Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | opsin-like receptor | 0.0106 | 0.0187 | 0.0187 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | histamine h1 receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | neuropeptide receptor | 0.0106 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | carboxylesterase | 0.0397 | 1 | 1 |
Schistosoma mansoni | amine GPCR | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | biogenic amine receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0106 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0397 | 1 | 1 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | adenoreceptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0106 | 0.0187 | 0.0187 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0106 | 0.0187 | 0.0187 |
Echinococcus multilocularis | acetylcholinesterase | 0.0397 | 1 | 1 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | amine GPCR | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | amine GPCR | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | amine GPCR | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0106 | 0.0187 | 0.0187 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0106 | 0.0187 | 0.0187 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0397 | 1 | 1 |
Schistosoma mansoni | biogenic amine receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0106 | 0.0187 | 0.0187 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0106 | 0.0187 | 0.0187 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | myosin xvIII | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0106 | 0.0187 | 0.0187 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0106 | 0.0187 | 0.0187 |
Echinococcus granulosus | carboxylesterase 5A | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0397 | 1 | 1 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0106 | 0.0187 | 0.0187 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0106 | 0.0187 | 0.0187 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0397 | 1 | 1 |
Schistosoma mansoni | amine GPCR | 0.0106 | 0.0187 | 0.0187 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | biogenic amine receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0397 | 1 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0106 | 0.0187 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0106 | 0.0187 | 0.5 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | opsin-like receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | neuropeptide receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0106 | 0.0187 | 0.0187 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | opsin-like receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0106 | 0.0187 | 0.0187 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | neuropeptide receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | neuropeptide receptor | 0.0106 | 0.0187 | 0.0187 |
Echinococcus granulosus | acetylcholinesterase | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0397 | 1 | 1 |
Onchocerca volvulus | 0.0106 | 0.0187 | 0.5 | |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0106 | 0.0187 | 0.0187 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0106 | 0.0187 | 0.0187 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16.676 nM | Inhibition of the NNRTI HIV-1 enzyme by 50% using enzyme assay. | ChEMBL. | 11212098 |
IC50 (binding) | = 16.676 nM | Inhibition of the NNRTI HIV-1 enzyme by 50% using enzyme assay. | ChEMBL. | 11212098 |
IC90 (functional) | > 1400 nM | Antiviral activity against HIV-1 in MT-2 (human leukaemia) cells in vitro. | ChEMBL. | 11212098 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.