Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 4 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3285 | 0.3273 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3285 | 0.3273 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3285 | 0.3273 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3285 | 0.3273 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0011 | 0.0164 | 0.0146 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3285 | 0.3273 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3285 | 0.3273 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | dep domain containing protein | 0.0011 | 0.0164 | 0.0499 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 0.0499 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0011 | 0.0164 | 0.0499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | ras GTP exchange factor | 0.0008 | 0.0018 | 0.0054 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0011 | 0.0164 | 0.0499 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 0.0499 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0011 | 0.0164 | 0.0499 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3285 | 1 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0008 | 0.0018 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0164 | 0.0146 | |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0008 | 0.0018 | 0.0054 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0011 | 0.0164 | 0.0146 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0011 | 0.0164 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | DIX domain containing protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3285 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.