TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 514.634 | Formula: C27H34N2O6S
H donors: 2 H acceptors: 4 LogP: 3.08 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@H]1O[C@H](C=C[C@@H]1NS(=O)(=O)c1ccc(cc1)OC)CC(=O)N1CCC(CC1)Cc1ccccc1
InChi: 1S/C27H34N2O6S/c1-34-22-7-10-24(11-8-22)36(32,33)28-25-12-9-23(35-26(25)19-30)18-27(31)29-15-13-21(14-16-29)17-20-5-3-2-4-6-20/h2-12,21,23,25-26,28,30H,13-19H2,1H3/t23-,25+,26-/m1/s1
InChiKey: CUGFMOXJBZJTJZ-DMTNHVFBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Brugia malayi	Protein kinase domain containing protein	0.0241	0.0406	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1331	0.5671	0.5497
Brugia malayi	SH2 domain containing protein	0.1331	0.5671	0.5497
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Onchocerca volvulus		0.1331	0.5671	0.3282
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0894	0.356	0.3563
Entamoeba histolytica	serine/threonine kinase, putative	0.0894	0.356	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Echinococcus granulosus	NCK adaptor protein	0.1331	0.5671	0.5671
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1333	0.568	0.5681
Brugia malayi	SH2 domain containing protein	0.1331	0.5671	0.5497
Echinococcus multilocularis	tyrosine protein kinase csk	0.0894	0.356	0.3563
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1331	0.5671	0.5497
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Echinococcus multilocularis	protein tyrosine kinase	0.0894	0.356	0.3563
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1331	0.5671	0.5671
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2226	0.9991	0.9991
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1331	0.5671	0.5668
Brugia malayi	protein-tyrosine kinase	0.2226	0.9991	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK protein kinase	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK/FER protein kinase	0.2226	0.9991	1
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0.356	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2226	0.9991	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0894	0.356	0.3297
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1331	0.5671	0.5676
Schistosoma mansoni	hypothetical protein	0.1331	0.5671	0.5668
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1331	0.5671	0.5497
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0894	0.356	0.356
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0894	0.356	1
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0894	0.356	0.3563
Loa Loa (eye worm)	STAT protein	0.1331	0.5671	0.5497
Echinococcus multilocularis	epidermal growth factor receptor	0.0894	0.356	0.3563
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0896	0.3569	0.3569
Loa Loa (eye worm)	TK protein kinase	0.0894	0.356	0.3297
Schistosoma mansoni	adapter molecule crk	0.1331	0.5671	0.5668
Brugia malayi	hypothetical protein	0.2226	0.9991	1
Brugia malayi	hypothetical protein	0.1331	0.5671	0.5497
Loa Loa (eye worm)	TK/FER protein kinase	0.2226	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.2226	0.9991	1
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1331	0.5671	0.5676
Echinococcus granulosus	insulin receptor	0.0894	0.356	0.356
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Brugia malayi	SH2 domain containing protein	0.1331	0.5671	0.5497
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0894	0.356	0.3297
Schistosoma mansoni	serine/threonine RGC	0.0894	0.356	0.3552
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0894	0.356	0.3563
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1331	0.5671	0.5676
Entamoeba histolytica	hypothetical protein	0.0894	0.356	0.3558
Plasmodium falciparum	tyrosine kinase-like protein	0.0894	0.356	0.9976
Loa Loa (eye worm)	TK/FER protein kinase	0.2226	0.9991	1
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1333	0.5681	0.5507
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Schistosoma mansoni	protein kinase	0.0894	0.356	0.3552
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0894	0.356	0.3552
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0161	0.0018	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0241	0.0406	0.001
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1331	0.5671	0.5671
Brugia malayi	Protein kinase domain containing protein	0.2226	0.9991	1
Brugia malayi	hypothetical protein	0.0894	0.356	0.3297
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Schistosoma mansoni	tyrosine kinase	0.2226	0.9991	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0894	0.356	0.356
Echinococcus multilocularis	SH2 motif	0.1331	0.5671	0.5676
Loa Loa (eye worm)	TK/FER protein kinase	0.2226	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Entamoeba histolytica	tyrosin kinase, putative	0.0894	0.356	0.3558
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2226	0.9991	0.9991
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1331	0.5671	0.5668
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0894	0.356	0.3297
Schistosoma mansoni	tyrosine kinase	0.2226	0.9991	1
Plasmodium falciparum	protein kinase, putative	0.0894	0.356	0.9976
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0894	0.356	0.3297
Schistosoma mansoni	suppressor of cytokine signaling	0.1331	0.5671	0.5668
Echinococcus multilocularis	tyrosine protein kinase csk	0.0894	0.356	0.3563
Schistosoma mansoni	tyrosine protein kinase	0.0894	0.356	0.3552
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Loa Loa (eye worm)	TK/FER protein kinase	0.0894	0.356	0.3297
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Echinococcus granulosus	activated cdc42 kinase 1	0.0894	0.356	0.356
Loa Loa (eye worm)	TK/FAK protein kinase	0.0894	0.356	0.3297
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Echinococcus granulosus	tyrosine protein kinase Blk	0.2226	0.9991	0.9991
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0894	0.356	0.356
Loa Loa (eye worm)	TK/FER protein kinase	0.2226	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Echinococcus granulosus	SH2 domain containing protein 7	0.1331	0.5671	0.5671
Onchocerca volvulus		0.2226	0.9991	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0894	0.356	0.3297
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1331	0.5671	0.5497
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0894	0.356	0.3563
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0894	0.356	0.356
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0894	0.356	0.356
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2226	0.9991	0.9991
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0894	0.356	0.356
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0894	0.356	0.3552
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0894	0.356	0.9973
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0894	0.356	0.356
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	SRC-1	0.2226	0.9991	1
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Brugia malayi	Protein kinase domain containing protein	0.2226	0.9991	1
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0894	0.356	0.3552
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0894	0.356	0.3297
Schistosoma mansoni	GTPase activating protein	0.1331	0.5671	0.5668
Brugia malayi	RhoGAP domain containing protein	0.1331	0.5671	0.5497
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0894	0.356	0.3297
Schistosoma mansoni	protein kinase	0.0896	0.3569	0.356
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0894	0.356	0.3563
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Echinococcus multilocularis	activin receptor type	0.0896	0.3569	0.3572
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0894	0.356	0.356
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Echinococcus multilocularis		0.1331	0.5671	0.5676
Brugia malayi	Furin-like cysteine rich region family protein	0.0894	0.356	0.3297
Schistosoma mansoni	protein kinase	0.0896	0.3569	0.356
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2226	0.9991	0.9991
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0159	0.0009	0.0009
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0894	0.356	0.3558
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1331	0.5671	0.5676
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Schistosoma mansoni	protein kinase	0.0894	0.356	0.3552
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2226	0.9991	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.2226	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Entamoeba histolytica	hypothetical protein	0.0894	0.356	0.3558
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2226	0.9991	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0894	0.356	0.9976
Schistosoma mansoni	protein tyrosine kinase	0.0894	0.356	0.3552
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2226	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2226	0.9991	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.1331	0.5671	0.5497
Loa Loa (eye worm)	TK/INSR protein kinase	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK/ROR protein kinase	0.0894	0.356	0.3297
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0894	0.356	0.356
Echinococcus multilocularis	tyrosine kinase	0.0894	0.356	0.3563
Entamoeba histolytica	hypothetical protein	0.0894	0.356	0.3558
Schistosoma mansoni	shc transforming protein	0.1331	0.5671	0.5668
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0894	0.356	0.3297
Entamoeba histolytica	protein kinase, putative	0.0241	0.0406	0.0398
Onchocerca volvulus		0.2226	0.9991	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2226	0.9991	0.9991
Entamoeba histolytica	hypothetical protein	0.0894	0.356	0.3558
Loa Loa (eye worm)	TK/FER protein kinase	0.2226	0.9991	1
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Echinococcus granulosus	protein kinase	0.0894	0.356	0.356
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	TK protein kinase	0.0894	0.356	0.3297
Schistosoma mansoni	tensin	0.1331	0.5671	0.5668
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Echinococcus granulosus	c src tyrosine kinase	0.2226	0.9991	0.9991
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Echinococcus multilocularis	heat shock protein 70	0.0894	0.356	0.3563
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0159	0.0009	0.0009
Echinococcus granulosus	protein tyrosine kinase	0.0894	0.356	0.356
Brugia malayi	SH2 domain containing protein	0.2226	0.9991	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2226	0.9991	1
Giardia lamblia	Kinase, NEK	0.0894	0.356	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0894	0.356	0.3563
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0894	0.356	0.9973
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Toxoplasma gondii	STE kinase	0.0894	0.356	0.9973
Echinococcus granulosus	SH2 motif	0.1331	0.5671	0.5671
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1331	0.5671	0.5497
Loa Loa (eye worm)	SH2 domain-containing protein	0.1331	0.5671	0.5497
Onchocerca volvulus		0.2226	0.9991	1
Schistosoma mansoni	serine/threonine protein kinase	0.0894	0.356	0.3552
Entamoeba histolytica	hypothetical protein	0.0894	0.356	0.3558
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Entamoeba histolytica	serine/threonine kinase, putative	0.0894	0.356	0.3558
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0894	0.356	0.3297
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0.356	1
Entamoeba histolytica	cysteine surface protein, putative	0.0894	0.356	0.3558
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Echinococcus granulosus	epidermal growth factor receptor	0.0894	0.356	0.356
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0896	0.3569	1
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Echinococcus granulosus	tyrosine protein kinase	0.0894	0.356	0.356
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	TK protein kinase	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK protein kinase	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0894	0.356	0.3297
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Schistosoma mansoni	serine/threonine protein kinase	0.0894	0.356	0.3552
Loa Loa (eye worm)	TK protein kinase	0.0894	0.356	0.3297
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0894	0.356	1
Brugia malayi	SH2 domain containing protein	0.1331	0.5671	0.5497
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1331	0.5671	0.5671
Trichomonas vaginalis	protein kinase atn1, putative	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Schistosoma mansoni	tyrosine kinase	0.2226	0.9991	1
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Echinococcus multilocularis	activated cdc42 kinase 1	0.0894	0.356	0.3563
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK/FER protein kinase	0.2226	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0894	0.356	0.3297
Echinococcus multilocularis	tyrosine protein kinase shark	0.2226	0.9991	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0894	0.356	0.3558
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2226	0.9991	0.9991
Giardia lamblia	Protein 21.1	0.0894	0.356	1
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Brugia malayi	Variant SH3 domain containing protein	0.1333	0.5681	0.5507
Schistosoma mansoni	serine/threonine protein kinase	0.0894	0.356	0.3552
Onchocerca volvulus		0.1331	0.5671	0.3282
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1331	0.5671	0.5676
Loa Loa (eye worm)	TK/ALK protein kinase	0.0894	0.356	0.3297
Trichomonas vaginalis	CAMK family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0894	0.356	0.3297
Echinococcus multilocularis	tyrosine protein kinase csk	0.0894	0.356	0.3563
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Trichomonas vaginalis	STE family protein kinase	0.0894	0.356	1
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Loa Loa (eye worm)	TK/FER protein kinase	0.2226	0.9991	1
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Entamoeba histolytica	protein kinase, putative	0.1333	0.568	0.5681
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Schistosoma mansoni	suppressor of cytokine signaling	0.1331	0.5671	0.5668
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Entamoeba histolytica	protein kinase, putative	0.0239	0.0396	0.0388
Schistosoma mansoni	signal transduction protein lnk-related	0.1331	0.5671	0.5668
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2226	0.9991	0.9991
Echinococcus granulosus	tyrosine kinase	0.2226	0.9991	0.9991
Brugia malayi	SRC-1	0.2226	0.9991	1
Brugia malayi	Variant SH3 domain containing protein	0.1331	0.5671	0.5497
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0894	0.356	0.3297
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1331	0.5671	0.5671
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0894	0.356	0.3563
Echinococcus granulosus	tensin	0.1331	0.5671	0.5671
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0894	0.356	0.3297
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2226	0.9991	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Onchocerca volvulus		0.1331	0.5671	0.3282
Onchocerca volvulus		0.1331	0.5671	0.3282
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1331	0.5671	0.3282
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1331	0.5671	0.5497
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Echinococcus multilocularis	SH2 motif	0.1331	0.5671	0.5676
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2226	0.9991	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0894	0.356	0.3297
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.2226	0.9991	0.9991
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2226	0.9991	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0894	0.356	0.3563
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0894	0.356	0.3563
Brugia malayi	integrin-linked kinase	0.0894	0.356	0.3297
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0894	0.356	0.356
Brugia malayi	Tensin	0.1331	0.5671	0.5497
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0896	0.3569	0.3572
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0894	0.356	0.3563
Brugia malayi	C-terminal src kinase protein 1	0.0894	0.356	0.3297
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1331	0.5671	0.5676
Echinococcus granulosus	tyrosine protein kinase csk	0.0894	0.356	0.356
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Loa Loa (eye worm)	TK/FER protein kinase	0.0894	0.356	0.3297
Schistosoma mansoni	ephrin receptor	0.0894	0.356	0.3552
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0894	0.356	1
Trypanosoma cruzi	protein kinase, putative	0.0894	0.356	0.9976
Schistosoma mansoni	protein kinase	0.0894	0.356	0.3552
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1331	0.5671	0.5671
Schistosoma mansoni	nck2/grb4	0.1331	0.5671	0.5668
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2226	0.9991	0.9991
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	hypothetical protein	0.1333	0.5681	0.5507
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trypanosoma cruzi	protein kinase, putative	0.0894	0.356	0.9976
Schistosoma mansoni	memapsin-2 (A01 family)	0.0503	0.167	0.1656
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2226	0.9991	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2226	0.9991	1
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0.356	1
Giardia lamblia	Kinase	0.0894	0.356	1
Echinococcus multilocularis	FL cytokine receptor	0.0894	0.356	0.3563
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK/FER protein kinase	0.2226	0.9991	1
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Schistosoma mansoni	ephrin receptor	0.0894	0.356	0.3552
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0894	0.356	0.3563
Schistosoma mansoni	tensin-related	0.1331	0.5671	0.5668
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0894	0.356	0.3563
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Entamoeba histolytica	tyrosin kinase, putative	0.0894	0.356	0.3558
Echinococcus granulosus	tyrosine protein kinase csk	0.0894	0.356	0.356
Schistosoma mansoni	tensin-related	0.1331	0.5671	0.5668
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0894	0.356	0.3563
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Echinococcus multilocularis	tensin	0.1331	0.5671	0.5676
Entamoeba histolytica	hypothetical protein	0.0894	0.356	0.3558
Schistosoma mansoni	hypothetical protein	0.0894	0.356	0.3552
Entamoeba histolytica	tyrosin kinase, putative	0.0894	0.356	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Brugia malayi	SH2 domain containing protein	0.1331	0.5671	0.5497
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2226	0.9991	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1331	0.5671	0.5668
Entamoeba histolytica	protein kinase domain containing protein	0.0896	0.3569	0.3566
Schistosoma mansoni	protein kinase	0.0894	0.356	0.3552
Echinococcus granulosus	expressed conserved protein	0.1331	0.5671	0.5671
Echinococcus granulosus	tyrosine protein kinase HCK	0.0894	0.356	0.356
Echinococcus multilocularis	protein kinase	0.0894	0.356	0.3563
Schistosoma mansoni	tensin	0.1331	0.5671	0.5668
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0894	0.356	0.3563
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Schistosoma mansoni	tensin	0.1331	0.5671	0.5668
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0894	0.356	0.3552
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0894	0.356	0.356
Brugia malayi	Protein kinase domain containing protein	0.2226	0.9991	1
Trypanosoma brucei	Pseudokinase, putative	0.0894	0.356	0.9973
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1331	0.5671	0.5676
Brugia malayi	SH2 domain containing protein	0.1331	0.5671	0.5497
Loa Loa (eye worm)	TK protein kinase	0.0894	0.356	0.3297
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Entamoeba histolytica	protein kinase, putative	0.0241	0.0406	0.0398
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0894	0.356	0.3563
Plasmodium falciparum	protein kinase, putative	0.0896	0.3569	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0894	0.356	0.356
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Entamoeba histolytica	hypothetical protein, conserved	0.0894	0.356	0.3558
Entamoeba histolytica	serine/threonine kinase, putative	0.0894	0.356	0.3558
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0896	0.3569	1
Echinococcus granulosus	tyrosine kinase	0.0894	0.356	0.356
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1331	0.5671	0.5671
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0896	0.3569	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0894	0.356	0.3297
Echinococcus granulosus	integrin linked protein kinase	0.0894	0.356	0.356
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2226	0.9991	1
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Echinococcus granulosus	tyrosine protein kinase shark	0.2226	0.9991	0.9991
Loa Loa (eye worm)	TK/Met protein kinase	0.0894	0.356	0.3297
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0894	0.356	0.356
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1331	0.5671	0.5676
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Loa Loa (eye worm)	TK/FER protein kinase	0.0894	0.356	0.3297
Trichomonas vaginalis	TK family protein kinase	0.0894	0.356	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Echinococcus multilocularis	tyrosine protein kinase csk	0.0894	0.356	0.3563
Entamoeba histolytica	receptor protein kinase, putative	0.0894	0.356	0.3558
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0894	0.356	0.3297
Echinococcus multilocularis	transfer RNA-Thr	0.0894	0.356	0.3563
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0894	0.356	0.3297
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0894	0.356	0.356
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Echinococcus multilocularis	integrin linked protein kinase	0.0894	0.356	0.3563
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1331	0.5671	0.5671
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Entamoeba histolytica	ankyrin repeat protein	0.0894	0.356	0.3558
Brugia malayi	SH2 domain containing protein	0.2226	0.9991	1
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Trichomonas vaginalis	AGC family protein kinase	0.0894	0.356	1
Echinococcus multilocularis	SHC transforming protein 3	0.1331	0.5671	0.5676
Entamoeba histolytica	serine/threonine kinase, putative	0.0894	0.356	0.3558
Giardia lamblia	Kinase, NEK	0.0894	0.356	1
Echinococcus granulosus	serine threonine protein kinase nrc	0.0159	0.0009	0.0009
Brugia malayi	Raf kinase	0.0894	0.356	0.3297
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0894	0.356	0.3552
Echinococcus multilocularis	protein kinase	0.0894	0.356	0.3563
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2226	0.9991	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0894	0.356	0.3297
Brugia malayi	Sex muscle abnormal protein 5	0.1331	0.5671	0.5497
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1331	0.5671	0.3282
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2226	0.9991	1
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Schistosoma mansoni	SH2A	0.1331	0.5671	0.5668
Schistosoma mansoni	protein kinase	0.0894	0.356	0.3552
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0161	0.0018	0.001
Schistosoma mansoni	tyrosine kinase	0.2226	0.9991	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0894	0.356	0.3297
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0894	0.356	1
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0894	0.356	1
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Echinococcus multilocularis	NCK adaptor protein	0.1331	0.5671	0.5676
Entamoeba histolytica	hypothetical protein	0.0894	0.356	0.3558
Schistosoma mansoni	vav2	0.1333	0.5681	0.5678
Onchocerca volvulus		0.2226	0.9991	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0894	0.356	0.356
Echinococcus granulosus	hypothetical protein	0.1331	0.5671	0.5671
Entamoeba histolytica	serine/threonine kinase, putative	0.0894	0.356	0.3558
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Echinococcus multilocularis	tyrosine kinase	0.2226	0.9991	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.1331	0.5671	0.5497
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0894	0.356	0.3297
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0894	0.356	0.9973
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Echinococcus granulosus	growth factor receptor bound protein 2	0.1331	0.5671	0.5671
Loa Loa (eye worm)	TK protein kinase	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK protein kinase	0.2226	0.9991	1
Echinococcus multilocularis	c src tyrosine kinase	0.2226	0.9991	1
Brugia malayi	Variant SH3 domain containing protein	0.1331	0.5671	0.5497
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0894	0.356	0.356
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Toxoplasma gondii	protein kinase domain-containing protein	0.0894	0.356	0.9973
Echinococcus multilocularis	signal transduction protein lnk realted	0.1331	0.5671	0.5676
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2226	0.9991	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0894	0.356	0.356
Entamoeba histolytica	receptor protein kinase, putative	0.0894	0.356	0.3558
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1331	0.5671	0.5671
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1331	0.5671	0.5676
Leishmania major	protein kinase, putative	0.0896	0.3569	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2226	0.9991	1
Brugia malayi	ephrin receptor 1 precursor	0.0894	0.356	0.3297
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Brugia malayi	SH2 domain containing protein	0.1331	0.5671	0.5497
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0894	0.356	0.3558
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0894	0.356	0.356
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Entamoeba histolytica	hypothetical protein	0.0894	0.356	0.3558
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2226	0.9991	0.9991
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Echinococcus multilocularis	insulin receptor	0.0894	0.356	0.3563
Brugia malayi	Protein kinase domain containing protein	0.2226	0.9991	1
Echinococcus granulosus	epidermal growth factor receptor	0.0894	0.356	0.356
Loa Loa (eye worm)	TK/CSK protein kinase	0.0894	0.356	0.3297
Schistosoma mansoni	tyrosine kinase	0.2226	0.9991	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0894	0.356	0.356
Brugia malayi	Guanylyl cyclase protein 23	0.0894	0.356	0.3297
Plasmodium vivax	protein kinase, putative	0.0894	0.356	1
Echinococcus multilocularis	tensin	0.1331	0.5671	0.5676
Brugia malayi	Tyrosine-protein kinase PR2	0.0894	0.356	0.3297
Schistosoma mansoni	serine/threonine protein kinase	0.0894	0.356	0.3552
Brugia malayi	Receptor family ligand binding region containing protein	0.0894	0.356	0.3297
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0894	0.356	0.3297
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0894	0.356	0.3563
Echinococcus multilocularis	SH2 motif	0.1331	0.5671	0.5676
Echinococcus granulosus	activin receptor type	0.0896	0.3569	0.3569
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Loa Loa (eye worm)	serine/threonine protein kinase	0.0894	0.356	0.3297
Echinococcus granulosus	activated cdc42 kinase 1	0.0894	0.356	0.356
Schistosoma mansoni	protein kinase	0.0894	0.356	0.3552
Schistosoma mansoni	hypothetical protein	0.1331	0.5671	0.5668
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Loa Loa (eye worm)	hypothetical protein	0.0894	0.356	0.3297
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0894	0.356	0.3563
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0894	0.356	0.3558
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0894	0.356	0.356
Schistosoma mansoni	growth factor receptor-bound protein	0.1331	0.5671	0.5668
Entamoeba histolytica	hypothetical protein	0.0894	0.356	0.3558
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2226	0.9991	1
Entamoeba histolytica	tyrosin kinase, putative	0.0894	0.356	0.3558
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trypanosoma brucei	protein kinase, putative	0.0896	0.3569	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.2226	0.9991	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2226	0.9991	0.9991
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0.356	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0894	0.356	0.3563
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Schistosoma mansoni	tyrosine kinase	0.2226	0.9991	1
Onchocerca volvulus		0.2226	0.9991	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Entamoeba histolytica	ankyrin repeat protein	0.0894	0.356	0.3558
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0894	0.356	0.3563
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1331	0.5671	0.5668
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1331	0.5671	0.5671
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0894	0.356	0.356
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0894	0.356	0.3297
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK/FER protein kinase	0.0894	0.356	0.3297
Echinococcus granulosus	signal transduction protein lnk realted	0.1331	0.5671	0.5671
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0894	0.356	0.3563
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0894	0.356	0.3297
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2226	0.9991	0.9991
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0161	0.0018	0.0027
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Entamoeba histolytica	hypothetical protein	0.0894	0.356	0.3558
Echinococcus multilocularis	tyrosine protein kinase	0.0894	0.356	0.3563
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Schistosoma mansoni	protein kinase	0.0894	0.356	0.3552
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Entamoeba histolytica	tyrosine kinase, putative	0.0894	0.356	0.3558
Entamoeba histolytica	hypothetical protein	0.0894	0.356	0.3558
Brugia malayi	Protein kinase domain containing protein	0.2226	0.9991	1
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0.356	1
Brugia malayi	Variant SH3 domain containing protein	0.1331	0.5671	0.5497
Echinococcus granulosus	SH2 motif	0.1331	0.5671	0.5671
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1331	0.5671	0.5497
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1331	0.5671	0.5497
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0.356	1
Trypanosoma cruzi	Protein kinase B	0.0161	0.0018	0.0027
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1331	0.5671	0.5497
Toxoplasma gondii	protein kinase	0.0894	0.356	0.9973
Echinococcus granulosus	tyrosine protein kinase csk	0.0894	0.356	0.356
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0896	0.3569	1
Echinococcus granulosus	SHC transforming protein 3	0.1331	0.5671	0.5671
Echinococcus granulosus	N chimaerin	0.1331	0.5671	0.5671
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0894	0.356	0.3297
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0894	0.356	0.3552
Echinococcus multilocularis	rac serine:threonine kinase	0.0161	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5671	0.5497
Onchocerca volvulus		0.1331	0.5671	0.3282
Schistosoma mansoni	protein kinase	0.0894	0.356	0.3552
Schistosoma mansoni	protein kinase	0.0896	0.3569	0.356
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Echinococcus granulosus	serine/threonine protein kinase	0.0161	0.0018	0.0018
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2226	0.9991	1
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK/EPH protein kinase	0.0894	0.356	0.3297
Loa Loa (eye worm)	TK/FER protein kinase	0.0894	0.356	0.3297
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Schistosoma mansoni	growth factor receptor-bound protein	0.1331	0.5671	0.5668
Entamoeba histolytica	SH2 domain containing protein	0.1331	0.5671	0.5672
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0894	0.356	0.3558
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0894	0.356	0.3563
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0894	0.356	0.3297
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Brugia malayi	hypothetical protein	0.0894	0.356	0.3297
Brugia malayi	Protein kinase domain containing protein	0.0894	0.356	0.3297
Entamoeba histolytica	protein kinase domain containing protein	0.0894	0.356	0.3558
Entamoeba histolytica	protein kinase, putative	0.0894	0.356	0.3558
Echinococcus multilocularis	N chimaerin	0.1331	0.5671	0.5676
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0894	0.356	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0894	0.356	0.356
Echinococcus multilocularis	epidermal growth factor receptor	0.0894	0.356	0.3563
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0894	0.356	0.3297
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1331	0.5671	0.5668
Echinococcus multilocularis	SH2 domain containing protein 7	0.1331	0.5671	0.5676
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0894	0.356	0.9973
Loa Loa (eye worm)	TK protein kinase	0.0894	0.356	0.3297
Echinococcus granulosus	tyrosine kinase	0.2226	0.9991	0.9991
Onchocerca volvulus		0.1331	0.5671	0.3282
Schistosoma mansoni	tyrosine kinase	0.0894	0.356	0.3552
Plasmodium falciparum	protein kinase, putative	0.0894	0.356	0.9976
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1331	0.5671	0.5676
Onchocerca volvulus		0.2226	0.9991	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0.356	1

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)	= 9.52 uM	PubChem BioAssay. HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2360959

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1749770