TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 585.645 | Formula: C32H28FN3O5S
H donors: 1 H acceptors: 4 LogP: 4.79 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccccc1N1CCN(CC1)c1ccc2c(c1)S(=O)(=O)c1c(C2=O)c(ccc1)C(=O)NCc1cccc(c1)F
InChi: 1S/C32H28FN3O5S/c1-41-27-10-3-2-9-26(27)36-16-14-35(15-17-36)23-12-13-24-29(19-23)42(39,40)28-11-5-8-25(30(28)31(24)37)32(38)34-20-21-6-4-7-22(33)18-21/h2-13,18-19H,14-17,20H2,1H3,(H,34,38)
InChiKey: KOUGYJAMBDDYQO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	parathyroid hormone 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04588 secretin receptor, putative	Get druggable targets OG5_139196	All targets in OG5_139196

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0033	0.0722	0.1694
Schistosoma mansoni	tyrosine kinase	0.0058	0.2947	0.6915
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0025	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0033	0.0722	0.245
Schistosoma mansoni	tensin	0.0033	0.0722	0.1694
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0058	0.2947	0.6915
Schistosoma mansoni	tensin-related	0.0033	0.0722	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Echinococcus granulosus	SHC transforming protein 3	0.0033	0.0722	0.1694
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Brugia malayi	protein-tyrosine kinase	0.0058	0.2947	0.2947
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.2947	0.6915
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0033	0.0722	0.245
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0033	0.0722	0.1694
Schistosoma mansoni	tyrosine kinase	0.0058	0.2947	0.6915
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus multilocularis	tensin	0.0033	0.0722	0.1694
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0058	0.2947	0.6915
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0033	0.0722	0.0722
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0025	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Schistosoma mansoni	tensin-related	0.0033	0.0722	0.1694
Trichomonas vaginalis	protein kinase atn1, putative	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Onchocerca volvulus		0.0033	0.0722	0.245
Giardia lamblia	Kinase	0.0025	0	0.5
Echinococcus multilocularis		0.0033	0.0722	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1476	0.1476
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.3188	0.3188
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0025	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0025	0	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0136	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0033	0.0722	0.0722
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Brugia malayi	SH2 domain containing protein	0.0033	0.0722	0.0722
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0058	0.2947	0.6915
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.4262	1
Echinococcus multilocularis	SH2 motif	0.0033	0.0722	0.1694
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0058	0.2947	0.6915
Schistosoma mansoni	growth factor receptor-bound protein	0.0033	0.0722	0.1694
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0033	0.0722	0.1694
Brugia malayi	Variant SH3 domain containing protein	0.0033	0.0722	0.0722
Echinococcus granulosus	tyrosine kinase	0.0058	0.2947	0.6915
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.2947	0.2947
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0033	0.0722	0.0722
Brugia malayi	RNA recognition motif domain containing protein	0.0072	0.4262	0.4262
Schistosoma mansoni	suppressor of cytokine signaling	0.0033	0.0722	0.1694
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.2947	0.2947
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0033	0.0722	0.1694
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0033	0.0722	0.245
Echinococcus granulosus	hypothetical protein	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0025	0	0.5
Echinococcus granulosus	tar DNA binding protein	0.0072	0.4262	1
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.2459	0.577
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Onchocerca volvulus		0.0058	0.2947	1
Onchocerca volvulus		0.0033	0.0722	0.245
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Trypanosoma brucei	protein kinase, putative	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.2947	0.2947
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0058	0.2947	0.6915
Echinococcus multilocularis	NCK adaptor protein	0.0033	0.0722	0.1694
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.2947	0.6915
Echinococcus multilocularis	N chimaerin	0.0033	0.0722	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0058	0.2947	0.6915
Onchocerca volvulus		0.0058	0.2947	1
Schistosoma mansoni	tyrosine kinase	0.0058	0.2947	0.6915
Trypanosoma cruzi	protein kinase, putative	0.0025	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0058	0.2947	0.2947
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0033	0.0722	0.1694
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0033	0.0722	0.1694
Echinococcus granulosus	SH2 motif	0.0033	0.0722	0.1694
Echinococcus granulosus	tensin	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Brugia malayi	RNA binding protein	0.0072	0.4262	0.4262
Echinococcus multilocularis	tensin	0.0033	0.0722	0.1694
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0033	0.0722	0.1694
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0033	0.0722	0.1694
Brugia malayi	Tyrosine-protein kinase abl-1	0.0058	0.2947	0.2947
Echinococcus granulosus	SH2 motif	0.0033	0.0722	0.1694
Onchocerca volvulus		0.0058	0.2947	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0058	0.2947	0.6915
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0058	0.2947	0.6915
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.2459	0.577
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0025	0	0.5
Leishmania major	protein kinase, putative	0.0025	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0058	0.2947	0.6915
Toxoplasma gondii	STE kinase	0.0025	0	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0058	0.2947	0.6915
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Schistosoma mansoni	nck2/grb4	0.0033	0.0722	0.1694
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.4262	1
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0058	0.2947	0.6915
Plasmodium falciparum	tyrosine kinase-like protein	0.0025	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0033	0.0722	0.1694
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.2947	0.2947
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Leishmania major	protein kinase, putative	0.0025	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0058	0.2947	0.6915
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Schistosoma mansoni	signal transduction protein lnk-related	0.0033	0.0722	0.1694
Schistosoma mansoni	shc transforming protein	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.2947	0.2947
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus granulosus	N chimaerin	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0058	0.2947	0.6915
Schistosoma mansoni	growth factor receptor-bound protein	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.2947	0.2947
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.2947	0.2947
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0033	0.0722	0.1694
Brugia malayi	SH2 domain containing protein	0.0033	0.0722	0.0722
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0025	0	0.5
Onchocerca volvulus		0.0058	0.2947	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.2459	0.577
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0058	0.2947	0.6915
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.4262	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0058	0.2947	0.6915
Trypanosoma cruzi	protein kinase, putative	0.0025	0	0.5
Schistosoma mansoni	GTPase activating protein	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0058	0.2947	0.6915
Loa Loa (eye worm)	SH2 domain-containing protein	0.0033	0.0722	0.0722
Brugia malayi	Tensin	0.0033	0.0722	0.0722
Trichomonas vaginalis	STE family protein kinase	0.0025	0	0.5
Onchocerca volvulus		0.0033	0.0722	0.245
Loa Loa (eye worm)	RNA binding protein	0.0072	0.4262	0.4262
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.2459	0.2459
Entamoeba histolytica	protein kinase, putative	0.0033	0.0722	0.245
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0058	0.2947	0.6915
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0033	0.0722	0.0722
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0058	0.2947	0.6915
Echinococcus granulosus	SH2 domain containing protein 7	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0033	0.0722	0.0722
Leishmania major	hypothetical protein, conserved	0.0025	0	0.5
Loa Loa (eye worm)	STAT protein	0.0033	0.0722	0.0722
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.2947	0.2947
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0058	0.2947	0.6915
Schistosoma mansoni	tensin	0.0033	0.0722	0.1694
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0025	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0058	0.2947	1
Brugia malayi	Protein kinase domain containing protein	0.0058	0.2947	0.2947
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.4262	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0033	0.0722	0.1694
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0033	0.0722	0.0722
Echinococcus multilocularis	tyrosine kinase	0.0058	0.2947	0.6915
Giardia lamblia	Protein 21.1	0.0025	0	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.2459	0.2459
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.2947	0.6915
Brugia malayi	Protein kinase domain containing protein	0.0058	0.2947	0.2947
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0033	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0033	0.0722	0.0722
Toxoplasma gondii	protein kinase	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.2947	0.2947
Brugia malayi	SH2 domain containing protein	0.0033	0.0722	0.0722
Onchocerca volvulus		0.0033	0.0722	0.245
Plasmodium falciparum	protein kinase, putative	0.0025	0	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0033	0.0722	0.1694
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0033	0.0722	0.1694
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0033	0.0722	0.245
Loa Loa (eye worm)	SRC-1	0.0058	0.2947	0.2947
Brugia malayi	Sex muscle abnormal protein 5	0.0033	0.0722	0.0722
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0033	0.0722	0.0722
Trichomonas vaginalis	AGC family protein kinase	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Loa Loa (eye worm)	TK/ABL protein kinase	0.0058	0.2947	0.2947
Toxoplasma gondii	protein kinase domain-containing protein	0.0025	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0058	0.2947	0.6915
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0033	0.0722	0.0722
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.1476	0.1476
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0058	0.2947	0.6915
Brugia malayi	Variant SH3 domain containing protein	0.0033	0.0722	0.0722
Schistosoma mansoni	suppressor of cytokine signaling	0.0033	0.0722	0.1694
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0058	0.2947	0.6915
Onchocerca volvulus		0.0058	0.2947	1
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0033	0.0722	0.0722
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0025	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0025	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0058	0.2947	0.6915
Echinococcus granulosus	signal transduction protein lnk realted	0.0033	0.0722	0.1694
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0033	0.0722	0.1694
Schistosoma mansoni	hypothetical protein	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Brugia malayi	SH2 domain containing protein	0.0033	0.0722	0.0722
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.3188	0.3188
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0072	0.4262	0.4262
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.2947	0.2947
Brugia malayi	hypothetical protein	0.0033	0.0722	0.0722
Loa Loa (eye worm)	TAR-binding protein	0.0072	0.4262	0.4262
Echinococcus multilocularis	SHC transforming protein 3	0.0033	0.0722	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Echinococcus multilocularis	SH2 domain containing protein 7	0.0033	0.0722	0.1694
Trypanosoma brucei	Pseudokinase, putative	0.0025	0	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0058	0.2947	0.6915
Loa Loa (eye worm)	hypothetical protein	0.006	0.3188	0.3188
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus granulosus	expressed conserved protein	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0058	0.2947	0.6915
Brugia malayi	SH2 domain containing protein	0.0058	0.2947	0.2947
Echinococcus multilocularis	signal transduction protein lnk realted	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.2459	0.577
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0058	0.2947	0.6915
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0025	0	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0025	0	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0058	0.2947	0.6915
Schistosoma mansoni	SH2A	0.0033	0.0722	0.1694
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0058	0.2947	0.6915
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.2459	0.577
Brugia malayi	hypothetical protein	0.0058	0.2947	0.2947
Brugia malayi	TAR-binding protein	0.0072	0.4262	0.4262
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.2947	0.6915
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0033	0.0722	0.0722
Echinococcus multilocularis	SH2 motif	0.0033	0.0722	0.1694
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0033	0.0722	0.0722
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Brugia malayi	SH2 domain containing protein	0.0058	0.2947	0.2947
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.4262	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0033	0.0722	0.1694
Echinococcus granulosus	growth factor receptor bound protein 2	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Giardia lamblia	Kinase, NEK	0.0025	0	0.5
Echinococcus multilocularis	SH2 motif	0.0033	0.0722	0.1694
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0025	0	0.5
Schistosoma mansoni	tensin	0.0033	0.0722	0.1694
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.2459	0.577
Onchocerca volvulus		0.0033	0.0722	0.245
Schistosoma mansoni	hypothetical protein	0.0033	0.0722	0.1694
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.2459	0.577
Brugia malayi	SH2 domain containing protein	0.0033	0.0722	0.0722
Onchocerca volvulus		0.0058	0.2947	1
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0058	0.2947	0.6915
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0033	0.0722	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2947	0.2947
Schistosoma mansoni	adapter molecule crk	0.0033	0.0722	0.1694
Echinococcus granulosus	tyrosine protein kinase Blk	0.0058	0.2947	0.6915
Brugia malayi	RhoGAP domain containing protein	0.0033	0.0722	0.0722
Brugia malayi	SRC-1	0.0058	0.2947	0.2947
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0033	0.0722	0.1694
Loa Loa (eye worm)	transcription factor SMAD2	0.0136	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.2947	0.2947
Echinococcus granulosus	NCK adaptor protein	0.0033	0.0722	0.1694
Brugia malayi	SH2 domain containing protein	0.0033	0.0722	0.0722
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0033	0.0722	0.1694
Echinococcus granulosus	tyrosine kinase	0.0058	0.2947	0.6915
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.2947	0.6915
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.2947	0.6915
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.3188	0.3188
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0058	0.2947	0.2947
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0	0.5
Schistosoma mansoni	vav2	0.0033	0.0722	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0722	0.0722
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Plasmodium vivax	protein kinase, putative	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0072	0.4262	1
Brugia malayi	SH2 domain containing protein	0.0033	0.0722	0.0722
Onchocerca volvulus		0.0033	0.0722	0.245
Schistosoma mansoni	hypothetical protein	0.0041	0.1476	0.3463
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.2947	0.6915
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0033	0.0722	0.0722
Giardia lamblia	Kinase, NEK	0.0025	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0025	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0058	0.2947	0.2947
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0058	0.2947	0.6915

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.6234 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2361730

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1750520