Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.4136 | 0.4136 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0085 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.4136 | 0.4136 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0085 | 1 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0085 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.4136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.4136 | 0.4136 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0085 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.4136 | 0.4136 |
Echinococcus multilocularis | laminin | 0.0085 | 1 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0085 | 1 | 1 |
Echinococcus granulosus | laminin | 0.0085 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.4136 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.1073 | 0.1073 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.4136 | 0.4136 |
Echinococcus multilocularis | fibrillin 1 | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0085 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0085 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.4136 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0085 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 67.4555 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.