Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | elastase, neutrophil expressed | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | transmembrane protease serine 3 | elastase, neutrophil expressed | 267 aa | 236 aa | 27.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0212 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0099 | 0.4335 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0212 | 1 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0212 | 1 | 1 |
Giardia lamblia | Cgi67 serine protease precursor-like protein | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0212 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.4335 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0212 | 1 | 1 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0212 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0099 | 0.4335 | 1 |
Schistosoma mansoni | amidase | 0.0099 | 0.4335 | 1 |
Toxoplasma gondii | esterase/lipase/thioesterase domain-containing protein | 0.0012 | 0 | 0.5 |
Toxoplasma gondii | phospholipase/carboxylesterase | 0.0012 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0212 | 1 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0212 | 1 | 1 |
Plasmodium vivax | PST-A protein | 0.0212 | 1 | 1 |
Leishmania major | monoglyceride lipase, putative | 0.0212 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0099 | 0.4335 | 1 |
Chlamydia trachomatis | hydrolase | 0.0012 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0212 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0099 | 0.4335 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0212 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0099 | 0.4335 | 1 |
Toxoplasma gondii | phospholipase | 0.0012 | 0 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0212 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0212 | 1 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0212 | 1 | 1 |
Brugia malayi | amidase | 0.0099 | 0.4335 | 1 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0212 | 1 | 1 |
Toxoplasma gondii | peptidase S15, putative | 0.0012 | 0 | 0.5 |
Toxoplasma gondii | protein c14orf29, putative | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0212 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0212 | 1 | 1 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.0012 | 0 | 0.5 |
Chlamydia trachomatis | acyltransferase family protein | 0.0012 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0212 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0012 | 0 | 0.5 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.0012 | 0 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0212 | 1 | 1 |
Plasmodium falciparum | esterase, putative | 0.0212 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0012 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 16 nM | Inhibitory activity against Human Neutrophil Elastase using acute lung injury model (ALIM) assay | ChEMBL. | 9191965 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.