Growth (functional)
|
= -98 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -98 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -97 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -97 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -96 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -96 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -90 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -90 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -85 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -85 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -85 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -85 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -77 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -77 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -73 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -73 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -44 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -44 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-4 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -36 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -36 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -25 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -25 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -23 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -23 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -21 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -21 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -10 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -10 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -2 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -2 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 0 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 0 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 1 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 1 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 3 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 3 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 4 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 4 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 9 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 9 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 17 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 17 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 18 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 18 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 25 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 25 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 28 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 28 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 31 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 31 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 38 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 38 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 38 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 38 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
IC50 (functional)
|
= 0.002 uM
|
In vitro cytotoxic activity against human colon adenocarcinoma (HT-29).
|
ChEMBL.
|
12825949
|
IC50 (functional)
|
= 0.002 uM
|
In vitro cytotoxic activity against human colon adenocarcinoma (HT-29).
|
ChEMBL.
|
12825949
|
K app (ADMET)
|
= 5.2 M-1
|
Apparent equilibrium constant for DNA binding (G-C)
|
ChEMBL.
|
12825949
|
K app (ADMET)
|
= 13 M-1
|
Apparent equilibrium constant for DNA binding (A-T)
|
ChEMBL.
|
12825949
|
K app (ADMET)
|
= 20 M-1
|
Apparent equilibrium constant for DNA binding (C-T)
|
ChEMBL.
|
12825949
|