Detailed information for compound 1749131

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 698.247 | Formula: C40H44ClN3O6
  • H donors: 5 H acceptors: 4 LogP: 4.04 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1ccc2c3c1OC1[C@@]43CCN([C@H](C2)C4(O)Cc2c1[nH]c1c2CC2(C34[C@H]1Oc1c4c(CC2N(CC3)CC2CC2)ccc1O)O)CC1CC1.Cl
  • InChi: 1S/C40H43N3O6.ClH/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19;/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2;1H/t27-,28?,35?,36+,37+,38?,39?,40?;/m1./s1
  • InChiKey: SQNOQAMOMUBPHK-VQFWECJBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAD52 homolog (S. cerevisiae) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia DNA repair protein RAD52 Get druggable targets OG5_130806 All targets in OG5_130806
Entamoeba histolytica DNA repair and recombination protein RAD52, putative Get druggable targets OG5_130806 All targets in OG5_130806
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0305 0.1039 0.1039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0037 0.0058
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0305 0.1039 0.1647
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0507 0.1748 0.1748
Schistosoma mansoni hypothetical protein 0.0042 0.0114 0.0181
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0312 0.161
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0037 0.0076
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0037 0.0058
Echinococcus multilocularis Cyclin L1 0.0098 0.0312 0.0495
Echinococcus multilocularis heat shock transcription factor 0.0073 0.0223 0.0353
Onchocerca volvulus 0.0098 0.0312 0.0774
Echinococcus granulosus cyclin dependent kinase 9 0.0246 0.0833 0.1319
Plasmodium vivax cyclin 4, putative 0.0098 0.0312 0.161
Echinococcus multilocularis cyclin b3 0.0285 0.0968 0.1534
Trichomonas vaginalis cyclins, putative 0.0098 0.0312 0.161
Entamoeba histolytica cyclin, domain containing protein 0.0098 0.0312 0.0665
Echinococcus multilocularis cyclin y 0.0098 0.0312 0.0495
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0049 0.0147
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0077 0.0236 0.0374
Echinococcus multilocularis cyclin 0.0172 0.0572 0.0907
Loa Loa (eye worm) carboxylesterase 0.0305 0.1039 0.1039
Loa Loa (eye worm) cyclin domain-containing protein 0.2856 1 1
Trypanosoma brucei protein kinase, putative 0.005 0.0143 0.0691
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0049 0.0049
Echinococcus multilocularis cyclin k 0.0098 0.0312 0.0495
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0309 0.0309
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0425 0.387
Loa Loa (eye worm) CYL-1 protein 0.0098 0.0312 0.0312
Brugia malayi Pre-SET motif family protein 0.0252 0.0853 0.0853
Brugia malayi hypothetical protein 0.0042 0.0114 0.0114
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0113 0.0442
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Trypanosoma brucei cyclin 3 0.0098 0.0312 0.1673
Echinococcus granulosus cyclin dependent kinase 1 0.0507 0.1748 0.2769
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0049 0.0147
Brugia malayi Carboxylesterase family protein 0.0305 0.1039 0.1039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0037 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0507 0.1748 0.2769
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0042 0.0114 0.0181
Echinococcus multilocularis G1:S specific cyclin D1 0.0263 0.0893 0.1414
Echinococcus granulosus BC026374 protein S09 family 0.0305 0.1039 0.1647
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0047 0.0047
Giardia lamblia Kinase, CAMK CAMKL 0.005 0.0143 0.0619
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0975 0.5482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0037 0.0037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0168 0.1307
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus multilocularis cyclin B 0.0312 0.1064 0.1685
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0047 0.0135
Loa Loa (eye worm) hypothetical protein 0.0134 0.0439 0.0439
Trichomonas vaginalis serine/threonine kinase, putative 0.005 0.0143 0.0619
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0037 0.0058
Loa Loa (eye worm) hypothetical protein 0.0305 0.1039 0.1039
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0002 0.0004
Onchocerca volvulus 0.0312 0.1064 0.2636
Onchocerca volvulus Cyclin L homolog 0.0098 0.0312 0.0774
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1702 0.2697
Trypanosoma cruzi cyclin, putative 0.0312 0.1064 0.6003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0853 0.0853
Plasmodium vivax cyclin homologue, putative 0.0098 0.0312 0.161
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0049 0.0147
Trichomonas vaginalis AGC family protein kinase 0.005 0.0143 0.0619
Schistosoma mansoni coup transcription factor 0.002 0.0037 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Onchocerca volvulus 0.0305 0.1039 0.2575
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0113 0.0178
Loa Loa (eye worm) hypothetical protein 0.028 0.0952 0.0952
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0097 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0097 0.0153
Brugia malayi Protein kinase domain containing protein 0.0076 0.0235 0.0235
Brugia malayi Carboxylesterase family protein 0.1806 0.6313 0.6313
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.028 0.0952 0.1508
Plasmodium vivax SET domain protein, putative 0.0037 0.0097 0.0349
Echinococcus granulosus cyclins 0.0285 0.0968 0.1534
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.1929 0.3056
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0113 0.0442
Echinococcus granulosus cyclins 0.0285 0.0968 0.1534
Entamoeba histolytica cyclin, putative 0.0312 0.1064 0.2549
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.001 0.0015
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1806 0.6313 1
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.005 0.0143 0.0226
Loa Loa (eye worm) acetylcholinesterase 1 0.1806 0.6313 0.6313
Brugia malayi Cyclin, N-terminal domain containing protein 0.0242 0.0816 0.0816
Echinococcus multilocularis acetylcholinesterase 0.1806 0.6313 1
Trichomonas vaginalis cyclin B, putative 0.0312 0.1064 0.6003
Toxoplasma gondii hypothetical protein 0.0187 0.0624 0.3429
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0507 0.1748 0.1748
Echinococcus multilocularis neuroligin 0.0305 0.1039 0.1647
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Echinococcus multilocularis serine:threonine protein kinase NLK 0.005 0.0143 0.0226
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0285 0.0968 0.1534
Giardia lamblia Kinase, CAMK CAMKL 0.005 0.0143 0.0619
Brugia malayi ecdysteroid receptor 0.002 0.0037 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus multilocularis dna polymerase eta 0.0023 0.0049 0.0078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0037 0.0058
Trichomonas vaginalis cyclins, putative 0.0312 0.1064 0.6003
Loa Loa (eye worm) cyclin domain-containing protein 0.0098 0.0312 0.0312
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0291 0.046
Giardia lamblia DNA repair protein RAD52 0.042 0.1442 0.8212
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0097 0.0153
Schistosoma mansoni thyroid hormone receptor 0.002 0.0037 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0097 0.0153
Echinococcus granulosus para nitrobenzyl esterase 0.0305 0.1039 0.1647
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0098 0.0312 0.161
Onchocerca volvulus 0.0035 0.0089 0.0221
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.005 0.0143 0.0619
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0425 0.387
Giardia lamblia Cyclin A 0.0285 0.0968 0.5445
Trichomonas vaginalis cyclins, putative 0.0312 0.1064 0.6003
Echinococcus granulosus muscleblind protein 0.018 0.0601 0.0952
Entamoeba histolytica hypothetical protein 0.0098 0.0312 0.0665
Trichomonas vaginalis cyclin B, putative 0.0312 0.1064 0.6003
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni neuroligin 3 (S09 family) 0.0305 0.1039 0.1647
Schistosoma mansoni cyclin G2 0.0098 0.0312 0.0495
Toxoplasma gondii thioredoxin reductase 0.0057 0.0168 0.0766
Giardia lamblia Kinase, CMGC CDK 0.0507 0.1748 1
Trichomonas vaginalis cyclin A, putative 0.0312 0.1064 0.6003
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0461 0.073
Onchocerca volvulus 0.002 0.0037 0.0091
Giardia lamblia Cyclin fold protein 1, putative 0.0098 0.0312 0.161
Trichomonas vaginalis cyclin A, putative 0.0098 0.0312 0.161
Trypanosoma cruzi cyclin, putative 0.0312 0.1064 0.6003
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0092 0.0291 0.0291
Plasmodium falciparum thioredoxin reductase 0.0057 0.0168 0.0766
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0037 0.0037
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0305 0.1039 0.1647
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0037 0.0058
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.005 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0097 0.0309 0.0309
Schistosoma mansoni hypothetical protein 0.0031 0.0075 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0049 0.0072
Echinococcus granulosus cyclin y 0.0098 0.0312 0.0495
Schistosoma mansoni heat shock transcription factor 0.0073 0.0223 0.0353
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0004 0.0006
Entamoeba histolytica cell division protein kinase 2, putative 0.0549 0.1895 0.4631
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0002 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0037 0.0037
Trypanosoma brucei unspecified product 0.0023 0.0049 0.0147
Loa Loa (eye worm) hypothetical protein 0.0134 0.0439 0.0439
Echinococcus multilocularis cyclin t1 0.0098 0.0312 0.0495
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0507 0.1748 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.1039 0.1039
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0476 1
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0037 0.0058
Leishmania major cyclin 0.0312 0.1064 0.6003
Schistosoma mansoni heat shock transcription factor 0.0073 0.0223 0.0353
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0047 0.006
Trichomonas vaginalis cyclins, putative 0.0285 0.0968 0.5445
Brugia malayi steroid hormone receptor 0.002 0.0037 0.0037
Trichomonas vaginalis AGC family protein kinase 0.005 0.0143 0.0619
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0476 0.4379
Schistosoma mansoni kinase 0.0246 0.0833 0.1319
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0049 0.0123
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0049 0.0147
Giardia lamblia G2/mitotic-specific cyclin B 0.0312 0.1064 0.6003
Onchocerca volvulus Protein CNPPD1 homolog 0.0098 0.0312 0.0774
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0037 0.0091
Schistosoma mansoni thyroid hormone receptor 0.002 0.0037 0.0058
Echinococcus multilocularis carboxylesterase 5A 0.1806 0.6313 1
Trichomonas vaginalis AGC family protein kinase 0.005 0.0143 0.0619
Loa Loa (eye worm) hypothetical protein 0.0165 0.0548 0.0548
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0037 0.0037
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0507 0.1748 1
Echinococcus multilocularis cyclins 0.0285 0.0968 0.1534
Echinococcus granulosus cyclin B3 1 0.0285 0.0968 0.1534
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0098 0.0312 0.161
Plasmodium falciparum glutathione reductase 0.0057 0.0168 0.0766
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0113 0.0442
Onchocerca volvulus 0.0305 0.1039 0.2575
Trichomonas vaginalis protein kinase atmrk1, putative 0.005 0.0143 0.0619
Loa Loa (eye worm) hypothetical protein 0.1418 0.495 0.495
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0037 0.0058
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0037 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0285 0.0968 0.5445
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0476 0.4379
Loa Loa (eye worm) haspin protein kinase 0.005 0.0143 0.0143
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0305 0.1039 1
Schistosoma mansoni protein kinase 0.005 0.0143 0.0226
Brugia malayi hypothetical protein 0.0098 0.0312 0.0312
Trichomonas vaginalis cyclins, putative 0.0125 0.0408 0.2168
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0049 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.0833 0.1319
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0507 0.1748 0.2769
Trichomonas vaginalis cyclin B3, putative 0.0098 0.0312 0.161
Echinococcus multilocularis hypothetical protein 0.0042 0.0114 0.0181
Schistosoma mansoni cpg binding protein 0.0037 0.0096 0.0152
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0037 0.0058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0047 0.006
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0305 0.1039 0.586
Entamoeba histolytica heat shock transcription factor, putative 0.0073 0.0223 0.044
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Schistosoma mansoni cyclin k 0.0098 0.0312 0.0495
Echinococcus granulosus tar DNA binding protein 0.0062 0.0186 0.0294
Loa Loa (eye worm) hypothetical protein 0.0066 0.0201 0.0201
Brugia malayi Pre-SET motif family protein 0.0037 0.0097 0.0097
Trichomonas vaginalis CMGC family protein kinase 0.0507 0.1748 1
Schistosoma mansoni heat shock transcription factor 0.0073 0.0223 0.0353
Loa Loa (eye worm) hypothetical protein 0.0031 0.0075 0.0075
Brugia malayi Cyclin, N-terminal domain containing protein 0.0312 0.1064 0.1064
Trichomonas vaginalis cyclin B, putative 0.0312 0.1064 0.6003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0089 0.0089
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0098 0.0312 0.0495
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0186 0.0294
Loa Loa (eye worm) haspin protein kinase 0.0042 0.0114 0.0114
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0002 0.0004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0075 0.0075
Echinococcus multilocularis muscleblind protein 0.018 0.0601 0.0952
Echinococcus multilocularis para nitrobenzyl esterase 0.0305 0.1039 0.1647
Trichomonas vaginalis cyclin B3, putative 0.0285 0.0968 0.5445
Brugia malayi hypothetical protein 0.0098 0.0312 0.0312
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.005 0.0143 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0049 0.0049
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0476 0.4379
Brugia malayi nuclear hormone receptor 0.002 0.0037 0.0037
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1702 0.2697
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0049 0.0147
Entamoeba histolytica heat shock transcription factor, putative 0.1158 0.4036 1
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0049 0.0078
Loa Loa (eye worm) hypothetical protein 0.1806 0.6313 0.6313
Schistosoma mansoni g1/s-specific cyclin C 0.0172 0.0572 0.0907
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0201 0.0201
Brugia malayi Cell division protein kinase 2 0.005 0.0143 0.0143
Echinococcus granulosus serine:threonine protein kinase NLK 0.005 0.0143 0.0226
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Echinococcus multilocularis cyclins 0.0285 0.0968 0.1534
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0049 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus granulosus cyclin dependent kinase 5 0.0507 0.1748 0.2769
Brugia malayi nuclear receptor NHR-88 0.002 0.0037 0.0037
Entamoeba histolytica heat shock transcription factor, putative 0.1158 0.4036 1
Plasmodium falciparum cyclin 0.0285 0.0968 0.5445
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0097 0.0153
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0305 0.1039 0.1647
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0037 0.0037
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.005 0.0143 0.0619
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0285 0.0968 0.1534
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0037 0.0037
Echinococcus granulosus cyclin t1 0.0098 0.0312 0.0495
Trichomonas vaginalis cyclins, putative 0.0312 0.1064 0.6003
Giardia lamblia Hypothetical protein 0.0098 0.0312 0.161
Echinococcus granulosus cyclin dependent kinase 7 0.0092 0.0291 0.046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0037 0.0037
Brugia malayi hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0186 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0312 0.161
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0037 0.0037
Trichomonas vaginalis cyclins, putative 0.0312 0.1064 0.6003
Schistosoma mansoni serine/threonine kinase 0.005 0.0143 0.0226
Echinococcus granulosus Cyclin L1 0.0098 0.0312 0.0495
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0037 0.0058
Echinococcus granulosus cyclin G2 0.0098 0.0312 0.0495
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0004 0.0006
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0098 0.0312 0.0495
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0049 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0049 0.0147
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0186 0.0294
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Echinococcus multilocularis BC026374 protein (S09 family) 0.0305 0.1039 0.1647
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0037 0.0058
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0461 0.0461
Echinococcus granulosus dna polymerase kappa 0.0023 0.0049 0.0078
Onchocerca volvulus 0.0305 0.1039 0.2575
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0047 0.006
Brugia malayi cyclin-dependent kinase 7 homolog 0.0134 0.0437 0.0437
Brugia malayi Carboxylesterase family protein 0.0305 0.1039 0.1039
Brugia malayi hypothetical protein 0.001 0.0004 0.0004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0037 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0098 0.0312 0.161
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0143 0.0619
Trichomonas vaginalis cyclin B, putative 0.0312 0.1064 0.6003
Loa Loa (eye worm) carboxylesterase 0.0305 0.1039 0.1039
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0075 0.0075
Echinococcus multilocularis GPCR, family 2 0.0031 0.0075 0.0119
Onchocerca volvulus Cyclin L homolog 0.0098 0.0312 0.0774
Schistosoma mansoni cyclin B 0.0312 0.1064 0.1685
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0037 0.5
Trypanosoma brucei cdc2-related kinase 1 0.0507 0.1748 1
Schistosoma mansoni cyclin d 0.0263 0.0893 0.1414
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0047 0.006
Echinococcus granulosus cyclin B 0.0312 0.1064 0.1685
Trypanosoma brucei trypanothione reductase 0.0057 0.0168 0.0836
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Plasmodium falciparum MO15-related protein kinase 0.005 0.0143 0.0619
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0049 0.0078
Loa Loa (eye worm) hypothetical protein 0.1806 0.6313 0.6313
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0037 0.0037
Loa Loa (eye worm) cyclin C 0.0172 0.0572 0.0572
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0037 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Leishmania major mitotic cyclin, putative 0.0098 0.0312 0.161
Toxoplasma gondii cyclin 4, putative 0.0098 0.0312 0.161
Echinococcus multilocularis cyclin dependent kinase 6 0.0191 0.0638 0.1011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0047 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0186 0.0294
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0049 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Schistosoma mansoni hypothetical protein 0.0031 0.0075 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0143 0.0226
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0119 0.0387 0.0852
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0049 0.0123
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0037 0.0076
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0047 0.006
Trichomonas vaginalis cyclin B, putative 0.0098 0.0312 0.161
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.1929 0.3056
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0009 0.0009
Onchocerca volvulus 0.0305 0.1039 0.2575
Brugia malayi nuclear receptor RXR 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0172 0.0572 0.0907
Brugia malayi Cyclin, N-terminal domain containing protein 0.0312 0.1064 0.1064
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.005 0.0143 0.0619
Trypanosoma brucei mitotic cyclin 0.0098 0.0312 0.1673
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Brugia malayi Thioredoxin reductase 0.0057 0.0168 0.0168
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0049 0.0123
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0037 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0049 0.0147
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0143 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Loa Loa (eye worm) carboxylesterase 0.1806 0.6313 0.6313
Echinococcus granulosus cyclin 0.0172 0.0572 0.0907
Loa Loa (eye worm) hypothetical protein 0.0312 0.1064 0.1064
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0113 0.0442
Echinococcus granulosus cyclin dependent kinase 0.0507 0.1748 0.2769
Trypanosoma cruzi CYC2-like cyclin, putative 0.0312 0.1064 0.6003
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0168 0.0766
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0047 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0037 0.0037
Brugia malayi HSF-type DNA-binding domain containing protein 0.1158 0.4036 0.4036
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0168 0.0766
Brugia malayi TAR-binding protein 0.0062 0.0186 0.0186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0312 0.1064 0.1064
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0049 0.0147
Loa Loa (eye worm) hypothetical protein 0.0037 0.0097 0.0097
Echinococcus granulosus cyclin dependent kinase 9 0.0288 0.0979 0.1551
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0049 0.0147
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0143 0.024
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0037 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus granulosus serine:threonine protein kinase haspin 0.0042 0.0114 0.0181
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.005 0.0143 0.0619
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0037 0.0091
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0037 0.0058
Echinococcus multilocularis muscleblind protein 1 0.018 0.0601 0.0952
Loa Loa (eye worm) hypothetical protein 0.1158 0.4036 0.4036
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0461 0.073
Toxoplasma gondii hypothetical protein 0.0098 0.0312 0.161
Echinococcus granulosus neuroligin 0.0305 0.1039 0.1647
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus multilocularis cyclin dependent kinase 9 0.0288 0.0979 0.1551
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.01 0.0372
Brugia malayi Protein kinase domain containing protein 0.005 0.0143 0.0143
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0049 0.0078
Giardia lamblia Hypothetical protein 0.0098 0.0312 0.161
Brugia malayi glutathione reductase 0.0057 0.0168 0.0168
Entamoeba histolytica heat shock transcription factor, putative 0.1158 0.4036 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0037 0.0037
Trypanosoma brucei cyclin 9 0.0098 0.0312 0.1673
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0097 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0246 0.0833 0.0833
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus multilocularis cyclin y 0.0098 0.0312 0.0495
Giardia lamblia Kinase, CAMK CAMKL 0.005 0.0143 0.0619
Schistosoma mansoni hypothetical protein 0.0031 0.0075 0.0119
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.028 0.0952 0.1508
Brugia malayi Cyclin, N-terminal domain containing protein 0.0098 0.0312 0.0312
Brugia malayi CXXC zinc finger family protein 0.0035 0.0089 0.0089
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0004 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0049 0.0147
Trypanosoma cruzi mitotic cyclin, putative 0.0098 0.0312 0.161
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.042 0.1442 0.3497
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0037 0.0037
Entamoeba histolytica cell division protein kinase 2, putative 0.0507 0.1748 0.4263
Schistosoma mansoni serine/threonine protein kinase 0.0507 0.1748 0.2769
Trichomonas vaginalis spcc417.12 protein, putative 0.0305 0.1039 0.586
Schistosoma mansoni acetylcholinesterase 0.0305 0.1039 0.1647
Trichomonas vaginalis cyclin B, putative 0.0098 0.0312 0.161
Entamoeba histolytica heat shock transcription factor, putative 0.0073 0.0223 0.044
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0312 0.1064 0.6003
Schistosoma mansoni cyclin G 0.0098 0.0312 0.0495
Schistosoma mansoni hypothetical protein 0.0066 0.0201 0.0318
Loa Loa (eye worm) cyclin domain-containing protein 0.0098 0.0312 0.0312
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0215 0.1041
Trypanosoma cruzi cdc2-related kinase 1 0.0507 0.1748 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0098 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0305 0.1039 0.1039
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0305 0.1039 0.1039
Giardia lamblia DINP protein human, muc B family 0.0023 0.0049 0.0072
Loa Loa (eye worm) cyclin domain-containing protein 0.0242 0.0816 0.0816
Echinococcus multilocularis cyclins 0.0285 0.0968 0.1534
Brugia malayi Cyclin, N-terminal domain containing protein 0.0263 0.0893 0.0893
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0002 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus granulosus mitogen activated protein kinase 15 0.005 0.0143 0.0226
Trypanosoma cruzi cyclin 6, putative 0.0312 0.1064 0.6003
Echinococcus granulosus G1:S specific cyclin D1 0.0263 0.0893 0.1414
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0168 0.0266
Loa Loa (eye worm) hypothetical protein 0.0305 0.1039 0.1039
Mycobacterium tuberculosis Probable reductase 0.013 0.0425 0.387
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Brugia malayi Muscleblind-like protein 0.018 0.0601 0.0601
Trypanosoma cruzi cdc2-related kinase 3 0.0507 0.1748 1
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0037 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0037 0.0037
Trypanosoma cruzi cyclin 9, putative 0.0098 0.0312 0.161
Schistosoma mansoni ap endonuclease 0.0023 0.0047 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.0312 0.161
Trichomonas vaginalis AGC family protein kinase 0.005 0.0143 0.0619
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0425 0.387
Echinococcus granulosus cyclins 0.0285 0.0968 0.1534
Brugia malayi Cyclin C 0.0172 0.0572 0.0572
Schistosoma mansoni gliotactin 0.0305 0.1039 0.1647
Brugia malayi hypothetical protein 0.0305 0.1039 0.1039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0309 0.0309
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0037 0.0058
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.005 0.0143 0.0619
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0143 0.0619
Loa Loa (eye worm) cyclin domain-containing protein 0.0098 0.0312 0.0312
Giardia lamblia Hypothetical protein 0.0285 0.0968 0.5445
Entamoeba histolytica cyclin C, putative 0.0098 0.0312 0.0665
Loa Loa (eye worm) hypothetical protein 0.0263 0.0893 0.0893
Schistosoma mansoni cyclin B3 0.0285 0.0968 0.1534
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0037 0.0058
Schistosoma mansoni cpg binding protein 0.0037 0.0096 0.0152
Brugia malayi GSG2 0.0042 0.0114 0.0114
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0037 0.0037
Trichomonas vaginalis cyclin B, putative 0.0285 0.0968 0.5445
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0037 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus granulosus cyclin A3 4 0.0098 0.0312 0.0495
Echinococcus granulosus serine:threonine protein kinase haspin 0.0042 0.0114 0.0181
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.028 0.0952 0.1508
Trichomonas vaginalis cyclin D, putative 0.0285 0.0968 0.5445
Echinococcus multilocularis cyclin G2 0.0098 0.0312 0.0495
Giardia lamblia Kinase, CMGC CDK 0.0507 0.1748 1
Leishmania major trypanothione reductase 0.0057 0.0168 0.0766
Plasmodium vivax protein kinase Crk2 0.0507 0.1748 1
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0076 0.0235 0.0235
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0037 0.0058
Onchocerca volvulus 0.0305 0.1039 0.2575
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0097 0.0153
Leishmania major serine/threonine kinase-like protein, putative 0.005 0.0143 0.0619
Echinococcus granulosus cyclin y 0.0098 0.0312 0.0495
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.01 0.0372
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0075 0.0119
Echinococcus granulosus FTZ F1 alpha 0.002 0.0037 0.0058
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0037 0.0058
Echinococcus granulosus acetylcholinesterase 0.1806 0.6313 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0049 0.0147
Loa Loa (eye worm) glutathione reductase 0.0057 0.0168 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Trypanosoma cruzi cdc2-related kinase 1 0.0507 0.1748 1
Toxoplasma gondii cyclin dependent kinase binding protein 0.0098 0.0312 0.161
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0002 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Trypanosoma brucei cdc2-related kinase 3 0.0507 0.1748 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0037 0.0037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0037 0.0058
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0075 0.0119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0075 0.0119
Echinococcus granulosus GPCR family 2 0.0031 0.0075 0.0119
Echinococcus granulosus cyclins 0.0285 0.0968 0.1534
Loa Loa (eye worm) cyclin domain-containing protein 0.0098 0.0312 0.0312
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0186 0.0186
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0018 0.0018
Echinococcus multilocularis cyclin dependent kinase 5 0.0507 0.1748 0.2769
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0037 0.0058
Brugia malayi RNA binding protein 0.0062 0.0186 0.0186
Toxoplasma gondii exonuclease III APE 0.0023 0.0047 0.006
Trichomonas vaginalis cyclin H, putative 0.0069 0.0211 0.1018
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0004 0.0004
Entamoeba histolytica cyclin, domain containing protein 0.0098 0.0312 0.0665
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus granulosus cpg binding protein 0.0037 0.0096 0.0152
Schistosoma mansoni hypothetical protein 0.0494 0.1702 0.2697
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0004 0.0004
Brugia malayi Carboxylesterase family protein 0.1806 0.6313 0.6313
Echinococcus multilocularis cyclin dependent kinase 1 0.0507 0.1748 0.2769
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.01 0.0134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0049 0.0072
Echinococcus granulosus serine:threonine protein kinase haspin 0.0042 0.0114 0.0181
Schistosoma mansoni cpg binding protein 0.0035 0.0089 0.0141
Onchocerca volvulus Heat shock factor protein 2 homolog 0.1158 0.4036 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0113 0.0442
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0049 0.0123
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Entamoeba histolytica heat shock transcription factor, putative 0.0073 0.0223 0.044
Echinococcus multilocularis cyclin B3 1 0.0285 0.0968 0.1534
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0168 0.0266
Trichomonas vaginalis cyclin D, putative 0.0098 0.0312 0.161
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0037 0.0058
Entamoeba histolytica protein kinase domain containing protein 0.0246 0.0833 0.1969
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0037 0.0037
Schistosoma mansoni ap endonuclease 0.0023 0.0047 0.0075
Trichomonas vaginalis AGC family protein kinase 0.005 0.0143 0.0619
Entamoeba histolytica cyclin family protein 0.0285 0.0968 0.231
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0047 0.0102
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0075 0.0119
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0309 0.0309
Echinococcus granulosus cyclin b3 0.0285 0.0968 0.1534
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0037 0.0058
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0004 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0049 0.0072
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0047 0.006
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0047 0.006
Schistosoma mansoni Cyclin fold protein 0.0098 0.0312 0.0495
Trypanosoma cruzi cdc2-related kinase 3 0.0507 0.1748 1
Echinococcus granulosus cyclin k 0.0098 0.0312 0.0495
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0037 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Brugia malayi Carboxylesterase family protein 0.0305 0.1039 0.1039
Loa Loa (eye worm) hypothetical protein 0.0305 0.1039 0.1039
Brugia malayi Cyclin, N-terminal domain containing protein 0.0098 0.0312 0.0312
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0098 0.0312 0.1673
Brugia malayi Carboxylesterase family protein 0.0305 0.1039 0.1039
Echinococcus multilocularis cyclin G2 0.0098 0.0312 0.0495
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0098 0.0312 0.161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0037 0.0037
Entamoeba histolytica heat shock transcription factor, putative 0.0073 0.0223 0.044
Trypanosoma cruzi mitotic cyclin, putative 0.0098 0.0312 0.161
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0047 0.0047
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0186 0.0186
Echinococcus multilocularis cyclin A3 4 0.0098 0.0312 0.0495
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0037 0.0037
Loa Loa (eye worm) cyclin domain-containing protein 0.0285 0.0968 0.0968
Echinococcus granulosus Cell division cycle 2 protein kinase 0.005 0.0143 0.0226
Onchocerca volvulus 0.0287 0.0975 0.2415
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0037 0.0058
Echinococcus granulosus carboxylesterase 5A 0.1806 0.6313 1
Brugia malayi cell division control protein 2 homolog 0.0507 0.1748 0.1748
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0037 0.0058
Loa Loa (eye worm) hypothetical protein 0.018 0.0601 0.0601
Echinococcus granulosus cyclins 0.0285 0.0968 0.1534
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0089 0.0141
Trichomonas vaginalis cyclins, putative 0.0098 0.0312 0.161
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0047 1
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Brugia malayi hypothetical protein 0.0134 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0499 0.1719 0.1719
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0098 0.0312 0.161
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0097 0.0349
Leishmania major DNA polymerase eta, putative 0.0023 0.0049 0.0072
Mycobacterium ulcerans carboxylesterase, LipT 0.0305 0.1039 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0047 0.0075
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0004 0.0004
Leishmania major DNA polymerase kappa, putative 0.0023 0.0049 0.0072
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0098 0.0312 0.161
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0049 0.0147
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0037 0.0037
Leishmania major cyclin 9, putative 0.0098 0.0312 0.161
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0186 0.0186
Plasmodium falciparum protein kinase 5 0.0507 0.1748 1
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0312 0.161
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.018 0.0601 0.0601
Echinococcus granulosus neuropeptide s receptor 0.0558 0.1929 0.3056
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.005 0.0143 0.0691
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0305 0.1039 0.1647
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0186 0.0294
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0047 0.0102
Echinococcus multilocularis cyclins 0.0285 0.0968 0.1534
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0037 0.0037
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0186 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0049 0.0147
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0447 0.0708
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0049 0.0072
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0507 0.1748 0.1748
Schistosoma mansoni peptidase 0.0012 0.0008 0.0013
Echinococcus granulosus heat shock transcription factor 0.0073 0.0223 0.0353
Brugia malayi Cyclin, N-terminal domain containing protein 0.0285 0.0968 0.0968
Trichomonas vaginalis AGC family protein kinase 0.005 0.0143 0.0619
Leishmania major mitotic cyclin, putative 0.0098 0.0312 0.161
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0638 0.1011
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0037 0.0058
Echinococcus granulosus cyclin dependent kinase 6 0.0191 0.0638 0.1011
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0037 0.0058
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0507 0.1748 1
Echinococcus granulosus dna polymerase eta 0.0023 0.0049 0.0078
Trichomonas vaginalis AGC family protein kinase 0.005 0.0143 0.0619
Trichomonas vaginalis cyclin D, putative 0.0285 0.0968 0.5445
Schistosoma mansoni nuclear hormone receptor 0.002 0.0037 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0291 0.046
Schistosoma mansoni BC026374 protein (S09 family) 0.0305 0.1039 0.1647
Brugia malayi Cyclin, N-terminal domain containing protein 0.0098 0.0312 0.0312
Trypanosoma cruzi serine/threonine protein kinase, putative 0.005 0.0143 0.0619
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0037 0.0058
Loa Loa (eye worm) RNA binding protein 0.0062 0.0186 0.0186
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Loa Loa (eye worm) histone methyltransferase 0.0012 0.001 0.001
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0049 0.0072
Schistosoma mansoni hypothetical protein 0.0031 0.0075 0.0119
Schistosoma mansoni hypothetical protein 0.0042 0.0114 0.0181
Echinococcus multilocularis cyclin dependent kinase 1 0.0507 0.1748 0.2769
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0305 0.1039 0.1647
Trypanosoma brucei mitotic cyclin 6 0.0312 0.1064 0.6033
Trichomonas vaginalis CMGC family protein kinase 0.0507 0.1748 1
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0425 0.387
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0168 0.0168
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0098 0.0312 0.0495
Entamoeba histolytica hypothetical protein 0.0119 0.0387 0.0852
Schistosoma mansoni hypothetical protein 0.0098 0.0312 0.0495
Plasmodium falciparum cyclin 1 0.0098 0.0312 0.161
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0507 0.1748 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0305 0.1039 1
Entamoeba histolytica hypothetical protein 0.0069 0.0211 0.0411
Echinococcus multilocularis acetylcholinesterase 0.1806 0.6313 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0049 0.0147
Echinococcus multilocularis cyclins 0.0285 0.0968 0.1534
Entamoeba histolytica cyclin, putative 0.0285 0.0968 0.231
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0076 0.0235 0.0372
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0312 0.161
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0042 0.0114 0.0181
Trichomonas vaginalis cyclin B3, putative 0.0098 0.0312 0.161
Echinococcus multilocularis cyclin dependent kinase 9 0.0246 0.0833 0.1319
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0143 0.0619
Schistosoma mansoni cyclins 0.0285 0.0968 0.1534
Schistosoma mansoni heat shock transcription factor 0.0073 0.0223 0.0353
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus granulosus cyclins 0.0098 0.0312 0.0495
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.1929 0.3056
Echinococcus multilocularis cpg binding protein 0.0037 0.0096 0.0152
Entamoeba histolytica cyclin family protein 0.0285 0.0968 0.231
Giardia lamblia Cyclin B-like protein 0.0098 0.0312 0.161
Schistosoma mansoni hypothetical protein 0.0098 0.0312 0.0495
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.023 0.0365
Loa Loa (eye worm) acetyltransferase 0.0141 0.0461 0.0461
Loa Loa (eye worm) haspin protein kinase 0.0042 0.0114 0.0114
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0047 1
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0098 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Mycobacterium tuberculosis Carboxylesterase LipT 0.0305 0.1039 1
Echinococcus granulosus acetylcholinesterase 0.1806 0.6313 1
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0143 0.0619
Echinococcus multilocularis cyclins 0.0285 0.0968 0.1534
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0037 0.0058
Brugia malayi Protein kinase domain containing protein 0.0507 0.1748 0.1748
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0042 0.0114 0.0181
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.001 0.0015
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0037 0.0037
Echinococcus multilocularis cyclin dependent kinase 7 0.0092 0.0291 0.046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0049 0.0072
Brugia malayi cyclin fold protein 1 variant b 0.0098 0.0312 0.0312
Entamoeba histolytica hypothetical protein 0.0042 0.0114 0.0168
Plasmodium vivax glutathione reductase, putative 0.0057 0.0168 0.0766
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0425 0.387
Echinococcus multilocularis cyclin dependent kinase 0.0507 0.1748 0.2769
Schistosoma mansoni DNA polymerase eta 0.0023 0.0049 0.0078
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.005 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0049 0.0078
Brugia malayi cyclin-dependent kinase 9 0.0246 0.0833 0.0833
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0172 0.0572 0.0907
Echinococcus multilocularis cyclins 0.0285 0.0968 0.1534
Onchocerca volvulus 0.0037 0.0097 0.0239
Echinococcus granulosus cyclin G2 0.0098 0.0312 0.0495
Schistosoma mansoni cyclin l 0.0098 0.0312 0.0495

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 11.05 uM PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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