Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.019 | 0.161 | 0.161 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.019 | 0.161 | 0.0355 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.0268 |
Trichomonas vaginalis | conserved hypothetical protein | 0.019 | 0.161 | 0.0268 |
Trypanosoma brucei | uridine phosphorylase | 0.019 | 0.161 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 0.7809 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.019 | 0.161 | 0.0355 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1398 | 0.0111 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.0268 |
Toxoplasma gondii | phosphorylase family protein | 0.019 | 0.161 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.0268 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0728 | 0.7809 | 0.7453 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.019 | 0.161 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.008 | 0.0343 | 0.0343 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.019 | 0.161 | 0.0355 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.019 | 0.161 | 0.0246 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.019 | 0.161 | 0.5 |
Toxoplasma gondii | phosphorylase family protein | 0.019 | 0.161 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.0268 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.019 | 0.161 | 0.0246 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.019 | 0.161 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0172 | 0.1398 | 0.0111 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.0728 | 0.7809 | 0.7453 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0057 | 0.0081 | 0.0081 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.019 | 0.161 | 0.1734 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.0268 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0057 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | uridine phosphorylase | 0.019 | 0.161 | 0.1734 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.008 | 0.0343 | 0.0264 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0918 | 1 | 1 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.019 | 0.161 | 0.161 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.019 | 0.161 | 0.5 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.019 | 0.161 | 0.0246 |
Leishmania major | nucleoside phosphorylase-like protein | 0.019 | 0.161 | 0.5 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.019 | 0.161 | 0.1542 |
Chlamydia trachomatis | AMP nucleosidase | 0.019 | 0.161 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0918 | 1 | 0.5 |
Treponema pallidum | pfs protein (pfs) | 0.019 | 0.161 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0728 | 0.7809 | 0.7453 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0411 | 0.0136 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0918 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Treponema pallidum | uridine phosphorylase (udp) | 0.019 | 0.161 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0918 | 1 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.019 | 0.161 | 0.0355 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.008 | 0.0343 | 0.0343 |
Trichomonas vaginalis | conserved hypothetical protein | 0.019 | 0.161 | 0.0268 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.019 | 0.161 | 0.1542 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.0268 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0113 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.1398 | 0.1452 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.019 | 0.161 | 0.0246 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.019 | 0.161 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.019 | 0.161 | 0.0355 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0918 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.019 | 0.161 | 0.1542 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0918 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.019 | 0.161 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 33 uM | Inhibition of collagen-induced human platelet aggregation. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.