Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0452 | 0.4591 | 0.4591 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0114 | 0.0651 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0114 | 0.0652 | 0.0001 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0118 | 0.0694 | 0.0694 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0058 | 0 | 0.5 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0114 | 0.0651 | 0.0651 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0118 | 0.0694 | 0.0046 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0114 | 0.0651 | 0.0651 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0114 | 0.0651 | 1 |
Toxoplasma gondii | AGC kinase | 0.0058 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0452 | 0.4591 | 0.4591 |
Brugia malayi | PXA domain containing protein | 0.0114 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0916 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0651 | 0.0651 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0114 | 0.0651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0651 | 0.0651 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.0652 | 0.0001 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0087 | 0.0329 | 0.5 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0118 | 0.0694 | 0.0053 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0114 | 0.0651 | 0.0651 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0118 | 0.0694 | 0.0046 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0114 | 0.0651 | 0.0651 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0114 | 0.0652 | 0.0001 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0148 | 0.1042 | 0.0488 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0651 | 1 |
Onchocerca volvulus | 0.0148 | 0.1042 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0916 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0114 | 0.0651 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0114 | 0.0652 | 0.0652 |
Echinococcus multilocularis | rho associated protein kinase | 0.0148 | 0.1042 | 0.0488 |
Brugia malayi | PXA domain containing protein | 0.0114 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0802 | 0.8667 | 0.8667 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0802 | 0.8667 | 0.8667 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0114 | 0.0651 | 1 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0114 | 0.0651 | 0.0651 |
Brugia malayi | hypothetical protein | 0.0114 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | RGS-3 protein | 0.0114 | 0.0651 | 0.0651 |
Brugia malayi | hypothetical protein | 0.0114 | 0.0651 | 0.0651 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0802 | 0.8667 | 1 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0114 | 0.0651 | 0.0651 |
Giardia lamblia | Kinase, AGC AKT | 0.0087 | 0.0329 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0114 | 0.0651 | 1 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0114 | 0.0651 | 0.0651 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0802 | 0.8667 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0114 | 0.0651 | 1 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0118 | 0.0694 | 0.0053 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0148 | 0.1042 | 0.0418 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0802 | 0.8667 | 0.8667 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0651 | 1 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0087 | 0.0329 | 0.0329 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.