TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 730.913 | Formula: C40H50N4O7S
H donors: 3 H acceptors: 5 LogP: 6.11 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@H](N1C[C@@H](C)[C@@H](OCCCC[C@H](Oc2c(C1=O)cc(cc2)NS(=O)(=O)c1ccc(cc1)C)C)CN(C(=O)Nc1cccc2c1cccc2)C)C
InChi: 1S/C40H50N4O7S/c1-27-16-19-33(20-17-27)52(48,49)42-32-18-21-37-35(23-32)39(46)44(29(3)26-45)24-28(2)38(50-22-9-8-11-30(4)51-37)25-43(5)40(47)41-36-15-10-13-31-12-6-7-14-34(31)36/h6-7,10,12-21,23,28-30,38,42,45H,8-9,11,22,24-26H2,1-5H3,(H,41,47)/t28-,29-,30-,38+/m1/s1
InChiKey: USSUINMNPXSLJL-ITCLNTCFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	paired box 8	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_139945	All targets in OG5_139945
Brugia malayi	Pax transcription factor protein 2	Get druggable targets OG5_139945	All targets in OG5_139945
Loa Loa (eye worm)	pax transcription factor protein 2	Get druggable targets OG5_139945	All targets in OG5_139945

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1349	0.5903	0.5904
Brugia malayi	ephrin receptor 1 precursor	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/INSR protein kinase	0.0904	0.389	0.3891
Brugia malayi	Protein kinase domain containing protein	0.2253	0.9998	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0904	0.389	0.3891
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1349	0.5905	0.33
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0904	0.389	0.389
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/FER protein kinase	0.2253	0.9998	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2253	0.9998	0.9998
Echinococcus multilocularis	heat shock protein 70	0.0904	0.389	0.3891
Schistosoma mansoni	protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.006	0.0067	0.0067
Echinococcus granulosus	tyrosine protein kinase csk	0.0904	0.389	0.389
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2253	0.9998	0.9998
Echinococcus multilocularis	tyrosine protein kinase csk	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0904	0.389	0.3891
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0904	0.389	0.9994
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0904	0.389	0.3891
Brugia malayi	Sex muscle abnormal protein 5	0.1349	0.5903	0.5904
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2253	0.9998	1
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Brugia malayi	Raf kinase	0.0904	0.389	0.3891
Brugia malayi	SH2 domain containing protein	0.1349	0.5903	0.5904
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0904	0.389	0.389
Leishmania major	hypothetical protein, conserved	0.0904	0.389	0.9994
Brugia malayi	Protein kinase domain containing protein	0.2253	0.9998	1
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Leishmania major	protein kinase, putative	0.0904	0.389	0.9994
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein kinase csk	0.0904	0.389	0.389
Trypanosoma cruzi	protein kinase, putative	0.0904	0.389	0.9994
Brugia malayi	SH2 domain containing protein	0.1349	0.5903	0.5904
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1349	0.5903	0.5904
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0904	0.389	0.389
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Entamoeba histolytica	protein kinase domain containing protein	0.0905	0.3892	0.0004
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1349	0.5903	0.5904
Loa Loa (eye worm)	SH2 domain-containing protein	0.1349	0.5903	0.5904
Schistosoma mansoni	tyrosine kinase	0.2253	0.9998	1
Loa Loa (eye worm)	TK protein kinase	0.0904	0.389	0.3891
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2253	0.9998	0.9998
Echinococcus granulosus	SH2 motif	0.1349	0.5903	0.5903
Loa Loa (eye worm)	TK/FER protein kinase	0.2253	0.9998	1
Onchocerca volvulus		0.0904	0.389	0.3891
Schistosoma mansoni	tensin-related	0.1349	0.5903	0.5904
Entamoeba histolytica	protein kinase, putative	0.0905	0.3891	0.0002
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1349	0.5903	0.5903
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2253	0.9998	0.9998
Brugia malayi	Furin-like cysteine rich region family protein	0.0904	0.389	0.3891
Schistosoma mansoni	protein kinase	0.0904	0.389	0.3891
Brugia malayi	Protein kinase domain containing protein	0.2253	0.9998	1
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Onchocerca volvulus		0.1349	0.5903	0.5904
Echinococcus multilocularis	SHC transforming protein 3	0.1349	0.5903	0.5904
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine kinase	0.2253	0.9998	0.9998
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/FER protein kinase	0.2253	0.9998	1
Onchocerca volvulus		0.0904	0.389	0.3891
Brugia malayi	SH2 domain containing protein	0.2253	0.9998	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/FER protein kinase	0.2253	0.9998	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1349	0.5903	0.5904
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2253	0.9998	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0905	0.3892	0.3892
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0904	0.389	0.5
Echinococcus granulosus	SH2 motif	0.1349	0.5903	0.5903
Echinococcus granulosus	activin receptor type	0.0905	0.3892	0.3892
Brugia malayi	Variant SH3 domain containing protein	0.1349	0.5903	0.5904
Schistosoma mansoni	serine/threonine protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK protein kinase	0.0904	0.389	0.3891
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1349	0.5903	0.5904
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/FER protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Echinococcus multilocularis	protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	SH2 domain containing protein 7	0.1349	0.5903	0.5904
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Entamoeba histolytica	hypothetical protein	0.0906	0.3897	0.0012
Loa Loa (eye worm)	CYP4Cod1	0.0059	0.0062	0.0062
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0905	0.3892	1
Echinococcus multilocularis	tyrosine kinase	0.0904	0.389	0.3891
Schistosoma mansoni	hypothetical protein	0.0904	0.389	0.3891
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2253	0.9998	0.9998
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	pax transcription factor protein 2	0.0291	0.1111	0.1111
Loa Loa (eye worm)	TK/ALK protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0904	0.389	0.3891
Echinococcus granulosus	raf serine:threonine protein kinase	0.0904	0.389	0.389
Onchocerca volvulus		0.1349	0.5903	0.5904
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2253	0.9998	0.9998
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2253	0.9998	0.9998
Echinococcus multilocularis	insulin receptor	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/FER protein kinase	0.2253	0.9998	1
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.2253	0.9998	1
Brugia malayi	SH2 domain containing protein	0.1349	0.5903	0.5904
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Schistosoma mansoni	growth factor receptor-bound protein	0.1349	0.5903	0.5904
Loa Loa (eye worm)	TK/FER protein kinase	0.0904	0.389	0.3891
Brugia malayi	Receptor family ligand binding region containing protein	0.0904	0.389	0.3891
Trypanosoma brucei	Pseudokinase, putative	0.0904	0.389	0.9994
Onchocerca volvulus		0.2253	0.9998	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0904	0.389	0.3891
Loa Loa (eye worm)	STAT protein	0.1349	0.5903	0.5904
Onchocerca volvulus		0.1349	0.5903	0.5904
Loa Loa (eye worm)	TK protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1349	0.5903	0.5904
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1349	0.5903	0.5904
Onchocerca volvulus		0.0904	0.389	0.3891
Brugia malayi	Cytochrome P450 family protein	0.0124	0.0358	0.0358
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Loa Loa (eye worm)	SRC-1	0.2253	0.9998	1
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0904	0.389	0.3891
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0904	0.389	0.3891
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1349	0.5903	0.5904
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Echinococcus granulosus	activated cdc42 kinase 1	0.0904	0.389	0.389
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0904	0.389	0.389
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Brugia malayi	SH2 domain containing protein	0.2253	0.9998	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.1349	0.5903	0.5903
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2253	0.9998	1
Onchocerca volvulus		0.0904	0.389	0.3891
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0904	0.389	0.3891
Entamoeba histolytica	protein kinase, putative	0.1349	0.5905	0.33
Schistosoma mansoni	suppressor of cytokine signaling	0.1349	0.5903	0.5904
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1349	0.5903	0.5904
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2253	0.9998	1
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0196	0.0682	0.0682
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2253	0.9998	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2253	0.9998	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2253	0.9998	0.9998
Echinococcus multilocularis	tyrosine protein kinase csk	0.0904	0.389	0.3891
Echinococcus granulosus	SHC transforming protein 3	0.1349	0.5903	0.5903
Loa Loa (eye worm)	TK/FER protein kinase	0.0904	0.389	0.3891
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0904	0.389	0.389
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.1384	0.606	0.6062
Onchocerca volvulus		0.2253	0.9998	1
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1349	0.5903	0.5904
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1349	0.5903	0.5903
Schistosoma mansoni	protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.0196	0.0682	0.0682
Echinococcus granulosus	hypothetical protein	0.1349	0.5903	0.5903
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/RYK protein kinase	0.0904	0.389	0.3891
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Trichomonas vaginalis	TKL family protein kinase	0.0906	0.3897	1
Brugia malayi	Tensin	0.1349	0.5903	0.5904
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1349	0.5903	0.5904
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	hypothetical protein	0.1349	0.5903	0.5904
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1349	0.5903	0.5904
Trypanosoma cruzi	protein kinase, putative	0.0904	0.389	0.9994
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0904	0.389	0.3891
Onchocerca volvulus		0.0904	0.389	0.3891
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Brugia malayi	hypothetical protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Echinococcus multilocularis	tensin	0.1349	0.5903	0.5904
Onchocerca volvulus		0.0904	0.389	0.3891
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1349	0.5903	0.5904
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1349	0.5903	0.5904
Onchocerca volvulus		0.0904	0.389	0.3891
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2253	0.9998	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0904	0.389	0.3891
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/FER protein kinase	0.0904	0.389	0.3891
Plasmodium falciparum	protein kinase, putative	0.0905	0.3892	1
Echinococcus granulosus	N chimaerin	0.1349	0.5903	0.5903
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0904	0.389	0.3891
Schistosoma mansoni	protein tyrosine kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2253	0.9998	1
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Echinococcus multilocularis	SH2 motif	0.1349	0.5903	0.5904
Loa Loa (eye worm)	TK/ROR protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Echinococcus multilocularis	SH2 motif	0.1349	0.5903	0.5904
Brugia malayi	Pax transcription factor protein 2	0.0291	0.1111	0.1111
Schistosoma mansoni	ephrin receptor	0.0904	0.389	0.3891
Onchocerca volvulus		0.0291	0.1111	0.1111
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Echinococcus multilocularis	tensin	0.1349	0.5903	0.5904
Brugia malayi	RhoGAP domain containing protein	0.1349	0.5903	0.5904
Giardia lamblia	Kinase, NEK	0.0904	0.389	0.5
Loa Loa (eye worm)	TK protein kinase	0.2253	0.9998	1
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/FER protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.2253	0.9998	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0904	0.389	0.389
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Brugia malayi	Variant SH3 domain containing protein	0.1349	0.5903	0.5904
Echinococcus granulosus	natriuretic peptide receptor 1	0.0904	0.389	0.389
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Onchocerca volvulus		0.1349	0.5903	0.5904
Echinococcus granulosus	epidermal growth factor receptor	0.0904	0.389	0.389
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/FER protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis		0.1349	0.5903	0.5904
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0904	0.389	0.3891
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1349	0.5903	0.5903
Brugia malayi	Variant SH3 domain containing protein	0.1349	0.5903	0.5904
Echinococcus granulosus	tyrosine protein kinase shark	0.2253	0.9998	0.9998
Echinococcus granulosus	signal transduction protein lnk realted	0.1349	0.5903	0.5903
Loa Loa (eye worm)	TK/ACK protein kinase	0.0904	0.389	0.3891
Brugia malayi	SH2 domain containing protein	0.1349	0.5903	0.5904
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2253	0.9998	1
Echinococcus granulosus	protein tyrosine kinase	0.0904	0.389	0.389
Echinococcus multilocularis	integrin linked protein kinase	0.0904	0.389	0.3891
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0904	0.389	0.389
Echinococcus granulosus	tyrosine kinase	0.0904	0.389	0.389
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Echinococcus granulosus	kinase suppressor of Ras 1	0.0904	0.389	0.389
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0905	0.3892	0.3893
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0904	0.389	0.3891
Echinococcus multilocularis	N chimaerin	0.1349	0.5903	0.5904
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1349	0.5903	0.5904
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0904	0.389	0.3891
Schistosoma mansoni	GTPase activating protein	0.1349	0.5903	0.5904
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0059	0.0062	0.5
Loa Loa (eye worm)	TK protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1349	0.5903	0.5904
Brugia malayi	SRC-1	0.2253	0.9998	1
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1349	0.5903	0.5904
Plasmodium vivax	protein kinase, putative	0.0904	0.389	0.5
Leishmania major	protein kinase, putative	0.0905	0.3892	1
Onchocerca volvulus		0.2253	0.9998	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0904	0.389	0.389
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0904	0.389	0.389
Loa Loa (eye worm)	hypothetical protein	0.1384	0.606	0.6062
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0067	0.0067
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1349	0.5903	0.5903
Brugia malayi	Variant SH3 domain containing protein	0.1349	0.5903	0.5904
Brugia malayi	SH2 domain containing protein	0.1349	0.5903	0.5904
Echinococcus granulosus	tyrosine protein kinase csk	0.0904	0.389	0.389
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0904	0.389	0.389
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1349	0.5903	0.5904
Onchocerca volvulus		0.2253	0.9998	1
Echinococcus granulosus	protein kinase	0.0904	0.389	0.389
Brugia malayi	SH2 domain containing protein	0.1349	0.5903	0.5904
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0905	0.3892	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2253	0.9998	0.9998
Loa Loa (eye worm)	TK/FER protein kinase	0.2253	0.9998	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1349	0.5903	0.5904
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0904	0.389	0.3891
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0904	0.389	0.3891
Schistosoma mansoni	serine/threonine protein kinase	0.0904	0.389	0.3891
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Echinococcus multilocularis	tyrosine protein kinase csk	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/ABL protein kinase	0.2253	0.9998	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2253	0.9998	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0904	0.389	0.3891
Schistosoma mansoni	protein kinase	0.0905	0.3892	0.3893
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1349	0.5903	0.5904
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1349	0.5903	0.5904
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0904	0.389	0.3891
Schistosoma mansoni	shc transforming protein	0.1349	0.5903	0.5904
Loa Loa (eye worm)	TK protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	SH2 domain-containing protein	0.1349	0.5903	0.5904
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0904	0.389	0.3891
Schistosoma mansoni	protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	cytochrome P450 family protein	0.0059	0.0062	0.0062
Schistosoma mansoni	protein kinase	0.0905	0.3892	0.3893
Loa Loa (eye worm)	TK/DDR protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	NCK adaptor protein	0.1349	0.5903	0.5904
Schistosoma mansoni	SH2A	0.1349	0.5903	0.5904
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0197	0.0688	0.0688
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0904	0.389	0.3891
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2253	0.9998	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2253	0.9998	0.9998
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	protein tyrosine kinase	0.0904	0.389	0.3891
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1349	0.5903	0.5904
Trypanosoma brucei	protein kinase, putative	0.0905	0.3892	1
Echinococcus multilocularis	transfer RNA-Thr	0.0904	0.389	0.3891
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0904	0.389	0.3891
Schistosoma mansoni	protein kinase	0.0905	0.3892	0.3893
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0904	0.389	0.3891
Onchocerca volvulus		0.0904	0.389	0.3891
Schistosoma mansoni	tensin	0.1349	0.5903	0.5904
Onchocerca volvulus		0.1349	0.5903	0.5904
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0904	0.389	0.3891
Brugia malayi	Protein kinase domain containing protein	0.2253	0.9998	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1349	0.5903	0.5904
Schistosoma mansoni	tyrosine kinase	0.2253	0.9998	1
Brugia malayi	hypothetical protein	0.2253	0.9998	1
Echinococcus granulosus	integrin linked protein kinase	0.0904	0.389	0.389
Brugia malayi	integrin-linked kinase	0.0904	0.389	0.3891
Brugia malayi	Cytochrome P450 family protein	0.0059	0.0062	0.0062
Loa Loa (eye worm)	cytochrome P450 family protein	0.0124	0.0358	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Schistosoma mansoni	tensin-related	0.1349	0.5903	0.5904
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Schistosoma mansoni	protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	suppressor of cytokine signaling	0.1349	0.5903	0.5904
Brugia malayi	hypothetical protein	0.1349	0.5903	0.5904
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein kinase	0.0904	0.389	0.389
Echinococcus multilocularis	FL cytokine receptor	0.0904	0.389	0.3891
Echinococcus granulosus	tensin	0.1349	0.5903	0.5903
Echinococcus granulosus	tyrosine kinase	0.2253	0.9998	0.9998
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Brugia malayi	Protein kinase domain containing protein	0.2253	0.9998	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1349	0.5903	0.5904
Giardia lamblia	Kinase, NEK	0.0904	0.389	0.5
Giardia lamblia	Kinase	0.0904	0.389	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0904	0.389	0.389
Schistosoma mansoni	tyrosine kinase	0.2253	0.9998	1
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0905	0.3892	1
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	SH2 domain-containing protein	0.1349	0.5903	0.5904
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0904	0.389	0.3891
Schistosoma mansoni	growth factor receptor-bound protein	0.1349	0.5903	0.5904
Echinococcus granulosus	SH2 domain containing protein 7	0.1349	0.5903	0.5903
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Echinococcus granulosus	epidermal growth factor receptor	0.0904	0.389	0.389
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1349	0.5903	0.5903
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0904	0.389	0.389
Schistosoma mansoni	hypothetical protein	0.1349	0.5903	0.5904
Brugia malayi	Tyrosine-protein kinase abl-1	0.2253	0.9998	1
Echinococcus multilocularis	c src tyrosine kinase	0.2253	0.9998	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1349	0.5903	0.5904
Entamoeba histolytica	hypothetical protein	0.0905	0.3891	0.0002
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1349	0.5903	0.5903
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Onchocerca volvulus		0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Echinococcus multilocularis	tyrosine protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	tensin	0.1349	0.5903	0.5904
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine protein kinase	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein kinase Blk	0.2253	0.9998	0.9998
Echinococcus multilocularis	tyrosine protein kinase csk	0.0904	0.389	0.3891
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2253	0.9998	1
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	epidermal growth factor receptor	0.0904	0.389	0.3891
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0904	0.389	0.389
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0904	0.389	0.3891
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1349	0.5903	0.5903
Echinococcus granulosus	insulin receptor	0.0904	0.389	0.389
Onchocerca volvulus		0.2253	0.9998	1
Echinococcus multilocularis	activin receptor type	0.0905	0.3892	0.3893
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1349	0.5903	0.5903
Onchocerca volvulus		0.2253	0.9998	1
Schistosoma mansoni	ephrin receptor	0.0904	0.389	0.3891
Echinococcus granulosus	c src tyrosine kinase	0.2253	0.9998	0.9998
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0904	0.389	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0904	0.389	0.3891
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2253	0.9998	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0904	0.389	0.3891
Brugia malayi	SH2 domain containing protein	0.1349	0.5903	0.5904
Brugia malayi	Tyrosine-protein kinase PR2	0.0904	0.389	0.3891
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2253	0.9998	0.9998
Brugia malayi	C-terminal src kinase protein 1	0.0904	0.389	0.3891
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	signal transduction protein lnk realted	0.1349	0.5903	0.5904
Schistosoma mansoni	signal transduction protein lnk-related	0.1349	0.5903	0.5904
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0904	0.389	0.3891
Echinococcus granulosus	NCK adaptor protein	0.1349	0.5903	0.5903
Echinococcus multilocularis	tyrosine kinase	0.2253	0.9998	1
Loa Loa (eye worm)	TK protein kinase	0.0904	0.389	0.3891
Onchocerca volvulus	Tyrosine kinase homolog	0.0904	0.389	0.3891
Echinococcus multilocularis	SH2 motif	0.1349	0.5903	0.5904
Echinococcus granulosus	expressed conserved protein	0.1349	0.5903	0.5903
Echinococcus multilocularis	tyrosine protein kinase shark	0.2253	0.9998	1
Loa Loa (eye worm)	TK protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	vav2	0.1349	0.5903	0.5904
Schistosoma mansoni	adapter molecule crk	0.1349	0.5903	0.5904
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2253	0.9998	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2253	0.9998	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2253	0.9998	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0067	0.0067
Loa Loa (eye worm)	serine/threonine protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.2253	0.9998	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/FER protein kinase	0.2253	0.9998	1
Entamoeba histolytica	hypothetical protein	0.0905	0.3891	0.0002
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0904	0.389	0.3891
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2253	0.9998	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0904	0.389	0.389
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Brugia malayi	protein-tyrosine kinase	0.2253	0.9998	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.2253	0.9998	0.9998
Loa Loa (eye worm)	TK/EPH protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0904	0.389	0.3891
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0904	0.389	0.389
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0904	0.389	0.9994
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0904	0.389	0.389
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0904	0.389	0.3891
Entamoeba histolytica	hypothetical protein	0.0905	0.3891	0.0002
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Echinococcus granulosus	receptor type guanylyl cyclase	0.0904	0.389	0.389
Brugia malayi	Guanylyl cyclase protein 23	0.0904	0.389	0.3891
Schistosoma mansoni	tensin	0.1349	0.5903	0.5904
Brugia malayi	hypothetical protein	0.0904	0.389	0.3891
Entamoeba histolytica	SH2 domain containing protein	0.1349	0.5903	0.3296
Schistosoma mansoni	serine/threonine protein kinase	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.0904	0.389	0.3891
Brugia malayi	Protein kinase domain containing protein	0.0196	0.0682	0.0682
Schistosoma mansoni	serine/threonine protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2253	0.9998	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0904	0.389	0.389
Brugia malayi	Protein kinase domain containing protein	0.0904	0.389	0.3891
Schistosoma mansoni	serine/threonine RGC	0.0904	0.389	0.3891
Schistosoma mansoni	protein kinase	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0904	0.389	0.389
Schistosoma mansoni	protein kinase	0.0904	0.389	0.3891
Echinococcus granulosus	tyrosine protein kinase pr2	0.0904	0.389	0.389
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0904	0.389	0.389
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0905	0.3891	0.0002
Schistosoma mansoni	nck2/grb4	0.1349	0.5903	0.5904
Giardia lamblia	Protein 21.1	0.0904	0.389	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0905	0.3892	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2253	0.9998	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0059	0.0062	0.0062
Brugia malayi	Cytochrome P450 family protein	0.0059	0.0062	0.0062
Loa Loa (eye worm)	TK/FER protein kinase	0.2253	0.9998	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0904	0.389	0.3891
Loa Loa (eye worm)	TK/FER protein kinase	0.2253	0.9998	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0904	0.389	0.3891
Schistosoma mansoni	tyrosine kinase	0.2253	0.9998	1
Schistosoma mansoni	protein kinase	0.0904	0.389	0.3891
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0904	0.389	0.3891
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1349	0.5903	0.5904
Onchocerca volvulus		0.1349	0.5903	0.5904
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1349	0.5903	0.5903
Loa Loa (eye worm)	hypothetical protein	0.1349	0.5903	0.5904
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1349	0.5903	0.5904

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)	= 5.78 uM	PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2362765

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1749574