TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 400.47 | Formula: C25H24N2O3
H donors: 0 H acceptors: 2 LogP: 5.93 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)C)Cc1c(nc2n1cc(cc2)C(=O)OC)c1ccc(cc1)C
InChi: 1S/C25H24N2O3/c1-16-5-7-18(8-6-16)24-22(14-19-9-11-21(29-3)13-17(19)2)27-15-20(25(28)30-4)10-12-23(27)26-24/h5-13,15H,14H2,1-4H3
InChiKey: QZAALZFUKGZKNS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0407	0.3977	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0407	0.3977	1
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0	0.5
Loa Loa (eye worm)	STAT protein	0.0248	0.1439	0.1439
Toxoplasma gondii	protein kinase	0.0158	0	0.5
Onchocerca volvulus		0.0407	0.3977	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0407	0.3977	0.3977
Schistosoma mansoni	adapter molecule crk	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Schistosoma mansoni	tensin	0.0248	0.1439	0.3619
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0158	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0407	0.3977	1
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0248	0.1439	0.1439
Leishmania major	protein kinase, putative	0.0158	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0407	0.3977	0.3977
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0	0.5
Giardia lamblia	Kinase, NEK	0.0158	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0158	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0407	0.3977	1
Echinococcus multilocularis	NCK adaptor protein	0.0248	0.1439	0.3619
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0248	0.1439	0.3619
Loa Loa (eye worm)	TK/FER protein kinase	0.0407	0.3977	0.3977
Echinococcus multilocularis	serotonin receptor	0.0196	0.0599	0.1506
Loa Loa (eye worm)	hypothetical protein	0.0407	0.3977	0.3977
Onchocerca volvulus		0.0407	0.3977	1
Plasmodium falciparum	protein kinase, putative	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Onchocerca volvulus		0.0407	0.3977	1
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Loa Loa (eye worm)	TK protein kinase	0.0407	0.3977	0.3977
Plasmodium vivax	protein kinase, putative	0.0158	0	0.5
Echinococcus multilocularis	tyrosine kinase	0.0407	0.3977	1
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0407	0.3977	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0407	0.3977	0.3977
Loa Loa (eye worm)	TK/FER protein kinase	0.0407	0.3977	0.3977
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Echinococcus granulosus	NCK adaptor protein	0.0248	0.1439	0.3619
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0248	0.1439	0.3619
Echinococcus granulosus	biogenic amine 5HT receptor	0.0196	0.0599	0.1506
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Schistosoma mansoni	nck2/grb4	0.0248	0.1439	0.3619
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0158	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.0248	0.1439	0.3619
Echinococcus multilocularis	tensin	0.0248	0.1439	0.3619
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0248	0.1439	0.3619
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Onchocerca volvulus		0.0248	0.1439	0.3619
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0248	0.1439	0.3619
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0407	0.3977	1
Brugia malayi	SH2 domain containing protein	0.0248	0.1439	0.1439
Onchocerca volvulus		0.0407	0.3977	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0248	0.1439	0.3619
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0407	0.3977	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0248	0.1439	0.3619
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0158	0	0.5
Echinococcus multilocularis	SH2 motif	0.0248	0.1439	0.3619
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0158	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0407	0.3977	1
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Giardia lamblia	Protein 21.1	0.0158	0	0.5
Brugia malayi	SH2 domain containing protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0248	0.1439	0.3619
Schistosoma mansoni	tensin	0.0248	0.1439	0.3619
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0407	0.3977	1
Loa Loa (eye worm)	hypothetical protein	0.0196	0.0599	0.0599
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0248	0.1439	0.3619
Schistosoma mansoni	tyrosine kinase	0.0407	0.3977	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0407	0.3977	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0407	0.3977	0.3977
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0407	0.3977	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0407	0.3977	1
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0248	0.1439	0.3619
Echinococcus granulosus	tyrosine protein kinase shark	0.0407	0.3977	1
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Brugia malayi	SH2 domain containing protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0407	0.3977	1
Brugia malayi	SH2 domain containing protein	0.0407	0.3977	0.3977
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0158	0	0.5
Echinococcus granulosus	hypothetical protein	0.0248	0.1439	0.3619
Brugia malayi	Protein kinase domain containing protein	0.0407	0.3977	0.3977
Onchocerca volvulus		0.0248	0.1439	0.3619
Onchocerca volvulus		0.0407	0.3977	1
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trypanosoma brucei	protein kinase, putative	0.0158	0	0.5
Echinococcus multilocularis	N chimaerin	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Leishmania major	hypothetical protein, conserved	0.0158	0	0.5
Brugia malayi	SH2 domain containing protein	0.0248	0.1439	0.1439
Echinococcus granulosus	N chimaerin	0.0248	0.1439	0.3619
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Echinococcus granulosus	SH2 domain containing protein 7	0.0248	0.1439	0.3619
Trypanosoma cruzi	protein kinase, putative	0.0158	0	0.5
Echinococcus granulosus	expressed conserved protein	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0407	0.3977	0.3977
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0407	0.3977	1
Brugia malayi	Variant SH3 domain containing protein	0.0248	0.1439	0.1439
Echinococcus granulosus	growth factor receptor bound protein 2	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0158	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0407	0.3977	0.3977
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0248	0.1439	0.3619
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Leishmania major	protein kinase, putative	0.0158	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0407	0.3977	1
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0407	0.3977	0.3977
Loa Loa (eye worm)	TK/FER protein kinase	0.0407	0.3977	0.3977
Schistosoma mansoni	tyrosine kinase	0.0407	0.3977	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0158	0	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0248	0.1439	0.3619
Brugia malayi	protein-tyrosine kinase	0.0407	0.3977	0.3977
Trichomonas vaginalis	protein kinase atn1, putative	0.0158	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0248	0.1439	0.3619
Echinococcus granulosus	SH2 motif	0.0248	0.1439	0.3619
Plasmodium falciparum	tyrosine kinase-like protein	0.0158	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0248	0.1439	0.1439
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0407	0.3977	1
Schistosoma mansoni	tensin-related	0.0248	0.1439	0.3619
Echinococcus granulosus	SH2 motif	0.0248	0.1439	0.3619
Brugia malayi	hypothetical protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0158	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Brugia malayi	SH2 domain containing protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0407	0.3977	1
Onchocerca volvulus		0.0407	0.3977	1
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0407	0.3977	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Toxoplasma gondii	STE kinase	0.0158	0	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus granulosus	tensin	0.0248	0.1439	0.3619
Brugia malayi	Protein kinase domain containing protein	0.0407	0.3977	0.3977
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0248	0.1439	0.3619
Echinococcus granulosus	tyrosine protein kinase Srms	0.0407	0.3977	1
Brugia malayi	Protein kinase domain containing protein	0.0407	0.3977	0.3977
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0248	0.1439	0.3619
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0407	0.3977	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0407	0.3977	0.3977
Schistosoma mansoni	tyrosine kinase	0.0407	0.3977	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0158	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0158	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0407	0.3977	1
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0407	0.3977	1
Trichomonas vaginalis	STE family protein kinase	0.0158	0	0.5
Brugia malayi	Tensin	0.0248	0.1439	0.1439
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0248	0.1439	0.3619
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0407	0.3977	1
Schistosoma mansoni	vav2	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Giardia lamblia	Kinase, NEK	0.0158	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0407	0.3977	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0248	0.1439	0.1439
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0407	0.3977	1
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0407	0.3977	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0248	0.1439	0.3619
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0248	0.1439	0.1439
Echinococcus multilocularis	SH2 motif	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0196	0.0599	0.1506
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0158	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0407	0.3977	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0248	0.1439	0.3619
Brugia malayi	Variant SH3 domain containing protein	0.0248	0.1439	0.1439
Brugia malayi	Protein kinase domain containing protein	0.0407	0.3977	0.3977
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0248	0.1439	0.3619
Loa Loa (eye worm)	TK/FER protein kinase	0.0407	0.3977	0.3977
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0407	0.3977	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0407	0.3977	1
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0248	0.1439	0.3619
Schistosoma mansoni	GTPase activating protein	0.0248	0.1439	0.3619
Schistosoma mansoni	SH2A	0.0248	0.1439	0.3619
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0158	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0407	0.3977	1
Loa Loa (eye worm)	SRC-1	0.0407	0.3977	0.3977
Loa Loa (eye worm)	hypothetical protein	0.0196	0.0599	0.0599
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0407	0.3977	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0248	0.1439	0.3619
Onchocerca volvulus		0.0248	0.1439	0.3619
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0248	0.1439	0.3619
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0248	0.1439	0.3619
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0407	0.3977	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0248	0.1439	0.1439
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0407	0.3977	1
Trypanosoma brucei	Pseudokinase, putative	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0248	0.1439	0.3619
Onchocerca volvulus		0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0158	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0248	0.1439	0.1439
Onchocerca volvulus		0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Brugia malayi	hypothetical protein	0.0407	0.3977	0.3977
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0407	0.3977	1
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1439	0.1439
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0248	0.1439	0.1439
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0248	0.1439	0.1439
Schistosoma mansoni	hypothetical protein	0.0248	0.1439	0.3619
Brugia malayi	SH2 domain containing protein	0.0248	0.1439	0.1439
Onchocerca volvulus		0.0248	0.1439	0.3619
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0248	0.1439	0.1439
Brugia malayi	SRC-1	0.0407	0.3977	0.3977
Brugia malayi	Variant SH3 domain containing protein	0.0248	0.1439	0.1439
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0248	0.1439	0.3619
Schistosoma mansoni	tyrosine kinase	0.0407	0.3977	1
Brugia malayi	Sex muscle abnormal protein 5	0.0248	0.1439	0.1439
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0248	0.1439	0.1439
Loa Loa (eye worm)	TK/FER protein kinase	0.0407	0.3977	0.3977
Schistosoma mansoni	hypothetical protein	0.0248	0.1439	0.3619
Plasmodium falciparum	tyrosine kinase-like protein	0.0158	0	0.5
Echinococcus multilocularis	tensin	0.0248	0.1439	0.3619
Brugia malayi	RhoGAP domain containing protein	0.0248	0.1439	0.1439
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0407	0.3977	1
Echinococcus multilocularis	SH2 motif	0.0248	0.1439	0.3619
Giardia lamblia	Kinase	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Brugia malayi	SH2 domain containing protein	0.0248	0.1439	0.1439
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0248	0.1439	0.3619
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0407	0.3977	1
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Brugia malayi	SH2 domain containing protein	0.0407	0.3977	0.3977
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0248	0.1439	0.3619
Echinococcus multilocularis		0.0248	0.1439	0.3619
Echinococcus granulosus	c src tyrosine kinase	0.0407	0.3977	1
Entamoeba histolytica	SH2 domain containing protein	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0407	0.3977	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0248	0.1439	0.1439
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0158	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0158	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Schistosoma mansoni	tensin	0.0248	0.1439	0.3619
Trichomonas vaginalis	TK family protein kinase	0.0158	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Schistosoma mansoni	tensin-related	0.0248	0.1439	0.3619
Schistosoma mansoni	shc transforming protein	0.0248	0.1439	0.3619
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0158	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0783	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0196	0.0599	0.1506
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0248	0.1439	0.1439
Plasmodium falciparum	protein kinase, putative	0.0158	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0407	0.3977	1
Trichomonas vaginalis	TKL family protein kinase	0.0158	0	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2361053

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1751398