Detailed information for compound 1749013

Basic information

Technical information
  • TDR Targets ID: 1749013
  • Name: N-hydroxy-2-methyl-2-phenylpropanamide
  • MW: 179.216 | Formula: C10H13NO2
  • H donors: 2 H acceptors: 2 LogP: 1.58 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)C(c1ccccc1)(C)C
  • InChi: 1S/C10H13NO2/c1-10(2,9(12)11-13)8-6-4-3-5-7-8/h3-7,13H,1-2H3,(H,11,12)
  • InChiKey: ZXXJKUBDSHZOAA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methyl-2-phenyl-propanehydroxamic acid
  • 2-methyl-2-phenylpropanehydroxamic acid
  • N-hydroxy-2-methyl-2-phenyl-propanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.017 0.4751 0.4751
Trypanosoma brucei histone deacetylase 4 0.0241 0.9499 0.5
Leishmania major histone deacetylase, putative 0.0241 0.9499 0.5
Echinococcus granulosus histone deacetylase 7 0.0241 0.9499 0.9296
Plasmodium vivax histone deacetylase 2, putative 0.0241 0.9499 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.017 0.4751 0.2626
Echinococcus granulosus histone deacetylase 0.0241 0.9499 0.9296
Trypanosoma cruzi histone deacetylase, putative 0.0241 0.9499 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.017 0.4751 0.4751
Echinococcus multilocularis histone deacetylase 6 0.0248 1 1
Plasmodium falciparum histone deacetylase, putative 0.0241 0.9499 0.5
Schistosoma mansoni coup transcription factor 0.017 0.4751 0.4751
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.017 0.4751 0.1954
Echinococcus multilocularis histone deacetylase 7 0.0241 0.9499 0.9296
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.017 0.4751 0.1954
Echinococcus multilocularis FTZ F1 alpha 0.017 0.4751 0.2626
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.017 0.4751 0.2626
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.017 0.4751 0.2626
Schistosoma mansoni histone deacetylase 4 5 0.0241 0.9499 0.9499
Brugia malayi Histone deacetylase family protein 0.0241 0.9499 1
Echinococcus granulosus FTZ F1 alpha 0.017 0.4751 0.2626
Loa Loa (eye worm) hypothetical protein 0.017 0.4751 0.1954
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.017 0.4751 0.2626
Loa Loa (eye worm) histone deacetylase 7A 0.0241 0.9499 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.017 0.4751 0.5
Trypanosoma brucei histone deacetylase, putative 0.0241 0.9499 0.5
Brugia malayi Histone deacetylase family protein 0.0241 0.9499 1
Loa Loa (eye worm) hypothetical protein 0.017 0.4751 0.1954
Leishmania major histone deacetylase, putative 0.0241 0.9499 0.5
Schistosoma mansoni nuclear hormone receptor 0.017 0.4751 0.4751
Plasmodium falciparum histone deacetylase 2 0.0241 0.9499 0.5
Schistosoma mansoni lipoxygenase 0.0142 0.2883 0.2883
Loa Loa (eye worm) hypothetical protein 0.0161 0.41 0.0849
Schistosoma mansoni RAR-like nuclear receptor 0.017 0.4751 0.4751
Schistosoma mansoni Tr4/Tr2 (homologue) 0.017 0.4751 0.4751
Loa Loa (eye worm) steroid hormone receptor 0.017 0.4751 0.1954
Echinococcus multilocularis thyroid hormone receptor alpha 0.017 0.4751 0.2626
Plasmodium vivax histone deacetylase, putative 0.0241 0.9499 0.5
Loa Loa (eye worm) hypothetical protein 0.017 0.4751 0.1954
Trypanosoma cruzi histone deacetylase, putative 0.0241 0.9499 0.5
Schistosoma mansoni histone deacetylase 4 5 0.0241 0.9499 0.9499
Echinococcus granulosus histone deacetylase 6 0.0241 0.9499 0.9296
Schistosoma mansoni thyroid hormone receptor 0.017 0.4751 0.4751
Loa Loa (eye worm) hypothetical protein 0.017 0.4751 0.1954
Schistosoma mansoni thyroid hormone receptor 0.017 0.4751 0.4751
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.017 0.4751 0.1954
Loa Loa (eye worm) histone deacetylase 0.0241 0.9499 1
Echinococcus multilocularis histone deacetylase 6 0.0241 0.9499 0.9296
Loa Loa (eye worm) hypothetical protein 0.017 0.4751 0.1954
Echinococcus granulosus nuclear receptor 2DBD gamma 0.017 0.4751 0.2626
Echinococcus granulosus nuclear receptor 2DBD gamma 0.017 0.4751 0.2626
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.017 0.4751 0.2626
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.017 0.4751 0.2626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.017 0.4751 0.1954
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.017 0.4751 0.2626
Toxoplasma gondii histone deacetylase HDAC1 0.0241 0.9499 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.017 0.4751 0.4751
Echinococcus multilocularis ecdysone induced protein 78C 0.017 0.4751 0.2626
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.017 0.4751 0.2626
Onchocerca volvulus Bile acid receptor homolog 0.017 0.4751 0.5
Echinococcus multilocularis histone deacetylase 0.0241 0.9499 0.9296
Echinococcus granulosus histone deacetylase 6 0.0241 0.9499 0.9296
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.017 0.4751 0.2626
Echinococcus multilocularis histone deacetylase 6 0.0241 0.9499 0.9296
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.017 0.4751 0.2626
Loa Loa (eye worm) hypothetical protein 0.017 0.4751 0.1954
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.017 0.4751 0.4751
Schistosoma mansoni retinoid-x-receptor (RXR) 0.017 0.4751 0.4751
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.017 0.4751 0.1954
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.017 0.4751 0.1954
Trypanosoma cruzi histone deacetylase, putative 0.0241 0.9499 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.017 0.4751 0.2626
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.017 0.4751 0.4751
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.017 0.4751 0.2626
Onchocerca volvulus 0.017 0.4751 0.5
Loa Loa (eye worm) hypothetical protein 0.017 0.4751 0.1954
Onchocerca volvulus Protein ultraspiracle homolog 0.017 0.4751 0.5
Schistosoma mansoni histone deacetylase hda2 0.0248 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.017 0.4751 0.4751
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.017 0.4751 0.1954
Trypanosoma brucei histone deacetylase 3 0.0241 0.9499 0.5
Loa Loa (eye worm) hypothetical protein 0.017 0.4751 0.1954

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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