
Schistosoma mansoni	dynamin	0.0466	0.0172	0.0257
Schistosoma mansoni	goodpasture antigen-binding protein	0.0466	0.0172	0.0257
Trichomonas vaginalis	protein transport protein sec7, putative	0.0466	0.0172	0.0172
Loa Loa (eye worm)	Plekhf2 protein	0.0466	0.0172	0.0172
Echinococcus multilocularis	oxysterol binding protein 3	0.0466	0.0172	0.0257
Schistosoma mansoni	hypothetical protein	0.0466	0.0172	0.0257
Echinococcus granulosus	nervana 2	1.1201	0.6363	0.949
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Entamoeba histolytica	protein kinase 2, putative	1.1327	0.6436	0.6436
Schistosoma mansoni	zinc finger protein	0.0466	0.0172	0.0257
Echinococcus granulosus	Oxysterol binding protein 11	0.0466	0.0172	0.0257
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0466	0.0172	0.0257
Entamoeba histolytica	protein kinase, putative	0.0592	0.0245	0.0245
Trypanosoma brucei	PH domain containing protein, putative	0.0466	0.0172	0.0172
Trichomonas vaginalis	hypothetical protein	0.0466	0.0172	0.0172
Echinococcus granulosus	myotubularin protein 13	0.0466	0.0172	0.0257
Schistosoma mansoni	serine/threonine protein kinase	0.584	0.3271	0.4879
Echinococcus multilocularis	Oxysterol binding protein 11	0.0466	0.0172	0.0257
Schistosoma mansoni	centaurin alpha	0.0466	0.0172	0.0257
Brugia malayi	PH domain containing protein	0.0466	0.0172	0.0172
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0631	0.0267	0.0398
Trichomonas vaginalis	AGC family protein kinase	0.584	0.3271	0.3271
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0466	0.0172	0.0257
Loa Loa (eye worm)	PH domain-containing protein	0.0466	0.0172	0.0172
Trypanosoma cruzi	rac serine-threonine kinase, putative	1.1794	0.6705	1
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0466	0.0172	0.0257
Schistosoma mansoni	serine/threonine protein kinase	0.584	0.3271	0.4879
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0466	0.0172	0.0172
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0592	0.0245	0.0245
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.584	0.3271	0.4879
Brugia malayi	PH domain containing protein	0.0466	0.0172	0.0172
Brugia malayi	probable spectrin beta chain	0.0466	0.0172	0.0172
Echinococcus multilocularis	dynamin 1	0.0466	0.0172	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Echinococcus granulosus	NDR protein kinase	0.584	0.3271	0.4879
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	1.7041	0.9731	0.9731
Echinococcus multilocularis	oxysterol binding protein 1	0.0466	0.0172	0.0257
Trypanosoma cruzi	Protein kinase B	1.1794	0.6705	1
Entamoeba histolytica	protein kinase, putative	1.7508	1	1
Echinococcus multilocularis	Pleckstrin y	0.0466	0.0172	0.0257
Echinococcus granulosus	Pleckstrin y	0.0466	0.0172	0.0257
Brugia malayi	Cadps2 protein	0.0466	0.0172	0.0172
Schistosoma mansoni	oxysterol-binding protein 1	0.0466	0.0172	0.0257
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.584	0.3271	0.4879
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0592	0.0245	0.0365
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0592	0.0245	0.0116
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0466	0.0172	0.0257
Entamoeba histolytica	hypothetical protein	0.0466	0.0172	0.0172
Onchocerca volvulus	Putative zinc finger protein	0.0466	0.0172	1
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0466	0.0172	0.0172
Mycobacterium ulcerans	oxidoreductase	0.0168	0	0.5
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0592	0.0245	0.0365
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0466	0.0172	0.0177
Leishmania major	folate/biopterin transporter, putative	0.0592	0.0245	1
Schistosoma mansoni	serine/threonine protein kinase	0.584	0.3271	0.4879
Loa Loa (eye worm)	cytohesin 3	0.0466	0.0172	0.0172
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Brugia malayi	Protein kinase domain containing protein	0.584	0.3271	0.3271
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0466	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Brugia malayi	Cytohesin 3	0.0466	0.0172	0.0172
Echinococcus multilocularis	oxysterol binding protein 9	0.0466	0.0172	0.0257
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Echinococcus granulosus	calcium dependent secretion activator 1	0.0466	0.0172	0.0257
Trichomonas vaginalis	centaurin/arf, putative	0.0466	0.0172	0.0172
Brugia malayi	PH domain containing protein	0.0466	0.0172	0.0172
Entamoeba histolytica	hypothetical protein	0.0592	0.0245	0.0245
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0466	0.0172	0.0257
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.584	0.3271	0.3271
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0466	0.0172	0.0172
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0466	0.0172	0.0172
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0592	0.0245	0.0365
Echinococcus multilocularis	nervana 2	1.1201	0.6363	0.949
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0466	0.0172	0.0172
Echinococcus granulosus	oxysterol binding protein 3	0.0466	0.0172	0.0257
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0466	0.0172	0.0257
Echinococcus multilocularis	Glutaredoxin protein 5	1.1201	0.6363	0.949
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0466	0.0172	0.0172
Trichomonas vaginalis	centaurin alpha, putative	0.0466	0.0172	0.0172
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0466	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Schistosoma mansoni	growth factor receptor-bound protein	0.0466	0.0172	0.0257
Entamoeba histolytica	hypothetical protein	0.0466	0.0172	0.0172
Echinococcus granulosus	beta 1 syntrophin	0.0466	0.0172	0.0257
Toxoplasma gondii	hypothetical protein	0.0466	0.0172	0.0177
Trichomonas vaginalis	alpha chimerin, putative	0.0466	0.0172	0.0172
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0466	0.0172	0.0257
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0592	0.0245	0.0245
Brugia malayi	p70 ribosomal S6 kinase beta	1.7041	0.9731	0.9731
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Onchocerca volvulus		0.0466	0.0172	1
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Trypanosoma cruzi	hypothetical protein	0.0466	0.0172	0.0257
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Echinococcus granulosus	Protein kinase C brain isozyme	0.584	0.3271	0.4879
Schistosoma mansoni	myotubularin-related protein	0.0466	0.0172	0.0257
Loa Loa (eye worm)	AGC/AKT protein kinase	1.7508	1	1
Schistosoma mansoni	serine/threonine-protein kinase	1.1794	0.6705	1
Loa Loa (eye worm)	uncoordinated protein 104	0.0466	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Leishmania major	hypothetical protein, conserved	0.0466	0.0172	0.7035
Onchocerca volvulus		0.0466	0.0172	1
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.584	0.3271	0.4879
Brugia malayi	Variant SH3 domain containing protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	centaurin beta, putative	0.0466	0.0172	0.0172
Brugia malayi	protein kinase C II.	0.584	0.3271	0.3271
Echinococcus multilocularis	beta 1 syntrophin	0.0466	0.0172	0.0257
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0466	0.0172	0.0257
Schistosoma mansoni	serine/threonine kinase	0.584	0.3271	0.4879
Trichomonas vaginalis	AGC family protein kinase	1.7508	1	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.584	0.3271	0.4879
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0466	0.0172	0.0172
Onchocerca volvulus		0.0466	0.0172	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0466	0.0172	0.0172
Echinococcus granulosus	cytohesin 1	0.0466	0.0172	0.0257
Echinococcus granulosus	serine threonine protein kinase nrc	1.1327	0.6436	0.9599
Trypanosoma cruzi	hypothetical protein	0.0466	0.0172	0.0257
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0466	0.0172	0.0257
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0466	0.0172	0.0257
Loa Loa (eye worm)	AGC/NDR protein kinase	0.584	0.3271	0.3271
Loa Loa (eye worm)	oxysterol binding protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Echinococcus multilocularis	protein kinase c epsilon type	0.584	0.3271	0.4879
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0466	0.0172	0.0257
Schistosoma mansoni	hypothetical protein	0.0466	0.0172	0.0257
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	1.1327	0.6436	0.9599
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0592	0.0245	0.0365
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Echinococcus granulosus	oxysterol binding protein 9	0.0466	0.0172	0.0257
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0466	0.0172	0.0172
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.584	0.3271	0.3271
Trypanosoma cruzi	hypothetical protein	0.0466	0.0172	0.0257
Schistosoma mansoni	hypothetical protein	0.0466	0.0172	0.0257
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.5714	0.3199	0.3199
Schistosoma mansoni	dynamin	0.0466	0.0172	0.0257
Schistosoma mansoni	atypical protein kinase C	0.584	0.3271	0.4879
Schistosoma mansoni	hypothetical protein	0.0466	0.0172	0.0257
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.584	0.3271	0.4879
Schistosoma mansoni	zinc finger protein	0.0466	0.0172	0.0257
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Mycobacterium tuberculosis	Probable oxidoreductase	0.0168	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0466	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	AGC family protein kinase	1.7508	1	1
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0466	0.0172	0.0257
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0466	0.0172	0.0257
Brugia malayi	Variant SH3 domain containing protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	AGC family protein kinase	0.6306	0.354	0.354
Leishmania major	protein kinase, putative	0.0592	0.0245	1
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0466	0.0172	0.0257
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	1.1201	0.6363	0.949
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0592	0.0245	0.0245
Brugia malayi	PH domain containing protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0592	0.0245	0.0245
Echinococcus granulosus	tm gpcr rhodopsin	0.0631	0.0267	0.0398
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0466	0.0172	0.0257
Brugia malayi	Dynamin	0.0466	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Onchocerca volvulus		0.0466	0.0172	1
Trichomonas vaginalis	AGC family protein kinase	0.584	0.3271	0.3271
Entamoeba histolytica	protein kinase, putative	0.0592	0.0245	0.0245
Schistosoma mansoni	syntrophin	0.0466	0.0172	0.0257
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0466	0.0172	0.0172
Trypanosoma cruzi	hypothetical protein	0.0466	0.0172	0.0257
Trichomonas vaginalis	kinesin light chain, putative	0.0466	0.0172	0.0172
Echinococcus granulosus	protein kinase c epsilon type	0.584	0.3271	0.4879
Entamoeba histolytica	hypothetical protein	0.0466	0.0172	0.0172
Entamoeba histolytica	hypothetical protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Trypanosoma cruzi	PH domain containing protein, putative	0.0466	0.0172	0.0257
Schistosoma mansoni	oxysterol-binding protein 1	0.0466	0.0172	0.0257
Onchocerca volvulus	Protein melted homolog	0.0466	0.0172	1
Echinococcus multilocularis	actin binding protein anillin	0.0466	0.0172	0.0257
Schistosoma mansoni	serine/threonine-protein kinase	1.1794	0.6705	1
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Echinococcus multilocularis	Pleckstrin y	0.0466	0.0172	0.0257
Trypanosoma brucei	rac serine-threonine kinase, putative	1.7508	1	1
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	1.1327	0.6436	1
Schistosoma mansoni	serine/threonine protein kinase	0.584	0.3271	0.4879
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0466	0.0172	0.0172
Entamoeba histolytica	hypothetical protein	0.0466	0.0172	0.0172
Echinococcus multilocularis	myotubularin protein 13	0.0466	0.0172	0.0257
Entamoeba histolytica	PH domain containing protein	0.0466	0.0172	0.0172
Entamoeba histolytica	protein kinase, putative	1.7041	0.9731	0.9731
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Echinococcus granulosus	protein kinase C gamma type	0.584	0.3271	0.4879
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0592	0.0245	0.0245
Brugia malayi	Protein kinase domain containing protein	0.584	0.3271	0.3271
Trichomonas vaginalis	AGC family protein kinase	1.7508	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0466	0.0172	0.0257
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Trypanosoma cruzi	PH domain containing protein, putative	0.0466	0.0172	0.0257
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0592	0.0245	0.0116
Onchocerca volvulus		0.0466	0.0172	1
Trichomonas vaginalis	AGC family protein kinase	1.7508	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0466	0.0172	0.0172
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0466	0.0172	1
Echinococcus granulosus	Rho GTPase activating protein 24	0.0466	0.0172	0.0257
Schistosoma mansoni	serine/threonine protein kinase	0.584	0.3271	0.4879
Onchocerca volvulus		0.0466	0.0172	1
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0466	0.0172	0.0257
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Echinococcus multilocularis	Pleckstrin y	0.0466	0.0172	0.0257
Echinococcus multilocularis	nervana 2	1.1201	0.6363	0.949
Trypanosoma cruzi	NIMA-related kinase, putative	0.0592	0.0245	0.0365
Echinococcus granulosus	Glutaredoxin protein 5	1.1201	0.6363	0.949
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0466	0.0172	0.0257
Trypanosoma cruzi	hypothetical protein	0.0466	0.0172	0.0257
Trichomonas vaginalis	protein transport protein sec7, putative	0.0466	0.0172	0.0172
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.584	0.3271	0.4879
Echinococcus multilocularis	serine:threonine protein kinase 38	0.584	0.3271	0.4879
Entamoeba histolytica	protein kinase, putative	0.584	0.3271	0.3271
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0466	0.0172	0.0172
Schistosoma mansoni	serine/threonine protein kinase	0.584	0.3271	0.4879
Trypanosoma cruzi	NIMA-related kinase, putative	0.0592	0.0245	0.0365
Trypanosoma cruzi	PH domain containing protein, putative	0.0466	0.0172	0.0257
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0592	0.0245	0.0365
Toxoplasma gondii	protein kinase domain-containing protein	0.0592	0.0245	0.0252
Giardia lamblia	Kinase, AGC PKA	1.1327	0.6436	1
Brugia malayi	hypothetical protein	0.0466	0.0172	0.0172
Echinococcus granulosus	pleckstrin y domain containing family A	0.0466	0.0172	0.0257
Schistosoma mansoni	goodpasture antigen-binding protein	0.0466	0.0172	0.0257
Entamoeba histolytica	protein kinase, putative	0.0592	0.0245	0.0245
Brugia malayi	PH domain containing protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	centaurin gamma, putative	0.0466	0.0172	0.0172
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0592	0.0245	0.0252
Echinococcus multilocularis	protein kinase c iota type	0.584	0.3271	0.4879
Echinococcus granulosus	serine:threonine protein kinase N2	0.584	0.3271	0.4879
Echinococcus granulosus	pdz domain containing protein	0.0466	0.0172	0.0257
Brugia malayi	TBC domain containing protein	0.0466	0.0172	0.0172
Schistosoma mansoni	hypothetical protein	0.0466	0.0172	0.0257
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0466	0.0172	0.0257
Entamoeba histolytica	hypothetical protein, conserved	0.0466	0.0172	0.0172
Trypanosoma cruzi	rac serine-threonine kinase, putative	1.1327	0.6436	0.9599
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0466	0.0172	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Onchocerca volvulus		0.0466	0.0172	1
Trichomonas vaginalis	AGC family protein kinase	0.0592	0.0245	0.0245
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0466	0.0172	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	1.1201	0.6363	0.949
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0592	0.0245	0.0365
Brugia malayi	PH domain containing protein	0.0466	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Entamoeba histolytica	hypothetical protein	0.0592	0.0245	0.0245
Entamoeba histolytica	PH domain containing protein	0.0466	0.0172	0.0172
Brugia malayi	PH domain containing protein	0.0466	0.0172	0.0172
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0466	0.0172	0.0172
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0592	0.0245	0.0245
Echinococcus granulosus	DCC interacting protein 13 beta	0.0466	0.0172	0.0257
Brugia malayi	Syntrophin-1	0.0466	0.0172	0.0172
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0592	0.0245	0.0245
Entamoeba histolytica	protein kinase, putative	1.7508	1	1
Loa Loa (eye worm)	hypothetical protein	0.0466	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0466	0.0172	0.0172
Toxoplasma gondii	AtPH1 family protein	0.0466	0.0172	0.0177
Brugia malayi	Oxysterol-binding protein	0.0466	0.0172	0.0172
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0466	0.0172	0.0172
Entamoeba histolytica	PH domain containing protein kinase, putative	1.1794	0.6705	0.6705
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0592	0.0245	0.0365
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	1.1327	0.6436	0.9599
Entamoeba histolytica	p21-activated kinase	0.0592	0.0245	0.0245
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0592	0.0245	0.0245
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0466	0.0172	0.0172
Echinococcus multilocularis	rac serine:threonine kinase	1.1794	0.6705	1
Brugia malayi	PH domain containing protein	0.0466	0.0172	0.0172
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0466	0.0172	0.0257
Toxoplasma gondii	hypothetical protein	0.0466	0.0172	0.0177
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0466	0.0172	0.0172
Trypanosoma cruzi	hypothetical protein	0.0466	0.0172	0.0257

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 253 nM	Inhibition of [3H]-naloxone binding to rat brain homogenate Opioid receptor mu	ChEMBL.	15863298
Ki (binding)	> 10000 nM	Inhibition of [3H]-naloxone binding to rat brain homogenate Opioid receptor delta	ChEMBL.	15863298

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2371866

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1745118