Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2664 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2664 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2664 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2664 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2664 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2664 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2664 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2664 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2664 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2664 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2664 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2664 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AbsAC40 (functional) | > 15 uM | PubChem BioAssay. HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.