Detailed information for compound 1748043

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1304.58 | Formula: C46H77N15O17S6
  • H donors: 16 H acceptors: 17 LogP: -11.15 Rotable bonds: 51
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)CS)C)CS)C)CC(=O)N)CS)CS)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)N)CS)CCC(=O)O
  • InChi: 1S/C46H77N15O17S6/c1-20(35(66)50-13-33(63)53-30(19-84)46(77)78)51-40(71)26(15-80)57-36(67)21(2)52-44(75)31-7-5-11-61(31)45(76)25(12-32(49)62)56-42(73)28(17-82)60-43(74)29(18-83)59-38(69)23(6-3-4-10-47)54-39(70)24(8-9-34(64)65)55-41(72)27(16-81)58-37(68)22(48)14-79/h20-31,79-84H,3-19,47-48H2,1-2H3,(H2,49,62)(H,50,66)(H,51,71)(H,52,75)(H,53,63)(H,54,70)(H,55,72)(H,56,73)(H,57,67)(H,58,68)(H,59,69)(H,60,74)(H,64,65)(H,77,78)/t20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-/m0/s1
  • InChiKey: OZVCXESYJFMVBY-CWZKXXPDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0142 0.0142
Mycobacterium ulcerans hypothetical protein 0.0037 0.0283 0.0283
Schistosoma mansoni hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0457 0.0456
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0825 0.0825
Brugia malayi RE15519p 0.08 0.9082 1
Brugia malayi hypothetical protein 0.08 0.9082 1
Echinococcus multilocularis neuropeptides capa receptor 0.08 0.9082 0.9292
Onchocerca volvulus 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Onchocerca volvulus 0.08 0.9082 1
Echinococcus multilocularis neuropeptide Y receptor 0.08 0.9082 0.9292
Echinococcus multilocularis solute carrier family 5 0.0041 0.0321 0.0329
Onchocerca volvulus 0.08 0.9082 1
Onchocerca volvulus 0.0052 0.0457 0.0352
Echinococcus multilocularis neuropeptide FF receptor 2 0.08 0.9082 0.9292
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1485 0.1636
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1485 0.152
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.08 0.9082 1
Loa Loa (eye worm) esterase D 0.0037 0.0283 0.0263
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0462 0.0461
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0019 0.0069 0.2368
Brugia malayi GH02984p 0.0368 0.4105 0.452
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0069 0.2487
Loa Loa (eye worm) hypothetical protein 0.0026 0.0147 0.0113
Mycobacterium ulcerans hypothetical protein 0.0037 0.0283 0.0283
Echinococcus granulosus neuropeptide Y receptor 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0026
Echinococcus multilocularis orexin receptor type 2 0.08 0.9082 0.9292
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Schistosoma mansoni hypothetical protein 0.0043 0.0351 0.0386
Brugia malayi hypothetical protein 0.08 0.9082 1
Echinococcus granulosus 7tm_1 domain containing protein 0.08 0.9082 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.08 0.9082 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0147 0.5282
Loa Loa (eye worm) hypothetical protein 0.0104 0.1057 0.1119
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0933 0.0933
Brugia malayi larval opioid receptor 0.08 0.9082 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0142 0.0142
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0069 0.2076
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0019 0.0069 0.0071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus multilocularis protein dispatched 1 0.0051 0.0442 0.0453
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0879 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.08 0.9082 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0019 0.0069 0.2083
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0273 0.2999 0.3269
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0142 0.5112
Echinococcus granulosus tachykinin peptides receptor 99D 0.08 0.9082 1
Echinococcus granulosus rhodopsin orphan GPCR 0.08 0.9082 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.08 0.9082 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.08 0.9082 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.086 0.9774 1
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0037 0.0283 0.0283
Echinococcus multilocularis biogenic amine (5HT) receptor 0.08 0.9082 0.9292
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0284 0.0313
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.0306
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0279 0.0258
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0019 0.0069 0.2368
Echinococcus multilocularis geminin 0.0515 0.5793 0.5927
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0069 0.236
Schistosoma mansoni neuropeptide F-like receptor 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus granulosus fmrfamide receptor 0.08 0.9082 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0142 0.0142
Echinococcus granulosus GTP binding nuclear protein Ran 0.0019 0.0069 0.0076
Echinococcus multilocularis serotonin receptor 0.08 0.9082 0.9292
Mycobacterium tuberculosis Possible conserved membrane protein 0.0037 0.0283 0.0283
Mycobacterium ulcerans hypothetical protein 0.0037 0.0283 0.0283
Brugia malayi hypothetical protein 0.08 0.9082 1
Echinococcus granulosus importin subunit beta 1 0.0026 0.0147 0.0162
Brugia malayi Serotonin/octopamine receptor family protein 7 0.08 0.9082 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0462 0.0509
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.08 0.9082 0.9292
Brugia malayi hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.0107
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0283 0.0283
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.08 0.9082 1
Brugia malayi hypothetical protein 0.08 0.9082 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.08 0.9082 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0293 0.2261
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.08 0.9082 0.9292
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0019 0.0069 0.2083
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0045 0.0046
Brugia malayi putative neuropeptide receptor NPR1 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.08 0.9082 0.9292
Leishmania major GTP-binding protein, putative 0.0019 0.0069 0.2487
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0462 0.0509
Echinococcus multilocularis expressed conserved protein 0.0098 0.0984 0.1007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0045 0.005
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Schistosoma mansoni hypothetical protein 0.0515 0.5793 0.6379
Echinococcus granulosus geminin 0.0515 0.5793 0.6379
Echinococcus multilocularis rhodopsin orphan GPCR 0.08 0.9082 0.9292
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.08 0.9082 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0041 0.0321 0.0329
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0019 0.0069 0.2487
Echinococcus multilocularis rhodopsin orphan GPCR 0.08 0.9082 0.9292
Mycobacterium tuberculosis Probable reductase 0.0084 0.0825 0.0825
Brugia malayi hypothetical protein 0.08 0.9082 1
Schistosoma mansoni adenoreceptor 0.08 0.9082 1
Schistosoma mansoni patched 1 0.0045 0.0369 0.0407
Echinococcus granulosus rhodopsin orphan GPCR 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.08 0.9082 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0142 0.0157
Echinococcus granulosus neuropeptide s receptor 0.08 0.9082 1
Schistosoma mansoni ran 0.0019 0.0069 0.0076
Brugia malayi sulfakinin receptor protein 0.08 0.9082 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.08 0.9082 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.08 0.9082 1
Echinococcus multilocularis neuropeptides capa receptor 0.08 0.9082 0.9292
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0142 0.0142
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0825 0.0825
Echinococcus multilocularis snurportin 1 0.0273 0.2999 0.3069
Brugia malayi neuropeptide F receptor 0.08 0.9082 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0091 0.2474
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Leishmania major importin beta-1 subunit, putative 0.0021 0.0091 0.328
Loa Loa (eye worm) G-protein coupled receptor 0.08 0.9082 1
Mycobacterium leprae Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0037 0.0283 0.0143
Echinococcus multilocularis sex peptide receptor 0.08 0.9082 0.9292
Schistosoma mansoni neuropeptide receptor 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0486 0.0487
Schistosoma mansoni biogenic amine (5HT) receptor 0.08 0.9082 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.08 0.9082 0.9292
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0045 0.0369 0.0358
Echinococcus multilocularis importin subunit beta 1 0.0026 0.0147 0.0151
Echinococcus granulosus g protein coupled receptor 0.08 0.9082 1
Echinococcus multilocularis neuropeptide receptor 0.08 0.9082 0.9292
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.08 0.9082 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.08 0.9082 0.9292
Brugia malayi gonadotropin-releasing hormone receptor 2 0.08 0.9082 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.08 0.9082 0.9292
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0825 0.0825
Echinococcus granulosus serotonin receptor 0.08 0.9082 1
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0369 0.0407
Echinococcus granulosus hypothetical protein 0.08 0.9082 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0381 0.0419
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Schistosoma mansoni biogenic amine receptor 0.08 0.9082 1
Echinococcus multilocularis high affinity choline transporter 1 0.0368 0.4105 0.42
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0142 0.074
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus granulosus tm gpcr rhodopsin 0.08 0.9082 1
Brugia malayi AKH receptor 0.08 0.9082 1
Schistosoma mansoni neuropeptide receptor 0.08 0.9082 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.08 0.9082 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0825 0.0692
Echinococcus granulosus g protein coupled receptor 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0269 0.0248
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0041 0.0321 0.0354
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0369 0.0407
Echinococcus granulosus high affinity choline transporter 1 0.0368 0.4105 0.452
Onchocerca volvulus 0.08 0.9082 1
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1485 0.1636
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0037 0.0283 0.0283
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0037 0.0283 0.0283
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0142 0.074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.08 0.9082 1
Toxoplasma gondii thioredoxin reductase 0.0037 0.0279 0.8375
Onchocerca volvulus 0.08 0.9082 1
Echinococcus granulosus sodium:glucose cotransporter 2 0.0041 0.0321 0.0354
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.0107
Echinococcus multilocularis serotonin receptor 0.08 0.9082 0.9292
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0381 0.0419
Onchocerca volvulus 0.08 0.9082 1
Echinococcus multilocularis dro:myosuppressin receptor 0.08 0.9082 0.9292
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Plasmodium falciparum thioredoxin reductase 0.0037 0.0279 0.9521
Schistosoma mansoni biogenic amine (dopamine) receptor 0.08 0.9082 1
Echinococcus granulosus neuropeptide receptor A26 0.08 0.9082 1
Onchocerca volvulus 0.08 0.9082 1
Onchocerca volvulus 0.08 0.9082 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.08 0.9082 1
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0041 0.0321 0.0329
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0142 0.5112
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.1057 0.1164
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Schistosoma mansoni amine GPCR 0.08 0.9082 1
Brugia malayi G protein-coupled receptor 0.08 0.9082 1
Echinococcus multilocularis S formylglutathione hydrolase 0.0037 0.0283 0.029
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0142 0.5112
Schistosoma mansoni biogenic amine (dopamine) receptor 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Plasmodium vivax importin-beta 2, putative 0.0026 0.0147 0.4423
Onchocerca volvulus 0.08 0.9082 1
Mycobacterium tuberculosis Probable conserved exported protein 0.0037 0.0283 0.0283
Echinococcus granulosus sex peptide receptor 0.08 0.9082 1
Schistosoma mansoni hypothetical protein 0.08 0.9082 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.08 0.9082 0.9292
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0026
Brugia malayi neuropeptide F receptor 0.08 0.9082 1
Brugia malayi Dopamine receptor 0.08 0.9082 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0279 0.8375
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0381 0.0419
Onchocerca volvulus 0.08 0.9082 1
Schistosoma mansoni hypothetical protein 0.0273 0.2999 0.3303
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.08 0.9082 1
Treponema pallidum NADH oxidase 0.0013 0 0.5
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.1574 0.161
Echinococcus multilocularis fmrfamide receptor 0.08 0.9082 0.9292
Loa Loa (eye worm) TYRA-2 protein 0.08 0.9082 1
Plasmodium falciparum importin beta, putative 0.0026 0.0147 0.5028
Echinococcus granulosus neuropeptides capa receptor 0.08 0.9082 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0069 1
Schistosoma mansoni high-affinity choline transporter 0.0368 0.4105 0.452
Brugia malayi G-protein coupled receptor 0.08 0.9082 1
Schistosoma mansoni myosin xvIII 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus multilocularis allatostatin A receptor 0.08 0.9082 0.9292
Schistosoma mansoni hypothetical protein 0.0017 0.0045 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.08 0.9082 1
Echinococcus multilocularis neuropeptide s receptor 0.08 0.9082 0.9292
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0069 0.0069
Echinococcus granulosus rhodopsin orphan GPCR 0.08 0.9082 1
Mycobacterium leprae SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR 0.0037 0.0283 0.0143
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.08 0.9082 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0069 0.2487
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0045 0.0046
Brugia malayi G-protein coupled receptor 0.08 0.9082 1
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0457 0.0504
Echinococcus granulosus snurportin 1 0.0273 0.2999 0.3303
Echinococcus multilocularis tachykinin peptides receptor 99D 0.08 0.9082 0.9292
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Schistosoma mansoni opsin-like receptor 0.08 0.9082 1
Echinococcus granulosus dro:myosuppressin receptor 0.08 0.9082 1
Schistosoma mansoni neuropeptide f receptor 76f 0.08 0.9082 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.1057 0.1081
Echinococcus multilocularis fmrfamide receptor 0.08 0.9082 0.9292
Schistosoma mansoni hypothetical protein 0.0036 0.0269 0.0296
Brugia malayi glutathione reductase 0.0037 0.0279 0.0307
Echinococcus granulosus solute carrier family 5 0.0041 0.0321 0.0354
Echinococcus granulosus neuropeptide receptor 0.08 0.9082 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0333 1
Schistosoma mansoni opsin-like receptor 0.08 0.9082 1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0041 0.0321 0.0329
Onchocerca volvulus 0.08 0.9082 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0142 0.0157
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0026
Schistosoma mansoni hypothetical protein 0.0017 0.0045 0.005
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0333 0.0366
Brugia malayi hypothetical protein 0.08 0.9082 1
Echinococcus multilocularis tumor protein p63 0.0358 0.3987 0.4079
Brugia malayi putative neuropeptide receptor 0.08 0.9082 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0284 0.0291
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0037 0.0283 0.2168
Echinococcus granulosus peptide allatostatin:somatostatin 0.08 0.9082 1
Schistosoma mansoni hypothetical protein 0.08 0.9082 1
Echinococcus granulosus expressed conserved protein 0.0098 0.0984 0.1083
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) neuropeptide F receptor 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Schistosoma mansoni biogenic amine receptor 0.08 0.9082 1
Schistosoma mansoni hypothetical protein 0.0515 0.5793 0.6379
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.08 0.9082 1
Brugia malayi hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) melatonin receptor type 1A 0.08 0.9082 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0021 0.0091 0.328
Schistosoma mansoni histamine h1 receptor 0.08 0.9082 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.08 0.9082 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0333 0.9007
Loa Loa (eye worm) neuropeptide F receptor 0.08 0.9082 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.08 0.9082 1
Echinococcus granulosus rhodopsin orphan GPCR 0.08 0.9082 1
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0037 0.0283 0.0283
Echinococcus granulosus 7TM GPCR rhodopsin 0.08 0.9082 1
Onchocerca volvulus 0.08 0.9082 1
Schistosoma mansoni neuropeptide F-like receptor 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0142 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0381 0.039
Echinococcus granulosus S formylglutathione hydrolase 0.0037 0.0283 0.0312
Echinococcus granulosus neuropeptides capa receptor 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.0107
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0045 0.005
Schistosoma mansoni amine GPCR 0.08 0.9082 1
Trichomonas vaginalis ran, putative 0.0019 0.0069 0.1876
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.08 0.9082 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.08 0.9082 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.08 0.9082 0.9292
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.08 0.9082 0.9292
Echinococcus multilocularis rhodopsin orphan GPCR 0.08 0.9082 0.9292
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0369 0.0378
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0147 0.5282
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Onchocerca volvulus 0.08 0.9082 1
Schistosoma mansoni biogenic amine receptor 0.08 0.9082 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0045 0.005
Echinococcus granulosus biogenic amine 5HT receptor 0.08 0.9082 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.1057 0.1164
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.08 0.9082 0.9292
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus multilocularis g protein coupled receptor 0.08 0.9082 0.9292
Loa Loa (eye worm) hypothetical protein 0.0368 0.4105 0.4493
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0381 0.0419
Leishmania major trypanothione reductase 0.0037 0.0279 1
Echinococcus granulosus neuropeptide receptor 0.08 0.9082 1
Echinococcus granulosus somatostatin receptor 0.08 0.9082 1
Echinococcus granulosus tm gpcr rhodopsin 0.08 0.9082 1
Mycobacterium ulcerans secreted antigen 85-B FbpB 0.0037 0.0283 0.0283
Schistosoma mansoni inositol transporter 0.0041 0.0321 0.0354
Echinococcus multilocularis G protein coupled receptor 139 0.08 0.9082 0.9292
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0142 0.0142
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0879 1 1
Echinococcus granulosus sodium:glucose cotransporter 0.0041 0.0321 0.0354
Schistosoma mansoni hypothetical protein 0.0017 0.0045 0.005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0381 0.039
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.08 0.9082 1
Echinococcus granulosus g protein coupled receptor 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.08 0.9082 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.08 0.9082 1
Echinococcus granulosus G protein coupled receptor 139 0.08 0.9082 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.08 0.9082 1
Echinococcus multilocularis g protein coupled receptor 0.08 0.9082 0.9292
Entamoeba histolytica hypothetical protein 0.0021 0.0091 0.0224
Echinococcus granulosus sodium:myo inositol cotransporter 0.0041 0.0321 0.0354
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Schistosoma mansoni neuropeptide receptor 0.08 0.9082 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Brugia malayi GnHR receptor homolog 0.08 0.9082 1
Schistosoma mansoni amine GPCR 0.08 0.9082 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0279 0.0279
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.144 0.1585
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0825 0.0825
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0019 0.0069 0.0076
Trichomonas vaginalis importin beta-1, putative 0.0021 0.0091 0.2474
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0333 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0019 0.0069 0.0027
Schistosoma mansoni hypothetical protein 0.0043 0.0351 0.0386
Schistosoma mansoni biogenic amine (5HT) receptor 0.08 0.9082 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0369 1
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0041 0.0321 0.9663
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0142 0.0157
Schistosoma mansoni sodium/solute symporter 0.0041 0.0321 0.0354
Schistosoma mansoni ran 0.0019 0.0069 0.0076
Loa Loa (eye worm) hypothetical protein 0.0053 0.0462 0.0461
Echinococcus multilocularis rhodopsin orphan GPCR 0.08 0.9082 0.9292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0381 0.0419
Mycobacterium ulcerans secreted antigen 85-A FbpA 0.0037 0.0283 0.0283
Schistosoma mansoni growth hormone secretagogue receptor 0.08 0.9082 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.08 0.9082 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0933 0.0802
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0142 0.0142
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0293 1
Brugia malayi CHE-14 protein 0.0045 0.0369 0.0407
Echinococcus multilocularis neuropeptide Y receptor 0.08 0.9082 0.9292
Brugia malayi Melatonin receptor type 1A 0.08 0.9082 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0045 0.005
Onchocerca volvulus 0.08 0.9082 1
Echinococcus multilocularis g-protein coupled receptor 0.08 0.9082 0.9292
Echinococcus multilocularis G-protein coupled receptor, putative 0.08 0.9082 0.9292
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0933 0.0933
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0069 0.0069
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.08 0.9082 0.9292
Schistosoma mansoni importin beta-1 0.0026 0.0147 0.0162
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0026
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.08 0.9082 0.9292
Plasmodium falciparum glutathione reductase 0.0037 0.0279 0.9521
Brugia malayi Serotonin receptor 0.08 0.9082 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0279 0.0258
Brugia malayi Dopamine receptor protein 2 0.08 0.9082 1
Onchocerca volvulus 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Plasmodium vivax glutathione reductase, putative 0.0037 0.0279 0.8375
Brugia malayi Tachykinin-like peptides receptor 99D 0.08 0.9082 1
Brugia malayi Importin beta-1 subunit 0.0026 0.0147 0.0162
Echinococcus multilocularis rhodopsin orphan GPCR 0.08 0.9082 0.9292
Toxoplasma gondii HEAT repeat-containing protein 0.0026 0.0147 0.4423
Echinococcus granulosus allatostatin A receptor 0.08 0.9082 1
Echinococcus granulosus rhodopsin orphan GPCR 0.08 0.9082 1
Echinococcus granulosus tumor protein p63 0.0358 0.3987 0.4389
Echinococcus multilocularis protein patched 0.0045 0.0369 0.0378
Loa Loa (eye worm) G-protein coupled receptor 0.08 0.9082 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0825 0.0825
Schistosoma mansoni rhodopsin-like orphan GPCR 0.08 0.9082 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.08 0.9082 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.08 0.9082 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0142 0.0142
Brugia malayi RNA, U transporter 1 0.0073 0.0691 0.076
Echinococcus granulosus GPCR family 2 0.0017 0.0045 0.005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0026
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.08 0.9082 0.9292
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0091 0.2474
Schistosoma mansoni hypothetical protein 0.08 0.9082 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0279 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0142 0.0142
Schistosoma mansoni opsin-like receptor 0.08 0.9082 1
Schistosoma mansoni hypothetical protein 0.0017 0.0045 0.005
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0333 1
Brugia malayi Thioredoxin reductase 0.0037 0.0279 0.0307
Echinococcus multilocularis rhodopsin orphan GPCR 0.08 0.9082 0.9292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0381 0.0419
Echinococcus granulosus neuropeptide Y receptor 0.08 0.9082 1
Brugia malayi hypothetical protein 0.08 0.9082 1
Schistosoma mansoni hypothetical protein 0.0043 0.0351 0.0386
Brugia malayi Serotonin receptor 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Brugia malayi ORL1-like opioid receptor 0.08 0.9082 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.1057 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus granulosus tm gpcr rhodopsin 0.08 0.9082 1
Echinococcus multilocularis GPCR, family 2 0.0017 0.0045 0.0046
Schistosoma mansoni inositol transporter 0.0041 0.0321 0.0354
Schistosoma mansoni amine GPCR 0.08 0.9082 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.08 0.9082 1
Mycobacterium ulcerans secreted Mpt51/Mpb51 antigen protein FbpD 0.0037 0.0283 0.0283
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0142 0.074
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0369 0.0358
Onchocerca volvulus 0.0041 0.0321 0.02
Schistosoma mansoni amine GPCR 0.08 0.9082 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.08 0.9082 1
Schistosoma mansoni hypothetical protein 0.0043 0.0351 0.0386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0057 0.0057
Brugia malayi hypothetical protein 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.08 0.9082 1
Brugia malayi G protein-coupled receptor F59B2.13 0.08 0.9082 1
Brugia malayi follicle stimulating hormone receptor 0.08 0.9082 1
Echinococcus multilocularis neuropeptide receptor 0.08 0.9082 0.9292
Echinococcus multilocularis somatostatin receptor 0.08 0.9082 0.9292
Schistosoma mansoni neuropeptide receptor 0.08 0.9082 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.08 0.9082 0.9292
Brugia malayi Sodium:solute symporter family protein 0.0041 0.0321 0.0354
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0293 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.08 0.9082 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.08 0.9082 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0381 0.0371
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.08 0.9082 1
Echinococcus granulosus neuropeptide FF receptor 2 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.1076 0.1184
Echinococcus granulosus orexin receptor type 2 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus granulosus rhodopsin orphan GPCR 0.08 0.9082 1
Echinococcus granulosus rhodopsin orphan GPCR 0.08 0.9082 1
Trypanosoma brucei trypanothione reductase 0.0037 0.0279 1
Loa Loa (eye worm) acetyltransferase 0.0141 0.1485 0.1594
Brugia malayi Dopamine receptor protein 1 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0333 0.9007
Onchocerca volvulus 0.08 0.9082 1
Onchocerca volvulus 0.08 0.9082 1
Brugia malayi Esterase D 0.0037 0.0283 0.0312
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0269 0.0296
Echinococcus granulosus g-protein coupled receptor 0.08 0.9082 1
Loa Loa (eye worm) hypothetical protein 0.08 0.9082 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.08 0.9082 1
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.1574 0.1733
Echinococcus multilocularis g protein coupled receptor 0.08 0.9082 0.9292
Echinococcus multilocularis neuropeptide receptor A26 0.08 0.9082 0.9292

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.