Detailed information for compound 1750313

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 314.333 | Formula: C18H18O5
  • H donors: 0 H acceptors: 1 LogP: 2.72 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1oc2c3c1C(=O)OCCOC3CCC2
  • InChi: 1S/C18H18O5/c1-20-12-7-5-11(6-8-12)17-16-15-13(3-2-4-14(15)23-17)21-9-10-22-18(16)19/h5-8,13H,2-4,9-10H2,1H3
  • InChiKey: AUQSYXLUJBLDCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0151 0.015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.1195 0.2492
Plasmodium vivax ataxin-2 like protein, putative 0.0016 0.0055 0.0074
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.0019 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.1195 0.1195
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0512 0.4793 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0049 0.0371 0.0371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1195 0.1179
Mycobacterium tuberculosis Conserved protein 0.0093 0.0788 0.1294
Schistosoma mansoni Smad4 0.0013 0.0024 0.0006
Echinococcus multilocularis fetal alzheimer antigen, falz 0.002 0.009 0.009
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0151 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0349 0.0695
Echinococcus multilocularis PHD finger protein rhinoceros 0.0021 0.0106 0.0106
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0151 0.0134
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0028 0.0174 0.0174
Entamoeba histolytica hypothetical protein 0.0024 0.0136 0.8817
Leishmania major hypothetical protein, conserved 0.0016 0.0055 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2619 1
Echinococcus multilocularis integrin alpha 3 0.0143 0.127 0.127
Plasmodium falciparum ataxin-2 like protein, putative 0.0016 0.0055 0.0074
Mycobacterium leprae Probable lipase LipE 0.0093 0.0788 0.1372
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.1781 0.6775
Loa Loa (eye worm) hypothetical protein 0.0147 0.1303 0.1302
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.002 0.009 0.0073
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1685 0.6406
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0512 0.4793 1
Onchocerca volvulus 0.0093 0.0788 0.137
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0013 0.0024 0.0006
Onchocerca volvulus 0.0093 0.0788 0.137
Onchocerca volvulus 0.0034 0.0223 0.0362
Loa Loa (eye worm) hypothetical protein 0.0016 0.0055 0.0054
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0088 0.0144
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0031 0.0195 0.0194
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0024 0.0136 0.0136
Schistosoma mansoni cpg binding protein 0.0033 0.0213 0.0195
Loa Loa (eye worm) hepatopoietin HPO2 0.0027 0.0156 0.0155
Schistosoma mansoni smad1 5 8 and 0.0013 0.0024 0.0006
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0013 0.0031 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0024 0.0136 0.0136
Schistosoma mansoni bromodomain containing protein 0.0052 0.0398 0.0381
Loa Loa (eye worm) cysteine protease 0.0012 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0022 0.0113 0.0112
Brugia malayi MH2 domain containing protein 0.0013 0.0024 0.0048
Brugia malayi CXXC zinc finger family protein 0.0033 0.0213 0.0442
Schistosoma mansoni transcription factor LCR-F1 0.0024 0.0136 0.0118
Schistosoma mansoni integrin alpha 0.0187 0.1686 0.1672
Echinococcus multilocularis tumor protein p63 0.0267 0.2458 0.2458
Entamoeba histolytica hypothetical protein 0.0024 0.0136 0.8817
Schistosoma mansoni hypothetical protein 0.0057 0.0443 0.0426
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.1195 0.1194
Echinococcus granulosus beta LACTamase domain containing family member 0.0093 0.0788 0.0788
Schistosoma mansoni smad 0.0013 0.0024 0.0006
Brugia malayi hypothetical protein 0.0024 0.0136 0.0282
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0087
Mycobacterium tuberculosis Conserved protein 0.0093 0.0788 0.1294
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0223 0.0206
Leishmania major hypothetical protein, conserved 0.0022 0.0113 0.02
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0088 0.5
Onchocerca volvulus Glucosylceramidase homolog 0.0187 0.1685 0.2967
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0204 0.0204
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0093 0.0788 0.1294
Brugia malayi Augmenter of liver regeneration 0.0027 0.0156 0.0324
Onchocerca volvulus 0.0022 0.0113 0.0167
Schistosoma mansoni hypothetical protein 0.1056 1 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0151 0.0315
Echinococcus granulosus jumonji domain containing protein 0.003 0.0186 0.0186
Echinococcus multilocularis integrin alpha ps 0.0084 0.0702 0.0702
Entamoeba histolytica hypothetical protein 0.0024 0.0136 0.8817
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0349 0.0695
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0352 0.0352
Brugia malayi beta-lactamase family protein 0.0093 0.0788 0.1644
Schistosoma mansoni hypothetical protein 0.0022 0.0113 0.0096
Echinococcus granulosus zinc finger protein 0.0017 0.0068 0.0068
Leishmania major cathepsin L-like protease 0.0012 0.0019 0.0004
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0106 0.0182
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0512 0.4793 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0151 0.028
Onchocerca volvulus 0.0026 0.0151 0.0235
Brugia malayi hypothetical protein 0.0243 0.2229 0.4649
Loa Loa (eye worm) hypothetical protein 0.0128 0.1121 0.1121
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.052 0.1049
Brugia malayi Pre-SET motif family protein 0.0034 0.0223 0.0464
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0349 0.0695
Schistosoma mansoni methyl-cpg binding protein mbd 0.0013 0.0031 0.0013
Loa Loa (eye worm) beta-lactamase 0.0093 0.0788 0.0788
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0113 0.02
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0349 0.0695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0349 0.0695
Brugia malayi Pre-SET motif family protein 0.023 0.2099 0.4377
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0633 0.0632
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0151 0.0134
Leishmania major cysteine peptidase A (CPA) 0.0012 0.0019 0.0004
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0284 0.2619 0.2619
Echinococcus granulosus fetal alzheimer antigen falz 0.002 0.009 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1685 0.6406
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.0254 0.0494
Brugia malayi Latrophilin receptor protein 2 0.0057 0.0443 0.0922
Brugia malayi hypothetical protein 0.0016 0.0055 0.0113
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0223 0.0206
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0106 0.0182
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0009 0.0009
Mycobacterium tuberculosis Probable lipase LipD 0.0093 0.0788 0.1294
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0021 0.0106 0.0089
Mycobacterium ulcerans thymidylate synthase 0.0512 0.4793 1
Brugia malayi hypothetical protein 0.0031 0.0195 0.0406
Brugia malayi Bromodomain containing protein 0.0061 0.0487 0.1015
Schistosoma mansoni jumonji domain containing protein 0.0056 0.0434 0.0417
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0182 0.0164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0349 0.0695
Brugia malayi Cathepsin L-like precursor 0.0012 0.0019 0.0039
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0009 0.0009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0179 0.1611 0.336
Loa Loa (eye worm) hypothetical protein 0.0026 0.0151 0.015
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0633 0.0617
Echinococcus granulosus muscleblind protein 0.0128 0.1121 0.1121
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0113 0.0197
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0352 0.0352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.1195 0.1195
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0057 0.004
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0284 0.2619 0.5464
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0057 0.0443 0.0443
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.1195 0.1195
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.0019 0.0019
Schistosoma mansoni zinc finger protein 0.0017 0.0068 0.005
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0512 0.4793 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1195 0.1179
Echinococcus granulosus Lipid transport protein N terminal 0.0599 0.5632 0.5632
Brugia malayi PHD-finger family protein 0.0021 0.0106 0.0221
Echinococcus granulosus Smad4 0.0013 0.0024 0.0024
Leishmania major cathepsin L-like protease 0.0047 0.0349 0.0695
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0633 0.0617
Echinococcus granulosus smad 0.0013 0.0024 0.0024
Echinococcus multilocularis peregrin 0.0023 0.0124 0.0124
Echinococcus multilocularis jumonji domain containing protein 0.003 0.0186 0.0186
Brugia malayi Integrin beta pat-3 precursor 0.0202 0.1833 0.3822
Echinococcus granulosus cathepsin l1 0.0012 0.0019 0.0019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0151 1
Schistosoma mansoni hypothetical protein 0.0057 0.0443 0.0426
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.0019 0.0019
Echinococcus multilocularis beta LACTamase domain containing family member 0.0093 0.0788 0.0788
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0151 0.028
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1685 0.6406
Plasmodium vivax SET domain protein, putative 0.0034 0.0223 0.0426
Trypanosoma cruzi cysteine peptidase, putative 0.0012 0.0019 0.0004
Brugia malayi Cathepsin L-like precursor 0.0012 0.0019 0.0039
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0027 0.0156 0.0289
Trichomonas vaginalis esterase, putative 0.0093 0.0788 0.2958
Mycobacterium ulcerans hypothetical protein 0.0026 0.0151 0.0134
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0349 0.0695
Trichomonas vaginalis D-aminoacylase, putative 0.0093 0.0788 0.2958
Loa Loa (eye worm) hypothetical protein 0.0056 0.0437 0.0436
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0179 0.1611 0.161
Echinococcus multilocularis smad 0.0013 0.0024 0.0024
Echinococcus granulosus methyl CpG binding domain protein 2 0.0013 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0036 0.0242 0.0241
Trypanosoma brucei hypothetical protein, conserved 0.0093 0.0788 0.1614
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0151 0.0133
Schistosoma mansoni integrin beta subunit 0.0119 0.1039 0.1023
Echinococcus multilocularis integrin beta 2 0.015 0.1332 0.1332
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0633 0.0632
Brugia malayi Muscleblind-like protein 0.0128 0.1121 0.2339
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0027 0.0156 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2619 1
Onchocerca volvulus 0.0512 0.4793 0.8506
Loa Loa (eye worm) bromodomain containing protein 0.0014 0.0035 0.0035
Loa Loa (eye worm) transcription factor SMAD2 0.0187 0.1689 0.1688
Toxoplasma gondii ABC1 family protein 0.0093 0.0788 0.1611
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0027 0.0156 0.0156
Loa Loa (eye worm) MH2 domain-containing protein 0.0013 0.0024 0.0023
Brugia malayi RNA binding protein 0.0076 0.0633 0.132
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0113 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0151 0.0134
Echinococcus multilocularis cpg binding protein 0.0036 0.0245 0.0245
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0151 0.0133
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0027 0.0156 0.0289
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0019 0.0002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0028 0.0174 0.0174
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0182 0.0181
Trypanosoma brucei PAB1-binding protein , putative 0.0016 0.0055 0.0078
Brugia malayi jmjC domain containing protein 0.007 0.0572 0.1192
Loa Loa (eye worm) hypothetical protein 0.0599 0.5632 0.5632
Toxoplasma gondii Erv1 / Alr family protein 0.0027 0.0156 0.0286
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0027 0.0156 0.0286
Schistosoma mansoni hypothetical protein 0.004 0.0285 0.0268
Echinococcus granulosus integrin alpha ps 0.0084 0.0702 0.0702
Echinococcus multilocularis zinc finger protein 0.0017 0.0068 0.0068
Brugia malayi Protein kinase domain containing protein 0.0022 0.0113 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.2229 0.8499
Mycobacterium ulcerans esterase/lipase LipP 0.0093 0.0788 0.1488
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0324 0.0323
Trichomonas vaginalis D-aminoacylase, putative 0.0093 0.0788 0.2958
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0788 0.1614
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0019 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0151 0.0315
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.2099 0.2098
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0512 0.4793 1
Echinococcus granulosus tumor protein p63 0.0267 0.2458 0.2458
Loa Loa (eye worm) hypothetical protein 0.0032 0.021 0.0209
Plasmodium falciparum phd finger protein, putative 0.0021 0.0106 0.0182
Echinococcus multilocularis muscleblind protein 1 0.0128 0.1121 0.1121
Brugia malayi Smad1 0.0013 0.0024 0.0048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0057 0.0443 0.0922
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0151 1
Brugia malayi Bromodomain containing protein 0.0023 0.0124 0.0258
Echinococcus granulosus lysine specific demethylase 5A 0.0029 0.0182 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0151 0.0134
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1685 0.6406
Plasmodium falciparum ataxin-2 like protein, putative 0.0016 0.0055 0.0074
Schistosoma mansoni hypothetical protein 0.0057 0.0443 0.0426
Leishmania major hypothetical protein, conserved 0.0093 0.0788 0.1614
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0179 0.1611 0.161
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0106 0.0182
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2619 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0012 0.0019 0.0019
Echinococcus granulosus integrin alpha ps 0.004 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0122 0.107 0.1069
Onchocerca volvulus Apolipophorins homolog 0.0599 0.5632 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0195 0.0194
Loa Loa (eye worm) hypothetical protein 0.0093 0.0788 0.0788
Echinococcus granulosus cathepsin L cysteine proteinase 0.0012 0.0019 0.0019
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0055 0.0078
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0093 0.0788 0.1644
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.007 0.0572 0.0572
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1685 0.6406
Brugia malayi PHD-finger family protein 0.0022 0.0108 0.0224
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0633 0.132
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0151 0.028
Loa Loa (eye worm) fibroinase 0.0012 0.0019 0.0018
Giardia lamblia PHD finger protein 15 0.0021 0.0106 0.5
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0013 0.0024 0.0024
Brugia malayi Kelch motif family protein 0.0031 0.0195 0.0406
Brugia malayi Cathepsin L-like precursor 0.0012 0.0019 0.0039
Echinococcus granulosus mothers against decapentaplegic 5 0.0013 0.0024 0.0024
Echinococcus multilocularis thymidylate synthase 0.0512 0.4793 0.4793
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0113 0.0113
Brugia malayi PHD-finger family protein 0.001 0.0001 0.0001
Echinococcus granulosus cpg binding protein 0.0036 0.0245 0.0245
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0027 0.0156 0.0289
Loa Loa (eye worm) hypothetical protein 0.0039 0.0276 0.0275
Leishmania major cathepsin L-like protease 0.0012 0.0019 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0349 0.0695
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0141 0.1252 0.2611
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0043 0.0311 0.0614
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0512 0.4793 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.0093 0.0788 0.0788
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0572 0.0556
Mycobacterium ulcerans hypothetical protein 0.0093 0.0788 0.1488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0349 0.0695
Schistosoma mansoni hypothetical protein 0.0021 0.0106 0.0089
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0106
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0213 0.0212
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0113 0.0112
Echinococcus multilocularis muscleblind protein 0.0128 0.1121 0.1121
Onchocerca volvulus 0.0033 0.0213 0.0344
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.1781 0.6775
Loa Loa (eye worm) hypothetical protein 0.0026 0.0151 0.015
Loa Loa (eye worm) hypothetical protein 0.0057 0.0443 0.0442
Echinococcus multilocularis Lipid transport protein, N terminal 0.0599 0.5632 0.5632
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0057 0.0443 0.0443
Trichomonas vaginalis penicillin-binding protein, putative 0.0093 0.0788 0.2958
Loa Loa (eye worm) hypothetical protein 0.0044 0.0318 0.0318
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0633 0.0633
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2619 1
Mycobacterium leprae conserved hypothetical protein 0.0093 0.0788 0.1372
Echinococcus multilocularis cysteine protease 0.0012 0.0019 0.0019
Echinococcus multilocularis lysine specific demethylase 5A 0.0026 0.0149 0.0149
Brugia malayi MH1 domain containing protein 0.0013 0.0024 0.0048
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.0349 0.0695
Brugia malayi jmjC domain containing protein 0.0029 0.0182 0.0378
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0113 0.0197
Brugia malayi TAR-binding protein 0.0076 0.0633 0.132
Toxoplasma gondii Erv1 / Alr family protein 0.0027 0.0156 0.0286
Loa Loa (eye worm) ctsf protein 0.0012 0.0019 0.0018
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0049 0.0371 0.0371
Schistosoma mansoni smad1 5 8 and 0.0013 0.0024 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0192 0.0191
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0055 0.0078
Brugia malayi Cathepsin L-like precursor 0.0012 0.0019 0.0039
Brugia malayi beta-lactamase 0.0093 0.0788 0.1644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0349 0.0695
Loa Loa (eye worm) hypothetical protein 0.0093 0.0788 0.0788
Mycobacterium tuberculosis Probable lipase LipE 0.0093 0.0788 0.1294
Echinococcus multilocularis microsomal triglyceride transfer protein large 0.1056 1 1
Brugia malayi beta-lactamase family protein 0.0093 0.0788 0.1644
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0057 0.0443 0.0443
Schistosoma mansoni methyl-cpg binding protein mbd 0.0013 0.0031 0.0013
Echinococcus granulosus peregrin 0.0023 0.0124 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1685 0.6406
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0009 0.0009
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.009 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0788 0.1614
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0165 0.0164
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0087
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0593 0.5566 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0512 0.4793 1
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0019 0.0039
Schistosoma mansoni hypothetical protein 0.0122 0.107 0.1054
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0179 0.1611 0.336
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0093 0.0788 0.1294
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0512 0.4793 0.4784
Echinococcus multilocularis mothers against decapentaplegic 5 0.0013 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0349 0.0695
Loa Loa (eye worm) integrin alpha pat-2 0.0288 0.2653 0.2652
Echinococcus multilocularis Smad4 0.0013 0.0024 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0633 0.0617
Schistosoma mansoni integrin alpha-ps 0.0044 0.0318 0.0301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0349 0.0695
Schistosoma mansoni cellular tumor antigen P53 0.0039 0.0276 0.0259
Echinococcus multilocularis integrin alpha ps 0.0084 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0223 0.0223
Echinococcus multilocularis integrin alpha ps 0.004 0.0285 0.0285
Trichomonas vaginalis D-aminoacylase, putative 0.0093 0.0788 0.2958
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0093 0.0788 0.0772
Toxoplasma gondii LsmAD domain-containing protein 0.0016 0.0055 0.0074
Loa Loa (eye worm) hypothetical protein 0.0103 0.0886 0.0886
Mycobacterium tuberculosis Conserved protein 0.0093 0.0788 0.1294
Loa Loa (eye worm) hypothetical protein 0.1056 1 1
Echinococcus granulosus GPCR family 2 0.0057 0.0443 0.0443
Brugia malayi thymidylate synthase 0.0512 0.4793 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0151 0.0315
Onchocerca volvulus 0.0261 0.2401 0.4244
Brugia malayi Kringle domain containing protein 0.0022 0.0113 0.0235
Leishmania major cathepsin L-like protease 0.0012 0.0019 0.0004
Mycobacterium ulcerans beta-lactamase 0.0093 0.0788 0.1488
Entamoeba histolytica hypothetical protein 0.0024 0.0136 0.8817
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0893 0.8434 0.8434
Loa Loa (eye worm) Smad1 0.0013 0.0024 0.0023
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.007 0.0572 0.0572
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1195 0.1179
Loa Loa (eye worm) hypothetical protein 0.0047 0.0352 0.0351
Leishmania major cathepsin L-like protease 0.0047 0.0349 0.0695
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0223 0.0426
Loa Loa (eye worm) RNA binding protein 0.0076 0.0633 0.0632
Brugia malayi Integrin alpha pat-2 precursor 0.0187 0.1686 0.3518
Loa Loa (eye worm) MH1 domain-containing protein 0.0013 0.0024 0.0023
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0151 0.0134
Echinococcus granulosus integrin alpha 3 0.0143 0.127 0.127
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0057 0.0443 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0349 0.0695
Loa Loa (eye worm) hypothetical protein 0.0093 0.0788 0.0788
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0512 0.4793 0.8592
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0633 0.0617
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0349 0.0695
Trichomonas vaginalis set domain proteins, putative 0.0261 0.2401 0.9161
Leishmania major cathepsin L-like protease 0.0012 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0087
Echinococcus granulosus tar DNA binding protein 0.0076 0.0633 0.0633
Schistosoma mansoni hypothetical protein 0.0016 0.0058 0.004
Echinococcus granulosus integrin beta 2 0.015 0.1332 0.1332
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0113 0.0197
Echinococcus granulosus thymidylate synthase 0.0512 0.4793 0.4793
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1685 0.6406
Echinococcus granulosus PHD finger protein rhinoceros 0.0021 0.0106 0.0106
Loa Loa (eye worm) MH2 domain-containing protein 0.0187 0.1689 0.1688
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0093 0.0788 0.1488
Mycobacterium tuberculosis Hypothetical protein 0.0243 0.2229 0.3919
Loa Loa (eye worm) hypothetical protein 0.0128 0.1121 0.1121
Onchocerca volvulus Alhambra homolog 0.0021 0.0106 0.0155
Brugia malayi Cathepsin L-like precursor 0.0012 0.0019 0.0039
Mycobacterium tuberculosis Probable hydrolase 0.0093 0.0788 0.1294
Onchocerca volvulus 0.0093 0.0788 0.137
Brugia malayi Cathepsin L-like precursor 0.0012 0.0019 0.0039
Brugia malayi Cytochrome P450 family protein 0.0027 0.0165 0.0342
Schistosoma mansoni smad1 5 8 and 0.0013 0.0024 0.0006
Echinococcus multilocularis cysteine protease 0.0012 0.0019 0.0019
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0088 0.0144
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0151 0.0134
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0182 0.0164
Brugia malayi MH1 domain containing protein 0.0013 0.0024 0.0048
Schistosoma mansoni hypothetical protein 0.0024 0.0136 0.0118
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0151 1
Schistosoma mansoni integrin alpha-ps 0.0084 0.0702 0.0686
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0352 0.0335
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.0058 0.0057
Brugia malayi latrophilin 2 splice variant baaae 0.0122 0.107 0.2232
Schistosoma mansoni cpg binding protein 0.0036 0.0245 0.0228
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0088 0.0019
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0019 0.0018
Schistosoma mansoni cpg binding protein 0.0036 0.0245 0.0228
Leishmania major cathepsin L-like protease 0.0047 0.0349 0.0695
Leishmania major cathepsin L-like protease 0.0012 0.0019 0.0004
Loa Loa (eye worm) integrin beta-2 0.0202 0.1833 0.1832
Echinococcus multilocularis GPCR, family 2 0.0057 0.0443 0.0443
Brugia malayi Bromodomain containing protein 0.003 0.0192 0.0399
Mycobacterium tuberculosis Probable esterase LipL 0.0093 0.0788 0.1294
Onchocerca volvulus 0.0039 0.0276 0.0457
Loa Loa (eye worm) hypothetical protein 0.0037 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0093 0.0788 0.0788
Trichomonas vaginalis penicillin-binding protein, putative 0.0093 0.0788 0.2958
Plasmodium vivax hypothetical protein, conserved 0.0093 0.0788 0.1611
Brugia malayi MH2 domain containing protein 0.0013 0.0024 0.0048
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0106 0.0106
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0012 0.0019 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0352 0.0335
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0093 0.0788 0.0788
Echinococcus granulosus TGF beta signal transducer SmadC 0.0013 0.0024 0.0024
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0027 0.0156 0.0286
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0633 0.0617
Loa Loa (eye worm) latrophilin receptor protein 2 0.0057 0.0443 0.0442
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0093 0.0788 0.0772
Loa Loa (eye worm) thymidylate synthase 0.0512 0.4793 0.4793
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0093 0.0788 0.1294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.1195 0.1195
Leishmania major hypothetical protein, conserved 0.0027 0.0156 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2619 1
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0027 0.0156 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.2619 1
Mycobacterium ulcerans lipase LipD 0.0093 0.0788 0.1488
Schistosoma mansoni hypothetical protein 0.0057 0.0443 0.0426
Loa Loa (eye worm) hypothetical protein 0.0141 0.1252 0.1251
Loa Loa (eye worm) hypothetical protein 0.0093 0.0788 0.0788
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0243 0.2229 0.463
Brugia malayi MH2 domain containing protein 0.0187 0.1689 0.3522

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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