Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Niemann Pick C1 protein | 0.0345 | 0.3461 | 0.3142 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0837 | 1 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0837 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0393 | 0.4099 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0837 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0345 | 0.3461 | 0.3142 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0345 | 0.3461 | 0.3142 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.3461 | 0.3461 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0345 | 0.3461 | 0.3461 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0393 | 0.4099 | 1 |
Brugia malayi | CHE-14 protein | 0.0345 | 0.3461 | 0.3142 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0096 | 0.0164 | 0.0164 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0837 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0837 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0837 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0837 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0345 | 0.3461 | 0.3142 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0837 | 1 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0345 | 0.3461 | 0.3142 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0345 | 0.3461 | 0.3142 |
Loa Loa (eye worm) | hypothetical protein | 0.0837 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0302 | 0.0302 |
Echinococcus multilocularis | protein dispatched 1 | 0.0345 | 0.3461 | 0.3142 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0393 | 0.4099 | 0.5 |
Onchocerca volvulus | 0.0119 | 0.0465 | 0.5 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0393 | 0.4099 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 30 uM | Inhibition of Kv1.3 ion channel. Measured in the Rb_Kv assay: [86Rb+] efflux from CHO cells stably transfected with Kv1.3 channel. | ChEMBL. | 12643934 |
IC50 (functional) | > 30 uM | Inhibition of Kv1.3 ion channel. Measured in the Rb_Kv assay: [86Rb+] efflux from CHO cells stably transfected with Kv1.3 channel. | ChEMBL. | 12643934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.