Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0022 | 0.0074 | 0.0074 |
Leishmania major | cytochrome p450-like protein | 0.0022 | 0.0074 | 0.1749 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.007 | 0.0421 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0074 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.0421 | 1 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.1394 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.0421 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.0074 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0022 | 0.0074 | 1 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.1394 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.007 | 0.0421 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.0074 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.0074 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.007 | 0.0421 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.0074 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0074 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.0421 | 0.0421 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.007 | 0.0421 | 0.0421 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.007 | 0.0421 | 0.0421 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.0421 | 0.0421 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.0421 | 0.0421 |
Trypanosoma brucei | cytochrome P450, putative | 0.0022 | 0.0074 | 1 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.1394 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 1000 uM | Compound was tested for inhibition of MAdCAM-1/alpha4 beta7 mediated cell adhesion to T-cell lymphoma, HUT78 cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.