Detailed information for compound 1749821

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 593.709 | Formula: C32H36FN3O5S
  • H donors: 1 H acceptors: 4 LogP: 4.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@@H](N1C[C@@H](C)[C@@H](OCc2c(c3c(C1=O)n(C)c1c3cccc1)cccc2)CN(S(=O)(=O)c1cccc(c1)F)C)C
  • InChi: 1S/C32H36FN3O5S/c1-21-17-36(22(2)19-37)32(38)31-30(27-14-7-8-15-28(27)35(31)4)26-13-6-5-10-23(26)20-41-29(21)18-34(3)42(39,40)25-12-9-11-24(33)16-25/h5-16,21-22,29,37H,17-20H2,1-4H3/t21-,22+,29+/m1/s1
  • InChiKey: QBEIQJOXWRLXRW-BXOOBUKZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens paired box 8 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Loa Loa (eye worm) pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Onchocerca volvulus Get druggable targets OG5_139945 All targets in OG5_139945
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi CXXC zinc finger family protein 0.006 0.0345 0.0636
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1614 0.8744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Schistosoma mansoni lamin 0.0027 0.0104 0.0094
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0102 0.0647 0.2504
Echinococcus granulosus metabotropic glutamate receptor 5 0.0926 0.6684 0.6684
Brugia malayi jmjC domain containing protein 0.0099 0.0631 0.1165
Giardia lamblia DNA repair protein RAD52 0.0357 0.2518 1
Echinococcus multilocularis nmda type glutamate receptor 0.0071 0.0421 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0094 0.0492
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0304 0.0294
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0021 0.0021
Loa Loa (eye worm) beta-lactamase 0.0037 0.0174 0.026
Schistosoma mansoni tyrosine kinase 0.0071 0.0421 0.0411
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0265 0.1846 0.3409
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0222 0.0558
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0304 0.0304
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0022 0.0031
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.033 0.0608
Leishmania major cathepsin L-like protease 0.0016 0.0022 0.0031
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0022 0.0022
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.033 0.033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.001 0.0038
Giardia lamblia Pyruvate kinase 0.0099 0.0627 0.2095
Giardia lamblia GTOR 0.0044 0.0222 0.0405
Leishmania major extracellular receptor, putative 0.0071 0.0421 0.1082
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0022 0.0012
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0022 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1846 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0421 0.063
Schistosoma mansoni dihydroorotate dehydrogenase 0.0533 0.3809 0.3803
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0163 0.0243
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0959 0.1435
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0222 0.0222
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0022 0.0051
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0071 0.0421 0.0421
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0071 0.0421 0.0421
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.001 0.0015
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0533 0.3809 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0246 0.0236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0127 0.0117
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0591 0.0885
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.033 0.033
Loa Loa (eye worm) MBCTL1 0.0058 0.033 0.0494
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 0.0102
Echinococcus granulosus pyruvate kinase 0.0051 0.0274 0.0274
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0011 0.0018
Leishmania major pyruvate kinase 0.0099 0.0627 0.1623
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0022 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0797 0.0797
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0371 0.0371
Brugia malayi Pax transcription factor protein 2 0.0291 0.2032 0.3754
Echinococcus granulosus GPCR family 2 0.0064 0.0371 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.001 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0174 0.0164
Loa Loa (eye worm) hypothetical protein 0.0138 0.0915 0.1369
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0249 0.063
Onchocerca volvulus 0.0051 0.0278 0.1274
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1073 0.1606
Schistosoma mansoni hypothetical protein 0.0064 0.0371 0.0362
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0304 0.0773
Loa Loa (eye worm) pyruvate kinase 0.0099 0.0627 0.0938
Schistosoma mansoni pyruvate kinase 0.0099 0.0627 0.0617
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0163 0.0866
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0021 0.0021
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0278 0.1274
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0222 0.0802
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0197 0.0187
Echinococcus multilocularis cpg binding protein 0.0064 0.037 0.037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0356 0.0911
Brugia malayi Pyruvate kinase, M2 isozyme 0.0099 0.0627 0.1157
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.033 0.033
Echinococcus multilocularis pyruvate kinase 0.0051 0.0274 0.0274
Loa Loa (eye worm) RGC/RGC protein kinase 0.0071 0.0421 0.063
Onchocerca volvulus 0.0047 0.0246 0.1112
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0197 0.0295
Schistosoma mansoni cpg binding protein 0.0064 0.037 0.036
Echinococcus multilocularis snurportin 1 0.0622 0.4462 0.4462
Echinococcus granulosus lamin 0.0027 0.0104 0.0104
Plasmodium falciparum dihydroorotate dehydrogenase 0.0533 0.3809 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0127 0.019
Echinococcus granulosus pyruvate kinase 0.0051 0.0274 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.003 0.0125 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.014 0.0745
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.001 0.0038
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0304 0.0744
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0959 0.1435
Schistosoma mansoni hypothetical protein 0.0688 0.4941 0.4936
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0163 0.0866
Onchocerca volvulus Pyruvate kinase homolog 0.0099 0.0627 0.3008
Onchocerca volvulus 0.0234 0.1614 0.7921
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0071 0.0421 0.063
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0039
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0127 0.0127
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0217 0.0564
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0371 0.0556
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0304 0.0773
Onchocerca volvulus 0.0037 0.0174 0.0756
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0071 0.0421 0.0411
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0071 0.0421 0.0421
Loa Loa (eye worm) hypothetical protein 0.0027 0.0104 0.0155
Loa Loa (eye worm) pyruvate kinase 0.0099 0.0627 0.0938
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0356 0.0911
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0163 0.0402
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.001 0.001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0222 0.0558
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0022 0.0022
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0212 0.0212
Plasmodium vivax pyruvate kinase, putative 0.0099 0.0627 0.1639
Brugia malayi mbt repeat family protein 0.0051 0.0278 0.0512
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1073 0.1982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Brugia malayi PHD-finger family protein 0.003 0.0125 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0075 0.0392
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.1633 0.4014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0163 0.0866
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0157 0.0387
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0058 0.033 0.0494
Loa Loa (eye worm) glutamate receptor 0.0296 0.207 0.3097
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1178 0.6375
Brugia malayi Zinc finger, C2H2 type family protein 0.0208 0.1428 0.2638
Schistosoma mansoni hypothetical protein 0.0064 0.0371 0.0362
Schistosoma mansoni hypothetical protein 0.0311 0.2183 0.2175
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0217 0.04
Leishmania major cathepsin L-like protease 0.0062 0.0356 0.0911
Schistosoma mansoni cpg binding protein 0.0064 0.037 0.036
Plasmodium vivax pyruvate kinase 2, putative 0.0051 0.0274 0.0714
Onchocerca volvulus 0.0071 0.0421 0.1985
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0157 0.0387
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0631 0.0631
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.1178 0.5749
Echinococcus granulosus dnaJ subfamily B 0.0859 0.6194 0.6194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 0.0102
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0222 0.0558
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0631 0.0631
Echinococcus granulosus pyruvate kinase 0.0099 0.0627 0.0627
Giardia lamblia Pyruvate kinase 0.0051 0.0274 0.0623
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0093 0.0083
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0278 0.0268
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.003 0.0122 0.0224
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.033 0.032
Entamoeba histolytica hypothetical protein 0.0047 0.0249 0.0911
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0304 0.0773
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0533 0.3809 1
Entamoeba histolytica hypothetical protein 0.0102 0.0647 0.2504
Loa Loa (eye worm) ctsf protein 0.0016 0.0022 0.0033
Echinococcus multilocularis GPCR, family 3, C terminal 0.0122 0.0797 0.0797
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0533 0.3809 0.5
Echinococcus granulosus GPCR family 3 C terminal 0.0122 0.0797 0.0797
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0533 0.3809 1
Schistosoma mansoni hypothetical protein 0.0138 0.0915 0.0906
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0371 0.0371
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0249 0.1336
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.1381 0.1381
Echinococcus granulosus importin subunit beta 1 0.0058 0.033 0.033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0222 0.1189
Onchocerca volvulus 0.0031 0.0127 0.0523
Schistosoma mansoni alpha glucosidase 0.0035 0.0163 0.0153
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0208 0.1428 0.1428
Echinococcus granulosus atrial natriuretic peptide receptor 0.0071 0.0421 0.0421
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0217 0.0516
Loa Loa (eye worm) hypothetical protein 0.0099 0.0627 0.0938
Schistosoma mansoni glutamate receptor NMDA 0.0071 0.0421 0.0411
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0591 0.0582
Echinococcus granulosus receptor type guanylyl cyclase 0.0071 0.0421 0.0421
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 0.0102
Toxoplasma gondii pyruvate kinase PyKII 0.0051 0.0274 0.0667
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0278 0.0268
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.026
Entamoeba histolytica pyruvate kinase, putative 0.0069 0.0408 0.1545
Trichomonas vaginalis pyruvate kinase, putative 0.0099 0.0627 0.3384
Loa Loa (eye worm) RGC/RGC protein kinase 0.0071 0.0421 0.063
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0371 0.0685
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0163 0.0866
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.026
Echinococcus multilocularis receptor type guanylyl cyclase 0.0071 0.0421 0.0421
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0533 0.3809 1
Echinococcus multilocularis cysteine protease 0.0016 0.0022 0.0022
Trypanosoma cruzi pyruvate kinase 2, putative 0.0099 0.0627 0.1623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0356 0.0911
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1178 0.6375
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0915 0.1689
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.014 0.0745
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0317 0.0807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0157 0.0835
Echinococcus granulosus tyrosine kinase 0.0071 0.0421 0.0421
Schistosoma mansoni importin beta-1 0.0058 0.033 0.032
Leishmania major cathepsin L-like protease 0.0016 0.0022 0.0031
Echinococcus multilocularis musashi 0.0027 0.0104 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 0.0102
Trypanosoma brucei pyruvate kinase 1, putative 0.0099 0.0627 0.1623
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.014 0.0313
Plasmodium vivax vivapain-2 0.0016 0.0022 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0174 0.0927
Trichomonas vaginalis esterase, putative 0.0037 0.0174 0.0927
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0125 0.0125
Schistosoma mansoni metabotropic glutamate receptor 0.063 0.4517 0.4512
Brugia malayi hypothetical protein 0.0071 0.0421 0.0776
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0356 0.0911
Entamoeba histolytica Ran family GTPase 0.0043 0.0217 0.0783
Echinococcus multilocularis metabotropic glutamate receptor 2 0.063 0.4517 0.4517
Brugia malayi MH2 domain containing protein 0.0144 0.0959 0.1771
Onchocerca volvulus Pyruvate kinase homolog 0.0099 0.0627 0.3008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0127 0.0278
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.011 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.014 0.0745
Echinococcus multilocularis pyruvate kinase 0.0051 0.0274 0.0274
Onchocerca volvulus 0.0027 0.0104 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.014 0.0745
Entamoeba histolytica hypothetical protein 0.0071 0.0421 0.1599
Brugia malayi intermediate filament protein 0.0027 0.0104 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0022 0.0102
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0304 0.0773
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0208 0.1428 0.7735
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0356 0.0911
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0163 0.0866
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0163 0.0866
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0591 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0075 0.0391
Brugia malayi MAP kinase sur-1 0.0055 0.0304 0.056
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1846 1
Leishmania major cathepsin L-like protease 0.0016 0.0022 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0222 0.1189
Echinococcus multilocularis cysteine protease 0.0016 0.0022 0.0022
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0222 0.0212
Brugia malayi pyruvate kinase 0.0021 0.0056 0.0101
Loa Loa (eye worm) pyruvate kinase 0.0021 0.0056 0.0083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0591 0.0582
Loa Loa (eye worm) hypothetical protein 0.0058 0.033 0.0494
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0222 0.0409
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1582 0.1582
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0174 0.0927
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0855 0.6166 0.6162
Leishmania major cathepsin L-like protease 0.0062 0.0356 0.0911
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0174 0.0174
Echinococcus multilocularis lamin 0.0027 0.0104 0.0104
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0246 0.0452
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1846 1
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0119 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0125 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0092 0.0482
Echinococcus granulosus snurportin 1 0.0622 0.4462 0.4462
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0125 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0174 0.0431
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0022 0.0039
Brugia malayi beta-lactamase family protein 0.0037 0.0174 0.032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0591 0.0591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0075 0.0392
Mycobacterium leprae Probable pyruvate kinase PykA 0.0099 0.0627 0.1246
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0371 0.0685
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0217 0.0564
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0071 0.0421 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.001 0.0038
Trypanosoma brucei pyruvate kinase 1 0.0099 0.0627 0.1623
Echinococcus multilocularis peregrin 0.003 0.0125 0.0125
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0197 0.0197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0356 0.0911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.014 0.0745
Onchocerca volvulus Alhambra homolog 0.003 0.0125 0.0514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0591 0.0591
Echinococcus multilocularis pyruvate kinase 0.0078 0.0474 0.0474
Onchocerca volvulus Pyruvate kinase homolog 0.0099 0.0627 0.3008
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0104 0.0155
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0174 0.0927
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0278 0.0278
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1073 0.1073
Echinococcus multilocularis lamin dm0 0.0027 0.0104 0.0104
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0163 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0356 0.0911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0117 0.0619
Brugia malayi metabotropic glutamate receptor type 2 0.0367 0.2588 0.4781
Loa Loa (eye worm) pyruvate kinase 0.0099 0.0627 0.0938
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0356 0.0911
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0217 0.0546
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0533 0.3809 1
Loa Loa (eye worm) hypothetical protein 0.0926 0.6684 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0021 0.0021
Trichomonas vaginalis ran, putative 0.0043 0.0217 0.1163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0094 0.0492
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0011 0.0016
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0054 0.0116
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.026
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0533 0.3809 0.7039
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.033 0.0814
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0127 0.0117
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1846 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0157 0.0387
Brugia malayi Pyruvate kinase, muscle isozyme 0.0099 0.0627 0.1157
Echinococcus granulosus metabotropic glutamate receptor 2 0.063 0.4517 0.4517
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0022 0.0102
Loa Loa (eye worm) glutamate receptor 0.0752 0.5411 0.8096
Loa Loa (eye worm) hypothetical protein 0.0071 0.0421 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0222 0.1189
Trypanosoma brucei glucosidase, putative 0.0035 0.0163 0.0402
Onchocerca volvulus 0.0027 0.0104 0.0408
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1073 0.1073
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.001 0.001
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0163 0.0564
Plasmodium falciparum pyruvate kinase 0.0099 0.0627 0.1639
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0362 0.0542
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0208 0.1428 0.7735
Onchocerca volvulus 0.0037 0.0174 0.0756
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0039
Schistosoma mansoni metabotropic glutamate receptor 0.0367 0.2588 0.258
Echinococcus granulosus geminin 0.0688 0.4941 0.4941
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0591 0.1091
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0222 0.0558
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0304 0.1631
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.026
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0356 0.0911
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0193 0.1315 0.1967
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0371 0.0371
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0278 0.0268
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0022 0.0012
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0222 0.0332
Loa Loa (eye worm) histone methyltransferase 0.002 0.0048 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0356 0.0911
Onchocerca volvulus 0.006 0.0345 0.1606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Schistosoma mansoni pyruvate kinase 0.0051 0.0274 0.0265
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0104 0.019
Echinococcus granulosus peregrin 0.003 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0064 0.0371 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0533 0.3809 1
Echinococcus granulosus glutamate receptor 2 0.0071 0.0421 0.0421
Loa Loa (eye worm) hypothetical protein 0.0052 0.0284 0.0425
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0104 0.0155
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0217 0.0546
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0222 0.0558
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0533 0.3809 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0122 0.0797 0.1472
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0259 0.0656
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0174 0.0431
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0304 0.0745
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0127 0.0117
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0222 0.0558
Schistosoma mansoni hypothetical protein 0.0047 0.0246 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0075 0.0391
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0208 0.1428 0.7735
Brugia malayi Receptor family ligand binding region containing protein 0.0193 0.1315 0.2429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0092 0.0482
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0212 0.0212
Echinococcus granulosus cpg binding protein 0.0064 0.037 0.037
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0127 0.0127
Brugia malayi Guanylyl cyclase protein 23 0.0071 0.0421 0.0776
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0039
Leishmania major cathepsin L-like protease 0.0016 0.0022 0.0031
Brugia malayi hypothetical protein 0.0229 0.1582 0.2923
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0075 0.0392
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0071 0.0421 0.0776
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0869 0.086
Leishmania major pyruvate kinase 0.0099 0.0627 0.1623
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0064 0.0371 0.0362
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0036 0.0067
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0174 0.032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 0.0102
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0304 0.0773
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0022 0.0051
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0222 0.0222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 0.0102
Onchocerca volvulus 0.0037 0.0174 0.0756
Brugia malayi pyruvate kinase, muscle isozyme 0.0021 0.0056 0.0101
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0208 0.1428 0.7735
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0174 0.0927
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0304 0.1631
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0622 0.4462 0.6675
Schistosoma mansoni hypothetical protein 0.0122 0.0797 0.0788
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0071 0.0421 0.063
Schistosoma mansoni microtubule-associated protein tau 0.1378 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1246 0.6747
Brugia malayi Receptor family ligand binding region containing protein 0.0071 0.0421 0.0776
Plasmodium vivax hypothetical protein, conserved 0.003 0.0125 0.0322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0127 0.0117
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0217 0.0546
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.001 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0176 0.0936
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 0.0102
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0163 0.0372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0157 0.0835
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0681 0.4893 0.9043
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0217 0.0325
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0222 0.0802
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.1381 0.1381
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.2032 0.304
Schistosoma mansoni ran 0.0043 0.0217 0.0207
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0208 0.1428 0.1428
Loa Loa (eye worm) fibroinase 0.0016 0.0022 0.0033
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.0869 0.0869
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.033 0.0842
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0163 0.0402
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0193 0.1315 0.1967
Onchocerca volvulus Poor gastrulation protein homolog 0.0122 0.0797 0.3856
Loa Loa (eye worm) hypothetical protein 0.0071 0.0421 0.063
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1073 0.1073
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0022 0.0033
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0022 0.0022
Onchocerca volvulus 0.0071 0.0421 0.1985
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1846 1
Onchocerca volvulus 0.0092 0.058 0.2776
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0797 0.0797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0075 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0094 0.0492
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1408 0.2106
Trypanosoma brucei protein kinase, putative 0.0055 0.0304 0.0773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0157 0.0835
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0174 0.0174
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0815 0.5872 0.5872
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0022 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0022 0.0022
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0208 0.1428 0.1428
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0217 0.0217
Brugia malayi jmjC domain containing protein 0.004 0.0197 0.0363
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0163 0.0163
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0304 0.0304
Schistosoma mansoni protein kinase 0.0071 0.0421 0.0411
Plasmodium vivax importin-beta 2, putative 0.0058 0.033 0.086
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0071 0.0421 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.014 0.0745
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0748 0.1917
Plasmodium falciparum importin beta, putative 0.0058 0.033 0.086
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1582 0.1582
Loa Loa (eye worm) hypothetical protein 0.0202 0.1383 0.2069
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.1383 0.2555
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0022 0.0051
Loa Loa (eye worm) hypothetical protein 0.0071 0.0421 0.063
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0174 0.0431
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.001 0.0017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.00000023122 0.00000023122
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.026
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1178 0.6375
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0125 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.011 0.0581
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0591 0.0591
Schistosoma mansoni lamin 0.0027 0.0104 0.0094
Brugia malayi mbt repeat family protein 0.0051 0.0278 0.0512
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0591 0.0591
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0926 0.6684 0.6684
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0304 0.1631
Echinococcus granulosus glutamate receptor 2 0.0071 0.0421 0.0421
Leishmania major cathepsin L-like protease 0.0016 0.0022 0.0031
Brugia malayi beta-lactamase family protein 0.0037 0.0174 0.032
Echinococcus multilocularis geminin 0.0688 0.4941 0.4941
Echinococcus granulosus nmda type glutamate receptor 0.0071 0.0421 0.0421
Echinococcus multilocularis dnaJ subfamily B 0.0859 0.6194 0.6194
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0208 0.1428 0.1428
Echinococcus multilocularis glutamate receptor 2 0.0071 0.0421 0.0421
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0265 0.1846 0.2761
Schistosoma mansoni hypothetical protein 0.0622 0.4462 0.4456
Trypanosoma cruzi pyruvate kinase 2, putative 0.0099 0.0627 0.1623
Echinococcus granulosus intermediate filament protein 0.0027 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.003 0.0125 0.0115
Echinococcus multilocularis pyruvate kinase 0.0099 0.0627 0.0627
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0208 0.1428 0.7735
Brugia malayi Metabotropic glutamate receptor precursor. 0.0752 0.5411 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.014 0.0745
Toxoplasma gondii pyruvate kinase PyK1 0.0099 0.0627 0.1597
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0163 0.0866
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1178 0.6375
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0163 0.0402
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0371 0.0371
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0249 0.1336
Schistosoma mansoni hypothetical protein 0.0122 0.0797 0.0788
Schistosoma mansoni alpha-glucosidase 0.0138 0.091 0.0901
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0533 0.3809 0.7039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0157 0.0835
Brugia malayi Bromodomain containing protein 0.003 0.0125 0.023
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0304 0.0773
Echinococcus granulosus cathepsin l1 0.0016 0.0022 0.0022
Echinococcus multilocularis GPCR, family 2 0.0064 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0051 0.0278 0.0416
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0848 0.0839
Trypanosoma cruzi extracellular receptor, putative 0.0071 0.0421 0.1082
Echinococcus multilocularis microtubule associated protein 2 0.1378 1 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0174 0.0401
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0039
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0278 0.0416
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0356 0.0911
Echinococcus multilocularis pyruvate kinase 0.0051 0.0274 0.0274
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0071 0.0421 0.0421
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0304 0.1631
Mycobacterium ulcerans pyruvate kinase 0.0099 0.0627 0.1246
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0304 0.0773
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0356 0.0911
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0869 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0127 0.0127
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0533 0.3809 1
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0482 0.0472
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.061
Schistosoma mansoni cpg binding protein 0.006 0.0345 0.0335
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0071 0.0421 0.0421
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0125 0.0273
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0125 0.0273
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0533 0.3809 1
Leishmania major cathepsin L-like protease 0.0062 0.0356 0.0911
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0174 0.045
Chlamydia trachomatis pyruvate kinase 0.0099 0.0627 0.5
Schistosoma mansoni ran 0.0043 0.0217 0.0207
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0174 0.0164
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0208 0.1428 0.7735
Schistosoma mansoni alpha-glucosidase 0.0138 0.091 0.0901
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0157 0.0835
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0039
Echinococcus multilocularis tyrosine kinase 0.0071 0.0421 0.0421
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0356 0.0911
Onchocerca volvulus 0.0291 0.2032 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0797 0.1193
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0071 0.0421 0.0421
Brugia malayi Pre-SET motif family protein 0.0031 0.0127 0.0233
Leishmania major importin beta-1 subunit, putative 0.0047 0.0249 0.063
Leishmania major dihydroorotate dehydrogenase 0.0533 0.3809 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0174 0.026
Plasmodium vivax vivapain-2 0.0016 0.0022 0.0051
Loa Loa (eye worm) hypothetical protein 0.0071 0.0421 0.063
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0071 0.0421 0.1985
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0208 0.1428 0.3733
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0021 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.1383 0.2069
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0249 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Echinococcus multilocularis pyruvate kinase 0.0099 0.0627 0.0627
Echinococcus multilocularis glutamate receptor 2 0.0071 0.0421 0.0421
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1846 1
Echinococcus granulosus pyruvate kinase 0.0099 0.0627 0.0627
Trichomonas vaginalis pyruvate kinase, putative 0.0099 0.0627 0.3384
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0304 0.0304
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.033 0.0842
Schistosoma mansoni hypothetical protein 0.0859 0.6194 0.6191
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0163 0.0564
Loa Loa (eye worm) hypothetical protein 0.0071 0.0421 0.063
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1178 0.6375
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0174 0.0927
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0163 0.0866
Echinococcus multilocularis importin subunit beta 1 0.0058 0.033 0.033
Plasmodium falciparum phd finger protein, putative 0.003 0.0125 0.0322
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0217 0.0384
Schistosoma mansoni hypothetical protein 0.0688 0.4941 0.4936
Plasmodium vivax SET domain protein, putative 0.0031 0.0127 0.0327
Brugia malayi RNA, U transporter 1 0.0166 0.1117 0.2064
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0099 0.0627 0.1246
Brugia malayi Importin beta-1 subunit 0.0058 0.033 0.0608
Plasmodium falciparum pyruvate kinase 2 0.0051 0.0274 0.0714
Loa Loa (eye worm) hypothetical protein 0.0229 0.1582 0.2367
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.015
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0197 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 0.0102
Brugia malayi Pre-SET motif family protein 0.0205 0.1408 0.26
Schistosoma mansoni pyruvate kinase 0.0099 0.0627 0.0617
Loa Loa (eye worm) hypothetical protein 0.0193 0.1315 0.1967
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0071 0.0421 0.0421
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1178 0.6375
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0304 0.0454
Echinococcus granulosus lamin dm0 0.0027 0.0104 0.0104
Schistosoma mansoni intermediate filament proteins 0.0027 0.0104 0.0094
Loa Loa (eye worm) pyruvate kinase-PB 0.0069 0.0408 0.061
Leishmania major hypothetical protein, conserved 0.0037 0.0174 0.0431
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0163 0.0163
Brugia malayi beta-lactamase 0.0037 0.0174 0.032
Loa Loa (eye worm) RGC/RGC protein kinase 0.0071 0.0421 0.063
Schistosoma mansoni hypothetical protein 0.0064 0.0371 0.0362
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0278 0.0278
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1246 0.6747
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0356 0.0911
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.1383 0.2555
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1178 0.6375
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0345 0.0516
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0217 0.0217
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0357 0.2518 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0208 0.1428 0.5635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0075 0.0392
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0163 0.0299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0356 0.0911
Loa Loa (eye worm) cysteine protease 0.0016 0.0022 0.0033
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0278 0.0278
Leishmania major GTP-binding protein, putative 0.0043 0.0217 0.0546
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.00000023122 0.00000023122
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0122 0.0797 0.3856
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.026
Echinococcus granulosus pyruvate kinase 0.0051 0.0274 0.0274

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 13.72 uM PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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