Detailed information for compound 1749895

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 592.704 | Formula: C35H32N2O5S
  • H donors: 0 H acceptors: 4 LogP: 5.05 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC1=C2[C@H]([C@@H]3[C@H](C1)C(=O)N(C3=O)c1ccccc1)CN([C@H]2c1cccc2c1cccc2)S(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C35H32N2O5S/c1-3-42-30-20-28-31(35(39)37(34(28)38)24-12-5-4-6-13-24)29-21-36(43(40,41)25-18-16-22(2)17-19-25)33(32(29)30)27-15-9-11-23-10-7-8-14-26(23)27/h4-19,28-29,31,33H,3,20-21H2,1-2H3/t28-,29-,31-,33-/m0/s1
  • InChiKey: JGWJSEYTADYPCE-QMUZHLSXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi protein-tyrosine kinase 0.0786 1 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Echinococcus granulosus tyrosine protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Loa Loa (eye worm) TK/Met protein kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) TK/ABL protein kinase 0.0786 1 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0445 0.5547 1
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0342 0.4205 0.4205
Loa Loa (eye worm) TK/FER protein kinase 0.0786 1 1
Schistosoma mansoni protein kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) protein kinase domain-containing protein 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Echinococcus granulosus tyrosine protein kinase Src42A 0.0342 0.4205 0.4205
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Trichomonas vaginalis conserved hypothetical protein 0.0445 0.5547 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0342 0.4205 0.4205
Echinococcus granulosus tyrosine protein kinase csk 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis FL cytokine receptor 0.0445 0.5547 0.5547
Loa Loa (eye worm) TK/FER protein kinase 0.0786 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Schistosoma mansoni GTPase activating protein 0.0342 0.4205 0.4205
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Onchocerca volvulus 0.0786 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Echinococcus granulosus hypothetical protein 0.0342 0.4205 0.4205
Brugia malayi Tyrosine-protein kinase abl-1 0.0786 1 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0445 0.5547 0.5547
Echinococcus granulosus suppressor of cytokine signaling 7 0.0342 0.4205 0.4205
Entamoeba histolytica serine/threonine kinase, putative 0.0445 0.5547 0.2316
Loa Loa (eye worm) TK/FER protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica hypothetical protein 0.0445 0.5547 0.2316
Loa Loa (eye worm) SH2 domain-containing protein 0.0342 0.4205 0.4205
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0342 0.4205 0.4205
Echinococcus granulosus integrin linked protein kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) TK/FER protein kinase 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Trichomonas vaginalis CAMK family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica hypothetical protein 0.0445 0.5547 0.2316
Trichomonas vaginalis conserved hypothetical protein 0.0445 0.5547 0.5
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0342 0.4205 0.4205
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Brugia malayi Protein kinase domain containing protein 0.0786 1 1
Schistosoma mansoni hypothetical protein 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0445 0.5547 0.2316
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Schistosoma mansoni protein kinase 0.0445 0.5547 0.5547
Echinococcus granulosus N chimaerin 0.0342 0.4205 0.4205
Schistosoma mansoni tyrosine kinase 0.0786 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Schistosoma mansoni protein kinase 0.0445 0.5547 0.5547
Brugia malayi SH2 domain containing protein 0.0342 0.4205 0.4205
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0445 0.5547 1
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Echinococcus multilocularis tyrosine protein kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Brugia malayi integrin-linked kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Echinococcus multilocularis tensin 0.0342 0.4205 0.4205
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Schistosoma mansoni suppressor of cytokine signaling 0.0342 0.4205 0.4205
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Plasmodium falciparum protein kinase, putative 0.0445 0.5547 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni tensin 0.0342 0.4205 0.4205
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0342 0.4205 0.4205
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0445 0.5547 0.5547
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0445 0.5547 0.5547
Loa Loa (eye worm) TK/FER protein kinase 0.0786 1 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0342 0.4205 0.4205
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica hypothetical protein 0.0445 0.5547 0.2316
Brugia malayi RhoGAP domain containing protein 0.0342 0.4205 0.4205
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Brugia malayi STAT protein, DNA binding domain containing protein 0.0342 0.4205 0.4205
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica cysteine surface protein, putative 0.0445 0.5547 0.2316
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0445 0.5547 0.5547
Echinococcus granulosus tyrosine kinase 0.0786 1 1
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Brugia malayi SH2 domain containing protein 0.0342 0.4205 0.4205
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Schistosoma mansoni serine/threonine protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Loa Loa (eye worm) TK protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni vav2 0.0342 0.4205 0.4205
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0445 0.5547 0.5547
Echinococcus multilocularis kinase suppressor of Ras 1 0.0445 0.5547 0.5547
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Brugia malayi Raf kinase 0.0445 0.5547 0.5547
Brugia malayi hypothetical protein 0.0342 0.4205 0.4205
Echinococcus granulosus SH2 motif 0.0342 0.4205 0.4205
Loa Loa (eye worm) TK protein kinase 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0342 0.4205 0.4205
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Loa Loa (eye worm) RGC/RGC protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica serine/threonine kinase, putative 0.0445 0.5547 0.2316
Plasmodium vivax tyrosine kinase-like protein, putative 0.0445 0.5547 1
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Echinococcus granulosus NCK adaptor protein 0.0342 0.4205 0.4205
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Echinococcus multilocularis tyrosine protein kinase csk 0.0445 0.5547 0.5547
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0445 0.5547 0.5547
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Echinococcus multilocularis integrin linked protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Schistosoma mansoni tyrosine kinase 0.0786 1 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0786 1 1
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Schistosoma mansoni growth factor receptor-bound protein 0.0342 0.4205 0.4205
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0445 0.5547 0.5
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Onchocerca volvulus 0.0445 0.5547 0.2316
Trichomonas vaginalis conserved hypothetical protein 0.0445 0.5547 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0342 0.4205 0.4205
Loa Loa (eye worm) SRC-1 0.0786 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0445 0.5547 0.2316
Loa Loa (eye worm) TK protein kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis insulin receptor 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Loa Loa (eye worm) TK/RYK protein kinase 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0445 0.5547 0.5547
Schistosoma mansoni serine/threonine RGC 0.0445 0.5547 0.5547
Onchocerca volvulus 0.0786 1 1
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Echinococcus multilocularis SHC transforming protein 3 0.0342 0.4205 0.4205
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0445 0.5547 0.5547
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0342 0.4205 0.4205
Entamoeba histolytica serine/threonine kinase, putative 0.0445 0.5547 0.2316
Trichomonas vaginalis TK family protein kinase 0.0445 0.5547 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0445 0.5547 1
Echinococcus multilocularis activated cdc42 kinase 1 0.0445 0.5547 0.5547
Echinococcus granulosus natriuretic peptide receptor 1 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0445 0.5547 0.5547
Echinococcus granulosus tensin 0.0342 0.4205 0.4205
Trichomonas vaginalis STE family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Echinococcus granulosus ephrin type A receptor 4 A 0.0445 0.5547 0.5547
Toxoplasma gondii STE kinase 0.0445 0.5547 1
Entamoeba histolytica ankyrin repeat protein 0.0445 0.5547 0.2316
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0786 1 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0445 0.5547 0.5547
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0342 0.4205 0.4205
Echinococcus granulosus receptor type guanylyl cyclase 0.0445 0.5547 0.5547
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Onchocerca volvulus 0.0445 0.5547 0.2316
Entamoeba histolytica hypothetical protein 0.0445 0.5547 0.2316
Echinococcus granulosus SH2 domain containing adapter protein F 0.0342 0.4205 0.4205
Schistosoma mansoni protein kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0445 0.5547 0.5547
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0786 1 1
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Loa Loa (eye worm) RGC/RGC protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Entamoeba histolytica tyrosin kinase, putative 0.0445 0.5547 0.2316
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Echinococcus granulosus tyrosine protein kinase Src64B 0.0786 1 1
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0445 0.5547 0.5547
Loa Loa (eye worm) SH2 domain-containing protein 0.0342 0.4205 0.4205
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis ephrin type A receptor 4 A 0.0445 0.5547 0.5547
Entamoeba histolytica serine/threonine kinase, putative 0.0445 0.5547 0.2316
Schistosoma mansoni protein kinase 0.0445 0.5547 0.5547
Trypanosoma cruzi protein kinase, putative 0.0445 0.5547 1
Echinococcus granulosus SH2 domain containing protein 7 0.0342 0.4205 0.4205
Trichomonas vaginalis conserved hypothetical protein 0.0445 0.5547 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) SH2 domain-containing protein 0.0342 0.4205 0.4205
Schistosoma mansoni protein kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0445 0.5547 0.5547
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0342 0.4205 0.4205
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0342 0.4205 0.4205
Schistosoma mansoni ephrin receptor 0.0445 0.5547 0.5547
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0786 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0445 0.5547 0.5547
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Brugia malayi Variant SH3 domain containing protein 0.0342 0.4205 0.4205
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Onchocerca volvulus 0.0445 0.5547 0.2316
Brugia malayi Guanylyl cyclase protein 23 0.0445 0.5547 0.5547
Entamoeba histolytica tyrosin kinase, putative 0.0445 0.5547 0.2316
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0342 0.4205 0.4205
Echinococcus multilocularis tyrosine protein kinase csk 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0786 1 1
Echinococcus granulosus signal transduction protein lnk realted 0.0342 0.4205 0.4205
Echinococcus multilocularis NCK adaptor protein 0.0342 0.4205 0.4205
Loa Loa (eye worm) TK/FER protein kinase 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica receptor protein kinase, putative 0.0445 0.5547 0.2316
Trypanosoma cruzi protein kinase, putative 0.0445 0.5547 1
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis receptor type guanylyl cyclase 0.0445 0.5547 0.5547
Echinococcus granulosus SH2 motif 0.0342 0.4205 0.4205
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Echinococcus granulosus tyrosine protein kinase HCK 0.0445 0.5547 0.5547
Echinococcus multilocularis tyrosine protein kinase pr2 0.0445 0.5547 0.5547
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Schistosoma mansoni tensin-related 0.0342 0.4205 0.4205
Echinococcus granulosus protein tyrosine kinase 0.0445 0.5547 0.5547
Brugia malayi SRC-1 0.0786 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni protein kinase 0.0445 0.5547 0.5547
Echinococcus granulosus tyrosine kinase 0.0786 1 1
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Entamoeba histolytica hypothetical protein 0.0445 0.5547 0.2316
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0342 0.4205 0.4205
Echinococcus granulosus tyrosine kinase 0.0445 0.5547 0.5547
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0445 0.5547 0.5
Echinococcus multilocularis 0.0342 0.4205 0.4205
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Leishmania major hypothetical protein, conserved 0.0445 0.5547 1
Entamoeba histolytica hypothetical protein 0.0445 0.5547 0.2316
Brugia malayi Tensin 0.0342 0.4205 0.4205
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0445 0.5547 0.5547
Echinococcus multilocularis raf serine:threonine protein kinase 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Echinococcus granulosus tyrosine protein kinase Lyn 0.0786 1 1
Trichomonas vaginalis protein kinase atn1, putative 0.0445 0.5547 0.5
Brugia malayi hypothetical protein 0.0786 1 1
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Loa Loa (eye worm) TK/CSK protein kinase 0.0445 0.5547 0.5547
Onchocerca volvulus 0.0445 0.5547 0.2316
Loa Loa (eye worm) TK protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni tyrosine kinase 0.0786 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0786 1 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0342 0.4205 0.4205
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis tyrosine protein kinase Blk 0.0786 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0342 0.4205 0.4205
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Onchocerca volvulus 0.0786 1 1
Echinococcus granulosus tyrosine protein kinase shark 0.0786 1 1
Echinococcus multilocularis heat shock protein 70 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Brugia malayi SH2 domain containing protein 0.0342 0.4205 0.4205
Loa Loa (eye worm) TK/ACK protein kinase 0.0445 0.5547 0.5547
Trypanosoma brucei protein kinase, putative 0.0445 0.5547 1
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Echinococcus granulosus activated cdc42 kinase 1 0.0445 0.5547 0.5547
Entamoeba histolytica hypothetical protein 0.0445 0.5547 0.2316
Echinococcus granulosus tyrosine protein kinase Fyn 0.0786 1 1
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0445 0.5547 0.5547
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0342 0.4205 0.4205
Echinococcus granulosus retinal guanylyl cyclase 2 0.0445 0.5547 0.5547
Loa Loa (eye worm) TK protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0786 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0445 0.5547 0.5547
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0445 0.5547 0.5547
Brugia malayi Variant SH3 domain containing protein 0.0342 0.4205 0.4205
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis SH2 motif 0.0342 0.4205 0.4205
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0786 1 1
Schistosoma mansoni ephrin receptor 0.0445 0.5547 0.5547
Schistosoma mansoni serine/threonine protein kinase 0.0445 0.5547 0.5547
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0445 0.5547 0.2316
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0342 0.4205 0.4205
Brugia malayi SH2 domain containing protein 0.0342 0.4205 0.4205
Echinococcus granulosus tyrosine protein kinase pr2 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Entamoeba histolytica serine/threonine kinase, putative 0.0445 0.5547 0.2316
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Echinococcus granulosus tyrosine protein kinase Src42A 0.0786 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0786 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0342 0.4205 0.4205
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0445 0.5547 0.2316
Schistosoma mansoni adapter molecule crk 0.0342 0.4205 0.4205
Entamoeba histolytica tyrosin kinase, putative 0.0445 0.5547 0.2316
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0342 0.4205 0.4205
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0445 0.5547 0.2316
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0445 0.5547 1
Loa Loa (eye worm) TK/FER protein kinase 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica hypothetical protein 0.0445 0.5547 0.2316
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0445 0.5547 0.5547
Echinococcus multilocularis tyrosine kinase 0.0786 1 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0342 0.4205 0.4205
Loa Loa (eye worm) serine/threonine protein kinase 0.0445 0.5547 0.5547
Leishmania major protein kinase, putative 0.0445 0.5547 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0342 0.4205 0.4205
Loa Loa (eye worm) TK/FER protein kinase 0.0786 1 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0786 1 1
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Brugia malayi hypothetical protein 0.0445 0.5547 0.5547
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Echinococcus multilocularis SH2 motif 0.0342 0.4205 0.4205
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Onchocerca volvulus 0.0786 1 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0445 0.5547 0.5547
Brugia malayi bone morphogenetic protein type 1 receptor 0.0445 0.5547 0.5547
Brugia malayi SH2 domain containing protein 0.0786 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Schistosoma mansoni tyrosine kinase 0.0786 1 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0786 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Brugia malayi Immunoglobulin I-set domain containing protein 0.0445 0.5547 0.5547
Echinococcus granulosus insulin receptor 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Schistosoma mansoni hypothetical protein 0.0342 0.4205 0.4205
Loa Loa (eye worm) TK/INSR protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica hypothetical protein 0.0445 0.5547 0.2316
Echinococcus granulosus activated cdc42 kinase 1 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Entamoeba histolytica tyrosin kinase, putative 0.0445 0.5547 0.2316
Echinococcus granulosus tyrosine protein kinase csk 0.0445 0.5547 0.5547
Echinococcus multilocularis protein KINase family member (kin 25) 0.0445 0.5547 0.5547
Loa Loa (eye worm) TK/FER protein kinase 0.0786 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0786 1 1
Schistosoma mansoni signal transduction protein lnk-related 0.0342 0.4205 0.4205
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Trypanosoma brucei Pseudokinase, putative 0.0445 0.5547 1
Entamoeba histolytica ankyrin repeat protein 0.0445 0.5547 0.2316
Echinococcus granulosus tyrosine protein kinase ABL1 0.0786 1 1
Schistosoma mansoni SH2A 0.0342 0.4205 0.4205
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0445 0.5547 0.5547
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0342 0.4205 0.4205
Schistosoma mansoni protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni protein kinase 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0786 1 1
Schistosoma mansoni tensin-related 0.0342 0.4205 0.4205
Trypanosoma brucei Flagellum attachment zone protein 20 0.0445 0.5547 1
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0445 0.5547 0.2316
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0786 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Onchocerca volvulus 0.0786 1 1
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Leishmania major protein kinase, putative 0.0445 0.5547 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Brugia malayi Tyrosine-protein kinase PR2 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus granulosus protein kinase 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0445 0.5547 0.5547
Onchocerca volvulus 0.0445 0.5547 0.2316
Plasmodium vivax protein kinase, putative 0.0445 0.5547 1
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0342 0.4205 0.4205
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0786 1 1
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0445 0.5547 0.5547
Brugia malayi SH2 domain containing protein 0.0342 0.4205 0.4205
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0445 0.5547 1
Schistosoma mansoni tyrosine kinase 0.0786 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Giardia lamblia Kinase, NEK 0.0445 0.5547 0.5
Loa Loa (eye worm) TK protein kinase 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Giardia lamblia Protein 21.1 0.0445 0.5547 0.5
Echinococcus multilocularis tensin 0.0342 0.4205 0.4205
Onchocerca volvulus 0.0445 0.5547 0.2316
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0342 0.4205 0.4205
Onchocerca volvulus 0.0445 0.5547 0.2316
Brugia malayi Variant SH3 domain containing protein 0.0342 0.4205 0.4205
Schistosoma mansoni hypothetical protein 0.0342 0.4205 0.4205
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0342 0.4205 0.4205
Loa Loa (eye worm) TK/DDR protein kinase 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus granulosus suppressor of cytokine signaling 6 0.0342 0.4205 0.4205
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0445 0.5547 0.5
Loa Loa (eye worm) TK protein kinase 0.0786 1 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0786 1 1
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Echinococcus multilocularis tyrosine protein kinase Abl 0.0786 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0786 1 1
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Schistosoma mansoni tyrosine kinase 0.0786 1 1
Brugia malayi C-terminal src kinase protein 1 0.0445 0.5547 0.5547
Echinococcus multilocularis transfer RNA-Thr 0.0445 0.5547 0.5547
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Loa Loa (eye worm) TK/FER protein kinase 0.0445 0.5547 0.5547
Trichomonas vaginalis AGC family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0445 0.5547 0.2316
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0445 0.5547 0.2316
Entamoeba histolytica receptor protein kinase, putative 0.0445 0.5547 0.2316
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis c src tyrosine kinase 0.0786 1 1
Brugia malayi SH2 domain containing protein 0.0786 1 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0445 0.5547 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Giardia lamblia Kinase 0.0445 0.5547 0.5
Loa Loa (eye worm) STAT protein 0.0342 0.4205 0.4205
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0445 0.5547 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0445 0.5547 0.5547
Giardia lamblia Kinase, NEK 0.0445 0.5547 0.5
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0445 0.5547 0.5547
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0786 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Echinococcus multilocularis tyrosine kinase 0.0445 0.5547 0.5547
Schistosoma mansoni shc transforming protein 0.0342 0.4205 0.4205
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Schistosoma mansoni serine/threonine protein kinase 0.0445 0.5547 0.5547
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0445 0.5547 1
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Brugia malayi Protein kinase domain containing protein 0.0786 1 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0445 0.5547 0.5
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis protein kinase 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0445 0.5547 1
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0786 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0786 1 1
Loa Loa (eye worm) TK protein kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis epidermal growth factor receptor 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0786 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Echinococcus multilocularis tyrosine protein kinase csk 0.0445 0.5547 0.5547
Echinococcus multilocularis SH2 motif 0.0342 0.4205 0.4205
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0445 0.5547 0.5547
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0445 0.5547 1
Echinococcus multilocularis epidermal growth factor receptor 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Echinococcus multilocularis growth factor receptor bound protein 2 0.0342 0.4205 0.4205
Loa Loa (eye worm) TK protein kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0786 1 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0445 0.5547 0.5547
Loa Loa (eye worm) TK/FER protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni tensin 0.0342 0.4205 0.4205
Echinococcus granulosus c src tyrosine kinase 0.0786 1 1
Schistosoma mansoni tensin 0.0342 0.4205 0.4205
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Trichomonas vaginalis conserved hypothetical protein 0.0445 0.5547 0.5
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica protein kinase, putative 0.0445 0.5547 0.2316
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0786 1 1
Echinococcus multilocularis N chimaerin 0.0342 0.4205 0.4205
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0342 0.4205 0.4205
Brugia malayi tRNA modification GTPase TrmE family protein 0.0342 0.4205 0.4205
Loa Loa (eye worm) TK/FER protein kinase 0.0786 1 1
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0786 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Echinococcus granulosus expressed conserved protein 0.0342 0.4205 0.4205
Onchocerca volvulus 0.0445 0.5547 0.2316
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0445 0.5547 0.5547
Onchocerca volvulus 0.0445 0.5547 0.2316
Toxoplasma gondii protein kinase 0.0445 0.5547 1
Entamoeba histolytica tyrosine kinase, putative 0.0445 0.5547 0.2316
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Echinococcus granulosus activin receptor type 0.0445 0.5547 0.5547
Echinococcus granulosus epidermal growth factor receptor 0.0445 0.5547 0.5547
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0342 0.4205 0.4205
Echinococcus multilocularis protein tyrosine kinase 0.0445 0.5547 0.5547
Brugia malayi SH2 domain containing protein 0.0342 0.4205 0.4205
Echinococcus granulosus tyrosine protein kinase Fyn 0.0786 1 1
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Echinococcus granulosus tyrosine protein kinase Blk 0.0786 1 1
Schistosoma mansoni nck2/grb4 0.0342 0.4205 0.4205
Brugia malayi hypothetical protein 0.0445 0.5547 0.5547
Brugia malayi Receptor family ligand binding region containing protein 0.0445 0.5547 0.5547
Echinococcus granulosus retinal guanylyl cyclase 2 0.0445 0.5547 0.5547
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0342 0.4205 0.4205
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0342 0.4205 0.4205
Brugia malayi ephrin receptor 1 precursor 0.0445 0.5547 0.5547
Onchocerca volvulus 0.0786 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0342 0.4205 0.4205
Echinococcus granulosus raf serine:threonine protein kinase 0.0445 0.5547 0.5547
Brugia malayi SH2 domain containing protein 0.0342 0.4205 0.4205
Echinococcus multilocularis signal transduction protein lnk realted 0.0342 0.4205 0.4205
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0445 0.5547 0.5547
Echinococcus granulosus SHC transforming protein 3 0.0342 0.4205 0.4205
Echinococcus multilocularis natriuretic peptide receptor 1 0.0445 0.5547 0.5547
Loa Loa (eye worm) TK protein kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis tyrosine protein kinase HCK 0.0445 0.5547 0.5547
Echinococcus granulosus epidermal growth factor receptor 0.0445 0.5547 0.5547
Plasmodium falciparum protein kinase, putative 0.0445 0.5547 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0445 0.5547 1
Brugia malayi Furin-like cysteine rich region family protein 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Schistosoma mansoni protein kinase 0.0445 0.5547 0.5547
Brugia malayi Protein kinase domain containing protein 0.0445 0.5547 0.5547
Toxoplasma gondii protein kinase domain-containing protein 0.0445 0.5547 1
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0445 0.5547 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0786 1 1
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Entamoeba histolytica hypothetical protein 0.0445 0.5547 0.2316
Loa Loa (eye worm) hypothetical protein 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0445 0.5547 0.5547
Loa Loa (eye worm) TK/FER protein kinase 0.0786 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0445 0.5547 0.5
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0786 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Brugia malayi Sex muscle abnormal protein 5 0.0342 0.4205 0.4205
Loa Loa (eye worm) TK/ALK protein kinase 0.0445 0.5547 0.5547
Loa Loa (eye worm) hypothetical protein 0.0342 0.4205 0.4205
Brugia malayi Immunoglobulin I-set domain containing protein 0.0445 0.5547 0.5547
Schistosoma mansoni tyrosine protein kinase 0.0445 0.5547 0.5547
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0445 0.5547 0.5547
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Trichomonas vaginalis TKL family protein kinase 0.0445 0.5547 0.5
Schistosoma mansoni protein kinase 0.0445 0.5547 0.5547
Entamoeba histolytica protein kinase domain containing protein 0.0445 0.5547 0.2316
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0786 1 1
Brugia malayi Variant SH3 domain containing protein 0.0342 0.4205 0.4205
Echinococcus multilocularis tyrosine protein kinase Srms 0.0786 1 1
Schistosoma mansoni tyrosine kinase 0.0445 0.5547 0.5547
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0786 1 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0 0.5
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0445 0.5547 0.5547
Plasmodium falciparum protein kinase, putative 0.0445 0.5547 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0445 0.5547 0.5547
Schistosoma mansoni protein tyrosine kinase 0.0445 0.5547 0.5547
Onchocerca volvulus Tyrosine kinase homolog 0.0445 0.5547 0.2316
Loa Loa (eye worm) TK/FER protein kinase 0.0786 1 1
Entamoeba histolytica hypothetical protein 0.0445 0.5547 0.2316
Echinococcus multilocularis activin receptor type 0.0445 0.5547 0.5547
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0445 0.5547 0.5547

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.581 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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