Detailed information for compound 1747505

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2562.35 | Formula: C104H104Na8O48S8
  • H donors: 24 H acceptors: 32 LogP: 2.18 Rotable bonds: 32
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC1[C@@H]2O[C@H]3OC(CSc4ccccc4C(=O)[O-])[C@H](C(C3O)O)O[C@H]3OC(CSc4ccccc4C(=O)[O-])[C@H](C(C3O)O)O[C@H]3OC(CSc4ccccc4C(=O)[O-])[C@H](C(C3O)O)O[C@H]3OC([C@@H](O[C@H]4OC([C@@H](O[C@H]5OC([C@@H](O[C@H]6OC([C@@H](O[C@H](C1O)OC2CSc1ccccc1C(=O)[O-])C(O)C6O)CSc1ccccc1C(=O)[O-])C(O)C5O)CSc1ccccc1C(=O)[O-])C(O)C4O)CSc1ccccc1C(=O)[O-])C(C3O)O)CSc1ccccc1C(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
  • InChi: 1S/C104H112O48S8.8Na/c105-65-73(113)97-137-49(33-153-57-25-9-1-17-41(57)89(121)122)81(65)145-98-74(114)66(106)83(51(138-98)35-155-59-27-11-3-19-43(59)91(125)126)147-100-76(116)68(108)85(53(140-100)37-157-61-29-13-5-21-45(61)93(129)130)149-102-78(118)70(110)87(55(142-102)39-159-63-31-15-7-23-47(63)95(133)134)151-104-80(120)72(112)88(56(144-104)40-160-64-32-16-8-24-48(64)96(135)136)152-103-79(119)71(111)86(54(143-103)38-158-62-30-14-6-22-46(62)94(131)132)150-101-77(117)69(109)84(52(141-101)36-156-60-28-12-4-20-44(60)92(127)128)148-99-75(115)67(107)82(146-97)50(139-99)34-154-58-26-10-2-18-42(58)90(123)124;;;;;;;;/h1-32,49-56,65-88,97-120H,33-40H2,(H,121,122)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,133,134)(H,135,136);;;;;;;;/q;8*+1/p-8/t49?,50?,51?,52?,53?,54?,55?,56?,65?,66?,67?,68?,69?,70?,71?,72?,73?,74?,75?,76?,77?,78?,79?,80?,81-,82-,83-,84-,85-,86-,87-,88-,97-,98-,99-,100-,101-,102-,103-,104-;;;;;;;;/m1......../s1
  • InChiKey: QZVDQPPUUXFNQM-FNSDMAFESA-F  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis SH2 motif 0.0306 0.5248 0.4527
Loa Loa (eye worm) TK/FER protein kinase 0.0512 1 1
Onchocerca volvulus 0.0306 0.5248 0.3264
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0206 0.2946 0.1876
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0206 0.2946 0.2669
Echinococcus granulosus tyrosine kinase 0.0512 1 1
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Schistosoma mansoni tyrosine kinase 0.0512 1 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0206 0.2946 0.1876
Echinococcus multilocularis tyrosine protein kinase 0.0206 0.2946 0.1876
Brugia malayi Tyrosine-protein kinase abl-1 0.0512 1 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0206 0.2946 0.1876
Brugia malayi cytokine inducible SH2-containing protein 5 0.0306 0.5248 0.3264
Echinococcus multilocularis tensin 0.0306 0.5248 0.4527
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0512 1 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0512 1 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Brugia malayi Protein kinase domain containing protein 0.0512 1 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0206 0.2946 0.1876
Echinococcus multilocularis 0.0306 0.5248 0.4527
Echinococcus multilocularis growth factor receptor bound protein 2 0.0306 0.5248 0.4527
Schistosoma mansoni tyrosine kinase 0.0512 1 1
Echinococcus multilocularis activin receptor type 0.0206 0.2946 0.1876
Schistosoma mansoni hypothetical protein 0.0206 0.2946 0.2669
Brugia malayi hypothetical protein 0.0512 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0206 0.2946 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Brugia malayi hypothetical protein 0.0306 0.5248 0.3264
Echinococcus multilocularis epidermal growth factor receptor 0.0206 0.2946 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0206 0.2946 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Plasmodium falciparum protein kinase, putative 0.0206 0.2946 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0512 1 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Onchocerca volvulus 0.0306 0.5248 0.3264
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus SH2 domain containing protein 7 0.0306 0.5248 0.4527
Echinococcus granulosus protein kinase 0.0206 0.2946 0.1876
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0306 0.5248 0.5062
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0306 0.5248 0.4527
Toxoplasma gondii protein kinase domain-containing protein 0.0206 0.2946 0.5
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0206 0.2946 0.5
Schistosoma mansoni tyrosine kinase 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0206 0.2946 0.1876
Echinococcus granulosus raf serine:threonine protein kinase 0.0206 0.2946 0.1876
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.2946 1
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.2946 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0512 1 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis protein kinase atn1, putative 0.0206 0.2946 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0512 1 1
Plasmodium vivax protein kinase, putative 0.0206 0.2946 0.5
Echinococcus granulosus insulin receptor 0.0206 0.2946 0.1876
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0206 0.2946 0.1876
Loa Loa (eye worm) SRC-1 0.0512 1 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0206 0.2946 0.1876
Giardia lamblia Kinase 0.0206 0.2946 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0206 0.2946 0.2669
Schistosoma mansoni suppressor of cytokine signaling 0.0306 0.5248 0.5062
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Plasmodium falciparum protein kinase, putative 0.0206 0.2946 0.5
Echinococcus granulosus growth factor receptor bound protein 2 0.0306 0.5248 0.4527
Onchocerca volvulus 0.0512 1 1
Entamoeba histolytica protein kinase, putative 0.0306 0.5248 0.3264
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0512 1 1
Onchocerca volvulus 0.0512 1 1
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0206 0.2946 0.1876
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.2946 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0512 1 1
Brugia malayi Variant SH3 domain containing protein 0.0306 0.5248 0.3264
Brugia malayi Variant SH3 domain containing protein 0.0306 0.5248 0.3264
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Schistosoma mansoni tyrosine kinase 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Loa Loa (eye worm) TK/FER protein kinase 0.0512 1 1
Trichomonas vaginalis TK family protein kinase 0.0206 0.2946 1
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Schistosoma mansoni serine/threonine RGC 0.0206 0.2946 0.2669
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Schistosoma mansoni protein tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus multilocularis tyrosine kinase 0.0206 0.2946 0.1876
Brugia malayi RhoGAP domain containing protein 0.0306 0.5248 0.3264
Onchocerca volvulus 0.0306 0.5248 0.3264
Schistosoma mansoni protein kinase 0.0206 0.2946 0.2669
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus granulosus activated cdc42 kinase 1 0.0206 0.2946 0.1876
Schistosoma mansoni protein kinase 0.0206 0.2946 0.2669
Echinococcus granulosus tyrosine protein kinase Src42A 0.0512 1 1
Onchocerca volvulus 0.0306 0.5248 0.3264
Schistosoma mansoni suppressor of cytokine signaling 0.0306 0.5248 0.5062
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0206 0.2946 0.1876
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0206 0.2946 1
Echinococcus granulosus tyrosine kinase 0.0206 0.2946 0.1876
Echinococcus granulosus receptor type guanylyl cyclase 0.0206 0.2946 0.1876
Echinococcus multilocularis c src tyrosine kinase 0.0512 1 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0206 0.2946 0.2669
Onchocerca volvulus 0.0306 0.5248 0.3264
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Echinococcus multilocularis kinase suppressor of Ras 1 0.0206 0.2946 0.1876
Echinococcus granulosus retinal guanylyl cyclase 2 0.0206 0.2946 0.1876
Echinococcus multilocularis insulin receptor 0.0206 0.2946 0.1876
Echinococcus granulosus tyrosine protein kinase ABL1 0.0512 1 1
Toxoplasma gondii protein kinase 0.0206 0.2946 0.5
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0306 0.5248 0.4527
Echinococcus granulosus activated cdc42 kinase 1 0.0206 0.2946 0.1876
Schistosoma mansoni growth factor receptor-bound protein 0.0306 0.5248 0.5062
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0206 0.2946 0.1876
Echinococcus granulosus retinal guanylyl cyclase 2 0.0206 0.2946 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Plasmodium falciparum tyrosine kinase-like protein 0.0206 0.2946 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0512 1 1
Schistosoma mansoni protein kinase 0.0206 0.2946 0.2669
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0306 0.5248 0.4527
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Plasmodium falciparum protein kinase, putative 0.0206 0.2946 0.5
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0306 0.5248 0.5062
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Brugia malayi Protein kinase domain containing protein 0.0512 1 1
Echinococcus multilocularis SH2 motif 0.0306 0.5248 0.4527
Brugia malayi SH2 domain containing protein 0.0306 0.5248 0.3264
Giardia lamblia Kinase, NEK 0.0206 0.2946 1
Onchocerca volvulus 0.0512 1 1
Echinococcus multilocularis N chimaerin 0.0306 0.5248 0.4527
Giardia lamblia Protein 21.1 0.0206 0.2946 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0206 0.2946 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0206 0.2946 0.1876
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.2946 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0306 0.5248 0.3264
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0512 1 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0206 0.2946 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0306 0.5248 0.3264
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0306 0.5248 0.5062
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0306 0.5248 0.3264
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0206 0.2946 0.1876
Echinococcus granulosus tensin 0.0306 0.5248 0.4527
Trichomonas vaginalis protein tyrosine kinase, putative 0.0206 0.2946 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0206 0.2946 0.1876
Schistosoma mansoni tyrosine kinase 0.0512 1 1
Onchocerca volvulus 0.0512 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0512 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.2946 0.2669
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Brugia malayi SH2 domain containing protein 0.0512 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0306 0.5248 0.4527
Plasmodium vivax tyrosine kinase-like protein, putative 0.0206 0.2946 0.5
Echinococcus granulosus hypothetical protein 0.0306 0.5248 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus activin receptor type 0.0206 0.2946 0.1876
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0512 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0306 0.5248 0.3264
Loa Loa (eye worm) TK/ABL protein kinase 0.0512 1 1
Schistosoma mansoni tyrosine kinase 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Schistosoma mansoni GTPase activating protein 0.0306 0.5248 0.5062
Schistosoma mansoni protein kinase 0.0206 0.2946 0.2669
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0206 0.2946 0.1876
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Brugia malayi Protein kinase domain containing protein 0.0512 1 1
Echinococcus granulosus N chimaerin 0.0306 0.5248 0.4527
Echinococcus granulosus SH2 motif 0.0306 0.5248 0.4527
Echinococcus granulosus ephrin type A receptor 4 A 0.0206 0.2946 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0206 0.2946 0.1876
Trypanosoma cruzi protein kinase, putative 0.0206 0.2946 0.5
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Echinococcus multilocularis tyrosine protein kinase shark 0.0512 1 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0206 0.2946 0.1876
Echinococcus multilocularis epidermal growth factor receptor 0.0206 0.2946 0.1876
Trypanosoma cruzi protein kinase, putative 0.0206 0.2946 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0306 0.5248 0.3264
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0206 0.2946 0.1876
Schistosoma mansoni tensin-related 0.0306 0.5248 0.5062
Brugia malayi STAT protein, DNA binding domain containing protein 0.0306 0.5248 0.3264
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0306 0.5248 0.4527
Echinococcus multilocularis natriuretic peptide receptor 1 0.0206 0.2946 0.1876
Schistosoma mansoni nck2/grb4 0.0306 0.5248 0.5062
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0206 0.2946 0.1876
Echinococcus multilocularis SH2 domain containing protein 7 0.0306 0.5248 0.4527
Echinococcus multilocularis signal transduction protein lnk realted 0.0306 0.5248 0.4527
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus multilocularis activated cdc42 kinase 1 0.0206 0.2946 0.1876
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0206 0.2946 0.1876
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.2946 1
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus granulosus tyrosine protein kinase csk 0.0206 0.2946 0.1876
Echinococcus granulosus NCK adaptor protein 0.0306 0.5248 0.4527
Echinococcus multilocularis protein KINase family member (kin 25) 0.0206 0.2946 0.1876
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0206 0.2946 0.5
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus multilocularis SHC transforming protein 3 0.0306 0.5248 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Brugia malayi Variant SH3 domain containing protein 0.0306 0.5248 0.3264
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.2946 0.2669
Schistosoma mansoni lipoxygenase 0.0136 0.1317 0.0977
Echinococcus multilocularis transfer RNA-Thr 0.0206 0.2946 0.1876
Schistosoma mansoni vav2 0.0306 0.5248 0.5062
Leishmania major hypothetical protein, conserved 0.0206 0.2946 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0206 0.2946 1
Schistosoma mansoni growth factor receptor-bound protein 0.0306 0.5248 0.5062
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus multilocularis heat shock protein 70 0.0206 0.2946 0.1876
Echinococcus multilocularis raf serine:threonine protein kinase 0.0206 0.2946 0.1876
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Schistosoma mansoni adapter molecule crk 0.0306 0.5248 0.5062
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0206 0.2946 0.1876
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0306 0.5248 0.4527
Echinococcus multilocularis receptor type guanylyl cyclase 0.0206 0.2946 0.1876
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0206 0.2946 0.1876
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0306 0.5248 0.4527
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0306 0.5248 0.4527
Brugia malayi SRC-1 0.0512 1 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0206 0.2946 0.1876
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Schistosoma mansoni tensin 0.0306 0.5248 0.5062
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0512 1 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0206 0.2946 0.1876
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0206 0.2946 0.1876
Schistosoma mansoni hypothetical protein 0.0306 0.5248 0.5062
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0306 0.5248 0.4527
Loa Loa (eye worm) TK/FER protein kinase 0.0512 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0512 1 1
Echinococcus multilocularis tensin 0.0306 0.5248 0.4527
Echinococcus granulosus SH2 motif 0.0306 0.5248 0.4527
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0206 0.2946 0.1876
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0206 0.2946 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0206 0.2946 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0206 0.2946 0.5
Echinococcus granulosus suppressor of cytokine signaling 7 0.0306 0.5248 0.4527
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0512 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 1 1
Echinococcus granulosus expressed conserved protein 0.0306 0.5248 0.4527
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0306 0.5248 0.5062
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0306 0.5248 0.3264
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Schistosoma mansoni signal transduction protein lnk-related 0.0306 0.5248 0.5062
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0306 0.5248 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0206 0.2946 0.5
Schistosoma mansoni protein kinase 0.0206 0.2946 0.2669
Brugia malayi SH2 domain containing protein 0.0306 0.5248 0.3264
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0206 0.2946 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0512 1 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0206 0.2946 0.2669
Echinococcus multilocularis protein tyrosine kinase 0.0206 0.2946 0.1876
Brugia malayi SH2 domain containing protein 0.0306 0.5248 0.3264
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Brugia malayi SH2 domain containing protein 0.0306 0.5248 0.3264
Trypanosoma brucei Pseudokinase, putative 0.0206 0.2946 0.5
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0206 0.2946 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0306 0.5248 0.5062
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0512 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Echinococcus granulosus tyrosine protein kinase pr2 0.0206 0.2946 0.1876
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0306 0.5248 0.4527
Schistosoma mansoni tensin-related 0.0306 0.5248 0.5062
Loa Loa (eye worm) SH2 domain-containing protein 0.0306 0.5248 0.3264
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0306 0.5248 0.3264
Echinococcus multilocularis SH2 motif 0.0306 0.5248 0.4527
Brugia malayi Protein kinase domain containing protein 0.0512 1 1
Schistosoma mansoni tensin 0.0306 0.5248 0.5062
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 1 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0206 0.2946 0.1876
Echinococcus multilocularis tyrosine protein kinase Abl 0.0512 1 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0306 0.5248 0.3264
Echinococcus multilocularis tyrosine protein kinase HCK 0.0206 0.2946 0.1876
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Echinococcus multilocularis tyrosine protein kinase pr2 0.0206 0.2946 0.1876
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0306 0.5248 0.3264
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Schistosoma mansoni protein kinase 0.0206 0.2946 0.2669
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0206 0.2946 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Brugia malayi Variant SH3 domain containing protein 0.0306 0.5248 0.3264
Schistosoma mansoni hypothetical protein 0.0306 0.5248 0.5062
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0206 0.2946 0.1876
Schistosoma mansoni protein kinase 0.0206 0.2946 0.2669
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.2946 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0306 0.5248 0.3264
Schistosoma mansoni ephrin receptor 0.0206 0.2946 0.2669
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0306 0.5248 0.3264
Brugia malayi SH2 domain containing protein 0.0306 0.5248 0.3264
Leishmania major protein kinase, putative 0.0206 0.2946 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0206 0.2946 0.1876
Brugia malayi tRNA modification GTPase TrmE family protein 0.0306 0.5248 0.3264
Schistosoma mansoni protein kinase 0.0206 0.2946 0.2669
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0206 0.2946 0.1876
Echinococcus multilocularis integrin linked protein kinase 0.0206 0.2946 0.1876
Echinococcus granulosus SHC transforming protein 3 0.0306 0.5248 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0206 0.2946 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0512 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 1 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0206 0.2946 0.1876
Loa Loa (eye worm) TK/FER protein kinase 0.0512 1 1
Echinococcus multilocularis NCK adaptor protein 0.0306 0.5248 0.4527
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0306 0.5248 0.4527
Leishmania major protein kinase, putative 0.0206 0.2946 0.5
Trichomonas vaginalis AGC family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0206 0.2946 0.2669
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0206 0.2946 0.2669
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0306 0.5248 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus tyrosine protein kinase 0.0206 0.2946 0.1876
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus granulosus tyrosine protein kinase shark 0.0512 1 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Brugia malayi protein-tyrosine kinase 0.0512 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0206 0.2946 0.1876
Schistosoma mansoni ephrin receptor 0.0206 0.2946 0.2669
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus tyrosine kinase 0.0512 1 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0512 1 1
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.2946 0.2669
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Onchocerca volvulus 0.0512 1 1
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Schistosoma mansoni protein kinase 0.0206 0.2946 0.2669
Schistosoma mansoni shc transforming protein 0.0306 0.5248 0.5062
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0306 0.5248 0.4527
Onchocerca volvulus 0.0306 0.5248 0.3264
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0512 1 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Giardia lamblia Kinase, NEK 0.0206 0.2946 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0512 1 1
Plasmodium falciparum tyrosine kinase-like protein 0.0206 0.2946 0.5
Trypanosoma brucei protein kinase, putative 0.0206 0.2946 0.5
Echinococcus granulosus tyrosine protein kinase HCK 0.0206 0.2946 0.1876
Echinococcus granulosus c src tyrosine kinase 0.0512 1 1
Echinococcus multilocularis tyrosine kinase 0.0512 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.0306 0.5248 0.4527
Trichomonas vaginalis STE family protein kinase 0.0206 0.2946 1
Echinococcus granulosus epidermal growth factor receptor 0.0206 0.2946 0.1876
Trypanosoma brucei Flagellum attachment zone protein 20 0.0206 0.2946 0.5
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Brugia malayi SH2 domain containing protein 0.0512 1 1
Echinococcus multilocularis FL cytokine receptor 0.0206 0.2946 0.1876
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.2946 0.2669
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus granulosus tyrosine protein kinase Fyn 0.0512 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0306 0.5248 0.4527
Echinococcus granulosus integrin linked protein kinase 0.0206 0.2946 0.1876
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0206 0.2946 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0512 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0512 1 1
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0512 1 1
Toxoplasma gondii STE kinase 0.0206 0.2946 0.5
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0512 1 1
Echinococcus granulosus protein tyrosine kinase 0.0206 0.2946 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0306 0.5248 0.4527
Echinococcus granulosus kinase suppressor of Ras 1 0.0206 0.2946 0.1876
Schistosoma mansoni protein kinase 0.0206 0.2946 0.2669
Echinococcus granulosus epidermal growth factor receptor 0.0206 0.2946 0.1876
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0512 1 1
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Brugia malayi Tensin 0.0306 0.5248 0.3264
Brugia malayi SH2 domain containing protein 0.0306 0.5248 0.3264
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Echinococcus multilocularis tyrosine protein kinase Blk 0.0512 1 1
Loa Loa (eye worm) STAT protein 0.0306 0.5248 0.3264
Echinococcus granulosus signal transduction protein lnk realted 0.0306 0.5248 0.4527
Loa Loa (eye worm) TK/FER protein kinase 0.0512 1 1
Onchocerca volvulus 0.0512 1 1
Brugia malayi Sex muscle abnormal protein 5 0.0306 0.5248 0.3264
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Echinococcus multilocularis protein kinase 0.0206 0.2946 0.1876
Schistosoma mansoni tensin 0.0306 0.5248 0.5062
Schistosoma mansoni tyrosine protein kinase 0.0206 0.2946 0.2669
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0512 1 1
Echinococcus multilocularis protein kinase 0.0206 0.2946 0.1876
Loa Loa (eye worm) TK protein kinase 0.0512 1 1
Entamoeba histolytica SH2 domain containing protein 0.0306 0.5248 0.3264
Loa Loa (eye worm) SH2 domain-containing protein 0.0306 0.5248 0.3264
Schistosoma mansoni SH2A 0.0306 0.5248 0.5062
Loa Loa (eye worm) hypothetical protein 0.0306 0.5248 0.3264
Echinococcus granulosus tyrosine protein kinase csk 0.0206 0.2946 0.1876
Loa Loa (eye worm) TK/FER protein kinase 0.0512 1 1
Schistosoma mansoni tyrosine kinase 0.0206 0.2946 0.2669
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0206 0.2946 0.5
Brugia malayi SH2 domain containing protein 0.0306 0.5248 0.3264
Trichomonas vaginalis TKL family protein kinase 0.0206 0.2946 1
Schistosoma mansoni protein kinase 0.0206 0.2946 0.2669

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 226.7 uM In vitro reversal activity versus ~90% block by rocuronium in isolated mouse hemidiaphragm,expressed as effective conc. ChEMBL. 11960492
Max reversal (functional) = 42.3 % In vitro reversal activity versus ~90% block by rocuronium in isolated mouse hemidiaphragm,expressed as % of maximum reversal at 216 uM conc. ChEMBL. 11960492

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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