TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 608.829 | Formula: C40H50NO4+
H donors: 0 H acceptors: 2 LogP: 9.54 Rotable bonds: 19
Rule of 5 violations (Lipinski): 2
SMILES: COC1=C(OC)C(=O)C(=C(C1=O)CCCCCCCCCC[N+](Cc1ccccc1)(Cc1ccccc1)Cc1ccccc1)C
InChi: 1S/C40H50NO4/c1-32-36(38(43)40(45-3)39(44-2)37(32)42)27-19-8-6-4-5-7-9-20-28-41(29-33-21-13-10-14-22-33,30-34-23-15-11-16-24-34)31-35-25-17-12-18-26-35/h10-18,21-26H,4-9,19-20,27-31H2,1-3H3/q+1
InChiKey: SUECNVHVOGPIML-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.4717	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.4717	1	1
Onchocerca volvulus	Putative hydrolase PNKD	0.0215	0.0391	0.0721
Loa Loa (eye worm)	metallo-beta-lactamase superfamily protein	0.0215	0.0391	0.0391
Wolbachia endosymbiont of Brugia malayi	amidophosphoribosyltransferase	0.0473	0.094	1
Trypanosoma cruzi	glyoxalase II	0.0215	0.0391	0.0391
Entamoeba histolytica	type A flavoprotein, putative	0.0215	0.0391	0.0391
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0215	0.0391	0.0391
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0026	0.0026
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Mycobacterium ulcerans	hydrolase	0.0215	0.0391	0.0921
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0026	0.0026
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0473	0.094	0.094
Plasmodium vivax	hydroxyacyl glutathione hydrolase, putative	0.0215	0.0391	0.0391
Leishmania major	hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative	0.0215	0.0391	0.0391
Onchocerca volvulus	Adenine phosphoribosyltransferase homolog	0.0473	0.094	0.1736
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.2019	0.4241	0.4241
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0215	0.0391	0.0391
Trypanosoma brucei	Casein kinase II	0.4717	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Trypanosoma brucei	cleavage and polyadenylation specificity factor subunit, putative	0.0215	0.0391	0.0391
Toxoplasma gondii	hydroxyacylglutathione hydrolase	0.0215	0.0391	0.0391
Schistosoma mansoni	orotidine 5'-phosphate decarboxylase	0.0473	0.094	0.094
Echinococcus granulosus	hydroxyacylglutathione hydrolase	0.0215	0.0391	0.0391
Plasmodium falciparum	casein kinase II beta chain	0.2569	0.5416	0.5416
Trichomonas vaginalis	beta lactamase domain, putative	0.0215	0.0391	0.0391
Trypanosoma brucei	glyoxalase II	0.0215	0.0391	0.0391
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.2569	0.5416	0.5416
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Echinococcus multilocularis	casein kinase ii subunit alpha	0.4717	1	1
Mycobacterium tuberculosis	Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor	0.1546	0.3232	1
Onchocerca volvulus		0.0215	0.0391	0.0721
Mycobacterium ulcerans	bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase	0.0473	0.094	0.2217
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Loa Loa (eye worm)	adenine phosphoribosyltransferase	0.0473	0.094	0.094
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Loa Loa (eye worm)	Csnk2b protein	0.2569	0.5416	0.5416
Trichomonas vaginalis	CMGC family protein kinase	0.4717	1	1
Echinococcus granulosus	uridine 5' monophosphate synthase	0.0473	0.094	0.094
Leishmania major	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative	0.0473	0.094	0.094
Mycobacterium ulcerans	hypothetical protein	0.0215	0.0391	0.0921
Trichomonas vaginalis	CMGC family protein kinase	0.4717	1	1
Brugia malayi	casein kinase II, putaitve	0.0751	0.1533	0.1533
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.2569	0.5416	1
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.2569	0.5416	0.5416
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0026	0.0026
Mycobacterium ulcerans	hypothetical protein	0.0473	0.094	0.2217
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0215	0.0391	0.0391
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0215	0.0391	0.0391
Entamoeba histolytica	protein kinase, putative	0.0032	0.000000012722	0.000000012722
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.0391	0.0391
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Mycobacterium tuberculosis	Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase)	0.0473	0.094	0.2909
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0751	0.1533	0.1533
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0181	0.0181
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0473	0.094	0.094
Entamoeba histolytica	type A flavoprotein, putative	0.0215	0.0391	0.0391
Schistosoma mansoni	protein kinase	0.4717	1	1
Echinococcus multilocularis	casein kinase ii subunit beta	0.2569	0.5416	0.5416
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0215	0.0391	0.0391
Mycobacterium tuberculosis	Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase)	0.0473	0.094	0.2909
Entamoeba histolytica	protein kinase domain containing protein	0.4717	1	1
Mycobacterium leprae	POSSIBLE HYDROLASE	0.0215	0.0391	0.1209
Trichomonas vaginalis	beta lactamase domain, putative	0.0215	0.0391	0.0391
Mycobacterium leprae	conserved hypothetical protein	0.0215	0.0391	0.1209
Entamoeba histolytica	alkyl sulfatase, putative	0.0215	0.0391	0.0391
Leishmania major	metallo-beta-lactamase family-like protein	0.0215	0.0391	0.0391
Trichomonas vaginalis	beta lactamase domain, putative	0.0215	0.0391	0.0391
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.2019	0.4241	0.4241
Brugia malayi	orotate phosphoribosyltransferase family protein	0.0473	0.094	0.094
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0215	0.0391	0.0391
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.2569	0.5416	0.5416
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Leishmania major	adenine phosphoribosyltransferase	0.0473	0.094	0.094
Mycobacterium ulcerans	amidophosphoribosyltransferase	0.0473	0.094	0.2217
Leishmania major	xanthine phosphoribosyltransferase	0.2019	0.4241	0.4241
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0473	0.094	0.094
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0215	0.0391	0.0391
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0473	0.094	0.094
Mycobacterium ulcerans	hypothetical protein	0.0215	0.0391	0.0921
Giardia lamblia	Metallo-beta-lactamase superfamily protein	0.0215	0.0391	0.0391
Mycobacterium leprae	Beta-lactamase-like protein	0.0215	0.0391	0.1209
Brugia malayi	Phosphoribosyl transferase domain containing protein	0.2019	0.4241	0.4241
Treponema pallidum	hypothetical protein	0.0473	0.094	1
Loa Loa (eye worm)	casein kinase II	0.0751	0.1533	0.1533
Trichomonas vaginalis	Ribose-phosphate pyrophosphokinase, putative	0.0473	0.094	0.094
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Entamoeba histolytica	hypothetical protein, conserved	0.0215	0.0391	0.0391
Giardia lamblia	Casein kinase II beta chain	0.0751	0.1533	0.1533
Mycobacterium tuberculosis	Conserved protein	0.0215	0.0391	0.1209
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0026	0.0026
Echinococcus granulosus	casein kinase ii subunit beta	0.2569	0.5416	0.5416
Entamoeba histolytica	casein kinase, putative	0.4717	1	1
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0215	0.0391	0.0391
Mycobacterium tuberculosis	Probable pyrimidine operon regulatory protein PyrR	0.0473	0.094	0.2909
Leishmania major	metallo-beta-lactamase family protein-like protein	0.0215	0.0391	0.0391
Mycobacterium ulcerans	glyoxalase II, GloB	0.0215	0.0391	0.0921
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0215	0.0391	0.0391
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Echinococcus multilocularis	zinc phosphodiesterase	0.0215	0.0391	0.0391
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0215	0.0391	0.0391
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0215	0.0391	0.0391
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Plasmodium falciparum	orotate phosphoribosyltransferase	0.0473	0.094	0.094
Brugia malayi	Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site.	0.0215	0.0391	0.0391
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.2019	0.4241	0.4241
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.2019	0.4241	0.4241
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.2569	0.5416	0.5416
Trypanosoma brucei	metallo-beta-lactamase-like protein, putative	0.0215	0.0391	0.0391
Giardia lamblia	Guanine phosphoribosyltransferase	0.2019	0.4241	0.4241
Trypanosoma cruzi	glyoxalase II	0.0215	0.0391	0.0391
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.2569	0.5416	0.5416
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0026	0.0026
Mycobacterium tuberculosis	Conserved protein	0.0473	0.094	0.2909
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0473	0.094	0.094
Echinococcus granulosus	adenine phosphoribosyltransferase	0.0473	0.094	0.094
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.2019	0.4241	0.4241
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Trichomonas vaginalis	beta lactamase domain, putative	0.0215	0.0391	0.0391
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.2569	0.5416	0.5416
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.2019	0.4241	0.4241
Echinococcus multilocularis	adenine phosphoribosyltransferase	0.0473	0.094	0.094
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0473	0.094	0.094
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0026	0.0026
Schistosoma mansoni	hypothetical protein	0.0215	0.0391	0.0391
Trichomonas vaginalis	CMGC family protein kinase	0.4717	1	1
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0215	0.0391	0.0391
Mycobacterium ulcerans	hypothetical protein	0.0215	0.0391	0.0921
Mycobacterium tuberculosis	Possible hydrolase	0.0215	0.0391	0.1209
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0473	0.094	0.2909
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Treponema pallidum	adenine phosphoribosyltransferase	0.0473	0.094	1
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0473	0.094	0.094
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase	0.0215	0.0391	0.0391
Mycobacterium tuberculosis	Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase)	0.0473	0.094	0.2909
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Mycobacterium ulcerans	hydrolase	0.0215	0.0391	0.0921
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0026	0.0026
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0215	0.0391	0.1209
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.0391	0.0391
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0215	0.0391	0.1209
Brugia malayi	Csnk2b protein	0.2569	0.5416	0.5416
Mycobacterium leprae	Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho	0.1546	0.3232	1
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0473	0.094	0.094
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0215	0.0391	0.0391
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.2019	0.4241	0.4241
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.2019	0.4241	0.4241
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0215	0.0391	0.0391
Mycobacterium leprae	conserved hypothetical protein	0.0215	0.0391	0.1209
Toxoplasma gondii	metallo-beta-lactamase domain-containing protein	0.0215	0.0391	0.0391
Brugia malayi	Adenine phosphoribosyltransferase	0.0473	0.094	0.094
Mycobacterium ulcerans	beta lactamase-like protein	0.0215	0.0391	0.0921
Plasmodium vivax	unspecified product	0.0215	0.0391	0.0391
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0026	0.0026
Mycobacterium tuberculosis	Possible hydrolase	0.0215	0.0391	0.1209
Echinococcus granulosus	zinc phosphodiesterase	0.0215	0.0391	0.0391
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.2019	0.4241	0.4241
Echinococcus granulosus	ETHE1 protein	0.0215	0.0391	0.0391
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Trypanosoma brucei	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0473	0.094	0.094
Plasmodium vivax	unspecified product	0.4717	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	0.2019	0.4241	0.4241
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0391	0.0391
Mycobacterium ulcerans	Zn-dependent glyoxylase	0.0215	0.0391	0.0921
Onchocerca volvulus		0.0215	0.0391	0.0721
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.2019	0.4241	0.4241
Echinococcus multilocularis	ETHE1 protein	0.0215	0.0391	0.0391
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0215	0.0391	0.0391
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0215	0.0391	0.0391
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0473	0.094	0.094
Mycobacterium tuberculosis	Conserved protein	0.0215	0.0391	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0391	0.0391
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.0391	0.0391
Onchocerca volvulus	Hydroxyacylglutathione hydrolase, mitochondrial homolog	0.0215	0.0391	0.0721
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0215	0.0391	0.1209
Trichomonas vaginalis	protein kinase ck2-beta, putative	0.0751	0.1533	0.1533
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.2019	0.4241	0.4241
Trichomonas vaginalis	A-type flavoprotein	0.0215	0.0391	0.0391
Schistosoma mansoni	hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)	0.0215	0.0391	0.0391
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.2569	0.5416	1
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0215	0.0391	0.0391
Schistosoma mansoni	hypothetical protein	0.0215	0.0391	0.0391
Leishmania major	casein kinase II, putative	0.4717	1	1
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0391	0.0391
Trypanosoma cruzi	glyoxalase II	0.0215	0.0391	0.0391
Mycobacterium tuberculosis	Conserved protein	0.0473	0.094	0.2909
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0181	0.0181
Trichomonas vaginalis	beta lactamase domain, putative	0.0215	0.0391	0.0391
Giardia lamblia	Adenine phosphoribosyltransferase	0.0473	0.094	0.094
Plasmodium falciparum	casein kinase 2, alpha subunit	0.4717	1	1
Plasmodium falciparum	casein kinase II beta chain	0.2569	0.5416	0.5416
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Echinococcus multilocularis	uridine 5' monophosphate synthase	0.0473	0.094	0.094
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	0.2019	0.4241	0.4241
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Schistosoma mansoni	casein kinase II beta subunit	0.2569	0.5416	0.5416
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.0391	0.0391
Trichomonas vaginalis	CMGC family protein kinase	0.4717	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.4717	1	1
Echinococcus granulosus	casein kinase ii subunit alpha	0.4717	1	1
Trichomonas vaginalis	hypoxanthine-guanine phosphoribosyltransferase, putative	0.2019	0.4241	0.4241
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	0.2019	0.4241	0.4241
Loa Loa (eye worm)	orotate phosphoribosyltransferase	0.0473	0.094	0.094
Wolbachia endosymbiont of Brugia malayi	orotate phosphoribosyltransferase	0.0473	0.094	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.4717	1	1
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0473	0.094	0.094
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.2569	0.5416	0.5416
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0215	0.0391	0.0391
Chlamydia trachomatis	ribonuclease Z	0.0215	0.0391	1
Leishmania major	hypothetical protein, conserved	0.0215	0.0391	0.0391
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.0391	0.0391
Schistosoma mansoni	zinc phosphodiesterase	0.0215	0.0391	0.0391
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0215	0.0391	0.0391
Mycobacterium ulcerans	hydrolase	0.0215	0.0391	0.0921
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0215	0.0391	0.0391
Leishmania major	cleavage and polyadenylation specificity factor, putative	0.0215	0.0391	0.0391
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.0391	0.0391
Trichomonas vaginalis	protein kinase ck2-beta, putative	0.0751	0.1533	0.1533
Giardia lamblia	Kinase, CMGC CK2	0.4717	1	1
Plasmodium vivax	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Plasmodium falciparum	cytosolic glyoxalase II	0.0215	0.0391	0.0391
Mycobacterium leprae	AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE)	0.0473	0.094	0.2909
Treponema pallidum	phosphoribosylpyrophosphate synthetase	0.0473	0.094	1
Trypanosoma brucei	hydroxyacylglutathione hydrolase, putative	0.0215	0.0391	0.0391
Toxoplasma gondii	ck2 beta subunit	0.2569	0.5416	0.5416
Mycobacterium ulcerans	adenine phosphoribosyltransferase	0.0473	0.094	0.2217
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.2569	0.5416	0.5416
Onchocerca volvulus		0.2019	0.4241	0.7831
Toxoplasma gondii	CMGC kinase, CK2 family	0.4717	1	1
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0473	0.094	0.094
Entamoeba histolytica	alkyl sulfatase, putative	0.0215	0.0391	0.0391
Echinococcus multilocularis	hydroxyacylglutathione hydrolase	0.0215	0.0391	0.0391
Brugia malayi	MH2 domain containing protein	0.0117	0.0181	0.0181
Toxoplasma gondii	orotate phosphoribosyltransferase	0.0473	0.094	0.094
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.2019	0.4241	0.4241
Giardia lamblia	Casein kinase II beta chain	0.2569	0.5416	0.5416
Brugia malayi	ethe1-prov protein	0.0215	0.0391	0.0391
Trypanosoma cruzi	casein kinase II, putative	0.4717	1	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0791	0.1621	0.1621
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase, putative	0.2019	0.4241	0.4241
Trichomonas vaginalis	ribose-phosphate pyrophosphokinase, putative	0.0473	0.094	0.094
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0473	0.094	0.094
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0026	0.0026
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0215	0.0391	0.0391
Mycobacterium ulcerans	orotate phosphoribosyltransferase	0.0473	0.094	0.2217
Mycobacterium tuberculosis	Beta lactamase like protein	0.0215	0.0391	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0391	0.0391
Schistosoma mansoni	hypothetical protein	0.0215	0.0391	0.0391
Mycobacterium ulcerans	hypothetical protein	0.0215	0.0391	0.0921
Mycobacterium leprae	PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE)	0.0473	0.094	0.2909
Trichomonas vaginalis	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Trichomonas vaginalis	beta lactamase domain, putative	0.0215	0.0391	0.0391
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase cytoplasmic	0.0215	0.0391	0.0391
Schistosoma mansoni	zinc phosphodiesterase	0.0215	0.0391	0.0391
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	0.2019	0.4241	0.4241
Mycobacterium tuberculosis	Conserved protein	0.0215	0.0391	0.1209
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0751	0.1533	0.1533
Trichomonas vaginalis	CMGC family protein kinase	0.4717	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0751	0.1533	0.1533
Plasmodium vivax	orotate phosphoribosyltransferase, putative	0.0473	0.094	0.094
Schistosoma mansoni	uracil phosphoribosyltransferase	0.0473	0.094	0.094
Plasmodium vivax	casein kinase II beta chain, putative	0.2569	0.5416	0.5416
Mycobacterium ulcerans	hypoxanthine-guanine phosphoribosyltransferase Hpt	0.2019	0.4241	1
Brugia malayi	hypothetical protein	0.0215	0.0391	0.0391

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2365948

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1748316