Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0052 | 0.011 | 0.5 | |
Echinococcus granulosus | expressed protein | 0.0019 | 0.0003 | 0.0014 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 0.0401 | 0.1769 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.011 | 0.0483 |
Schistosoma mansoni | apoferritin-2 | 0.0019 | 0.0003 | 0.0014 |
Schistosoma mansoni | ferritin | 0.0019 | 0.0003 | 0.0014 |
Echinococcus multilocularis | expressed protein | 0.0019 | 0.0003 | 0.0014 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.313 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0367 | 0.1619 |
Schistosoma mansoni | ferritin light chain | 0.0019 | 0.0003 | 0.0014 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0066 | 0.0292 |
Schistosoma mansoni | ferritin light chain | 0.0019 | 0.0003 | 0.0014 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0123 | 0.1587 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0019 | 0.0003 | 0.5 |
Schistosoma mansoni | ferritin | 0.0019 | 0.0003 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0123 | 0.1587 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0123 | 0.1587 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.011 | 0.1409 |
Schistosoma mansoni | ferritin | 0.0019 | 0.0003 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0066 | 0.0852 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0132 | 0.0367 | 0.1619 |
Echinococcus multilocularis | ferritin | 0.0019 | 0.0003 | 0.0014 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.313 | 1 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.026 | 0.0777 | 1 |
Schistosoma mansoni | ferritin | 0.0019 | 0.0003 | 0.0014 |
Brugia malayi | MH2 domain containing protein | 0.026 | 0.0777 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0132 | 0.0367 | 0.1619 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0019 | 0.0003 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 0.0401 | 0.1769 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0066 | 0.0852 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0143 | 0.0401 | 0.1769 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.026 | 0.0777 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0354 | 0.1081 | 0.4768 |
Echinococcus granulosus | tumor protein p63 | 0.0354 | 0.1081 | 0.4768 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0724 | 0.2268 | 1 |
Trichomonas vaginalis | ferritin, putative | 0.0019 | 0.0003 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0724 | 0.2268 | 1 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.313 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0724 | 0.2268 | 1 |
Echinococcus granulosus | ferritin | 0.0019 | 0.0003 | 0.0014 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0123 | 0.1587 |
Schistosoma mansoni | apoferritin-2 | 0.0019 | 0.0003 | 0.0014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.