Detailed information for compound 1746765

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1250.65 | Formula: C66H111N11O12
  • H donors: 5 H acceptors: 12 LogP: 8.23 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC/C=C/C[C@H]([C@H]([C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)O)C
  • InChi: 1S/C66H111N11O12/c1-23-25-27-30-43(13)56(79)55-60(83)69-47(24-2)62(85)71(16)37-52(78)72(17)49(36-46-31-28-26-29-32-46)59(82)70-53(41(9)10)65(88)73(18)48(33-38(3)4)58(81)67-44(14)57(80)68-45(15)61(84)74(19)50(34-39(5)6)63(86)75(20)51(35-40(7)8)64(87)76(21)54(42(11)12)66(89)77(55)22/h25-29,31-32,38-45,47-51,53-56,79H,23-24,30,33-37H2,1-22H3,(H,67,81)(H,68,80)(H,69,83)(H,70,82)/b27-25+/t43-,44+,45-,47+,48-,49+,50+,51+,53-,54+,55+,56-/m1/s1
  • InChiKey: QFBHUTLKESKPGE-WZULUUDFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens formyl peptide receptor 1 Starlite/ChEMBL References
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Abl 0.2888 0.4037 0.4037
Brugia malayi Carboxylesterase family protein 0.35 0.4906 0.8132
Echinococcus granulosus N chimaerin 0.0117 0.0096 0.0096
Brugia malayi nuclear hormone receptor 0.011 0.0086 0.0143
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0591 0.0771 1
Loa Loa (eye worm) hypothetical protein 0.35 0.4906 0.4906
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.0086 0.0086
Brugia malayi SH2 domain containing protein 0.0101 0.0074 0.0123
Schistosoma mansoni C-fyn 0.0099 0.007 0.0071
Loa Loa (eye worm) protein-tyrosine kinase 0.0099 0.007 0.007
Schistosoma mansoni retinoic acid receptor RXR 0.011 0.0086 0.0088
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0058 0.0013 0.0013
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0591 0.0771 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0101 0.0074 0.0917
Loa Loa (eye worm) nuclear receptor NHR-67 0.0052 0.0004 0.0004
Echinococcus granulosus tyrosine protein kinase Srms 0.0132 0.0118 0.0118
Echinococcus granulosus tyrosine kinase 0.0132 0.0118 0.0118
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0099 0.007 0.007
Brugia malayi hypothetical protein 0.0591 0.0771 0.1277
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0101 0.0074 0.0074
Echinococcus granulosus acetylcholinesterase 0.35 0.4906 0.4906
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.011 0.0086 0.0088
Echinococcus multilocularis SH2 motif 0.0101 0.0074 0.0074
Echinococcus granulosus NCK adaptor protein 0.02 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0591 0.0771 0.0771
Brugia malayi nuclear receptor RXR 0.0058 0.0013 0.0021
Echinococcus multilocularis transfer RNA-Ala 0.0099 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0114 0.0116
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0101 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Schistosoma mansoni tyrosine kinase 0.0231 0.0258 0.0262
Loa Loa (eye worm) hypothetical protein 0.0591 0.0771 0.0771
Brugia malayi Nuclear hormone receptor family member nhr-1 0.011 0.0086 0.0143
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0013 0.0021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.011 0.0086 0.0086
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.02 0.0215 0.0218
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0101 0.0074 0.0759
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0099 0.007 0.0071
Schistosoma mansoni hypothetical protein 0.0099 0.007 0.0071
Loa Loa (eye worm) TK/FER protein kinase 0.0132 0.0118 0.0118
Schistosoma mansoni suppressor of cytokine signaling 0.0101 0.0074 0.0075
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0231 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Schistosoma mansoni dreadlocks/dock 0.0099 0.007 0.0071
Echinococcus granulosus endophilin A3 0.0099 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.011 0.0086 0.0143
Echinococcus multilocularis neuroligin 0.0591 0.0771 0.0771
Brugia malayi SH3 domain containing protein 0.0099 0.007 0.0117
Schistosoma mansoni GTPase activating protein 0.0101 0.0074 0.0075
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.011 0.0086 0.0086
Echinococcus multilocularis signal transduction protein lnk realted 0.0101 0.0074 0.0074
Onchocerca volvulus 0.0101 0.0074 0.0917
Onchocerca volvulus Bile acid receptor homolog 0.011 0.0086 0.108
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0099 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.011 0.0086 0.0086
Schistosoma mansoni acetylcholinesterase 0.0591 0.0771 0.0782
Echinococcus multilocularis FTZ F1 alpha 0.011 0.0086 0.0086
Brugia malayi SH2 domain containing protein 0.0101 0.0074 0.0123
Brugia malayi RhoGAP domain containing protein 0.0117 0.0096 0.0159
Loa Loa (eye worm) hypothetical protein 0.0591 0.0771 0.0771
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.0086 0.0143
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Schistosoma mansoni SH2A 0.0101 0.0074 0.0075
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0052 0.0004 0.0004
Onchocerca volvulus 0.0591 0.0771 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.011 0.0086 0.0086
Schistosoma mansoni tyrosine kinase 0.0132 0.0118 0.0119
Echinococcus granulosus tyrosine protein kinase Src42A 0.0101 0.0074 0.0074
Loa Loa (eye worm) thyroid receptor interactor 0.0099 0.007 0.007
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0175 0.0178 0.0178
Onchocerca volvulus 0.0099 0.007 0.087
Echinococcus multilocularis tyrosine protein kinase Srms 0.0132 0.0118 0.0118
Echinococcus granulosus SHC transforming protein 3 0.0101 0.0074 0.0074
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.011 0.0086 0.0086
Schistosoma mansoni cell polarity protein 0.0099 0.007 0.0071
Brugia malayi Variant SH3 domain containing protein 0.0099 0.007 0.0117
Brugia malayi Carboxylesterase family protein 0.0591 0.0771 0.1277
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.007 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0231 0.0258 0.0258
Schistosoma mansoni signal transduction protein lnk-related 0.0101 0.0074 0.0075
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0231 0.0258 0.0258
Echinococcus granulosus growth factor receptor bound protein 2 0.02 0.0215 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.0086 0.0143
Schistosoma mansoni tensin 0.0101 0.0074 0.0075
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0101 0.0074 0.0074
Onchocerca volvulus 0.0099 0.007 0.087
Brugia malayi nuclear receptor RXR 0.0052 0.0004 0.0006
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0099 0.007 0.0071
Echinococcus granulosus SH2 domain containing adapter protein F 0.0101 0.0074 0.0074
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0099 0.007 0.007
Brugia malayi Steroid receptor seven-up type 2 0.011 0.0086 0.0143
Schistosoma mansoni apoptosis stimulating of P53 0.0099 0.007 0.0071
Echinococcus granulosus retinoic acid receptor rxr beta a 0.011 0.0086 0.0086
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0132 0.0118 0.0118
Loa Loa (eye worm) TK/FER protein kinase 0.0132 0.0118 0.0118
Onchocerca volvulus 0.0132 0.0118 0.1486
Brugia malayi hypothetical protein 0.0132 0.0118 0.0195
Brugia malayi Variant SH3 domain containing protein 0.0099 0.007 0.0117
Schistosoma mansoni nuclear receptor 0.0052 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.011 0.0086 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0475 0.0606 0.0615
Loa Loa (eye worm) guanylate kinase 0.0099 0.007 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.007 0.5
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0099 0.007 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.011 0.0086 0.0143
Echinococcus multilocularis para nitrobenzyl esterase 0.0591 0.0771 0.0771
Loa Loa (eye worm) p53BP2 0.0099 0.007 0.007
Echinococcus granulosus fch and double sh3 domains protein 2 0.0099 0.007 0.007
Echinococcus multilocularis tensin 0.0101 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Echinococcus granulosus tyrosine kinase 0.0132 0.0118 0.0118
Echinococcus granulosus signal transduction protein lnk realted 0.0101 0.0074 0.0074
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.011 0.0086 0.0086
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0099 0.007 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.011 0.0086 0.0086
Brugia malayi STAT protein, DNA binding domain containing protein 0.0101 0.0074 0.0123
Loa Loa (eye worm) carboxylesterase 0.0591 0.0771 0.0771
Echinococcus multilocularis nuclear receptor nhr 48 0.0052 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Echinococcus granulosus SH2 motif 0.0101 0.0074 0.0074
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0132 0.0118 0.0118
Schistosoma mansoni adapter molecule crk 0.02 0.0215 0.0218
Loa Loa (eye worm) hypothetical protein 0.35 0.4906 0.4906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.011 0.0086 0.0086
Onchocerca volvulus 0.0132 0.0118 0.1486
Brugia malayi Spectrin alpha chain 0.0099 0.007 0.0117
Echinococcus granulosus BC026374 protein S09 family 0.0591 0.0771 0.0771
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0231 0.0258 0.0258
Brugia malayi cytokine inducible SH2-containing protein 5 0.0101 0.0074 0.0123
Schistosoma mansoni tensin 0.0101 0.0074 0.0075
Onchocerca volvulus Putative cortactin 0.0099 0.007 0.087
Echinococcus granulosus suppressor of cytokine signaling 7 0.0101 0.0074 0.0074
Brugia malayi protein-tyrosine kinase 0.0099 0.007 0.0117
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0004 0.0004
Brugia malayi Variant SH3 domain containing protein 0.0099 0.007 0.0117
Schistosoma mansoni eps8-related protein 0.0099 0.007 0.0071
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.0013 0.0013
Brugia malayi hypothetical protein 0.0058 0.0013 0.0021
Loa Loa (eye worm) TK/ABL protein kinase 0.7082 1 1
Brugia malayi Carboxylesterase family protein 0.0591 0.0771 0.1277
Brugia malayi Nuclear hormone receptor family member nhr-14 0.011 0.0086 0.0143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.0086 0.0086
Echinococcus granulosus tyrosine protein kinase Fyn 0.0231 0.0258 0.0258
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0052 0.0004 0.0004
Onchocerca volvulus 0.0591 0.0771 1
Brugia malayi Variant SH3 domain containing protein 0.0099 0.007 0.0117
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0099 0.007 0.007
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0282 0.0331 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.0086 0.0143
Loa Loa (eye worm) TK/FER protein kinase 0.0132 0.0118 0.0118
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.0004 0.0004
Schistosoma mansoni thyroid hormone receptor 0.011 0.0086 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-40 0.011 0.0086 0.0143
Schistosoma mansoni Dab2-interacting protein-like 0.0099 0.007 0.0071
Loa Loa (eye worm) acetylcholinesterase 1 0.35 0.4906 0.4906
Schistosoma mansoni tensin-related 0.0101 0.0074 0.0075
Brugia malayi Peripheral plasma membrane protein CASK 0.0099 0.007 0.0117
Echinococcus granulosus tyrosine protein kinase Src64B 0.0231 0.0258 0.0258
Brugia malayi Protein kinase domain containing protein 0.0132 0.0118 0.0195
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.011 0.0086 0.0088
Loa Loa (eye worm) variant SH3 domain-containing protein 0.02 0.0215 0.0215
Leishmania major hypothetical protein, conserved 0.0099 0.007 0.5
Onchocerca volvulus 0.0132 0.0118 0.1486
Loa Loa (eye worm) STAT protein 0.0101 0.0074 0.0074
Schistosoma mansoni Tr4/Tr2 (homologue) 0.011 0.0086 0.0088
Echinococcus multilocularis growth factor receptor bound protein 2 0.02 0.0215 0.0215
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0132 0.0118 0.0118
Brugia malayi SH2 domain containing protein 0.0101 0.0074 0.0123
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0058 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0058 0.0013 0.0013
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0101 0.0074 0.0074
Echinococcus multilocularis c src tyrosine kinase 0.0231 0.0258 0.0258
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0099 0.007 0.007
Brugia malayi protein-tyrosine kinase 0.0132 0.0118 0.0195
Brugia malayi hypothetical protein 0.0058 0.0013 0.0021
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0101 0.0074 0.0123
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0231 0.0258 0.0262
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0052 0.0004 0.0004
Brugia malayi Nuclear hormone receptor E75 0.0052 0.0004 0.0006
Mycobacterium ulcerans carboxylesterase, LipT 0.0591 0.0771 0.5
Loa Loa (eye worm) hypothetical protein 0.0591 0.0771 0.0771
Brugia malayi Nuclear hormone receptor family member nhr-3 0.011 0.0086 0.0143
Loa Loa (eye worm) hypothetical protein 0.0058 0.0013 0.0013
Echinococcus multilocularis NCK adaptor protein 0.02 0.0215 0.0215
Brugia malayi SRC-1 0.0231 0.0258 0.0428
Echinococcus multilocularis BC026374 protein (S09 family) 0.0591 0.0771 0.0771
Schistosoma mansoni hypothetical protein 0.0268 0.031 0.0315
Echinococcus multilocularis ecdysone induced protein 78C 0.011 0.0086 0.0086
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0099 0.007 0.007
Echinococcus multilocularis expressed protein 0.0099 0.007 0.007
Brugia malayi tRNA modification GTPase TrmE family protein 0.0101 0.0074 0.0123
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.011 0.0086 0.0086
Brugia malayi Variant SH3 domain containing protein 0.0099 0.007 0.0117
Loa Loa (eye worm) hypothetical protein 0.0099 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0101 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Brugia malayi Carboxylesterase family protein 0.35 0.4906 0.8132
Brugia malayi Carboxylesterase family protein 0.0591 0.0771 0.1277
Schistosoma mansoni tyrosine kinase 0.0231 0.0258 0.0262
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0099 0.007 0.007
Echinococcus multilocularis carboxylesterase 5A 0.35 0.4906 0.4906
Loa Loa (eye worm) TK/FER protein kinase 0.0132 0.0118 0.0118
Schistosoma mansoni tyrosine kinase 0.0132 0.0118 0.0119
Schistosoma mansoni suppressor of cytokine signaling 0.0101 0.0074 0.0075
Schistosoma mansoni nuclear hormone receptor 0.011 0.0086 0.0088
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0101 0.0074 0.0074
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.011 0.0086 0.0086
Schistosoma mansoni shc transforming protein 0.0101 0.0074 0.0075
Schistosoma mansoni nuclear receptor 0.0052 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0099 0.007 0.007
Brugia malayi Variant SH3 domain containing protein 0.0101 0.0074 0.0123
Loa Loa (eye worm) TK/FER protein kinase 0.0132 0.0118 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.011 0.0086 0.0086
Echinococcus multilocularis SH2 motif 0.0101 0.0074 0.0074
Echinococcus granulosus neuroligin 0.0591 0.0771 0.0771
Loa Loa (eye worm) TK/FER protein kinase 0.0132 0.0118 0.0118
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0591 0.0771 0.0782
Loa Loa (eye worm) hypothetical protein 0.011 0.0086 0.0086
Brugia malayi Variant SH3 domain containing protein 0.02 0.0215 0.0356
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.0086 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.007 0.5
Echinococcus granulosus c src tyrosine kinase 0.0231 0.0258 0.0258
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0099 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Echinococcus multilocularis endophilin A3 0.0099 0.007 0.007
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0101 0.0074 0.0074
Brugia malayi SH2 domain containing protein 0.0132 0.0118 0.0195
Echinococcus granulosus raf serine:threonine protein kinase 0.0475 0.0606 0.0606
Loa Loa (eye worm) SRC-1 0.0231 0.0258 0.0258
Loa Loa (eye worm) SH2 domain-containing protein 0.0101 0.0074 0.0074
Echinococcus granulosus tyrosine protein kinase Lyn 0.0231 0.0258 0.0258
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0099 0.007 0.007
Echinococcus granulosus expressed conserved protein 0.0101 0.0074 0.0074
Trichomonas vaginalis spcc417.12 protein, putative 0.0591 0.0771 1
Brugia malayi Protein kinase domain containing protein 0.0132 0.0118 0.0195
Brugia malayi Protein kinase domain containing protein 0.0132 0.0118 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-31 0.011 0.0086 0.0143
Echinococcus granulosus hypothetical protein 0.0101 0.0074 0.0074
Schistosoma mansoni RAR-like nuclear receptor 0.011 0.0086 0.0088
Echinococcus multilocularis N chimaerin 0.0117 0.0096 0.0096
Onchocerca volvulus 0.0099 0.007 0.087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.0086 0.0143
Brugia malayi nuclear hormone receptor 0.0052 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0099 0.007 0.0071
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0231 0.0258 0.0258
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0052 0.0004 0.0004
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0231 0.0258 0.0258
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.011 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.011 0.0086 0.0086
Echinococcus multilocularis intersectin 2 0.0099 0.007 0.007
Brugia malayi nuclear receptor NHR-88 0.0052 0.0004 0.0006
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0101 0.0074 0.0074
Brugia malayi Protein kinase domain containing protein 0.0132 0.0118 0.0195
Onchocerca volvulus 0.011 0.0086 0.108
Schistosoma mansoni tyrosine kinase 0.6981 0.9856 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0117 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0591 0.0771 0.0771
Echinococcus granulosus FTZ F1 alpha 0.011 0.0086 0.0086
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.0099 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Schistosoma mansoni vav2 0.0117 0.0096 0.0098
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0231 0.0258 0.0258
Onchocerca volvulus Protein ultraspiracle homolog 0.011 0.0086 0.108
Loa Loa (eye worm) carboxylesterase 0.0591 0.0771 0.0771
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Echinococcus multilocularis acetylcholinesterase 0.35 0.4906 0.4906
Schistosoma mansoni hypothetical protein 0.0101 0.0074 0.0075
Echinococcus granulosus acetylcholinesterase 0.35 0.4906 0.4906
Loa Loa (eye worm) hypothetical protein 0.011 0.0086 0.0086
Echinococcus granulosus SH2 motif 0.0101 0.0074 0.0074
Schistosoma mansoni dynamin-associated protein 0.0099 0.007 0.0071
Loa Loa (eye worm) carboxylesterase 0.35 0.4906 0.4906
Schistosoma mansoni tyrosine kinase 0.0231 0.0258 0.0262
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.011 0.0086 0.0086
Brugia malayi nuclear receptor NHR-88 0.011 0.0086 0.0143
Loa Loa (eye worm) TK/FER protein kinase 0.0132 0.0118 0.0118
Onchocerca volvulus 0.0591 0.0771 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.011 0.0086 0.0086
Loa Loa (eye worm) sex muscle abnormal protein 5 0.02 0.0215 0.0215
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0175 0.0178 0.0178
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0231 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0058 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor 0.0052 0.0004 0.0004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0058 0.0013 0.0013
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0101 0.0074 0.0075
Loa Loa (eye worm) hypothetical protein 0.0132 0.0118 0.0118
Brugia malayi Nuclear hormone receptor E75 0.0052 0.0004 0.0006
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0117 0.0096 0.0096
Onchocerca volvulus 0.0101 0.0074 0.0917
Onchocerca volvulus 0.0132 0.0118 0.1486
Brugia malayi Sex muscle abnormal protein 5 0.02 0.0215 0.0356
Loa Loa (eye worm) TK/FER protein kinase 0.0132 0.0118 0.0118
Schistosoma mansoni BC026374 protein (S09 family) 0.0591 0.0771 0.0782
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0058 0.0013 0.0013
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.0004 0.0004
Onchocerca volvulus 0.0099 0.007 0.087
Schistosoma mansoni formin binding protein and related proteins 0.0099 0.007 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0004 0.0004
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0052 0.0004 0.0006
Brugia malayi hypothetical protein 0.0101 0.0074 0.0123
Schistosoma mansoni steroid hormone receptor ad4bp 0.011 0.0086 0.0088
Loa Loa (eye worm) hypothetical protein 0.2688 0.3752 0.3752
Brugia malayi SH2 domain containing protein 0.0101 0.0074 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-41 0.011 0.0086 0.0143
Onchocerca volvulus 0.0101 0.0074 0.0917
Echinococcus granulosus Spectrin alpha actinin 0.0099 0.007 0.007
Schistosoma mansoni growth factor receptor-bound protein 0.02 0.0215 0.0218
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.011 0.0086 0.0086
Brugia malayi ecdysone receptor 0.0052 0.0004 0.0006
Loa Loa (eye worm) TK protein kinase 0.0132 0.0118 0.0118
Echinococcus granulosus suppressor of cytokine signaling 6 0.0101 0.0074 0.0074
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.0004 0.0004
Brugia malayi SH2 domain containing protein 0.0132 0.0118 0.0195
Schistosoma mansoni hypothetical protein 0.0101 0.0074 0.0075
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0101 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Entamoeba histolytica SH2 domain containing protein 0.0101 0.0074 0.0759
Echinococcus multilocularis tyrosine protein kinase ABL1 0.7082 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.011 0.0086 0.108
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0132 0.0118 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0101 0.0074 0.0074
Echinococcus granulosus intersectin 2 0.0099 0.007 0.007
Schistosoma mansoni sorting nexin 0.0099 0.007 0.0071
Brugia malayi Tyrosine-protein kinase abl-1 0.2888 0.4037 0.6691
Loa Loa (eye worm) SH2 domain-containing protein 0.0101 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Echinococcus multilocularis SH2 motif 0.0101 0.0074 0.0074
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.011 0.0086 0.0086
Brugia malayi Tensin 0.0101 0.0074 0.0123
Brugia malayi nuclear hormone receptor family member nhr-6 0.0052 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.011 0.0086 0.0086
Brugia malayi tailless protein 0.0052 0.0004 0.0006
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0052 0.0004 0.0004
Brugia malayi Carboxylesterase family protein 0.0591 0.0771 0.1277
Schistosoma mansoni sorbin 0.0099 0.007 0.0071
Echinococcus multilocularis tensin 0.0101 0.0074 0.0074
Brugia malayi steroid hormone receptor 0.011 0.0086 0.0143
Echinococcus multilocularis tyrosine protein kinase Blk 0.0132 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0591 0.0771 0.0771
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.011 0.0086 0.0088
Brugia malayi Variant SH3 domain containing protein 0.02 0.0215 0.0356
Brugia malayi hypothetical protein 0.0052 0.0004 0.0006
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0101 0.0074 0.0074
Brugia malayi nuclear receptor NHR-67 0.0052 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Brugia malayi photoreceptor-specific nuclear receptor 0.011 0.0086 0.0143
Echinococcus granulosus tensin 0.0101 0.0074 0.0074
Echinococcus granulosus tyrosine protein kinase shark 0.0132 0.0118 0.0118
Schistosoma mansoni tensin-related 0.0101 0.0074 0.0075
Brugia malayi Raf kinase 0.046 0.0584 0.0967
Brugia malayi Fes/CIP4 homology domain containing protein 0.0099 0.007 0.0117
Brugia malayi Variant SH3 domain containing protein 0.0099 0.007 0.0117
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0231 0.0258 0.0258
Echinococcus multilocularis nostrin 0.0099 0.007 0.007
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0117 0.0096 0.0098
Loa Loa (eye worm) SH2 domain-containing protein 0.0101 0.0074 0.0074
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0591 0.0771 0.0782
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0099 0.007 0.0071
Loa Loa (eye worm) steroid hormone receptor 0.011 0.0086 0.0086
Onchocerca volvulus 0.0591 0.0771 1
Brugia malayi Src substrate cortactin 0.0099 0.007 0.0117
Onchocerca volvulus 0.0101 0.0074 0.0917
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0099 0.007 0.0071
Mycobacterium tuberculosis Carboxylesterase LipT 0.0591 0.0771 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0132 0.0118 0.0118
Schistosoma mansoni coup transcription factor 0.011 0.0086 0.0088
Brugia malayi conserved hypotetical protein 0.0052 0.0004 0.0006
Echinococcus granulosus tyrosine protein kinase Fyn 0.0231 0.0258 0.0258
Echinococcus multilocularis Spectrin alpha actinin 0.0099 0.007 0.007
Echinococcus multilocularis 0.0101 0.0074 0.0074
Echinococcus granulosus nostrin 0.0099 0.007 0.007
Brugia malayi Protein kinase domain containing protein 0.0132 0.0118 0.0195
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0099 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0591 0.0771 0.0771
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0099 0.007 0.087
Schistosoma mansoni thyroid hormone receptor 0.011 0.0086 0.0088
Schistosoma mansoni retinoid-x-receptor (RXR) 0.011 0.0086 0.0088
Echinococcus granulosus tyrosine protein kinase Fyn 0.0231 0.0258 0.0258
Echinococcus granulosus carboxylesterase 5A 0.35 0.4906 0.4906
Brugia malayi SH2 domain containing protein 0.0101 0.0074 0.0123
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0591 0.0771 1
Brugia malayi hypothetical protein 0.0052 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0591 0.0771 0.0771
Echinococcus multilocularis acetylcholinesterase 0.35 0.4906 0.4906
Echinococcus granulosus nuclear receptor nhr 48 0.0052 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0058 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0099 0.007 0.007
Entamoeba histolytica protein kinase, putative 0.0101 0.0074 0.0759
Echinococcus multilocularis thyroid hormone receptor alpha 0.011 0.0086 0.0086
Onchocerca volvulus 0.0591 0.0771 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0132 0.0118 0.0118
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0117 0.0096 0.0098
Brugia malayi SH2 domain containing protein 0.0101 0.0074 0.0123
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0099 0.007 0.007
Brugia malayi orphan nuclear receptor NR2E1 0.0052 0.0004 0.0006
Echinococcus granulosus tyrosine protein kinase Blk 0.0132 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0099 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Schistosoma mansoni growth factor receptor-bound protein 0.02 0.0215 0.0218
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.35 0.4906 0.4978
Loa Loa (eye worm) hypothetical protein 0.0052 0.0004 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.0086 0.0086
Onchocerca volvulus 0.0132 0.0118 0.1486
Trypanosoma brucei conserved protein 0.0099 0.007 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.0086 0.0143
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0117 0.0096 0.0096
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0231 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0099 0.007 0.007
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0004 0.0004
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0101 0.0074 0.0074
Echinococcus granulosus ecdysone induced protein 78C 0.011 0.0086 0.0086
Loa Loa (eye worm) TK/FER protein kinase 0.0132 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0099 0.007 0.007
Schistosoma mansoni tyrosine kinase 0.0231 0.0258 0.0262
Echinococcus multilocularis SHC transforming protein 3 0.0101 0.0074 0.0074
Schistosoma mansoni zinc finger protein 0.0052 0.0004 0.0004
Brugia malayi Variant SH3 domain containing protein 0.0117 0.0096 0.0159
Echinococcus granulosus src region 0.0099 0.007 0.007
Echinococcus multilocularis SH2 domain containing protein 7 0.0101 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Echinococcus multilocularis raf serine:threonine protein kinase 0.0475 0.0606 0.0606
Brugia malayi nuclear hormone receptor family member odr-7 0.0052 0.0004 0.0006
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0052 0.0004 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.0086 0.0143
Echinococcus granulosus para nitrobenzyl esterase 0.0591 0.0771 0.0771
Loa Loa (eye worm) hypothetical protein 0.0101 0.0074 0.0074
Onchocerca volvulus 0.0132 0.0118 0.1486
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0099 0.007 0.007
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0231 0.0258 0.0258
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0101 0.0074 0.0074
Schistosoma mansoni neuroligin 3 (S09 family) 0.0591 0.0771 0.0782
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.011 0.0086 0.0086
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0099 0.007 0.007
Echinococcus granulosus expressed protein 0.0099 0.007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0132 0.0118 0.0118
Brugia malayi SH2 domain containing protein 0.0101 0.0074 0.0123
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0231 0.0258 0.0258
Schistosoma mansoni nck2/grb4 0.02 0.0215 0.0218
Loa Loa (eye worm) hypothetical protein 0.011 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0058 0.0013 0.0013
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0101 0.0074 0.0074
Loa Loa (eye worm) DR-78 0.0052 0.0004 0.0004
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0101 0.0074 0.0917
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0231 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.02 0.0215 0.0215
Onchocerca volvulus 0.0101 0.0074 0.0917
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0591 0.0771 0.0782
Loa Loa (eye worm) hypothetical protein 0.0099 0.007 0.007
Loa Loa (eye worm) raf kinase 0.0445 0.0562 0.0562
Brugia malayi Myosin tail family protein 0.0099 0.007 0.0117
Schistosoma mansoni run and tbc1 domain containing 0.0099 0.007 0.0071
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.011 0.0086 0.0086
Brugia malayi Tyrosine-protein kinase abl-1 0.4293 0.6034 1
Brugia malayi ecdysteroid receptor 0.011 0.0086 0.0143
Echinococcus granulosus SH2 domain containing protein 7 0.0101 0.0074 0.0074
Onchocerca volvulus 0.0099 0.007 0.087
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0231 0.0258 0.0258
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0101 0.0074 0.0075
Brugia malayi Guanylate kinase family protein 0.0099 0.007 0.0117
Loa Loa (eye worm) hypothetical protein 0.0099 0.007 0.007
Echinococcus multilocularis tyrosine kinase 0.0132 0.0118 0.0118
Schistosoma mansoni gliotactin 0.0591 0.0771 0.0782
Echinococcus granulosus epidermal growth factor receptor kinase 0.0099 0.007 0.007
Onchocerca volvulus 0.0101 0.0074 0.0917
Echinococcus granulosus thyroid hormone receptor alpha 0.0052 0.0004 0.0004
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0591 0.0771 0.0771
Schistosoma mansoni tensin 0.0101 0.0074 0.0075
Schistosoma mansoni nuclear receptor nhr-48 0.0052 0.0004 0.0004
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0101 0.0074 0.0074

Activities

Activity type Activity value Assay description Source Reference
IC20 (binding) = 4 uM Inhibitory activity against Human formylpeptide receptor (FPR) of human leukemia HL-60 cells ChEMBL. 12361388
IC50 (binding) = 2.4 uM Inhibitory activity against Human MDR1 P-Glycoprotein ABC Transporter using leukemia CEM cells ChEMBL. 12361387
IC50 (binding) > 10 uM Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells ChEMBL. 12361388

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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