Detailed information for compound 1747197

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 470.495 | Formula: C23H22N2O7S
  • H donors: 1 H acceptors: 5 LogP: 3.11 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)C)[N+](=O)[O-])O[C@H]1[C@H](Cc2ccccc2)NS(=O)(=O)[C@@H]2[C@@]31C=C[C@@H](O3)C2
  • InChi: 1S/C23H22N2O7S/c1-14-11-16(7-8-19(14)25(27)28)22(26)31-21-18(12-15-5-3-2-4-6-15)24-33(29,30)20-13-17-9-10-23(20,21)32-17/h2-11,17-18,20-21,24H,12-13H2,1H3/t17-,18+,20+,21+,23-/m1/s1
  • InChiKey: NSCMGPQZHUCTNP-JWKIXQPRSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0847 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1161 0.1161
Trypanosoma cruzi cysteine peptidase, putative 0.0847 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0156 0.1161 0.1161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0847 1 1
Loa Loa (eye worm) hypothetical protein 0.0567 0.6417 0.6417
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0156 0.1161 0.1161
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1161 0.1161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.4744 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0847 1 1
Echinococcus multilocularis cathepsin b 0.0156 0.1161 0.1161
Schistosoma mansoni cathepsin S (C01 family) 0.0156 0.1161 0.1161
Entamoeba histolytica cysteine proteinase, putative 0.0436 0.4744 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.4744 0.4054
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0156 0.1161 0.1161
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Giardia lamblia Cysteine protease 0.0156 0.1161 0.5
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0436 0.4744 0.4054
Trypanosoma cruzi cysteine proteinase, putative 0.0436 0.4744 0.4054
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Onchocerca volvulus 0.0847 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0847 1 1
Giardia lamblia Cathepsin B precursor 0.0156 0.1161 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0847 1 1
Echinococcus granulosus cathepsin L 0.0436 0.4744 0.4744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.028 0.2744 0.2744
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0847 1 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.1161 0.1161
Echinococcus granulosus cathepsin L 0.0156 0.1161 0.1161
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0436 0.4744 0.4054
Loa Loa (eye worm) hypothetical protein 0.0847 1 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0156 0.1161 0.5
Giardia lamblia Hypothetical protein 0.0156 0.1161 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.4744 0.4054
Echinococcus granulosus cathepsin L cysteine protease 0.0436 0.4744 0.4744
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0847 1 1
Brugia malayi cathepsin L precursor 0.0156 0.1161 0.1161
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1161 0.1161
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0436 0.4744 0.4054
Brugia malayi Cathepsin L-like precursor 0.0847 1 1
Plasmodium vivax vivapain-1 0.0436 0.4744 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.4744 0.4054
Giardia lamblia Hypothetical protein 0.0156 0.1161 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0847 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0156 0.1161 0.1161
Loa Loa (eye worm) fibroinase 0.0847 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0847 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.1161 0.5
Brugia malayi Cathepsin L-like precursor 0.028 0.2744 0.2744
Toxoplasma gondii cathepsin CPL 0.0847 1 1
Giardia lamblia Cathepsin L-like protease 0.0156 0.1161 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0847 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0847 1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.2066 0.2066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0567 0.6417 0.5946
Giardia lamblia Cathepsin B precursor 0.0156 0.1161 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0847 1 1
Loa Loa (eye worm) cathepsin B 0.0156 0.1161 0.1161
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0847 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.028 0.2744 0.2744
Leishmania major cathepsin L-like protease 0.0847 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1161 0.1161
Leishmania major cathepsin L-like protease 0.0847 1 1
Giardia lamblia Cathepsin B precursor 0.0156 0.1161 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0847 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0156 0.1161 0.1161
Onchocerca volvulus 0.0847 1 1
Giardia lamblia Cathepsin L precursor 0.0156 0.1161 0.5
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Loa Loa (eye worm) hypothetical protein 0.0567 0.6417 0.6417
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Echinococcus multilocularis cysteine protease 0.0847 1 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.1161 0.1161
Giardia lamblia Cathepsin L precursor 0.0156 0.1161 0.5
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.2066 0.2066
Loa Loa (eye worm) hypothetical protein 0.028 0.2744 0.2744
Giardia lamblia Cysteine protease 0.0156 0.1161 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0847 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0436 0.4744 0.4054
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0156 0.1161 0.1161
Giardia lamblia Cathepsin B precursor 0.0156 0.1161 0.5
Echinococcus granulosus cathepsin l1 0.0847 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0847 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0436 0.4744 0.4744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Loa Loa (eye worm) cysteine protease 0.0847 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Giardia lamblia Encystation-specific protease 0.0156 0.1161 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.028 0.2744 0.1791
Schistosoma mansoni cathepsin C 0.0156 0.1161 0.1161
Brugia malayi Cathepsin L-like precursor 0.0847 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0847 1 1
Onchocerca volvulus 0.0847 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0847 1 1
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Onchocerca volvulus 0.0847 1 1
Plasmodium vivax unspecified product 0.0436 0.4744 0.4054
Trypanosoma cruzi cysteine proteinase, putative 0.0436 0.4744 0.4054
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0436 0.4744 0.4744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0847 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0156 0.1161 0.1161
Brugia malayi Cathepsin L-like precursor 0.0847 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.1161 0.1161
Echinococcus multilocularis cathepsin L 0.0156 0.1161 0.1161
Loa Loa (eye worm) hypothetical protein 0.0156 0.1161 0.1161
Brugia malayi cathepsin L-like cysteine proteinase 0.0156 0.1161 0.1161
Echinococcus granulosus cathepsin l1 0.0567 0.6417 0.6417
Brugia malayi Cathepsin L-like precursor 0.0567 0.6417 0.6417
Leishmania major cathepsin L-like protease 0.0847 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0847 1 1
Echinococcus granulosus cysteine protease 0.0436 0.4744 0.4744
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.1161 0.1161
Plasmodium vivax vivapain-2 0.0847 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.1161 0.1161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0847 1 1
Loa Loa (eye worm) hypothetical protein 0.028 0.2744 0.2744
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1161 0.1161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0847 1 1
Giardia lamblia Cathepsin L precursor 0.0156 0.1161 0.5
Onchocerca volvulus Cathepsin F homolog 0.0847 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0567 0.6417 0.6417
Onchocerca volvulus 0.0847 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0847 1 1
Echinococcus granulosus cathepsin b 0.0156 0.1161 0.1161
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0847 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0847 1 1
Brugia malayi Cathepsin L-like precursor 0.0567 0.6417 0.6417
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0847 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1161 0.1161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0847 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.028 0.2744 0.2744
Brugia malayi Papain family cysteine protease containing protein 0.0436 0.4744 0.4744
Loa Loa (eye worm) hypothetical protein 0.028 0.2744 0.2744
Echinococcus granulosus cathepsin l cysteine peptidase 0.0847 1 1
Brugia malayi cathepsin L-like precursor 0.0567 0.6417 0.6417
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0847 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0847 1 1
Giardia lamblia Cathepsin L precursor 0.0156 0.1161 0.5
Loa Loa (eye worm) hypothetical protein 0.0156 0.1161 0.1161
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.1161 0.5
Giardia lamblia Cathepsin B precursor 0.0156 0.1161 0.5
Loa Loa (eye worm) hypothetical protein 0.0567 0.6417 0.6417
Echinococcus multilocularis cathepsin b 0.0156 0.1161 0.1161
Trypanosoma cruzi cysteine protease, putative 0.0436 0.4744 0.4054
Leishmania major cathepsin L-like protease 0.0847 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0567 0.6417 0.5946
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1161 0.1161
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.4744 0.4054
Entamoeba histolytica cysteine proteinase 2 0.0436 0.4744 0.4054
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Brugia malayi cathepsin Z-like cysteine proteinase 0.0156 0.1161 0.1161
Trypanosoma cruzi cysteine peptidase, putative 0.0847 1 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.1161 0.1161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0847 1 1
Onchocerca volvulus Cathepsin L homolog 0.0847 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0436 0.4744 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0436 0.4744 0.4744
Entamoeba histolytica cysteine protease, putative 0.0847 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1161 0.1161
Entamoeba histolytica cysteine proteinase, putative 0.0567 0.6417 0.5946
Trypanosoma cruzi cruzipain precursor, putative 0.0847 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0567 0.6417 0.5946
Schistosoma mansoni cathepsin s 0.028 0.2744 0.2744
Leishmania major cathepsin L-like protease 0.0847 1 1
Brugia malayi fibroinase precursor 0.0156 0.1161 0.1161
Giardia lamblia Cathepsin B precursor 0.0156 0.1161 0.5
Leishmania major cysteine peptidase A (CPA) 0.0847 1 1
Leishmania major cathepsin L-like protease 0.0847 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0847 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Giardia lamblia Cathepsin B precursor 0.0156 0.1161 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0847 1 1
Leishmania major cathepsin L-like protease 0.0847 1 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0156 0.1161 0.1161
Loa Loa (eye worm) hypothetical protein 0.0156 0.1161 0.1161
Trypanosoma cruzi cysteine peptidase, putative 0.0847 1 1
Echinococcus multilocularis cysteine protease 0.0847 1 1
Giardia lamblia Cathepsin L precursor 0.0156 0.1161 0.5
Schistosoma mansoni hypothetical protein 0.035 0.3642 0.3642
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.1161 0.1161
Brugia malayi Papain family cysteine protease containing protein 0.0436 0.4744 0.4744
Giardia lamblia Cysteine protease 0.0156 0.1161 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0436 0.4744 0.4054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0847 1 1
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Onchocerca volvulus 0.0567 0.6417 0.5946
Echinococcus multilocularis cathepsin L cysteine protease 0.0847 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.1161 0.1161
Loa Loa (eye worm) ctsf protein 0.0847 1 1
Giardia lamblia Cathepsin B precursor 0.0156 0.1161 0.5
Loa Loa (eye worm) hypothetical protein 0.0156 0.1161 0.1161
Onchocerca volvulus 0.0847 1 1
Brugia malayi Cathepsin L-like precursor 0.0847 1 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0156 0.1161 0.1161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0847 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1161 0.1161
Plasmodium vivax unspecified product 0.028 0.2744 0.1791
Echinococcus granulosus cathepsin b 0.0156 0.1161 0.1161
Leishmania major cathepsin L-like protease 0.0847 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0156 0.1161 0.1161
Giardia lamblia Cathepsin L precursor 0.0156 0.1161 0.5
Giardia lamblia Cathepsin L-like protease 0.0156 0.1161 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Echinococcus multilocularis cathepsin L 0.0436 0.4744 0.4744
Schistosoma mansoni cathepsin F (C01 family) 0.0567 0.6417 0.6417
Brugia malayi Cathepsin L-like precursor 0.0847 1 1
Entamoeba histolytica cysteine protease, putative 0.0436 0.4744 0.4054
Onchocerca volvulus 0.0847 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.028 0.2744 0.1791
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.1161 0.5
Plasmodium vivax vivapain-2 0.0847 1 1
Plasmodium vivax vivapain-3 0.0436 0.4744 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0847 1 1
Giardia lamblia Cysteine protease 0.0156 0.1161 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0847 1 1
Onchocerca volvulus Cathepsin L homolog 0.0847 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0847 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0847 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0156 0.1161 0.1161

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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