Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0292 | 0.8388 | 1 | |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0234 | 0.0279 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0023 | 0.0234 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0136 | 0.3661 | 0.8135 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.1069 | 0.2375 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0234 | 0.0279 |
Loa Loa (eye worm) | CBP-B | 0.0077 | 0.1857 | 0.2213 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0528 | 0.0361 | |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0234 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.4824 | 0.5751 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.3661 | 0.4364 |
Brugia malayi | Bromodomain containing protein | 0.0071 | 0.1693 | 0.2018 |
Echinococcus granulosus | acetylcholinesterase | 0.0136 | 0.3661 | 0.3661 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1069 | 0.1274 |
Echinococcus multilocularis | CREB binding protein | 0.0017 | 0.0052 | 0.0052 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0071 | 0.1693 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0071 | 0.1693 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0234 | 0.0279 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0234 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0234 | 0.0279 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0896 | 0.4541 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0175 | 0.4824 | 0.5629 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0535 | 0.119 |
Echinococcus granulosus | acetylcholinesterase | 0.0136 | 0.3661 | 0.3661 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0108 | 0.2815 | 0.6257 |
Echinococcus granulosus | geminin | 0.0164 | 0.45 | 0.45 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0234 | 0.0279 |
Toxoplasma gondii | bromodomain-containing protein | 0.0033 | 0.0528 | 1 |
Echinococcus granulosus | CREB binding protein | 0.0108 | 0.2815 | 0.2815 |
Echinococcus multilocularis | acetylcholinesterase | 0.0136 | 0.3661 | 0.3661 |
Brugia malayi | Bromodomain containing protein | 0.0071 | 0.1693 | 0.2018 |
Brugia malayi | Carboxylesterase family protein | 0.0136 | 0.3661 | 0.4364 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0234 | 0.0279 |
Echinococcus multilocularis | CREB binding protein | 0.0017 | 0.0052 | 0.0052 |
Echinococcus multilocularis | tumor protein p63 | 0.0346 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0234 | 0.052 |
Schistosoma mansoni | gliotactin | 0.0023 | 0.0234 | 0.052 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0023 | 0.0234 | 0.0234 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0896 | 0.4541 |
Echinococcus multilocularis | acetylcholinesterase | 0.0136 | 0.3661 | 0.3661 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1693 | 0.2018 |
Echinococcus granulosus | CREB binding protein | 0.0069 | 0.1613 | 0.1613 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0023 | 0.0234 | 0.052 |
Echinococcus granulosus | neuroligin | 0.0023 | 0.0234 | 0.0234 |
Echinococcus multilocularis | Bromodomain containing protein | 0.0033 | 0.0528 | 0.0528 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0023 | 0.0234 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0234 | 0.0279 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0071 | 0.1693 | 0.3761 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0234 | 0.0279 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0108 | 0.2815 | 0.6257 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0234 | 0.0279 |
Trichomonas vaginalis | histone acetyltransferase gcn5, putative | 0.0033 | 0.0528 | 0.2016 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0334 | 0.0398 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0535 | 0.0638 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.45 | 1 |
Trichomonas vaginalis | bromodomain-containing protein 4, brd4, putative | 0.0033 | 0.0528 | 0.2016 |
Echinococcus multilocularis | bromodomain containing 2 | 0.0071 | 0.1693 | 0.1693 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0528 | 0.2016 |
Brugia malayi | Carboxylesterase family protein | 0.0136 | 0.3661 | 0.4364 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0234 | 0.0279 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0136 | 0.3661 | 0.3661 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0234 | 0.052 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0997 | 0.1189 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0023 | 0.0234 | 0.0234 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0896 | 0.4541 |
Loa Loa (eye worm) | carboxylesterase | 0.0136 | 0.3661 | 0.4364 |
Brugia malayi | TAZ zinc finger family protein | 0.0108 | 0.2815 | 0.3356 |
Giardia lamblia | Kinase, putative | 0.0033 | 0.0528 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0234 | 0.0279 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0136 | 0.3661 | 0.4364 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.0234 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0136 | 0.3661 | 0.3661 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0997 | 0.1189 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0234 | 0.0279 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0896 | 0.4541 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.8388 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.3661 | 0.4364 |
Brugia malayi | N-terminal motif family protein | 0.0175 | 0.4824 | 0.5751 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0702 | 0.3208 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0023 | 0.0234 | 0.0234 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Echinococcus granulosus | bromodomain containing 2 | 0.0071 | 0.1693 | 0.1693 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.0234 | 1 |
Entamoeba histolytica | bromodomain-containing protein | 0.0033 | 0.0528 | 0.5 |
Onchocerca volvulus | 0.0051 | 0.1069 | 0.1024 | |
Echinococcus multilocularis | CREB binding protein | 0.0017 | 0.0052 | 0.0052 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0033 | 0.0528 | 0.063 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0023 | 0.0234 | 0.0234 |
Entamoeba histolytica | bromodomain-containing protein | 0.0033 | 0.0528 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0023 | 0.0234 | 0.0234 |
Echinococcus multilocularis | neuroligin | 0.0023 | 0.0234 | 0.0234 |
Echinococcus granulosus | CREB binding protein | 0.0017 | 0.0052 | 0.0052 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0045 | 0.0896 | 0.4541 |
Echinococcus granulosus | CREB binding protein | 0.0017 | 0.0052 | 0.0052 |
Echinococcus multilocularis | CREB binding protein | 0.0076 | 0.1829 | 0.1829 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0234 | 0.0279 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.45 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0023 | 0.0234 | 0.5 |
Echinococcus multilocularis | geminin | 0.0164 | 0.45 | 0.45 |
Brugia malayi | hypothetical protein | 0.0292 | 0.8388 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0997 | 0.1189 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1011 | 0.1205 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0535 | 0.0638 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0023 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0997 | 0.1189 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0023 | 0.0234 | 0.052 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0033 | 0.0528 | 0.2016 |
Entamoeba histolytica | bromodomain-containing protein | 0.0033 | 0.0528 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.158 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.413 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.