TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 533.059 | Formula: C27H37ClN4O5
H donors: 3 H acceptors: 5 LogP: 2.59 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: ClCC(=O)CCCCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)C(NC1=O)(C)C)Cc1ccccc1
InChi: 1S/C27H37ClN4O5/c1-27(2)26(37)30-21(16-18-10-5-3-6-11-18)25(36)32-15-9-14-22(32)24(35)29-20(23(34)31-27)13-8-4-7-12-19(33)17-28/h3,5-6,10-11,20-22H,4,7-9,12-17H2,1-2H3,(H,29,35)(H,30,37)(H,31,34)/t20-,21-,22+/m0/s1
InChiKey: VJLNTQMEQSWXIM-FDFHNCONSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.009	0.056	0.1193
Echinococcus multilocularis	neuropeptide receptor	0.009	0.056	0.1427
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.0456	0.1108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0078	0.0455	0.3201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.009	0.056	0.1193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0078	0.0455	0.0455
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	0.1035	0.2688
Giardia lamblia	Cathepsin B precursor	0.0145	0.1035	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0078	0.0455	0.6383
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0455	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0056	0.0268	0.0268
Echinococcus granulosus	tm gpcr rhodopsin	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.009	0.056	0.1427
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.009	0.056	0.1427
Trypanosoma cruzi	cruzipain precursor, putative	0.0078	0.0455	0.086
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Echinococcus multilocularis	rhodopsin orphan GPCR	0.009	0.056	0.1427
Schistosoma mansoni	cathepsin F (C01 family)	0.0078	0.0455	0.086
Schistosoma mansoni	opsin-like receptor	0.009	0.056	0.1193
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0053	0.0238	0.044
Echinococcus multilocularis	dro:myosuppressin receptor	0.009	0.056	0.1427
Echinococcus multilocularis	G-protein coupled receptor, putative	0.009	0.056	0.1427
Brugia malayi	Dopamine receptor protein 2	0.009	0.056	0.056
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0455	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0078	0.0455	0.3201
Echinococcus multilocularis		0.0051	0.0224	0.0397
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0078	0.0455	0.3201
Onchocerca volvulus		0.0078	0.0455	0.6383
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Brugia malayi	Cathepsin L-like precursor	0.0078	0.0455	0.0455
Echinococcus multilocularis	epidermal growth factor receptor	0.0088	0.0545	0.1382
Echinococcus granulosus	neuropeptide Y receptor	0.009	0.056	0.1427
Schistosoma mansoni	amine GPCR	0.009	0.056	0.1193
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.009	0.056	0.1427
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0165	0.1199	0.1096
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0455	0.3201
Loa Loa (eye worm)	ctsf protein	0.0078	0.0455	0.0343
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0456	0.5
Brugia malayi	Melatonin receptor type 1A	0.009	0.056	0.056
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0455	0.3201
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0145	0.1035	1
Brugia malayi	hypothetical protein	0.009	0.056	0.056
Toxoplasma gondii	cathepsin CPL	0.0078	0.0455	0.4295
Loa Loa (eye worm)	neuropeptide F receptor	0.009	0.056	0.045
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0416	0.3359	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.009	0.056	0.1193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.009	0.056	0.1427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Onchocerca volvulus		0.009	0.056	1
Toxoplasma gondii	cathepsin B	0.0145	0.1035	1
Echinococcus granulosus	neuropeptide receptor	0.009	0.056	0.1427
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.0809	0.0702
Loa Loa (eye worm)	TK/INSR protein kinase	0.0053	0.0238	0.0124
Echinococcus granulosus	rhodopsin orphan GPCR	0.009	0.056	0.1427
Brugia malayi	Papain family cysteine protease containing protein	0.0046	0.0181	0.0181
Schistosoma mansoni	hypothetical protein	0.009	0.056	0.1193
Echinococcus granulosus	serotonin receptor	0.009	0.056	0.1427
Schistosoma mansoni	histamine h1 receptor	0.009	0.056	0.1193
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0056	0.0268	0.0268
Brugia malayi	Bromodomain containing protein	0.0038	0.0115	0.0115
Brugia malayi	GnHR receptor homolog	0.009	0.056	0.056
Onchocerca volvulus		0.009	0.056	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.009	0.056	0.056
Brugia malayi	Papain family cysteine protease containing protein	0.0046	0.0181	0.0181
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0078	0.0455	0.3201
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.0456	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.009	0.056	0.1427
Echinococcus granulosus	somatostatin receptor	0.009	0.056	0.1427
Echinococcus multilocularis	neuropeptides capa receptor	0.009	0.056	0.1427
Echinococcus granulosus	cathepsin b	0.0416	0.3359	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.009	0.056	0.045
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0416	0.3359	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.009	0.056	0.1427
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0078	0.0455	0.3201
Onchocerca volvulus		0.009	0.056	1
Echinococcus granulosus	neuropeptides capa receptor	0.009	0.056	0.1427
Echinococcus granulosus	dro:myosuppressin receptor	0.009	0.056	0.1427
Echinococcus multilocularis	orexin receptor type 2	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Brugia malayi	G protein-coupled receptor	0.009	0.056	0.056
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0456	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.009	0.056	0.1427
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0226	0.0402
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0456	1
Echinococcus granulosus	neuropeptide s receptor	0.009	0.056	0.1427
Echinococcus granulosus	cathepsin L	0.0046	0.0181	0.0266
Echinococcus granulosus	rhodopsin orphan GPCR	0.009	0.056	0.1427
Loa Loa (eye worm)	G-protein coupled receptor	0.009	0.056	0.045
Echinococcus granulosus	tachykinin peptides receptor 99D	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Onchocerca volvulus		0.009	0.056	1
Brugia malayi	hypothetical protein	0.009	0.056	0.056
Onchocerca volvulus		0.009	0.056	1
Schistosoma mansoni	neuropeptide receptor	0.009	0.056	0.1193
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.0809	0.0702
Echinococcus granulosus	sex peptide receptor	0.009	0.056	0.1427
Schistosoma mansoni	tyrosine kinase	0.0088	0.0545	0.1146
Brugia malayi	sulfakinin receptor protein	0.119	1	1
Echinococcus multilocularis	g protein coupled receptor	0.009	0.056	0.1427
Echinococcus granulosus	7tm_1 domain containing protein	0.009	0.056	0.1427
Brugia malayi	cathepsin B-like cysteine proteinase	0.0416	0.3359	0.3359
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.009	0.056	0.1427
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.009	0.056	0.1193
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0053	0.0238	0.044
Brugia malayi	ORL1-like opioid receptor	0.009	0.056	0.056
Onchocerca volvulus		0.009	0.056	1
Echinococcus multilocularis	neuropeptide receptor A26	0.009	0.056	0.1427
Onchocerca volvulus		0.009	0.056	1
Loa Loa (eye worm)	TYRA-2 protein	0.009	0.056	0.045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.009	0.056	0.1193
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0456	0.4311
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus granulosus	neuropeptide receptor A26	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.009	0.056	0.1193
Echinococcus multilocularis	serotonin receptor	0.009	0.056	0.1427
Echinococcus granulosus	peptide allatostatin:somatostatin	0.009	0.056	0.1427
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.009	0.056	0.1193
Loa Loa (eye worm)	cysteine protease	0.0078	0.0455	0.0343
Onchocerca volvulus		0.0078	0.0455	0.6383
Schistosoma mansoni	tyrosine kinase	0.0053	0.0238	0.0179
Brugia malayi	hypothetical protein	0.009	0.056	0.056
Echinococcus granulosus	g protein coupled receptor	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0416	0.3359	0.3281
Echinococcus multilocularis	fmrfamide receptor	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.009	0.056	0.1193
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.009	0.056	0.1427
Echinococcus multilocularis	neuropeptide FF receptor 2	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0152	0.0037
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0078	0.0455	0.0343
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Schistosoma mansoni	neuropeptide F-like receptor	0.009	0.056	0.1193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Onchocerca volvulus		0.009	0.056	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0268	0.0155
Brugia malayi	follicle stimulating hormone receptor	0.009	0.056	0.056
Entamoeba histolytica	cysteine proteinase, putative	0.0078	0.0455	1
Entamoeba histolytica	cysteine proteinase, putative	0.0056	0.0268	0.3182
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0078	0.0455	0.0343
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Schistosoma mansoni	tyrosine kinase	0.0087	0.0537	0.1121
Echinococcus granulosus	cathepsin b	0.0416	0.3359	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0078	0.0455	0.086
Echinococcus granulosus	tm gpcr rhodopsin	0.009	0.056	0.1427
Echinococcus granulosus	cysteine protease	0.0046	0.0181	0.0266
Echinococcus granulosus	epidermal growth factor receptor	0.0165	0.1199	0.3383
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus multilocularis	g protein coupled receptor	0.009	0.056	0.1427
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.009	0.056	0.056
Schistosoma mansoni	neuropeptide receptor	0.009	0.056	0.1193
Echinococcus multilocularis	neuropeptides capa receptor	0.009	0.056	0.1427
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0455	0.3201
Schistosoma mansoni	myosin xvIII	0.009	0.056	0.1193
Schistosoma mansoni	biogenic amine receptor	0.009	0.056	0.1193
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.009	0.056	0.1193
Schistosoma mansoni	amine GPCR	0.009	0.056	0.1193
Schistosoma mansoni	adenoreceptor	0.009	0.056	0.1193
Schistosoma mansoni	biogenic amine (5HT) receptor	0.009	0.056	0.1193
Onchocerca volvulus		0.0078	0.0455	0.6383
Echinococcus granulosus	cathepsin L cysteine protease	0.0046	0.0181	0.0266
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Onchocerca volvulus		0.009	0.056	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.0456	0.0865
Onchocerca volvulus		0.009	0.056	1
Loa Loa (eye worm)	G-protein coupled receptor	0.009	0.056	0.045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0455	0.3201
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.009	0.056	0.1427
Schistosoma mansoni	biogenic amine (5HT) receptor	0.009	0.056	0.1193
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.0456	1
Brugia malayi	Dopamine receptor	0.009	0.056	0.056
Brugia malayi	hypothetical protein	0.009	0.056	0.056
Onchocerca volvulus		0.0078	0.0455	0.6383
Echinococcus multilocularis	neuropeptide Y receptor	0.009	0.056	0.1427
Echinococcus multilocularis	cysteine protease	0.0078	0.0455	0.1104
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.009	0.056	0.1193
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0046	0.0181	0.3734
Onchocerca volvulus	Cathepsin F homolog	0.0078	0.0455	0.6383
Echinococcus multilocularis	serotonin receptor	0.009	0.056	0.1427
Plasmodium vivax	vivapain-2	0.0078	0.0455	0.9964
Echinococcus granulosus	insulin receptor	0.0053	0.0238	0.044
Onchocerca volvulus		0.009	0.056	1
Brugia malayi	putative neuropeptide receptor NPR1	0.009	0.056	0.056
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.0268	0.1018
Brugia malayi	Papain family cysteine protease containing protein	0.0078	0.0455	0.0455
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0145	0.1035	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0456	0.5
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0078	0.0455	0.1104
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0456	0.5
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0268	0.0155
Brugia malayi	Protein kinase domain containing protein	0.0053	0.0238	0.0238
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.0456	0.1108
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus granulosus	g-protein coupled receptor	0.009	0.056	0.1427
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.009	0.056	0.045
Echinococcus multilocularis	allatostatin A receptor	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.009	0.056	0.1193
Brugia malayi	hypothetical protein	0.009	0.056	0.056
Brugia malayi	Cathepsin L-like precursor	0.0078	0.0455	0.0455
Schistosoma mansoni	neuropeptide F-like receptor	0.009	0.056	0.1193
Entamoeba histolytica	cysteine protease, putative	0.0078	0.0455	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0456	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0078	0.0455	0.1104
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0078	0.0455	0.1104
Loa Loa (eye worm)	fibroinase	0.0078	0.0455	0.0343
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.009	0.056	0.056
Echinococcus multilocularis	epidermal growth factor receptor	0.0165	0.1199	0.3383
Plasmodium vivax	unspecified product	0.0046	0.0181	0.3734
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.009	0.056	1
Echinococcus granulosus	neuropeptide receptor	0.009	0.056	0.1427
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.009	0.056	0.1193
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0078	0.0455	0.1104
Onchocerca volvulus	Cathepsin L homolog	0.0078	0.0455	0.6383
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.0226	0.5
Echinococcus granulosus	orexin receptor type 2	0.009	0.056	0.1427
Brugia malayi	Cathepsin L-like precursor	0.0056	0.0268	0.0268
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0078	0.0455	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0078	0.0455	0.3201
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0145	0.1035	0.2688
Brugia malayi	hypothetical protein	0.009	0.056	0.056
Brugia malayi	putative neuropeptide receptor	0.009	0.056	0.056
Schistosoma mansoni	tyrosine kinase	0.0087	0.0537	0.1121
Echinococcus granulosus	rhodopsin orphan GPCR	0.009	0.056	0.1427
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.009	0.056	0.1193
Echinococcus multilocularis	g protein coupled receptor	0.009	0.056	0.1427
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.009	0.056	0.1193
Brugia malayi	Dopamine receptor protein 1	0.009	0.056	0.056
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus granulosus	7TM GPCR rhodopsin	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.119	1	1
Schistosoma mansoni	tyrosine kinase	0.0053	0.0238	0.0179
Echinococcus granulosus	rhodopsin orphan GPCR	0.009	0.056	0.1427
Echinococcus granulosus	neuropeptides capa receptor	0.009	0.056	0.1427
Onchocerca volvulus	Neuropeptide F receptor homolog	0.009	0.056	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.0298	0.0623
Schistosoma mansoni	opsin-like receptor	0.009	0.056	0.1193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.009	0.056	0.1193
Brugia malayi	Serotonin receptor	0.009	0.056	0.056
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0455	0.0343
Schistosoma mansoni	amine GPCR	0.009	0.056	0.1193
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Brugia malayi	Tachykinin-like peptides receptor 99D	0.009	0.056	0.056
Onchocerca volvulus		0.009	0.056	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.009	0.056	0.1427
Brugia malayi	MH2 domain containing protein	0.0119	0.0809	0.0809
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Echinococcus multilocularis	somatostatin receptor	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Brugia malayi	hypothetical protein	0.009	0.056	0.056
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0456	0.5
Onchocerca volvulus		0.009	0.056	1
Schistosoma mansoni	amine GPCR	0.009	0.056	0.1193
Echinococcus multilocularis	fmrfamide receptor	0.009	0.056	0.1427
Echinococcus multilocularis	cathepsin b	0.0416	0.3359	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0078	0.0455	0.3201
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0088	0.0545	0.1382
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.009	0.056	0.1193
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.009	0.056	0.045
Echinococcus multilocularis	cysteine protease	0.0078	0.0455	0.1104
Schistosoma mansoni	hypothetical protein	0.009	0.056	0.1193
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0226	0.0402
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Echinococcus multilocularis	G protein coupled receptor 139	0.009	0.056	0.1427
Brugia malayi	Probable ClpP-like protease	0.0078	0.0456	0.0456
Echinococcus granulosus	fmrfamide receptor	0.009	0.056	0.1427
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0145	0.1035	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.009	0.056	0.1427
Schistosoma mansoni	hypothetical protein	0.009	0.056	0.1193
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.009	0.056	0.045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.009	0.056	0.1193
Brugia malayi	G-protein coupled receptor	0.009	0.056	0.056
Plasmodium vivax	vivapain-1	0.0046	0.0181	0.3734
Onchocerca volvulus		0.009	0.056	1
Brugia malayi	Cathepsin L-like precursor	0.0078	0.0455	0.0455
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.009	0.056	0.1193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.009	0.056	0.1427
Onchocerca volvulus		0.0078	0.0455	0.6383
Onchocerca volvulus		0.009	0.056	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.009	0.056	0.056
Echinococcus multilocularis	neuropeptide receptor	0.009	0.056	0.1427
Echinococcus granulosus	allatostatin A receptor	0.009	0.056	0.1427
Schistosoma mansoni	cathepsin F (C01 family)	0.0056	0.0268	0.0274
Schistosoma mansoni	opsin-like receptor	0.009	0.056	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0135	0.0021
Loa Loa (eye worm)	neuropeptide F receptor	0.009	0.056	0.045
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.009	0.056	0.056
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.009	0.056	0.1193
Onchocerca volvulus		0.009	0.056	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0078	0.0455	0.3201
Echinococcus multilocularis	neuropeptide Y receptor	0.009	0.056	0.1427
Plasmodium vivax	vivapain-3	0.0046	0.0181	0.3734
Echinococcus multilocularis	insulin receptor	0.0053	0.0238	0.044
Onchocerca volvulus		0.009	0.056	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Schistosoma mansoni	alpha-1 adrenergic receptor	0.009	0.056	0.1193
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0078	0.0455	0.9964
Trypanosoma cruzi	cysteine peptidase, putative	0.0078	0.0455	0.086
Brugia malayi	G-protein coupled receptor	0.009	0.056	0.056
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.009	0.056	0.1427
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0416	0.3359	1
Giardia lamblia	Cathepsin B precursor	0.0145	0.1035	0.5
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0078	0.0455	0.9964
Schistosoma mansoni	neuropeptide f receptor 76f	0.009	0.056	0.1193
Brugia malayi	larval opioid receptor	0.009	0.056	0.056
Brugia malayi	RE15519p	0.009	0.056	0.056
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Schistosoma mansoni	tyrosine kinase	0.0165	0.1199	0.3203
Brugia malayi	cathepsin L-like precursor	0.0056	0.0268	0.0268
Echinococcus granulosus	neuropeptide Y receptor	0.009	0.056	0.1427
Schistosoma mansoni	tyrosine kinase	0.0088	0.0545	0.1146
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus granulosus	biogenic amine 5HT receptor	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus multilocularis	cathepsin b	0.0416	0.3359	1
Echinococcus granulosus	cathepsin l1	0.0078	0.0455	0.1104
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0455	0.3201
Brugia malayi	Serotonin receptor	0.009	0.056	0.056
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0078	0.0455	0.3201
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.009	0.056	0.056
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0455	0.3201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0416	0.3359	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.0226	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.0078	0.0455	0.1104
Echinococcus multilocularis	rhodopsin orphan GPCR	0.009	0.056	0.1427
Echinococcus granulosus	g protein coupled receptor	0.009	0.056	0.1427
Loa Loa (eye worm)	melatonin receptor type 1A	0.009	0.056	0.045
Echinococcus multilocularis	cathepsin L cysteine protease	0.0078	0.0455	0.1104
Echinococcus multilocularis	cathepsin L	0.0046	0.0181	0.0266
Brugia malayi	Cathepsin L-like precursor	0.0078	0.0455	0.0455
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.009	0.056	0.1427
Echinococcus granulosus	epidermal growth factor receptor	0.0088	0.0545	0.1382
Echinococcus multilocularis	neuropeptide s receptor	0.009	0.056	0.1427
Schistosoma mansoni	amine GPCR	0.009	0.056	0.1193
Echinococcus multilocularis	sex peptide receptor	0.009	0.056	0.1427
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.009	0.056	0.1427
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.009	0.056	0.1193
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0456	0.4311
Echinococcus granulosus	G protein coupled receptor 139	0.009	0.056	0.1427
Echinococcus granulosus	cathepsin l1	0.0056	0.0268	0.0533
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0078	0.0455	0.3201
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.0298	0.0623
Trypanosoma cruzi	cysteine peptidase, putative	0.0078	0.0455	0.086
Schistosoma mansoni	neuropeptide receptor	0.009	0.056	0.1193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Onchocerca volvulus		0.0078	0.0455	0.6383
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0078	0.0455	0.9964
Echinococcus granulosus	hypothetical protein	0.009	0.056	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0392	0.028
Brugia malayi	Furin-like cysteine rich region family protein	0.0165	0.1199	0.1199
Brugia malayi	hypothetical protein	0.009	0.056	0.056
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0456	0.0345
Entamoeba histolytica	cysteine proteinase, putative	0.0078	0.0455	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.009	0.056	0.1427
Onchocerca volvulus		0.0078	0.0455	0.6383
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Brugia malayi	Cathepsin L-like precursor	0.0078	0.0455	0.0455
Echinococcus multilocularis	g-protein coupled receptor	0.009	0.056	0.1427
Brugia malayi	Bromodomain containing protein	0.0075	0.0429	0.0429
Brugia malayi	AKH receptor	0.009	0.056	0.056
Schistosoma mansoni	biogenic amine receptor	0.009	0.056	0.1193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.0268	0.1018
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0078	0.0455	0.3201
Brugia malayi	neuropeptide F receptor	0.009	0.056	0.056
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.0268	0.0274
Schistosoma mansoni	hypothetical protein	0.009	0.056	0.1193
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Schistosoma mansoni	cathepsin F (C01 family)	0.0078	0.0455	0.086
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0416	0.3359	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.009	0.056	0.1427
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.009	0.056	0.1427
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0226	0.4744
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0328	0.0463
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.009	0.056	0.1427
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.009	0.056	0.1427
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.009	0.056	0.045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0455	0.3201
Giardia lamblia	Cathepsin B precursor	0.0145	0.1035	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.009	0.056	0.1427
Echinococcus granulosus	g protein coupled receptor	0.009	0.056	0.1427
Schistosoma mansoni	neuropeptide receptor	0.009	0.056	0.1193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.009	0.056	0.1427
Brugia malayi	hypothetical protein	0.009	0.056	0.056
Loa Loa (eye worm)	cathepsin B	0.0145	0.1035	0.0931
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Schistosoma mansoni	growth hormone secretagogue receptor	0.009	0.056	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0268	0.0155
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.009	0.056	0.1427
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0078	0.0455	0.3201
Loa Loa (eye worm)	hypothetical protein	0.009	0.056	0.045
Echinococcus granulosus	alpha 1A adrenergic receptor	0.009	0.056	0.1427
Trypanosoma cruzi	cysteine peptidase, putative	0.0078	0.0455	0.086
Plasmodium vivax	vivapain-2	0.0078	0.0455	0.9964
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.009	0.056	0.1193
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.009	0.056	0.1427
Echinococcus multilocularis	rhodopsin orphan GPCR	0.009	0.056	0.1427
Schistosoma mansoni	tyrosine kinase	0.0087	0.0537	0.1121
Brugia malayi	neuropeptide F receptor	0.009	0.056	0.056
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.009	0.056	0.1427
Echinococcus granulosus	tm gpcr rhodopsin	0.009	0.056	0.1427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.009	0.056	0.1193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0455	0.3201
Schistosoma mansoni	biogenic amine receptor	0.009	0.056	0.1193

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 10 ng ml-1	Compound was evaluated for the inhibition of Con A (concanavalin A) stimulated murine thymocyte mitogenesis.	ChEMBL.	3806605

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	3806605

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2371445

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1745822