Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1669 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1291 | 0.1291 |
Onchocerca volvulus | 0.0282 | 0.1291 | 0.5 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0282 | 0.1291 | 0.1291 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1291 | 0.1291 |
Echinococcus granulosus | acetylcholinesterase | 0.1669 | 1 | 1 |
Onchocerca volvulus | 0.0282 | 0.1291 | 0.5 | |
Onchocerca volvulus | 0.0282 | 0.1291 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0282 | 0.1291 | 0.1291 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0273 | 0.1233 | 1 |
Brugia malayi | glutathione reductase | 0.0273 | 0.1233 | 0.1233 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0282 | 0.1291 | 0.1291 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0282 | 0.1291 | 0.1291 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1291 | 0.1291 |
Brugia malayi | Carboxylesterase family protein | 0.0282 | 0.1291 | 0.1291 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0481 | 0.2537 | 0.2537 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1291 | 0.1291 |
Schistosoma mansoni | gliotactin | 0.0282 | 0.1291 | 0.1291 |
Trypanosoma brucei | trypanothione reductase | 0.0273 | 0.1233 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0095 | 0.0113 | 0.0113 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0273 | 0.1233 | 0.1233 |
Plasmodium vivax | glutathione reductase, putative | 0.0273 | 0.1233 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.0113 | 0.5 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0095 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.1669 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1669 | 1 | 1 |
Onchocerca volvulus | 0.0282 | 0.1291 | 0.5 | |
Onchocerca volvulus | 0.0282 | 0.1291 | 0.5 | |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0273 | 0.1233 | 0.9508 |
Loa Loa (eye worm) | carboxylesterase | 0.0282 | 0.1291 | 0.1291 |
Treponema pallidum | NADH oxidase | 0.0095 | 0.0113 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1669 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0282 | 0.1291 | 0.1291 |
Echinococcus granulosus | acetylcholinesterase | 0.1669 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0282 | 0.1291 | 0.1291 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1669 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0273 | 0.1233 | 0.1233 |
Loa Loa (eye worm) | hypothetical protein | 0.1669 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0282 | 0.1291 | 0.1291 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0095 | 0.0113 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0282 | 0.1291 | 0.1291 |
Plasmodium falciparum | thioredoxin reductase | 0.0273 | 0.1233 | 1 |
Brugia malayi | hypothetical protein | 0.0282 | 0.1291 | 0.1291 |
Loa Loa (eye worm) | glutathione reductase | 0.0273 | 0.1233 | 0.1233 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0282 | 0.1291 | 0.1291 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0282 | 0.1291 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1291 | 0.1291 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0282 | 0.1291 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0282 | 0.1291 | 0.1291 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0095 | 0.0113 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0282 | 0.1291 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0273 | 0.1233 | 0.1233 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0282 | 0.1291 | 0.1291 |
Schistosoma mansoni | acetylcholinesterase | 0.0282 | 0.1291 | 0.1291 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0095 | 0.0113 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0282 | 0.1291 | 0.1291 |
Echinococcus granulosus | carboxylesterase 5A | 0.1669 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1291 | 0.1291 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0282 | 0.1291 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0273 | 0.1233 | 1 |
Echinococcus granulosus | neuroligin | 0.0282 | 0.1291 | 0.1291 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0095 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0273 | 0.1233 | 0.1233 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0095 | 0.0113 | 0.0113 |
Brugia malayi | Carboxylesterase family protein | 0.0282 | 0.1291 | 0.1291 |
Brugia malayi | Carboxylesterase family protein | 0.0282 | 0.1291 | 0.1291 |
Toxoplasma gondii | thioredoxin reductase | 0.0273 | 0.1233 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0282 | 0.1291 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1669 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1669 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0282 | 0.1291 | 0.1291 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1291 | 0.1291 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1669 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0282 | 0.1291 | 0.1291 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0282 | 0.1291 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0273 | 0.1233 | 1 |
Leishmania major | trypanothione reductase | 0.0273 | 0.1233 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0095 | 0.0113 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.