Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1094 | 0.1094 |
Loa Loa (eye worm) | amidase | 0.0037 | 0.0536 | 0.0536 |
Brugia malayi | Carboxylesterase family protein | 0.0054 | 0.1094 | 0.1094 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.031 | 0.9677 | 0.9677 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.9677 | 0.9677 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0054 | 0.1094 | 1 |
Trypanosoma cruzi | amidase, putative | 0.0037 | 0.0536 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0037 | 0.0536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.5909 | 0.5909 |
Brugia malayi | Carboxylesterase family protein | 0.0054 | 0.1094 | 0.1094 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0219 | 0.6626 | 0.6626 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0155 | 0.4498 | 0.4498 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0319 | 1 | 1 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0219 | 0.6626 | 0.6626 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0037 | 0.0536 | 0.0536 |
Echinococcus granulosus | carboxylesterase 5A | 0.0319 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.031 | 0.9677 | 0.9677 |
Echinococcus multilocularis | acetylcholinesterase | 0.0319 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0054 | 0.1094 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1094 | 0.1094 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0054 | 0.1094 | 0.1094 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0037 | 0.0536 | 0.0536 |
Onchocerca volvulus | 0.0054 | 0.1094 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 1 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0037 | 0.0536 | 1 |
Brugia malayi | putative amidase | 0.0037 | 0.0536 | 0.0536 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0054 | 0.1094 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.6626 | 0.6626 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0037 | 0.0536 | 0.5 |
Schistosoma mansoni | amidase | 0.031 | 0.9677 | 0.9677 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.031 | 0.9677 | 0.9677 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0054 | 0.1094 | 0.1094 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0054 | 0.1094 | 0.1094 |
Onchocerca volvulus | 0.0054 | 0.1094 | 1 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0054 | 0.1094 | 0.1094 |
Brugia malayi | hypothetical protein | 0.0054 | 0.1094 | 0.1094 |
Brugia malayi | Amidase family protein | 0.0037 | 0.0536 | 0.0536 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0319 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0319 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0054 | 0.1094 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1094 | 0.1094 |
Loa Loa (eye worm) | carboxylesterase | 0.0319 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.031 | 0.9677 | 0.9677 |
Loa Loa (eye worm) | carboxylesterase | 0.0054 | 0.1094 | 0.1094 |
Echinococcus multilocularis | neuroligin | 0.0054 | 0.1094 | 0.1094 |
Brugia malayi | Carboxylesterase family protein | 0.0319 | 1 | 1 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0219 | 0.6626 | 0.6626 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0172 | 0.5067 | 0.5067 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0536 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0054 | 0.1094 | 0.1094 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.0037 | 0.0536 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0037 | 0.0536 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0054 | 0.1094 | 0.1094 |
Onchocerca volvulus | 0.0054 | 0.1094 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1094 | 0.1094 |
Echinococcus granulosus | ankyrin repeat protein | 0.0155 | 0.4498 | 0.4498 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0155 | 0.4498 | 0.4498 |
Toxoplasma gondii | hypothetical protein | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0319 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0054 | 0.1094 | 0.1094 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0054 | 0.1094 | 0.1094 |
Brugia malayi | Amidase family protein | 0.0037 | 0.0536 | 0.0536 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0054 | 0.1094 | 1 |
Schistosoma mansoni | gliotactin | 0.0054 | 0.1094 | 0.1094 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0037 | 0.0536 | 0.0536 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0054 | 0.1094 | 0.1094 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0037 | 0.0536 | 0.0536 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | amidase, putative | 0.0037 | 0.0536 | 1 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0037 | 0.0536 | 0.0536 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0054 | 0.1094 | 0.1094 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0054 | 0.1094 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0172 | 0.5059 | 0.5059 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1094 | 0.1094 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0037 | 0.0536 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0319 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0054 | 0.1094 | 0.1094 |
Echinococcus multilocularis | acetylcholinesterase | 0.0319 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0037 | 0.0536 | 0.0536 |
Onchocerca volvulus | 0.0054 | 0.1094 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1094 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1094 | 0.1094 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0021 | 0 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0037 | 0.0536 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0054 | 0.1094 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0054 | 0.1094 | 0.1094 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0054 | 0.1094 | 0.1094 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.031 | 0.9677 | 0.9677 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0054 | 0.1094 | 1 |
Onchocerca volvulus | 0.0054 | 0.1094 | 1 | |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0037 | 0.0536 | 0.5 |
Brugia malayi | amidase | 0.031 | 0.9677 | 0.9677 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | amidase | 0.0037 | 0.0536 | 0.0536 |
Brugia malayi | Carboxylesterase family protein | 0.0054 | 0.1094 | 0.1094 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.