TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 482.507 | Formula: C24H27FN6O4
H donors: 1 H acceptors: 5 LogP: 3 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(OC(C)(C)C)Nc1ccccc1n1nnnc1C(C(=O)c1ccc(cc1)F)N1CCOCC1
InChi: 1S/C24H27FN6O4/c1-24(2,3)35-23(33)26-18-6-4-5-7-19(18)31-22(27-28-29-31)20(30-12-14-34-15-13-30)21(32)16-8-10-17(25)11-9-16/h4-11,20H,12-15H2,1-3H3,(H,26,33)
InChiKey: GEKVJDJTMKWJIA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	dro:myosuppressin receptor	0.0115	0.5247	1
Schistosoma mansoni	hypothetical protein	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Brugia malayi	larval opioid receptor	0.0115	0.5247	0.5072
Echinococcus granulosus	rhodopsin orphan GPCR	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Loa Loa (eye worm)	neuropeptide F receptor	0.0115	0.5247	0.5247
Schistosoma mansoni	amine GPCR	0.0115	0.5247	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0115	0.5247	0.5247
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0101	0.4313	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0115	0.5247	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0115	0.5247	1
Echinococcus granulosus	hypothetical protein	0.0115	0.5247	1
Schistosoma mansoni	hypothetical protein	0.0115	0.5247	1
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0062	0.1753	0.5
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0062	0.1753	0.5
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Onchocerca volvulus		0.0115	0.5247	0.5
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Brugia malayi	cytochrome P450	0.0062	0.1753	0.1449
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0115	0.5247	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Brugia malayi	neuropeptide F receptor	0.0115	0.5247	0.5072
Echinococcus multilocularis	serotonin receptor	0.0115	0.5247	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0115	0.5247	1
Brugia malayi	Serotonin receptor	0.0115	0.5247	0.5072
Echinococcus granulosus	rhodopsin orphan GPCR	0.0115	0.5247	1
Schistosoma mansoni	histamine h1 receptor	0.0115	0.5247	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0115	0.5247	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0115	0.5247	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0115	0.5247	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0101	0.4313	0.4313
Brugia malayi	Cytochrome P450 family protein	0.0101	0.4313	0.4103
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0115	0.5247	1
Brugia malayi	Dopamine receptor protein 1	0.0115	0.5247	0.5072
Brugia malayi	GnHR receptor homolog	0.0115	0.5247	0.5072
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus granulosus	neuropeptide receptor A26	0.0115	0.5247	1
Brugia malayi	hypothetical protein	0.0115	0.5247	0.5072
Schistosoma mansoni	neuropeptide receptor	0.0115	0.5247	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0115	0.5247	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0062	0.1753	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0115	0.5247	0.5247
Echinococcus granulosus	tm gpcr rhodopsin	0.0115	0.5247	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0115	0.5247	1
Echinococcus multilocularis	serotonin receptor	0.0115	0.5247	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0115	0.5247	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0115	0.5247	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0115	0.5247	1
Onchocerca volvulus		0.0115	0.5247	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0115	0.5247	0.5
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0062	0.1753	0.5
Echinococcus granulosus	g protein coupled receptor	0.0115	0.5247	1
Onchocerca volvulus		0.0115	0.5247	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.022	0.022
Echinococcus granulosus	fmrfamide receptor	0.0115	0.5247	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0115	0.5247	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0115	0.5247	1
Brugia malayi	Dopamine receptor protein 2	0.0115	0.5247	0.5072
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0115	0.5247	1
Echinococcus multilocularis	g protein coupled receptor	0.0115	0.5247	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus granulosus	sex peptide receptor	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0115	0.5247	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0115	0.5247	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0115	0.5247	1
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0062	0.1753	0.5
Brugia malayi	hypothetical protein	0.0115	0.5247	0.5072
Echinococcus granulosus	neuropeptides capa receptor	0.0115	0.5247	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0115	0.5247	1
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0062	0.1753	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0115	0.5247	0.5247
Loa Loa (eye worm)	G-protein coupled receptor	0.0115	0.5247	0.5247
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0115	0.5247	1
Brugia malayi	hypothetical protein	0.0115	0.5247	0.5072
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus granulosus	biogenic amine 5HT receptor	0.0115	0.5247	1
Echinococcus granulosus	neuropeptide Y receptor	0.0115	0.5247	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0179	0.5
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0041	0.0356	0.0356
Echinococcus granulosus	neuropeptide receptor	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Onchocerca volvulus		0.0115	0.5247	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0115	0.5247	1
Brugia malayi	hypothetical protein	0.0115	0.5247	0.5072
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0115	0.5247	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus granulosus	neuropeptide receptor	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Schistosoma mansoni	opsin-like receptor	0.0115	0.5247	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0115	0.5247	1
Onchocerca volvulus		0.0115	0.5247	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0115	0.5247	1
Echinococcus multilocularis	somatostatin receptor	0.0115	0.5247	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0115	0.5247	1
Onchocerca volvulus		0.0115	0.5247	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0115	0.5247	1
Schistosoma mansoni	neuropeptide receptor	0.0115	0.5247	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0115	0.5247	1
Onchocerca volvulus		0.0115	0.5247	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0062	0.1753	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0115	0.5247	1
Schistosoma mansoni	hypothetical protein	0.0062	0.1753	0.2476
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0115	0.5247	1
Brugia malayi	G protein-coupled receptor	0.0115	0.5247	0.5072
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus granulosus	G protein coupled receptor 139	0.0115	0.5247	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus granulosus	tm gpcr rhodopsin	0.0115	0.5247	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0115	0.5247	1
Onchocerca volvulus		0.0115	0.5247	0.5
Echinococcus granulosus	serotonin receptor	0.0115	0.5247	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0115	0.5247	1
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0062	0.1753	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0062	0.1753	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Brugia malayi	putative neuropeptide receptor NPR1	0.0115	0.5247	0.5072
Brugia malayi	Melatonin receptor type 1A	0.0115	0.5247	0.5072
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0115	0.5247	0.5247
Onchocerca volvulus		0.0115	0.5247	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0115	0.5247	0.5072
Echinococcus granulosus	cytochrome P450 2K1	0.0062	0.1753	0.2857
Brugia malayi	G-protein coupled receptor	0.0115	0.5247	0.5072
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0062	0.1753	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0115	0.5247	0.5072
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0115	0.5247	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0115	0.5247	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0115	0.5247	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus multilocularis	g protein coupled receptor	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0062	0.1753	0.5
Echinococcus multilocularis	sex peptide receptor	0.0115	0.5247	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0115	0.5247	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0115	0.5247	1
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0062	0.1753	0.5
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0115	0.5247	1
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0062	0.1753	0.5
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus multilocularis	neuropeptide s receptor	0.0115	0.5247	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0179	0.5
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Brugia malayi	hypothetical protein	0.0115	0.5247	0.5072
Brugia malayi	hypothetical protein	0.0115	0.5247	0.5072
Brugia malayi	hypothetical protein	0.0115	0.5247	0.5072
Schistosoma mansoni	cytochrome P450	0.0062	0.1753	0.2476
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0115	0.5247	1
Onchocerca volvulus		0.0115	0.5247	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Brugia malayi	hypothetical protein	0.0115	0.5247	0.5072
Schistosoma mansoni	amine GPCR	0.0115	0.5247	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0115	0.5247	0.5247
Brugia malayi	neuropeptide F receptor	0.0115	0.5247	0.5072
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Loa Loa (eye worm)	TYRA-2 protein	0.0115	0.5247	0.5247
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0115	0.5247	1
Brugia malayi	hypothetical protein	0.0115	0.5247	0.5072
Schistosoma mansoni	biogenic amine receptor	0.0115	0.5247	1
Brugia malayi	follicle stimulating hormone receptor	0.0115	0.5247	0.5072
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0115	0.5247	0.5072
Echinococcus granulosus	allatostatin A receptor	0.0115	0.5247	1
Brugia malayi	Dopamine receptor	0.0115	0.5247	0.5072
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus granulosus	orexin receptor type 2	0.0115	0.5247	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0115	0.5247	1
Onchocerca volvulus		0.0115	0.5247	0.5
Onchocerca volvulus		0.0115	0.5247	0.5
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0062	0.1753	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0101	0.4313	1
Schistosoma mansoni	amine GPCR	0.0115	0.5247	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus multilocularis	G protein coupled receptor 139	0.0115	0.5247	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0115	0.5247	0.5072
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0115	0.5247	0.5247
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0062	0.1753	0.5
Schistosoma mansoni	hypothetical protein	0.0115	0.5247	1
Schistosoma mansoni	biogenic amine receptor	0.0115	0.5247	1
Mycobacterium leprae	putative cytochrome p450	0.0062	0.1753	0.5
Echinococcus multilocularis		0.0062	0.1753	0.2857
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0115	0.5247	1
Brugia malayi	G-protein coupled receptor	0.0115	0.5247	0.5072
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0115	0.5247	1
Schistosoma mansoni	hypothetical protein	0.0115	0.5247	1
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0062	0.1753	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0115	0.5247	1
Schistosoma mansoni	amine GPCR	0.0115	0.5247	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0115	0.5247	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0187	1	1
Brugia malayi	sulfakinin receptor protein	0.0115	0.5247	0.5072
Schistosoma mansoni	neuropeptide receptor	0.0115	0.5247	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Loa Loa (eye worm)	cytochrome P450 family protein	0.0101	0.4313	0.4313
Echinococcus granulosus	biogenic amine 5HT receptor	0.0115	0.5247	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0115	0.5247	0.5072
Trypanosoma cruzi	cytochrome P450, putative	0.0101	0.4313	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0115	0.5247	0.5072
Echinococcus multilocularis	allatostatin A receptor	0.0115	0.5247	1
Brugia malayi	RE15519p	0.0115	0.5247	0.5072
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0115	0.5247	1
Echinococcus multilocularis	fmrfamide receptor	0.0115	0.5247	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0115	0.5247	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0115	0.5247	1
Echinococcus multilocularis	neuropeptide receptor	0.0115	0.5247	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0115	0.5247	0.5247
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0062	0.1753	0.5
Schistosoma mansoni	myosin xvIII	0.0115	0.5247	1
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0062	0.1753	0.5
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Schistosoma mansoni	opsin-like receptor	0.0115	0.5247	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0115	0.5247	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0115	0.5247	1
Echinococcus granulosus	neuropeptides capa receptor	0.0115	0.5247	1
Echinococcus multilocularis	fmrfamide receptor	0.0115	0.5247	1
Trypanosoma brucei	cytochrome P450, putative	0.0101	0.4313	1
Schistosoma mansoni	amine GPCR	0.0115	0.5247	1
Echinococcus multilocularis	g-protein coupled receptor	0.0115	0.5247	1
Brugia malayi	AKH receptor	0.0115	0.5247	0.5072
Echinococcus granulosus	g-protein coupled receptor	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0115	0.5247	1
Brugia malayi	ORL1-like opioid receptor	0.0115	0.5247	0.5072
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0062	0.1753	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0115	0.5247	0.5247
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus granulosus	g protein coupled receptor	0.0115	0.5247	1
Loa Loa (eye worm)	cytochrome P450	0.0062	0.1753	0.1753
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0115	0.5247	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0115	0.5247	1
Echinococcus granulosus	somatostatin receptor	0.0115	0.5247	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0115	0.5247	1
Schistosoma mansoni	opsin-like receptor	0.0115	0.5247	1
Echinococcus multilocularis	g protein coupled receptor	0.0115	0.5247	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0115	0.5247	0.5072
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0115	0.5247	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0115	0.5247	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0115	0.5247	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0062	0.1753	0.5
Onchocerca volvulus		0.0115	0.5247	0.5
Brugia malayi	putative neuropeptide receptor	0.0115	0.5247	0.5072
Echinococcus multilocularis	orexin receptor type 2	0.0115	0.5247	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0115	0.5247	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0115	0.5247	1
Schistosoma mansoni	biogenic amine receptor	0.0115	0.5247	1
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0062	0.1753	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus granulosus	neuropeptide Y receptor	0.0115	0.5247	1
Schistosoma mansoni	neuropeptide receptor	0.0115	0.5247	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0115	0.5247	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Onchocerca volvulus		0.0115	0.5247	0.5
Brugia malayi	Cytochrome P450 family protein	0.0062	0.1753	0.1449
Onchocerca volvulus		0.0115	0.5247	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0115	0.5247	1
Brugia malayi	Serotonin receptor	0.0115	0.5247	0.5072
Schistosoma mansoni	adenoreceptor	0.0115	0.5247	1
Brugia malayi	hypothetical protein	0.0115	0.5247	0.5072
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0115	0.5247	1
Loa Loa (eye worm)	CYP4Cod1	0.0101	0.4313	0.4313
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus granulosus	g protein coupled receptor	0.0115	0.5247	1
Brugia malayi	Cytochrome P450 family protein	0.0101	0.4313	0.4103
Onchocerca volvulus		0.0115	0.5247	0.5
Onchocerca volvulus		0.0115	0.5247	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0115	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5247	0.5247
Echinococcus multilocularis	dro:myosuppressin receptor	0.0115	0.5247	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0115	0.5247	1
Mycobacterium leprae	Conserved hypothetical protein	0.0062	0.1753	0.5
Leishmania major	cytochrome p450-like protein	0.0101	0.4313	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2362864

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1750933