Detailed information for compound 1746264

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 423.548 | Formula: C25H33N3O3
  • H donors: 1 H acceptors: 3 LogP: 2.7 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)[C@H]1N[C@@]2([C@@H]3[C@H]1C(=O)N(C3=O)C)CCCN(C2=O)CC1CCCCC1
  • InChi: 1S/C25H33N3O3/c1-16-9-11-18(12-10-16)21-19-20(23(30)27(2)22(19)29)25(26-21)13-6-14-28(24(25)31)15-17-7-4-3-5-8-17/h9-12,17,19-21,26H,3-8,13-15H2,1-2H3/t19-,20-,21-,25-/m1/s1
  • InChiKey: CGFANJNPTMMVRV-QTDDQOEGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0175 0.0495
Loa Loa (eye worm) carboxylesterase 0.0147 0.0559 0.1522
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0107 0.1342
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0068
Trichomonas vaginalis spcc417.12 protein, putative 0.0147 0.0559 0.1518
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0175 0.0671 0.1832
Onchocerca volvulus 0.0028 0.0069 0.0196
Onchocerca volvulus 0.0035 0.0097 0.0471
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0068
Mycobacterium ulcerans hypothetical protein 0.0023 0.0049 0.0172
Brugia malayi TAR-binding protein 0.0062 0.0207 0.058
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0385 0.2145
Brugia malayi hypothetical protein 0.0147 0.0559 0.1577
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0061 0.0174
Loa Loa (eye worm) hypothetical protein 0.0054 0.0175 0.0428
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0035 0.0043
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0049 0.0039
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0205 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0175 0.0671 0.3717
Schistosoma mansoni ap endonuclease 0.002 0.0035 0.0099
Echinococcus multilocularis protein dispatched 1 0.0047 0.0147 0.0147
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0433 0.2428
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.002 0.002
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0433 0.2428
Leishmania major hypothetical protein, conserved 0.0025 0.0056 0.1972
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0198 0.056
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.0264 0.0747
Schistosoma mansoni hypothetical protein 0.0338 0.1342 0.3798
Echinococcus multilocularis expressed conserved protein 0.009 0.0323 0.0323
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0123 0.0123
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0061 0.0061
Brugia malayi PHD-finger family protein 0.0023 0.0049 0.0132
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0033 0.0093
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0033 0.1067
Echinococcus granulosus neuroligin 0.0147 0.0559 0.1582
Plasmodium falciparum phd finger protein, putative 0.0059 0.0198 0.2734
Trichomonas vaginalis set domain proteins, putative 0.0272 0.107 0.2954
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0516 0.1461
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0041 0.0325
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0049 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0187 0.2573
Echinococcus granulosus geminin 0.0338 0.1342 0.3798
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0513 0.1452
Schistosoma mansoni cpg binding protein 0.0032 0.0084 0.0238
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0056 0.297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0173 0.049
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0147 0.0559 0.1582
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0068
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0025 0.0082
Loa Loa (eye worm) RNA binding protein 0.0062 0.0207 0.0519
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0872 0.3533 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0068
Plasmodium falciparum thioredoxin reductase 0.0046 0.0143 0.1895
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0033 0.0093
Loa Loa (eye worm) hypothetical protein 0.0147 0.0559 0.1522
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.0934 0.2592
Toxoplasma gondii hypothetical protein 0.006 0.0201 0.2787
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0353 0.1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0049 0.0039
Schistosoma mansoni cpg binding protein 0.0032 0.0084 0.0238
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.028 0.0787
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0123 0.0291
Loa Loa (eye worm) hypothetical protein 0.0041 0.0123 0.0279
Brugia malayi glutathione reductase 0.0046 0.0143 0.0399
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0049 0.1574
Echinococcus granulosus dnaJ subfamily B 0.0398 0.1587 0.4493
Echinococcus granulosus zinc finger protein 0.0023 0.0048 0.0136
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0207 0.0519
Brugia malayi RNA binding protein 0.0062 0.0207 0.058
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0049 0.0172
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0089 0.0253
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.0008
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.006 0.0201 0.091
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0033 0.0093
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0293 0.0293
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0882 0.3573 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0207 0.0586
Trichomonas vaginalis glutaminase, putative 0.0313 0.1238 0.343
Brugia malayi Carboxylesterase family protein 0.0872 0.3533 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0882 0.3573 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0205 0.0581
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0513 0.1452
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0385 0.2008
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0123 0.0348
Schistosoma mansoni peptidase Clp (S14 family) 0.0175 0.0671 0.1898
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0107 0.0246
Loa Loa (eye worm) inositol-1 0.0037 0.0107 0.0234
Brugia malayi Latrophilin receptor protein 2 0.0079 0.028 0.0787
Echinococcus multilocularis acetylcholinesterase 0.0872 0.3533 0.3533
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0034 0.0217
Loa Loa (eye worm) glutaminase 0.0313 0.1238 0.3459
Plasmodium vivax SET domain protein, putative 0.0035 0.0097 0.1187
Trypanosoma brucei trypanothione reductase 0.0046 0.0143 1
Echinococcus granulosus expressed conserved protein 0.009 0.0323 0.0916
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0175 0.0671 0.0671
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0041 0.0325
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0194 0.0752 0.0752
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0033 0.0093
Echinococcus granulosus BC026374 protein S09 family 0.0147 0.0559 0.1582
Plasmodium falciparum glutathione reductase 0.0046 0.0143 0.1895
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.003 0.0086
Schistosoma mansoni hypothetical protein 0.0059 0.0198 0.056
Loa Loa (eye worm) hypothetical protein 0.0172 0.0659 0.1806
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0147 0.0559 0.1518
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0035 0.0043
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0035 0.0099
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0175 0.0671 1
Brugia malayi PHD-finger family protein 0.0059 0.0198 0.0553
Loa Loa (eye worm) glutaminase 2 0.0313 0.1238 0.3459
Brugia malayi glutaminase DH11.1 0.0313 0.1238 0.3501
Treponema pallidum fructose-bisphosphate aldolase 0.0882 0.3573 1
Brugia malayi CHE-14 protein 0.0041 0.0123 0.0342
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.0331
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0205 0.0581
Schistosoma mansoni cpg binding protein 0.0028 0.0069 0.0195
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0049 0.1574
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0882 0.3573 1
Onchocerca volvulus 0.0147 0.0559 0.4997
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0049 0.0172
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0347 0.0883
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0347 0.0977
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0107 0.4703
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0207 0.0519
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0385 0.2145
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0033 0.0093
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.002 0.0049
Schistosoma mansoni bromodomain containing protein 0.007 0.0243 0.0689
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0083 0.0227
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0107 0.708
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0114 0.0424 0.2375
Brugia malayi Carboxylesterase family protein 0.0147 0.0559 0.1577
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0198 0.056
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0056 0.0563
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.0513 0.1447
Toxoplasma gondii exonuclease III APE 0.002 0.0035 0.0235
Loa Loa (eye worm) hypothetical protein 0.0147 0.0559 0.1522
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.006 0.0201 0.2787
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0107 0.0513
Trypanosoma cruzi ISWI complex protein 0.0017 0.0023 0.0234
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0046 0.0061
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0147 0.0559 0.3168
Loa Loa (eye worm) hypothetical protein 0.0147 0.0559 0.1522
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0025 0.0031
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0143 0.0337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0513 0.1452
Brugia malayi AF-10 protein 0.0019 0.0034 0.0089
Brugia malayi hypothetical protein 0.0016 0.002 0.005
Loa Loa (eye worm) carboxylesterase 0.0147 0.0559 0.1522
Schistosoma mansoni inositol monophosphatase 0.0037 0.0107 0.0303
Brugia malayi Pre-SET motif family protein 0.0239 0.0934 0.264
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0025 0.0082
Schistosoma mansoni hypothetical protein 0.0079 0.028 0.0793
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0194 0.0752 0.2127
Trypanosoma brucei ISWI complex protein 0.0017 0.0023 0.0234
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0025 0.0082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0035 0.1238
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0035 0.0822
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0033 0.0093
Schistosoma mansoni neuroligin 3 (S09 family) 0.0147 0.0559 0.1582
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0205 0.0581
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0175 0.0671 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0882 0.3573 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0198 0.0198
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0175 0.0671 0.1898
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0035 0.0043
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0033 0.0022
Onchocerca volvulus 0.0272 0.107 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0385 0.2145
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0205 0.1091
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0207 0.0207
Echinococcus multilocularis cpg binding protein 0.0032 0.0084 0.0084
Schistosoma mansoni BC026374 protein (S09 family) 0.0147 0.0559 0.1582
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0049 0.0132
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0173 0.0173
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0035 0.0028
Loa Loa (eye worm) acetylcholinesterase 1 0.0872 0.3533 1
Onchocerca volvulus 0.0054 0.0175 0.1236
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0048 0.0136
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0033 0.0033
Echinococcus granulosus carboxylesterase 5A 0.0872 0.3533 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0035 0.0235
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0049 0.0132
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0205 0.2853
Echinococcus granulosus cpg binding protein 0.0032 0.0084 0.0238
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0049 0.0172
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0198 0.0492
Leishmania major trypanothione reductase 0.0046 0.0143 0.6642
Schistosoma mansoni hypothetical protein 0.0019 0.0034 0.0096
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.0331
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0347 0.0983
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0033 0.0202
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0433 0.2428
Plasmodium vivax JmjC domain containing protein 0.0019 0.0033 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0207 0.0586
Echinococcus multilocularis carboxylesterase 5A 0.0872 0.3533 0.3533
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.0513 0.1391
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0107 0.0246
Loa Loa (eye worm) carboxylesterase 0.0872 0.3533 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0147 0.0559 0.0559
Brugia malayi jmjC domain containing protein 0.0019 0.0033 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0097 0.0274
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0097 0.1187
Echinococcus multilocularis geminin 0.0338 0.1342 0.1342
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0056 0.297
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0175 0.0671 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0264 0.0747
Echinococcus granulosus microtubule associated protein 2 0.0751 0.3035 0.8591
Plasmodium vivax glutathione reductase, putative 0.0046 0.0143 0.1895
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0227 0.0643
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0034 0.1147
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0067 0.0191
Echinococcus multilocularis protein patched 0.0041 0.0123 0.0123
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0198 0.2734
Schistosoma mansoni hypothetical protein 0.0079 0.028 0.0793
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.1587 0.1587
Brugia malayi Carboxylesterase family protein 0.0147 0.0559 0.1577
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.0008
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0091 0.0252
Echinococcus granulosus GPCR family 2 0.0079 0.028 0.0793
Echinococcus multilocularis BC026374 protein (S09 family) 0.0147 0.0559 0.0559
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.0008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0143 0.0143
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0035 0.0235
Brugia malayi Probable ClpP-like protease 0.0175 0.0671 0.1893
Brugia malayi Pre-SET motif family protein 0.0035 0.0097 0.0268
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0175 0.0671 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0033 0.0022
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0433 0.2295
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0097 0.0097
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0033 0.0033
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0033 0.0033
Echinococcus granulosus peregrin 0.0062 0.0208 0.0589
Echinococcus multilocularis acetylcholinesterase 0.0872 0.3533 0.3533
Loa Loa (eye worm) hypothetical protein 0.0147 0.0559 0.1522
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0516 0.0516
Schistosoma mansoni zinc finger protein 0.0017 0.0023 0.0064
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0438 0.1176
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0431 0.1722 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0048 0.0048
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0107 0.1342
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.006 0.0201 0.0511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0173 0.049
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0114 0.0424 0.2241
Loa Loa (eye worm) glutathione reductase 0.0046 0.0143 0.0337
Brugia malayi Inositol-1 0.0037 0.0107 0.0297
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0207 0.0586
Brugia malayi Carboxylesterase family protein 0.0147 0.0559 0.1577
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0069 0.0125
Schistosoma mansoni inositol monophosphatase 0.0037 0.0107 0.0303
Brugia malayi MH2 domain containing protein 0.0118 0.0438 0.1233
Echinococcus granulosus acetylcholinesterase 0.0872 0.3533 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0056 0.0563
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0143 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0882 0.3573 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0205 0.0205
Brugia malayi Carboxylesterase family protein 0.0147 0.0559 0.1577
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0143 0.0725
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0056 0.0563
Loa Loa (eye worm) hypothetical protein 0.0048 0.0151 0.036
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0034 0.0217
Schistosoma mansoni ap endonuclease 0.002 0.0035 0.0099
Echinococcus granulosus tar DNA binding protein 0.0062 0.0207 0.0586
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.0659 0.1858
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0293 0.0829
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0882 0.3573 1
Schistosoma mansoni microtubule-associated protein tau 0.0751 0.3035 0.8591
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0033 0.0022
Brugia malayi Bromodomain containing protein 0.0083 0.0296 0.0831
Loa Loa (eye worm) hypothetical protein 0.0059 0.0198 0.0492
Loa Loa (eye worm) hypothetical protein 0.0872 0.3533 1
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0033 0.0093
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0114 0.0424 0.2375
Brugia malayi Bromodomain containing protein 0.0062 0.0208 0.0583
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0175 0.0671 1
Onchocerca volvulus Alhambra homolog 0.0059 0.0198 0.1458
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0882 0.3573 1
Echinococcus multilocularis peregrin 0.0062 0.0208 0.0208
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.0984 0.2782
Loa Loa (eye worm) hypothetical protein 0.0872 0.3533 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0061 0.0174
Leishmania major hypothetical protein, conserved 0.0019 0.0033 0.0709
Brugia malayi CXXC zinc finger family protein 0.0028 0.0069 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0207 0.0586
Leishmania major hypothetical protein, conserved 0.0017 0.0023 0.0155
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0107 0.708
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0064
Loa Loa (eye worm) hypothetical protein 0.0147 0.0559 0.1522
Onchocerca volvulus 0.0147 0.0559 0.4997
Loa Loa (eye worm) hypothetical protein 0.0147 0.0559 0.1522
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0056 0.297
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0123 0.0279
Loa Loa (eye worm) hypothetical protein 0.0102 0.0372 0.0988
Schistosoma mansoni hypothetical protein 0.0079 0.028 0.0793
Schistosoma mansoni acetylcholinesterase 0.0147 0.0559 0.1582
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0049 0.0172
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0049 0.0172
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0398 0.1587 0.4493
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0513 0.1452
Echinococcus granulosus tumor protein p63 0.0368 0.1463 0.414
Brugia malayi jmjC domain containing protein 0.0019 0.0033 0.0086
Loa Loa (eye worm) hypothetical protein 0.0053 0.0173 0.0422
Giardia lamblia PHD finger protein 15 0.0059 0.0198 0.0501
Echinococcus multilocularis neuroligin 0.0147 0.0559 0.0559
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0431 0.1722 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0091 0.0419
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0049 0.1574
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0513 0.1452
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.0457 0.1231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0513 0.0513
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0107 0.0107
Mycobacterium tuberculosis Carboxylesterase LipT 0.0147 0.0559 0.3168
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0147 0.0559 0.1582
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0175 0.0671 1
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.0331
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0107 0.0303
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0264 0.0747
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.028 0.028
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0264 0.0681
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0033 0.1067
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0207 0.058
Loa Loa (eye worm) hypothetical protein 0.0079 0.028 0.0728
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0035 0.1238
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0175 0.0671 1
Brugia malayi jmjC domain containing protein 0.0075 0.0264 0.0741
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0438 0.1176
Echinococcus multilocularis GPCR, family 2 0.0079 0.028 0.028
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0882 0.3573 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0049 0.0172
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.003 0.003
Onchocerca volvulus 0.0147 0.0559 0.4997
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.002 0.0056
Schistosoma mansoni patched 1 0.0041 0.0123 0.0348
Mycobacterium ulcerans carboxylesterase, LipT 0.0147 0.0559 0.3168
Loa Loa (eye worm) hypothetical protein 0.0175 0.0671 0.1841
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0035 0.009
Schistosoma mansoni glutaminase 0.0313 0.1238 0.3505
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0147 0.0559 0.1582
Brugia malayi Bromodomain containing protein 0.0042 0.0125 0.0348
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0882 0.3573 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.006 0.0201 0.2787
Brugia malayi PHD-finger family protein 0.0029 0.0072 0.0197
Onchocerca volvulus 0.0147 0.0559 0.4997
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0035 0.1238
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0173 0.049
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0034 0.1147
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.003 0.0086
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0107 0.708
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.003 0.0086
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.0984 0.2782
Loa Loa (eye worm) hypothetical protein 0.0025 0.0056 0.0089
Brugia malayi hypothetical protein 0.0025 0.0056 0.0153
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0035 0.0043
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0431 0.1722 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0513 0.0513
Echinococcus granulosus phd:f box containing protein 0.0019 0.0033 0.0093
Loa Loa (eye worm) hypothetical protein 0.0044 0.0136 0.0317
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.002 0.0056
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0035 0.009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0385 0.2145
Schistosoma mansoni jumonji domain containing protein 0.0154 0.0588 0.1664
Loa Loa (eye worm) hypothetical protein 0.0077 0.027 0.0698
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0175 0.0671 0.3825
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0056 0.0563
Schistosoma mansoni hypothetical protein 0.0079 0.028 0.0793
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0033 0.0023
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.028 0.0793
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0107 0.0246
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0143 0.0405
Onchocerca volvulus 0.0147 0.0559 0.4997
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0097 0.0274
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0198 0.2734
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0033 0.0093
Echinococcus multilocularis tumor protein p63 0.0368 0.1463 0.1463
Schistosoma mansoni hypothetical protein 0.0338 0.1342 0.3798
Echinococcus multilocularis peptidase Clp (S14 family) 0.0114 0.0424 0.0424
Brugia malayi Thioredoxin reductase 0.0046 0.0143 0.0399
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0035 0.0235
Toxoplasma gondii thioredoxin reductase 0.0046 0.0143 0.1895
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0025 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0207 0.0586
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0347 0.0347
Brugia malayi jmjC domain containing protein 0.0019 0.0033 0.0086
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0147 0.0559 0.1582
Echinococcus multilocularis para nitrobenzyl esterase 0.0147 0.0559 0.0559
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0049 0.0172
Trypanosoma cruzi ISWI complex protein 0.0017 0.0023 0.0234
Giardia lamblia Fructose-bisphosphate aldolase 0.0882 0.3573 1
Echinococcus granulosus acetylcholinesterase 0.0872 0.3533 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0022
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0123 0.0348
Brugia malayi jmjC domain containing protein 0.0194 0.0752 0.2122
Mycobacterium tuberculosis Probable reductase 0.0105 0.0385 0.2145
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.0984 0.2735
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0107 0.0204
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.028 0.028
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0049 0.0172
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0205 0.1091
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0147 0.0559 0.3168
Brugia malayi Carboxylesterase family protein 0.0872 0.3533 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0249 0.0249
Echinococcus granulosus peptidase Clp S14 family 0.0114 0.0424 0.12
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0385 0.2145
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.005 0.0161 0.0387
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0035 0.0092
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0115 0.0325
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.0008
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0033 0.0202
Schistosoma mansoni gliotactin 0.0147 0.0559 0.1582
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.028 0.0793
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0205 0.1091
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0022
Schistosoma mansoni zinc finger protein 0.0023 0.0048 0.0136
Echinococcus multilocularis microtubule associated protein 2 0.0751 0.3035 0.3035
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.0331
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0049 0.0132
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.028 0.0728
Mycobacterium ulcerans glutaminase 0.0313 0.1238 0.7159
Echinococcus granulosus para nitrobenzyl esterase 0.0147 0.0559 0.1582
Loa Loa (eye worm) hypothetical protein 0.0042 0.0126 0.0287
Echinococcus multilocularis zinc finger protein 0.0023 0.0048 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0205 0.1091
Loa Loa (eye worm) hypothetical protein 0.0251 0.0984 0.2735
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0198 0.2734
Schistosoma mansoni hypothetical protein 0.0022 0.0046 0.0131
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0033 0.0202
Loa Loa (eye worm) hypothetical protein 0.0096 0.0347 0.0919
Loa Loa (eye worm) hypothetical protein 0.0147 0.0559 0.1522
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0143 0.1895
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0049 0.0172
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0227 0.0227
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0882 0.3573 1
Schistosoma mansoni hypothetical protein 0.0172 0.0659 0.1864
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0175 0.0671 0.3825
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0033 0.1067
Brugia malayi jmjC domain containing protein 0.0019 0.0033 0.0086
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0203 0.0573

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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