Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.1684 | 0.7089 | 0.7089 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0025 | 0.0032 | 0.0032 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0095 | 0.033 | 0.033 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0018 | 0.0002 | 0.0002 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.003 | 0.0054 | 0.0054 |
Schistosoma mansoni | tyrosine kinase | 0.0095 | 0.033 | 0.033 |
Echinococcus multilocularis | c src tyrosine kinase | 0.003 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0025 | 0.0032 | 0.0032 |
Schistosoma mansoni | tyrosine kinase | 0.0095 | 0.033 | 0.033 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.003 | 0.0054 | 0.0054 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.003 | 0.0054 | 0.0054 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0002 | 0.0002 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0083 | 0.0278 | 0.0278 |
Trichomonas vaginalis | STE family protein kinase | 0.1684 | 0.7089 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.046 | 0.1884 | 0.1884 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0095 | 0.033 | 0.033 |
Brugia malayi | thymidylate synthase | 0.046 | 0.1884 | 0.1884 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0078 | 0.0256 | 0.0256 |
Echinococcus multilocularis | tyrosine kinase | 0.0018 | 0.0002 | 0.0002 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0018 | 0.0002 | 0.0002 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.1684 | 0.7089 | 0.7089 |
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.1684 | 0.7089 | 0.7089 |
Trichomonas vaginalis | STE family protein kinase | 0.1684 | 0.7089 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.007 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | TK protein kinase | 0.0083 | 0.0278 | 0.0278 |
Brugia malayi | hypothetical protein | 0.0219 | 0.0858 | 0.0858 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0025 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0032 | 0.0032 |
Echinococcus granulosus | thymidylate synthase | 0.046 | 0.1884 | 0.1884 |
Schistosoma mansoni | dihydrofolate reductase | 0.2368 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.1684 | 0.7089 | 0.7089 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0095 | 0.033 | 0.033 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0095 | 0.033 | 0.033 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0002 | 0.0002 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2368 | 1 | 1 |
Brugia malayi | SRC-1 | 0.0095 | 0.033 | 0.033 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0083 | 0.0278 | 0.0278 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0095 | 0.033 | 0.033 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0018 | 0.0002 | 0.0002 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1482 | 0.6229 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.046 | 0.1884 | 0.1884 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.007 | 0.0224 | 0.0224 |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.0002 | 0.0002 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0025 | 0.0032 | 0.0032 |
Brugia malayi | SH2 domain containing protein | 0.0018 | 0.0002 | 0.0002 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0078 | 0.0256 | 0.0256 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1482 | 0.6229 | 0.5 |
Giardia lamblia | Kinase, STE STE20 | 0.1684 | 0.7089 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0095 | 0.033 | 0.033 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.0002 | 0.0002 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0018 | 0.0002 | 0.0002 |
Brugia malayi | Variant SH3 domain containing protein | 0.0025 | 0.0032 | 0.0032 |
Echinococcus granulosus | NCK adaptor protein | 0.0025 | 0.0032 | 0.0032 |
Brugia malayi | protein-tyrosine kinase | 0.0083 | 0.0278 | 0.0278 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.1684 | 0.7089 | 0.7089 |
Echinococcus granulosus | c src tyrosine kinase | 0.003 | 0.0054 | 0.0054 |
Schistosoma mansoni | tyrosine kinase | 0.003 | 0.0054 | 0.0054 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.002 | 0.0011 | 0.0011 |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.1684 | 0.7089 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0018 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0018 | 0.0002 | 0.0002 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.003 | 0.0054 | 0.0054 |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.0002 | 0.0002 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0024 | 0.0027 | 0.1125 |
Echinococcus granulosus | dihydrofolate reductase | 0.2368 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.2368 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2368 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2368 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0106 | 0.0377 | 0.0377 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.046 | 0.1884 | 0.1884 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0095 | 0.033 | 0.033 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1482 | 0.6229 | 0.862 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.0002 | 0.0002 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1482 | 0.6229 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0023 | 0.0025 | 0.0126 | |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0095 | 0.033 | 0.033 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0095 | 0.033 | 0.033 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0083 | 0.0278 | 0.0278 |
Echinococcus granulosus | tyrosine kinase | 0.0083 | 0.0278 | 0.0278 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.0002 | 0.0002 |
Schistosoma mansoni | nck2/grb4 | 0.0025 | 0.0032 | 0.0032 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.0002 | 0.0002 |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.0002 | 0.0002 |
Trichomonas vaginalis | STE family protein kinase | 0.1684 | 0.7089 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.003 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.046 | 0.1884 | 1 | |
Brugia malayi | Variant SH3 domain containing protein | 0.0025 | 0.0032 | 0.0032 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0095 | 0.033 | 0.033 |
Echinococcus granulosus | roundabout 2 | 0.002 | 0.0011 | 0.0011 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0095 | 0.033 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.002 | 0.0011 | 0.0011 |
Entamoeba histolytica | protein kinase, putative | 0.007 | 0.0224 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0025 | 0.0032 | 0.0032 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0018 | 0.0002 | 0.0002 |
Echinococcus multilocularis | roundabout 2 | 0.002 | 0.0011 | 0.0011 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0095 | 0.033 | 0.033 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0083 | 0.0278 | 0.0278 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2368 | 1 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0022 | 0.0022 | 0.0022 |
Schistosoma mansoni | nephrin | 0.002 | 0.0011 | 0.0011 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0018 | 0.0002 | 0.0002 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0025 | 0.0032 | 0.0032 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0025 | 0.0032 | 0.0032 |
Entamoeba histolytica | protein kinase, putative | 0.0024 | 0.0027 | 0.1125 |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0011 | 0.0011 |
Echinococcus granulosus | neuroglian | 0.002 | 0.0011 | 0.0011 |
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.1684 | 0.7089 | 1 |
Echinococcus granulosus | twitchin | 0.0031 | 0.0058 | 0.0058 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.1684 | 0.7089 | 1 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.007 | 0.0224 | 0.0224 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0095 | 0.033 | 0.033 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0095 | 0.033 | 0.033 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2368 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.003 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.0002 | 0.0002 |
Schistosoma mansoni | adapter molecule crk | 0.0025 | 0.0032 | 0.0032 |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.0002 | 0.0002 |
Echinococcus multilocularis | NCK adaptor protein | 0.0025 | 0.0032 | 0.0032 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.046 | 0.1884 | 0.1123 |
Echinococcus multilocularis | neuroglian | 0.002 | 0.0011 | 0.0011 |
Echinococcus granulosus | tyrosine kinase | 0.0018 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | SRC-1 | 0.0095 | 0.033 | 0.033 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0095 | 0.033 | 0.033 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0025 | 0.0032 | 0.0032 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0022 | 0.0022 | 0.0022 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0095 | 0.033 | 0.033 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0083 | 0.0278 | 0.0278 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2368 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0018 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.0002 | 0.0002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2803 uM | Anti-thrombin activity by competitive enzyme assay using the fluorogenic substrate Tos-Gly-Pro-Arg-AMC at pH 8.3. | ChEMBL. | 9873411 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.