Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.6723 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.6723 | 1 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0269 | 0.0232 | 0.0206 |
Loa Loa (eye worm) | carboxylesterase | 0.6723 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1136 | 0.1544 | 0.1522 |
Schistosoma mansoni | gliotactin | 0.1136 | 0.1544 | 0.1522 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.1136 | 0.1544 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.6723 | 1 | 1 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0176 | 0.0091 | 0.0065 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1136 | 0.1544 | 0.1522 |
Brugia malayi | Carboxylesterase family protein | 0.1136 | 0.1544 | 0.1522 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0176 | 0.0091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1136 | 0.1544 | 0.1522 |
Schistosoma mansoni | glutaminase | 0.0269 | 0.0232 | 0.0206 |
Loa Loa (eye worm) | carboxylesterase | 0.1136 | 0.1544 | 0.1522 |
Loa Loa (eye worm) | glutaminase | 0.0269 | 0.0232 | 0.0206 |
Brugia malayi | Carboxylesterase family protein | 0.1136 | 0.1544 | 0.1522 |
Echinococcus granulosus | carboxylesterase 5A | 0.6723 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.1136 | 0.1544 | 0.1522 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.1136 | 0.1544 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1136 | 0.1544 | 0.1522 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.1136 | 0.1544 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.1136 | 0.1544 | 0.1522 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.6723 | 1 | 1 |
Leishmania major | N-myristoyl transferase, putative | 0.0176 | 0.0091 | 0.5 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0176 | 0.0091 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.1136 | 0.1544 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1136 | 0.1544 | 0.1522 |
Echinococcus multilocularis | acetylcholinesterase | 0.6723 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1136 | 0.1544 | 1 |
Onchocerca volvulus | 0.1136 | 0.1544 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1136 | 0.1544 | 0.1522 |
Echinococcus multilocularis | neuroligin | 0.1136 | 0.1544 | 0.1522 |
Giardia lamblia | CDC72 | 0.0176 | 0.0091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1136 | 0.1544 | 0.1522 |
Loa Loa (eye worm) | hypothetical protein | 0.6723 | 1 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0176 | 0.0091 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.6723 | 1 | 1 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0176 | 0.0091 | 0.0065 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.1136 | 0.1544 | 0.1522 |
Onchocerca volvulus | 0.1136 | 0.1544 | 1 | |
Onchocerca volvulus | 0.1136 | 0.1544 | 1 | |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0176 | 0.0091 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.6723 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.1136 | 0.1544 | 0.1522 |
Onchocerca volvulus | 0.1136 | 0.1544 | 1 | |
Loa Loa (eye worm) | glutaminase 2 | 0.0269 | 0.0232 | 0.0206 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0176 | 0.0091 | 0.059 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.1136 | 0.1544 | 0.1522 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0176 | 0.0091 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.1136 | 0.1544 | 0.1522 |
Echinococcus granulosus | acetylcholinesterase | 0.6723 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1136 | 0.1544 | 0.1522 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1136 | 0.1544 | 0.1522 |
Schistosoma mansoni | N-myristoyltransferase | 0.0176 | 0.0091 | 0.0065 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0176 | 0.0091 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.6723 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.1136 | 0.1544 | 0.1522 |
Echinococcus granulosus | neuroligin | 0.1136 | 0.1544 | 0.1522 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0176 | 0.0091 | 0.0065 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.1136 | 0.1544 | 0.1522 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1136 | 0.1544 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1136 | 0.1544 | 0.1522 |
Onchocerca volvulus | 0.1136 | 0.1544 | 1 | |
Brugia malayi | N-myristoyltransferase 2 | 0.0176 | 0.0091 | 0.0065 |
Trichomonas vaginalis | glutaminase, putative | 0.0269 | 0.0232 | 0.1503 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.1136 | 0.1544 | 0.1522 |
Echinococcus granulosus | BC026374 protein S09 family | 0.1136 | 0.1544 | 0.1522 |
Trypanosoma brucei | N-myristoyltransferase | 0.0176 | 0.0091 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1136 | 0.1544 | 0.1522 |
Loa Loa (eye worm) | hypothetical protein | 0.1136 | 0.1544 | 0.1522 |
Loa Loa (eye worm) | hypothetical protein | 0.1136 | 0.1544 | 0.1522 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 38 uM | Anti-thrombin activity by competitive enzyme assay using the fluorogenic substrate Tos-Gly-Pro-Arg-AMC at pH 8.3. | ChEMBL. | 9873411 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.